Mesalamine et Impuretés

<p>Applications N-Acetyl Mesalazine-d3 is the labeled analogue of N-Acetyl Mesalazine (A168320), a metabolite of Mesalazine. A Salicylic Acid derivative. Inhibitor of recombinant human thiopurine methyltransferase (hTPMT).<br>References Bondesen, S., et al.: Br. J. Clin. Pharmacol., 25, 269 (1988); Brogden, R., et al.: Drugs, 38, 500 (1989); Jensen, J., et al.: Biochem. Pharmacol., 45, 1201 (1993); Liu, Z., et al.: Drug Metab. Dispos., 23, 246 (1995); Vree, T., et al.: Clin. Drug Invest., 20, 35 (2000)<br></p>

<p>Stability Hygroscopic<br>Applications 5-[2-Formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]-2-hydroxybenzoic Acid, is used for the synthesis of (-)-Funebrine, and (-)-Funebral, a unique pyrrole alkaloids isolated from flowers in Mexico, having therapeutic properties.<br>References Tamura, O., et al.: J. Org. Chem., 69, 1475 (2004);<br></p>

<p>Impurity Mesalazine EP Impurity R<br>Applications A nitrohumic acid which has been shown to bind to Molybdenum to impart fertility to soil and water and is a key element in the activity of nitrogenase.<br>References Merce, A.R. et al.: J Braz. Chem. Soc., 17, 482 (2006); Silverman, F.P. et al.: J. Agric. Food Chem., 53, 9775 (2005);<br></p>

<p>Impurity Mesalazine EP Impurity E<br>Stability Hygroscopic<br>Applications 4-Aminosalicylic Acid is an antibiotic used to treat tuberculosis.<br>References Horita, Y., et al.: Bioorg. Med. Chem. Lett., 19, 6313 (2009); Martins, M., et al.: J. Biol. Chem., 284, 18726 (2009); Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010);<br></p>

<p>Impurity Paracetamol EP Impurity K/ Mesalazine EP Impurity A<br>Stability Hygroscopic<br>Applications 4-Aminophenol is a nephrotoxic metabolite of Acetaminophen (A161220) and Phenacetin (P294580) (1). It is also used as a N-formylating agent for solvent-and catalyst-free N-formylations of amines at ambient condition (2).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Watanabe, et al.: Drug Metab. Dispos., 38, 1532 (2010)(2) Batuta, S. and Begum, N. A. Synth. Commun. 47, 137-147 (2017)<br></p>

<p>Impurity Mesalazine EP Impurity N<br>Applications 5-Nitrosalicylic Acid is a salicylic acid derivative with anti-inflammatory effect against colitis.<br>References Kim, J.H., et al.: Euro. J. Med. Chem., 48, 36 (2012);<br></p>

<p>Impurity Mesalazine EP Impurity G<br>Applications 2,5-Dihydroxybenzoic Acid is an active metabolite of salicylic acid degradation. Evidence indicates that gentisic acid has anti-inflammatory, antirheumatic and antioxidant properties. It is also a byproduct of both tyrosine and benzoate metabolisms.<br>References Helbig, D., et al.: Brit. J. Nut., 102, 554 (2009), Zhang, M., et al.: J. Food Sci., 74, C441 (2009), Hara, S., et al.: Toxicol., 262, 271 (2009), Lee, S., et al.: J. Enz. Inhibit. Med. Chem., 24, 957 (2009),<br></p>

<p>Mesalamine impurity S is a mesalamine metabolite that has been identified as an impurity in the drug product. Mesalamine impurity S is an analytical standard that is used for HPLC analysis and can be used as a reference material for the pharmacopoeia. Mesalamine impurity S can also be synthesized from natural or synthetic sources.</p>