Étalons pharmaceutiques

Applications An intermediate for the prepararion of 1-Hydroxypyrene β-D-Glucuronide, a metabolite of 1-Hydroxypyrene.

Applications 6-Chloro-2-cyclohexyl-2,3-dihydro-1,3-dioxo-1H-isoindole-5-sulfonamide is an intermediate in the synthesis of Chlorexolone (C327080), a sulfonamide based antibiotic.

Applications Indoxacarb is an oxadiazine pesticide that acts against lepidopteran larvae and is the active ingredient in a number of household insecticides including cockroach baits.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, H., et al.: Water. Sci. Technol., 61, 2733 (2010); Shono, T., et al.: Pesticide. Biochem. Physiol., 75, 1 (2003);

Applications 2,6-Dimethoxybenzoyl Chloride is used in the synthesis of penicillins and cephalosporins.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Newall, C. et al.: Comp. Med. Chem., 2, 609 (1990); Kanao, M. et al.: J. Med. Chem., 25, 1358 (1982);

Applications N-Isopropyl-3,4-dimethyl-2,6-dinitroaniline is a dinitro herbicides.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chen, Y., et al.: Green Chemistry, 15, 91 (2013)

Applications A reactant used in the preparation of Liraglutide, a GLP-1R agonist.

Applications ((2R,5S)-5-(4-Amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate is an impurity of Emtricitabine (E525000), a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).
References FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. InfecSchinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: . Dis., 182, 599 (2000)

Applications rac cis-Paroxetine N-Methyl is an impurity formed in the synthesis Paroxetine (P205750) related compounds.
References Gangula, S., et al.: Syn. Commun., 42, 3344 (2012);

Applications 7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-[(carboxymethoxy)imino]acetyl]amino]-cefixime is a cefixime impurity. Cefixime (C242800) is an orally active, third generation cephalosporin antibiotic.
References Kamimura, T., et al.: Antimicrob. Agents Chemother., 25, 98 (1984),Yamanaka, H., et al.: J. Antibiot., 38, 1738 (1985), Guay, D.R.P., et al.: Antimicrob. Agents Chemother., 30, 485 (1986),

Applications Oleoyl-L-carnitine-d3 is labelled Oleoyl-L-carnitine (O526700, HCl salt), a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Oleoyl-L-carnitine can be diagnostic for a number of ß-oxidation defects.
References Adams, S., et al.: J. Nutrition, 139, 1073 (2009); Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)

Applications 3-Acetyl-1-Boc-pyrrolidine is a boc protected reagent that is used for selective inhibitors of H. influenzae TrmD that mimic tRNA interaction by inducing TrmD lid domain ordering.
References Hill, P.J., et al.: J. Med. Chem., 56, 7278 (2013);

Applications 6-Methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide is an intermediate of Dorzolamide Hydrochloride (D535100), a carbonic anhydrase inhibitor. Antiglaucoma agent.
References Jiang, X., et. al.: Yingyong Huagong, 36, 1215 (2007); Lippa, E.A., et al.: Ophthalmology, 98, 308 (1991); Wang, R.-F., et al.: Arch. Ophthalmol., 109, 1297 (1991); Whikehart, D., et al.: J. Ocul. Pharmacol., 7, 195 (1991); Sjoquist, B., et al.: Drug Metab. Dispos., 26, 745 (1998)

Stability Hygroscopic
Applications A metabolite of Venlafaxine.