Étalons pharmaceutiques

N-a-t-Boc-N-g-trityl-L-asparagine is a recombinant human protein that has been synthesized in E. coli. It is a peptide with 17β-estradiol at its C terminus, and it binds to the oestrogen receptor α (ERα) via hydrogen bonding interactions. The linker between the asparagine and estradiol is a Boc group that can be removed by protease activity, revealing the active form of 17β-estradiol. ERα ligates to N-a-t-Boc-N-g-trityl L asparagine with high affinity, and this interaction is reversible. The linker also contains a functional group for surface attachment, which may be used to attach this peptide to a solid support or tissue culture substrate for use in cell cultures.
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3,3'-Diheptyloxacarbocyanineiodide (DHCI) is a fluorescent probe that is used in the treatment of solid tumours. It is taken up by tumor cells and causes them to fluoresce, which can be seen under a microscope. DHCI has been shown to be effective against hypoxic tumours and tumors with low oxygen levels due to its ability to penetrate tumor cells and deliver oxygen. The uptake of DHCI by cancer cells is also dependent on the permeability of the blood vessels present in the tumor. This drug has been shown to have a large therapeutic window for treatment of solid tumours.

3,5-Difluoro-4-hydroxybenzoic acid methyl ester (DFHBME) is a chemical compound that belongs to the class of useful building blocks. It is used in research as a reagent and in the synthesis of various complex compounds. DFHBME reacts with nucleophiles such as amines or alcohols to produce useful intermediates or scaffolds for organic synthesis. This compound is also useful as a speciality chemical due to its high quality and versatility.

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Camphorquinone-10-sulfonic acid hydrate is a soybean trypsin inhibitor that is used as a preparative agent in organic synthesis. It reacts with histidine, lysine residues, and other molecules to form a light-chain kinase that inhibits the action of the enzyme trypsin. Camphorquinone-10-sulfonic acid hydrate has been shown to be resistant to proteolysis by gastrointestinal enzymes. This agent also has diabetogenic properties by inhibiting the activity of membrane potential and chloride channels in pancreatic β cells. Camphorquinone-10-sulfonic acid hydrate forms an ion pair with choline, which can inhibit the enzyme acetylcholinesterase, leading to accumulation of acetylcholine at nerve endings.

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1-(3-Chlorophenyl) thiourea is a curcumin analog that has been shown to inhibit the epidermal growth factor (EGF) receptor. It is synthesized from 1,2-dichlorobenzene and urea in a two-step process. The anhydrous potassium carbonate is first converted to the potassium salt with an acid chloride. The second step is the reaction of this salt with urea in the presence of excess anhydrous potassium carbonate. This product has been shown to be effective against cancer cells and may be used as a potential anticancer agent for treatment of skin cancer. 1-(3-Chlorophenyl) thiourea inhibits EGF receptor by binding to it and preventing its activation, which prevents cell proliferation and reduces tumor size.

N-(4-Fluorophenyl)thiourea (FPTU) is a molecule that belongs to the class of thioureas. It has been shown to have a constant dihedral angle and is membrane transportable, which may be due to its ability to bind receptor proteins. FPTU has also been shown to inhibit chloride ion transport through the intestinal wall. In addition, it has been shown to have anti-inflammatory properties in animal models, which may be due to its ability to inhibit γ-aminobutyric acid (GABA) synthesis.

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Copper naphthenate is a cross-linking agent that contains copper and nitrogen atoms. It reacts with potassium dichromate, sodium carbonate, and other substances to form a copper complex. Copper naphthenate is used in the manufacture of biodiesel as a preservative. The product also has insecticidal properties, which have been shown to be due to its ability to inhibit the activity of chitin synthase enzymes found in insects. Copper naphthenate has been shown to be effective as a contraceptive when used vaginally and may also be used topically on the skin for this purpose. This product is acidic and should not be mixed with other acidic substances or materials such as plastics or rubber.

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