Étalons pharmaceutiques

Applications A metabolite of Rosiglitazone.
References Balton, G.C., et al.: Xenobiotica, 26, 6, 627 (1996), Kim, K., et al.: J. Clin. Pharmacol., 45, 941 (2005), Kirchheiner, J., et al.: Clin. Pharmacol. Ther., 80, 657 (2006), O'Maille, G., et al.: J. Pharm. Biomed. Anal., 48, 934 (2008),

Applications An optically active metabolite of Tramadol.
References Garrido, M., et al.: J. Pharmacol. Exp. Ther., 305, 710 (2003), Pedersen, R., et al.: Eur. J. Clin. Pharmacol., 62, 513 (2006),

Impurity Beclomethasone Dipropionate EP Impurity I
Applications (16β)-16-Methyl-17,21-bis(1-oxopropoxy)pregna-1,4,9(11)-triene-3,20-dione (Beclomethasone Dipropionate EP Impurity I) is an impurity of Beclomethasone (B131000), a glucocorticoid. Used in chronic asthma and allergic rhinitis. Antiallergic, antiasthmatic (inhalant). Anti-inflammatory (topical).
References Malfitan, V.A., et al.: Clin. Ther., 4, 472 (1982), Rao, M., et al.: J. Asthma, 19, 21 (1982), Small, P., et al.: Ann. Allergy, 49, 127 (1982), Brogden, R.N., et al.: Drugs, 28, 99 (1984),

Applications α-Cholesterol-d6 is labelled α-Cholesterol which is a stereoisomer of Cholesterol (C432501), a major component of all biological membranes and the principal sterol of the higher animals.
References Rosin, Z., et al.: Physiol. Chem., 124, 282 (1923), Schoenheimer, et al.: J. Biol. Chem., 105, 355 (1934), Gemant, et al.: Life Sci., 1, 233 (1962), Johnson, K., et al.: 4, 457 (1964),

Applications Bivalirudin 1-11 Fragment is an impurity of Bivalirudin, a direct thrombin inhibitor acting as an anticoagulant through inhibition of the enzyme thrombin.
References Bertrand, O. et al.: Am. J. Cardio., 110, 599 (2012); Patti, G. et al.: Am. J. Cardio., 110, 478 (2012)

Applications [2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium Hydroxide is a reagent in the synthesis of PVA/SBMA crosslinked hydrogels used in tissue mimicking, vascular cell culturing and implanting. For use in soft-tissue surgery and keeping it minimally invasive.
References Jian, S. et al.: J. Mech. Bwhav. Biomed. Mat., 4, 1228 (2011); Xu, S. et al.: Ann. Tech. Conf. Soc. Plastics Emg., 71, 1032 (2013);

Applications Aluminum Glycinate is an antacid which is used in the treatment of peptic ulceration. It is used in the development of a transdermal hydrogel patch for ferulic acid to treat skin damage induced by UV radiation.
References Rice, M., et al.: Am. J. Gastroenterol., 25, 74 (1956); Bai, J., et al.: Pak. J. Pharm Sci., 27, 369 (2014);

Applications The R-enantiomer of Baclofen (B108000) metabolite.

Applications 9-Bromononanoic Acid is an intermediate in synthesizing Rumenic Acid (R701590), a trans fatty acid that may potentially reduce the risk of cancer and cardiovascular diseases. It may also prevent disease processes that lead to chronic inflammation, atherosclerosis, and diabetes.
References Baer, D. J.: Am J Clin Nutr 95, 267 (2012); Gebauer, S. K., et al.:  Adv Nutr 2, 332 (2011); Duffy, P. E., et al.: Tetrahedron 62, 4838 (2006)

Applications Dihydronaftazone-d4 O-β-D-Glucuronide is labelled Dihydronaftazone O-β-D-Glucuronide (D450330) which is a metabolite of Naftazone (N359270) which is a novel anti-anflammatory agent as well as an anti-proliferative agent due to its 1,2-napthoquinone substructure.
References Marrero-Ponce, Y. et al.: Eur. J. Med. Chem., 46, 5736 (2011)

Applications N-Substituted picolinamides as drowsiness-free central muscle relaxants.
References Takahashi, H., et al.: Bioorg. Med. Chem. Lett., 19, 5436 (2009),

Applications Intermediate in the preparation of Azasetron.
References Kawakita, T., et al.: Chem. Pharm. Bull., 40, 624 (1992),

Applications A derivative of 1-Adamantanecarboxylic Acid.