Étalons pharmaceutiques

Applications Propylthiouracil N-β-D-Glucuronide Methyl Ester is a compound useful in organic synthesis.

Impurity Vonoprazan Impurity 31
Applications 2'-Fluoroacetophenone (Vonoprazan Impurity 31)

Applications 4-Phthalimidoacetoacetic Acid Ethyl Ester-13C is an intermediate in the synthesis of 5-Aminolevulinic Acid-3-13C Hydrochloride which is a naturally occurring amino acid; precursor of tetrapyrroles in the biosynthesis of chlorophyll and heme. Antineoplastic (photosensitizer).
References Sisler, E.C., et al.: Physiol. Plant., 16, 315 (1963), Herdeis, C., et al.: Arch. Pharm., 317, 304 (1984), Peng, Q., et al.: Cancer, 79, 2282(1997),

Applications An intermediate in the preparation of a potential inhibitor of GAR Tfase.
References Cheng, H. et al.: Bioorg. Med. Chem., 13, 3593 (2005)

Applications N,​N-​Dimethyl-​5-​(phenylmethoxy)​-1H-​indole-​3-​ethan-​α,​α,​β,​β-​d4-​amine is an intermediate in the synthesis of Bufotenine-d4 Hydrochloride (B689467), which is labelled bufotenine Hydrochloride (B689465) which is a weak hallucinogenic agent active by intravenous injection. It is a constituent of toad poison.
References Stoll, et al.: Helv. Chim. Acta, 38, 1452 (1955), Bhattacharya, S., et al.: Indian. J. Physiol. Pharmacol., 15, 133 (1971), Falkenberg, G., et al.: Acta Crystallogr., 28B, 3219 (1972)

Applications 4-​(1,​2-​Dimethyl-​1-​propen-​1-​yl)​-​benzoic Acid Methyl Ester is an intermediate in synthesizing 1-Desmethyl-2-methylpropyl Amorolfine (D292315), an analogue of Amorolfine Hydrochloride (A634170). Amorolfine hydrochloride is a salt of Amorolfine which is a morpholine antifungal drug. It is a topical solution for the treatment of toenail infections.
References Rotta, I., et al.: JAMA Dermatol., 149, 341 (2013); Espinel-Ingroff, A., et al.: Antimicrob. Agents Ch., 26, 5 (1984)

Applications α-(Phenylmethylene)-1-naphthaleneacetic Acid is an intermediate in the synthesis of chrysene based polycyclic aromatic ketones found in environmental gas samples of wood and coal combustion gasses, municipal incineration waste gases, diesel exhaust, Al plant workplace and urban ambient air.
References Dai, W., et al.: Org. Prep. Proc. Int., 29, 347 (1997);

Applications An intermediate for the synthesis of a benzimidazole PARP inhibitor I (succinate salt) (ABT-472).
References Denny, W., et al.: J. Med. Chem., 33, 814 (1990), Anon., et al.: Curr. Med. Chem., 10, 321 (2003),

Applications 3-Chloro-2,7-naphthalenedisulfonic Acid is an intermediate used in the synthesis of 2,3,6-Trichloronaphthalene (T774070), which can bind to the aryl hydrocarbon receptor (AhR) and induce a wide range of pleotrophic effects.
References Petrulis, J., et al.: Toxicol. Lett., 105, 251 (1999), Hilscherova, K., et al.: Environ. Sci. Pollut. Res., 7, 159 (2000),

Applications 3-Iodopropylene-1-naphthalene Methyl Amine (cas# 1076198-32-7) is a compound useful in organic synthesis.

Applications 4,6-Bis(4-nitrophenoxy)pyrimidine is an intermediate in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.
References Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);

Applications An intermediate for the synthesis of mivacurium and and other neuromuscular blocking agents.

