Étalons pharmaceutiques

Applications Intermediate in the synthesis of polycyclic aromatic systems.

Applications α-Ionol derivative.

Applications Palbociclib 1,2,3,4-Tetra-O-acetyl-β-D-glucuronic Acid Methyl Ester is an intermediate in synthesizing Palbociclib N-β-D-Glucuronide Sodium Salt (P139910), a derivative of Palbociclib (P139900) which is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.
References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)

Applications An intermediate in the synthesis of the Daspone metabolite.

Applications N,​N-​Dimethyl-​5-​(phenylmethoxy)​-1H-​indole-​3-​ethan-​α,​α,​β,​β-​d4-​amine is an intermediate in the synthesis of Bufotenine-d4 Hydrochloride (B689467), which is labelled bufotenine Hydrochloride (B689465) which is a weak hallucinogenic agent active by intravenous injection. It is a constituent of toad poison.
References Stoll, et al.: Helv. Chim. Acta, 38, 1452 (1955), Bhattacharya, S., et al.: Indian. J. Physiol. Pharmacol., 15, 133 (1971), Falkenberg, G., et al.: Acta Crystallogr., 28B, 3219 (1972)

Stability Moisture Sensitive
Applications 9,10-Dibromoanthracene-2-sulfonyl Chloride (cas# 210174-74-6) is a compound useful in organic synthesis.

Applications 5-Chloro-2-methoxy-1,3-benzenedicarboxylic Acid is an intermediate in the synthesis of Ochratoxin A (O148490). Ochratoxins are toxic metabolites from Aspergillus ochraceus. Also they are environmental and food contaminants.
References Belli, N., et al.: Int. J. Food Microb., 96, 19 ( 2004); Pardo, E., et al.: Food Microb., 23, 35 (2006)

Applications 2-​Ethyl-​2,​5-​dihydro-​4-​hydroxy-​3-​methyl-​5-​oxo-2-​furancarboxylic Acid Methyl Ester is an by-product intermediate formed during the synthesis of 4,5-Dimethyl-3-hydroxy-2(5H)-furanone (D473600), a fragrant compound that is a key indicator of maple syrup urine disease, a disorder affecting newborn children that is the result of its inability to properly metabolize Valine (V094205), Leucine (L330110) and Isoleucine (I820175). 4,5-Dimethyl-3-hydroxy-2(5H)-furanone is naturally found in fenugreek seeds, and is an odourant present in sherry wines.
References Blank, I., et al.: Prog. Flav. Prec. Stud., No vol. given, 103 (1993); Guerra, P. & Yaylayan, V.: J. Agr. Food Chem., 59, 4699 (2011); Mackenzie, D. & Woolf, L.: Brit. Med. J., 1, 90 (1959); Podebrad, F., et al.: J. Inh. Metab. Dis., 22, 107 (1999)

Applications A labelled carcinogen.
References Kirkland, D., et al.: Mut. Res., Gen. Toxicol. Environ. Mutagen., 588, 70 (2005), Ahlstroem, M., et al.: J. Med. Chem., 50, 4444 (2007),

Applications 2,4,5-Trichlorophenoxyacetic Acid-d5 is an isotope labelled analog of 2,4,5-Trichlorophenoxyacetic Acid. It is suitable for plant cell culture tested. Post-emergence herbicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Smith, J., et al.: Science, 203, 1090 (1979), Salunkhe, C., et al.: Plant Cell Reports, 18, 670 (1999), Jheng, F., et al.: Plant Sci., 170, 1133 (2006),

Applications 1-[(4-Chlorophenyl)methyl]-2-oxocyclopentanecarboxylic Acid Methyl Ester is an intermediate in the synthesis of Isotope labelled Metconazole (M225795), an conazole based fungicide used for the control of black sigatoka disease on banana.
References Kato, A., et al.: Chem. Pharma. Bull., 43, 2152 (1995);

Applications Protected 2-Thiouridine.
References El-Tayeb, A., et al.: J. Med. Chem., 49, 7076 (2006),

Applications Intermediate for the synthesis of 9-cis-Retinoids
References Rosen, J., et al.: J. Med. Chem., 38, 4855 (1995), Haupt, U., et al.: Biochem., 36, 2 (1997).

Applications Gibberellic Acid Methyl Ester is a derivative of the plant hormone Gibberellin which regulates growth and various developmental processes.
References Stolp, C.F., et al.: Plant Cell Physiol, 18, 721-8 (1977)

Applications Isomer of (3R)-3-Hydroxy Quinine

Applications 2-Acetamido-3-acetoxybenzoic Acid Methyl Ester is an intermediate in the synthesis of metabolites of Bentazon (B120580), a selective post-emergence herbicide.

Applications 1,3-Dihydro-N-nitro-1,3-dioxo-2H-isoindole-2-carboximidothioic acid Methyl Ester-13C is an intermediate used in the synthesis of Clothianidin-d3,13C1 (C588502), which is the isotope labelled analog of Clothianidin. Clothianidin is a neonicotinoid insecticide for use in food crops.
References Kamel, A., et al.: J. Agric. Food Chem., 58, 5926 (2010), Lynd, L., et al.: Energy Environ. Sci., 3, 1150 (2010), Cresswell, J., et al.: Ecotoxicology, 20, 149 (2011),

Applications 2-tert-Butyl-1,3-diisopropylisourea is a useful synthetic intermediate in the synthesis of 5-Oxo Atorvastatin tert-Butyl Ester (O847160) which is a Boc-protected derivative of Atorvastatin (A791750, Ca Salt). 2-tert-Butyl-1,3-diisopropylisourea is also used as a reagent in the total synthesis of Citrafungin A which is an antifungal natural product.
References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996); Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000); Calo, F., et al.: J. Org. Chem., 73, 9692 (2008)

Applications ((2S,4S)-2-(Chloromethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-Methylbenzenesulfonate is an intermediate in the synthesis of Itraconazole (I937500), an orally active antimycotic structurally related to Ketoconazole. Antifungal.
References Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993)

Applications A protected metabolite of Propylthiouracil. Propylthiouracil N-β-D-Glucuronide (P838315) derivative.
References Lindsay, R. H., et al.: J. Pharm. Sci., 63 1383 (1974)Taurog, A., et al.: Endocrinology, 122, 592 (1988)

Applications trans-Cinnamoyl chloride (cas# 102-92-1) is a useful research chemical.

