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1,3,5-Trimethoxybenzene is used for the analysis of drugs in human serum and as a precursor to pharmaceuticals. It is also used as a reagent in organic synthesis. Trimethyl 1,3,5-trimethoxybenzene reacts with nitrite ion to produce an unstable intermediate that undergoes hydrolysis to form trifluoroacetic acid and hydrogen gas. The reaction mechanism involves an intramolecular hydrogen transfer from the hydroxyl group of the methoxy benzene ring to the methyl group on carbon 3. This leads to formation of a highly reactive trimethyl cation that abstracts hydrogen from water or hydroxyl groups on nearby molecules and eventually undergoes hydrolysis to produce trifluoroacetic acid and hydrogen gas.

Applications 2-Hydroxy-4,6-dimethoxybenzoic acid is a reagent used in the synthesis of rac Zearalenone-d6 (Z270502). rac Zearalenone-d6 s an estrogenic mycotoxin produced by Fusarium fungi commonly found in grains. One of a group of compounds known as resorcylic acid lactones.
References Tanaka, T., et al.: J. Agric. Food Chem., 36, 979 (1988), Hamilton, S., et al.: Anticancer Res., 16, 3597 (1996), Hecht, S., et al.: Cancer Lett., 150, 49 (2000), Hussein, H., et al.: Toxicology, 167, 101 (2001), Lim, H., et al.: J. Immunol., 175, 4180 (2005),

1-Hydroxy-2,3-dimethylbenzene (1,2-DMB) is a chemical compound that is used as an industrial catalyst. It has been shown to be an efficient catalyst for the treatment of wastewater, and has been studied in the removal of nitrogen from industrial gases. 1,2-DMB has also been found to be active against bacteria such as Pseudomonas aeruginosa and Staphylococcus aureus. This compound reacts with copper ions to form an organometallic complex, which then reacts with trifluoroacetic acid in an organic solution to form an aldehyde group.

Stability Light Sensitive
Applications p-Toluenesulfonyl Hydrazide is a reactant that has been used in the synthesis of paspaline.
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References Sharpe, R.J., Johnson, J.S.: J. Am. Chem. Soc., 137, 4968 (2015)