Applications Penicillanic Acid Sodium Salt-d2 is an intermediate in the synthesis of Tazobactam-d4 which is the labeled analog of Tazobactam (T010095), a β-Lactamase inhibitor, used with β-lactam antibiotics to enhance their effect.
References Gould, I.M., et al.: Drugs Exp. Clin. Res., 17, 187 (1991); Roland, R.K., et al.: J. Infect. Dis., 4, 226 (2000); Bonomo, R.A., et al.: Biochim. Biophys. Acta, 1547, 196 (2001)

Applications Dimethyl L-Aspartate Hydrochloride was used in the synthesis of enzyme and pH dual responsive L-amino acid based biodegradable polymer nanocarrier that can be used for multidrug delivery to cancer cells.
References Saxena, S., et al.: J. Polym. Sci. Pol. Chem., 54, 3279 (2016);

Applications Tetrabromophthalic Anhydride-13C6 is an intermediate in synthesizing 2,3,4,5-Tetrabromobenzoic Acid-13C6 (T291142). It is an isotope labelled analog of 2,3,4,5-Tetrabromobenzoic Acid. 2,3,4,5-Tetrabromobenzoic Acid is an in vitro metabolite of the flame retardant 2-Ethylhexyl 2,3,4,5-Tetrabromobenzoate (E918780) in human and rat tissues.
References Roberts, S.C., et al.: Chem. Res. Toxicol., 25, 1435 (2012); Gouteux, B., et al.: Environ. Sci. Technol., 42, 9039 (2008); Lee, E., et al.: J. Toxicol. Sci., 2010, 35, 535 (2010); Arp, H., et al.: J. Environ. Monit., 13, 505 (2011)

Applications (5-Chloro-2-nitrophenyl)(phenyl)carbamic Acid tert-Butyl Ester is an intermediate in the synthesis of Clobazam (C582500), a benzodiazepine psychotherapeutic agent and anxiolytic agent.

Applications Labelled Anabaseine intermediate.

Applications 5-Chloro-2-methoxy-1,3-benzenedicarboxylic Acid is an intermediate in the synthesis of Ochratoxin A (O148490). Ochratoxins are toxic metabolites from Aspergillus ochraceus. Also they are environmental and food contaminants.
References Belli, N., et al.: Int. J. Food Microb., 96, 19 ( 2004); Pardo, E., et al.: Food Microb., 23, 35 (2006)

Applications 2,​3,​4-​Triacetate 1-​(2,​2,​2-​Trichloroethanimidat​e) 6-​O-​(2,​3,​4,​6-​Tetra-​O-​acetyl-​β-​D-​glucopyranosyl)​-β-​D-​glucopyranose is an intermediate in the synthesis of Guaiacol-beta-D-gentiobioside (G245570), which is a Guaiacol Conjugate, that has shown to present in fermentation of grapes that had been exposed to bushfire smoke and can potentially yield unpalatable, smoke-affected wine.
References Hayasaka, Y.m et al.: J. Arg. Food Chem., Vol. 58, Issue 4, P: 2076; 2081 (2010);

Applications 4-Nitrophenyl Phosphorodichloridate is used as a reagent in the synthesis of dihydrobenzodioxaphosphocine oxide derivatives which have antioxidant activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Siva Prasad, S., et al.: J. Heterocyclic Chem., no vol., no pp. (2016, ahead of print)

Applications Used in the new synthesis of alkylsulphanylnaphthalenes and the synthesis and mesomorphic properties of novel naphthylisothiocyanates.
References Lauk, u., et al.: Helv. Chim. Acta, 68, 1406 (1985), Collina, S., et al.: Bioorg. Med. Chem., 8, 1925 (2000),

Applications Methyl-(4-nitrophenylethyl)-4-(nitrophenoxyethyl)amine-d4 (cas# 1189869-42-8) is a compound useful in organic synthesis.

Applications Acetophenone-13C8 is an intermediate in synthesizing Mandelic Acid-13C8 (M162523). It is a C13 labelled Mandelic Acid which is used as an antiseptic (urinary). It is also used as a short-term exposure biomarker in urine from styrene exposed workers.
References Pessela, B., et al.: Enzyme Microb. Technol., 40, 310 (2007); Carrasco-Lopez, C., et al.: J. Biol. Chem., 284, 4365 (2009); Fustinoni, S., et al.: Toxicol. Lett., 192, 40 (2010)

Applications O-TBS Hexadec-7-enoic acid is an intermediate in the synthesis of 3-Hydroxy-9-hexadecenoyl-L-carnitine which is an analogue of 3-Hydroxyhexadecanoylcarnitine Inner Salt (H943005), a derivative of Carnitine, essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado. Also 3-Hydroxyhexadecanoylcarnitine works similar to the endogenous non-toxic molecule L-Carnitine (C184110) whose bioavailablity is improved due to the transport systems in place for Carnitine.
References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978), Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001), Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002), Karlic, H., et al.: Nutrition, 20, 709 (2004), O. Piermatti. et al.: Bioorg. Med. Chem., 16, 1444 (2008)

Applications 8-Bromo-3’,5’-Di-O-tert-butyldimethylsilyl-2’-deoxyguanosine is a compound useful in organic synthesis.