Applications N,N'-Dimethylurea

Stability Temperature Sensitive - Recommended Storage at -20°C
Applications 4-Acetamido-4’-aminostilbene-2,2’-disulfonic Acid Disodium Salt (cas# 78211-74-2) is a compound useful in organic synthesis.

Applications 6,7-Dibromo-2-naphthalenecarbonitrile is an intermediate in the synthesis of potent and orally active small molecule PTP1B inhibitors.
References Han, Y.X., et al.: Bioorg. Med. Chem. Lett., 18, 3200 (2008);

Applications 2,4-Dichloro-5-nitropyrimidine (cas# 49845-33-2) is a compound useful in organic synthesis.

Applications Simvastatin t-Butyldimethylsilyl Acyl-β-D-glucuronide-O-acrylate is an intermediate in synthesizing Simvastatin Acyl-β-D-glucuronide (S485005), a metabolite of Simvastatin.
References Billecke, S., et al.: Drug Metab. Dispos., 28, 1335 (2000); Draganov, D., et al.: J. Biol. Chem., 275, 33435 (2000); Igel, M., et al.: Eur. J. Clin. Pharmacol., 57, 357 (2001)

Applications rac Propranolol β-D-Glucuronide Triacetate Methyl Ester ia an intermediate in the synthesis of rac Propranolol β-D-Glucuronide Sodium Salt which is a metabolite of Propranolol. Antihypertensive; antianginal; antiarrhythmic (class II).
References Reeves, P., et al.: Xenobiotica, 8, 313 (1978), Balon, K., et al.: Pharm. Res., 16, 882(1999), Lange, R., et al.: Toxicol. Lett., 131, 97 (2002),

Applications S-Deoxyo-5-Hydroxy Acetate Omeprazole is an isotope labelled intermediate in the synthesis of 5-Hydroxy Omeprazole (H948863), the main metabolite of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.
References Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)

Applications 2-Diisopropylaminoethyl Chloride Hydrochloride-d14 is an intermediate in synthesizing Disopyramide-d14 Tosylate Salt (D493452). Antiarrhythmic (class IA). Sodium channel blocker.
References Adelstein, et al.: J. Med. Chem., 16, 309 (1973); Czeisler, J.L., et al.: J. Pharm. Sci., 74, 750 (1985); Taylor, E.H., et al.: Ann. Clin. Lab. Sci., 16, 289 (1986);

Applications 2,3,7,8-Tetrachloro-[1,4]dioxino[2,3-b:5,6-b']dipyridine is used in analytical studies for the presence and formation of dioxin-like compounds in heat-treated chlorpyrifos herbicide, a potential precursor of pyridine analog of 2,3,7,8-Tetrachloro-p-dioxin (T291370).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sakiyaama, T., et al.: Organohalogen Compounds, 73, 146 (2011);

Applications 3-Hydroxy Carbamazepine tert-Butyldimethylsilyl Ether is an protected metabolite of Carbamazepine (C175840).
References Park, B., et al.: Biochem. Pharmacol., 36, 581 (1987), Yamazaki, H., et al.: Drug Metab. Dispos., 27, 1260 (1999), Dieckhaus, C., et al.: Chem. Res. Toxicol., 14, 958 (2001),

Applications 4-[1-(4-Iodophenyl)-5-(2,4-dinitrophenyl)-formaz-3-yl]-1,3-benzene Disulfonate, Disodium Salt (cas# 161617-44-3) is a compound useful in organic synthesis.

Applications (9Z)-Erythromycin A Oxime is a metabolite of Roxithromycin (R700850) in humans.
References Zhong, D. et al.: Drug Metab. Dispos., 28, 552 (2000)

Applications 3’,4’-Dihydroxy-1-phenyl-2-butanone (cas# 17386-89-9) is a compound useful in organic synthesis.
References Strader, C., et al.: J. Biol. Chem., 266, 5 (1991),

Applications Isotope labelled ammonium hydroxide is in numerous household cleaning agents.
References Lokshin, E.P., et al.: Russ. J. App. Chem., 86, 450 (2013); Alghamdi, A.A., et al.: J. Material. Chem. A. Mater. Energy. Sustain., 1, 5165 (2013);

Stability Moisture Sensitive
Applications An unknown impurity from the synthesis of Telmisartan (T017000).
References Wienen, W., et al.: Brit. J. Pharmacol., 110, 245 (1993), Neutel, J.M., and Smith, D.H.G.: Adv. Ther., 15, 206 (1998);

Applications cis-(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-naphthalen-1-ol-d4 (cas# 1217717-42-4) is a compound useful in organic synthesis.

Applications The parent compound whose derivatives can be applied as corrosion inhibitors for API J55 steel.
References Growcock, F., et al.: Corrosion (Houston, TX, U. S.), 45, 1007 (1989),

Applications N-Ethyl-N-methyl-O-(4-nitrophenyl)carbamate (cas# 90870-20-5) is a compound useful in organic synthesis.