Phénols

Brevifolincarboxylic acid shows moderate antibacterial activity against Salmonella enteritidis , Salmonella typhimurium , and Salmonella abony, it (IC50 = 18.0 uM) also shows good antioxidant activity. Brevifolincarboxylic acid shows marked inhibitory effects on aryl hydrocarbon receptor -based bioassay activation by TCDD, and its effect is dose dependent.

Aflatoxin G1 (AFG1 ),cytotoxic and carcinogenic, could cause DNA damage in alveolar type II (AT-II) cells and induce lung adenocarcinoma.

Gingerenone A, an Nrf2-Gpx4 activator isolated from ginger, has anticancer activity and inhibits iron death in mice with colitis secondary to liver injury (SLI)

m-Tyramine hydrobromide (3-(2-aminoethyl)phenol hydrobromide) is a dopamine derivative that acts by releasing newly synthesized catecholamines or 5-HT.

Cis-Vitisin B is a hydroxystilbene analog found in the roots of the plant Kyohou.

Gallic Acid Monohydrate, a natural polyhydroxyphenol, which inhibits the free radical scavenging effect of COX-2,antioxidant, anti-tumor, and antibacterial.

Rhaponticin(Rhaponiticin) has a noticeable antidiabetic effect and could be potentially used as a new agent to treat type 2 diabetes mellitus and its complications, it can alleviate liver steatosis and improve blood glucose and lipid profiles in KK/Ay diabetic mice.

Lasalocid (Lasalocid-A) is an ion carrier antibiotic produced by Streptomyces, which has antimicrobial and parasitic properties and is often added to feed.

Prim-O-glucosylcimifugin is main medicinal component of the traditional Chinese drug Saposhnikovia divaricata, can increase concentrations of astragaloside IV and atractylenolide I in the serum, when they were given together.

Rhapontigenin has antioxidative, antihyperlipidemic, antifungal and anticancer activities. Rhapontigenin inhibits HIF-1α accumulation and angiogenesis in PC-3 prostate cancer cells, suppresses breast cancer cell migration and invasion, which is involved in inhibiting the PI3K-dependent Rac1 signaling pathway. Rhapontigenin exhibits dose-dependent inhibition of tyrosinase activity and melanin synthesis in B16F10 melanoma cells.

Hericenone C (Hericium erinaceus ketone C) is a natural product and α-glucosidase inhibitor, which can be used for biochemical experiments and drug synthesis.

Bakuchiol is isolated from the seeds of Psoralea corylifolia, a tree native to China with various uses in traditional medicine, it shows bactericidal effects against all bacteria tested, including S. mutans, Streptococcus sanguis, Streptococcus salivarius, Streptococcus sobrinus, Enterococcus faecalis, Enterococcus faecium, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus plantarum, Actinomyces viscosus, and Porphyromonas gingivalis, with MICs ranging from 1 to 4 microg/ml and the sterilizing concentration for 15 min ranging from 5 to 20 microg/ml; furthermore, bakuchiol is also effective against adherent cells of S. mutans in water-insoluble glucan in the presence of sucrose and inhibited the reduction of pH in the broth; thus, bakuchiol would be a useful compound for development of antibacterial agents against oral pathogens and has great potential for use in food additives and mouthwash for preventing and treating dental caries.

Alnustone has anti-inflammatory, antihepatotoxic and antiemetic activities,

3,5-Dihydroxyacetophenone is an endogenous metabolite widely used in biochemical experiments and drug synthesis research.

Curculigoside has potent antioxidant, anti-osteoporotic, immunomodulatory, and neuroprotective effects. Curculigoside can improve cognitive function in aged animals, possibly by decreasing the activity of AchE in the cerebra and inhibiting the expression of BACE1 in the hippocampus. Curculigoside exhibits potent inhibitory activity against matrix metalloproteinase-1 in cultured human skin fibroblasts, and increases the levels of ALP and Runx2 in osteoblasts under oxidative stress via anti-oxidative character.

3-Ethylphenol exhibits ciliate toxicity and inhibits Tetrahymena pyriformis, and is widely used in biochemical experiments and drug synthesis research.

Paeonol , the main active compound of the traditionally used Chinese herb Paeonia lactiflora Pallas, has anti-inflammatory, antioxidant and cardiovascular protective activities;Paeonol inhibits U937 monocyte adhesion to HUVECs stimulated by TNF-α, the inhibitory effect of paeonol on ICAM-1 production may be mediated by inhibiting p38, ERK and NF-κB signaling pathways, which are involved in TNF-α-induced ICAM-1 production, thus, paeonol may be beneficial in the treatment of cardiovascular disorders such as atherosclerosis.