Applications cis-Dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2''-tricyclo[3.3.1.13,7]decane]-4-acetic Acid is an intermediate for the synthesis of Arterolane p-Toluenesulfonic Acid (A614161), which is an antimalaria agent.
References Valecha, N., et al.: Clin Infect Dis. 55, 663 (2012); Patil, C. Y., et al.: Ann Med Health Sci Res. 4, 466 (2014)

Applications Labelled 4’-Bromoacetophenone (B679060). Possess activity against positive phototaxis of Chlamydomonas cells.A fundamental starting material for organic synthesis.
References Evans, S., et al.: Chem. Biol. Drug. Des., 75, 333 (2010), Rajabi, L., et al.: Lett Appl Microbiol., 40, 212 (2005),

Applications 4,4,4-Trimethoxybutanoic Acid Methyl Ester is an substituent in the synthesis of Methyl Prednisolone (M325934).
References Ueno, H., et al.: J. Med. Chem., 34, 2468 (1991);

Applications 3-Aminobenzoic-d4 Acid (A591492) derivative. It increases attractiveness when combines with sex pheromones.
References Maekawa, M. et al.: Appl. Entomol. Zool., 34, 9 (1999)

Applications 1-(2’,5’-Dimethoxyphenyl)-2-chloroethanone (cas# 1204-22-4) is a compound useful in organic synthesis.

Applications 4-Fluoro-1-naphthoic acid (cas# 573-03-5) is a useful research chemical.

Applications N-Methyl-6-(4-nitrophenoxy)-4-pyrimidinamine is an intermediate in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.
References Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);

Applications 7-​Chloro-​1-​ethyl-​6-​fluoro-​1,​4-​dihydro-​4-​oxo-3-​quinolinecarboxylic Acid Ethyl-d5 Ester is the unlabelled form of 7-​Chloro-​1-​ethyl-​6-​fluoro-​1,​4-​dihydro-​4-​oxo-3-​quinolinecarboxylic Acid Ethyl Ester (C315510), which is an impurity of Norfloxacin (N681000), an antibacterial agent and a contaminant of emerging concern (CECs). 7-​Chloro-​1-​ethyl-​6-​fluoro-​1,​4-​dihydro-​4-​oxo-3-​quinolinecarboxylic Acid Ethyl-d5 Ester is also an intermediate in the synthesis of Norfloxacin-d5 (N681003).
References Koga, H., et al.: J. Med. Chem., 23, 1358 (1980); Hirai, K., et al.: Antimicrob. Agents Chemother., 19, 188 (1981); Holmes, B., et al.: Drugs, 30, 482 (1985)

Applications O-Methyloxime Guanosine-13C15N2 is an isotope labelled intermediate in the preparation of nucleotide analogs.
References Robins, M. J., et al.: J. Am. Chem. Soc., 105, 4059 (1983);

Applications (S)-2-(Dimethoxymethyl)-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate in synthesizing Tilivalline (T440350), which is a metabolite from Klebsiella oxytoca. Tilivalline, is shown to be cytotoxin, and the key event causing Antibiotic-Associated Hemorrhagic Colitis.
References Mori, Sh., et al.: Tetrahedron, 47, No.27, 5051 (1991); Nagasaka, T., et al.: Tetrahedron Lett., 14, 1871 (1989);

Applications 9-Chlorophenazine-1-carboxylic Acid is an intermediate in the synthesis of Endophenazine A which is a new phenazine antibiotic isolated from the arthropod associated endosymbiont Streptomyces anulatus and shows antimicrobial activities against Gram-positive bacteria and some filamentous fungi, and herbicidal activity against Lemna minor (duckweed).
References Gebhardt, K., et al.: J. Antibiot., 55, 794 (2002)

Applications 2'-(Methylamino)-5'-nitro-succinanilic Acid is an intermediate in synthesizing 4-(6-(2-Chloroethyl)-3-methyl-3,6,7,8-tetrahydroimidazo[4',5':5,6]benzo[1,2-b][1,4]thiazin-2-yl)butanoic Acid (C367195), a degradation production of Bendamustine (B132500), which is used as an anticancer drug.
References Bremer, K., et al.: Tumordiagn. Ther., 17, 1 (1996); Barman Balfour, J.A., et al.: Drugs, 61, 631 (2001)

Applications (S)-2-(Acetylthio)-propanoic Acid is an intermediate in synthesizing (R)-(+)-Thiolactomycin (T350880). It is a natural product inhibitor of β-Ketoacyl-AcpM Synthase A (KasA). It inhibits the synthesis of mycolic acid which is a major cell wall component of Mycobacterium tuberculosis. Also an inhibitor of D-Aspartate oxidase (DDO).
References Kapilashrami, K., et al.: J. Biol. Chem., 288, 6045 (2013); Paneerselvam, V., et al.: J. Pharm. Res., 4, 4618 (2011); Katane, M., et al.: Biochimie, 92, 1371 (2010)

Applications 2-Diisopropylaminoethyl Chloride Hydrochloride-d14 is an intermediate in synthesizing Disopyramide-d14 Tosylate Salt (D493452). Antiarrhythmic (class IA). Sodium channel blocker.
References Adelstein, et al.: J. Med. Chem., 16, 309 (1973); Czeisler, J.L., et al.: J. Pharm. Sci., 74, 750 (1985); Taylor, E.H., et al.: Ann. Clin. Lab. Sci., 16, 289 (1986);

Applications 10-(3-Chloropropyl)-2',8-bis(trifluoromethyl)-10H-3,10'-biphenothiazine is an intermediate for the synthesis of 2-(4-(3-(2',8-Bis(trifluoromethyl)-10H-[3,10'-biphenothiazin]-10-yl)propyl)piperazin-1-yl)ethanol (B586700), an impurity of Fluphenazine Decanoate (F598350) which is used in psychotropic drug treatments like those relating to schizophrenia.
References Frasch, K. et al.: Pharmacopay., 45, 138 (2012); Aggarwal, N. et al.: J. Clin. Psychopharmacol., 32, 323 (2012)

Applications 4,4a,5,6,7,8-Hexahydro-6-isopropyl-2(3H)naphthalenone, is one of the perfume component. It can be used in the perfumery industry. It is also an intermediate in the synthesis of other compounds.

Applications 2,6-Dimethylnaphthalene is a polyaromatic hydrocarbon (PAH) environmental contaminant. 2,6-Dimethylnaphthalene is found in oil, coal and tar deposits and are produced by gasoline operating vehicles. It is a persistent environmental pollutant with carcinogenic and mutagenic activity.This compound is a contaminant of emerging concern (CECs)
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hays, M. et al.: Environ. Sci. Tech., 47, 14502 (2013); Lemieux, C. et al.: Environ. Toxicol. Chem., 27, 978 (2008); Gruger, E., et al.: Aquat. Toxicol., 5, 291(1984); Barnsley, E.: Appl. Environ. Microb., 54, 428 (1988); Miyachi N., et al.: Environ. Toxicol. Chem., 59, 1504 (1993)

Applications 5-Bromo-2',3',5'-tri-O-acetyluridine (cas# 105659-32-3) is a compound useful in organic synthesis.

Applications Hippurate analog. Inhibitor of peptidylglycine α-hydroxylating monooxygenase (PHM). Pesticide.
References Merkler, D. et al. Bioorgan. Med. Chem. 16, 10061 (2008)

Applications 6-Isopropyl-2-decahydronaphthalenol, is a fragrance raw material, used in the perfumery industry.
References Ford, R. A, et al.: Food and Chemical Toxicology, 23, 367 (1988);

Applications 1-[(4-Chlorophenyl)methyl]-2-oxocyclopentanecarboxylic Acid Methyl Ester is an intermediate in the synthesis of Isotope labelled Metconazole (M225795), an conazole based fungicide used for the control of black sigatoka disease on banana.
References Kato, A., et al.: Chem. Pharma. Bull., 43, 2152 (1995);

Applications Dithio-2,2'-bis(N-methylbenzamide)-d6 is an labelled intermediate in the synthesis of analogue of Axitinib, a tyrosine kinase inhibitor used for cancer therapy.
References Brown, D.W., et al.: Sci. Synthesis., 11, 573 (2002);

Applications 2-Bromocinnamic Acid (cas# 7499-56-1) is a compound useful in organic synthesis.
References Belley, M., et al.: Bioorg. Med. Chem. Lett., 15, 527 (2005),

Applications 5-Acetamidonaphthalene-1-sulfonamide (cas# 32327-48-3) is a compound useful in organic synthesis.