Étalons pharmaceutiques

Applications 4-(2-methyl-1,3-oxazol-4-yl)benzene-1-sulfonyl chloride (cas# 1086376-81-9) is a useful research chemical.

Applications 1,2-benzisoxazol-3-amine (cas# 36216-80-5) is a useful research chemical.

Applications 7,13-Bisside chainpacltaxel is a derivative of Paclitaxel (P132500) which has anticancer properties.
References Zhong, T., et al.: Bioconjugate Chem., 29, 437-444 (2018)

Stability Hygroscopic
Applications Desfuroyl Ceftiofur Dimer is an impurity of the drug Ceftiofur (C244695), a third generation cephalosporin antibiotic used in veterinary medicine.
References Donaldson, S.C. et al.: Appl. Environ. Microbiol., 72, 3940 (2006); Yancey, R.J. et al.: Am. J. Vet. Res., 48, 1050 (1987);

Applications Ethyl 7-Chloro-4-ethoxy-6-fluoro-3,4-dihydroquinoline-3-carboxylate is an intermediate in the synthesis of Norfloxacin (N681000), which is a Pefloxacin derivative as antibacterial. Fluorinated quinolone antibacterial. This compound is a contaminant of emerging concern (CECs).
References Koga, H., et al.: J. Med. Chem., 23, 1358 (1980); Hirai, K., et al.: Antimicrob. Agents Chemother., 19, 188 (1981); Holmes, B., et al.: Drugs, 30, 482 (1985)

Applications A metabolite of the agricultural fungicide Kresoxim-methyl(K659000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Salmon, F. et a.: Xenobiotica, 26, 803 (1996); Gold, R.E. et al: Mod. Fungic. Antifungal Compd., 11, 79 (1996);

Applications 2,6-Dimethoxybenzoyl Chloride is used in the synthesis of penicillins and cephalosporins.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Newall, C. et al.: Comp. Med. Chem., 2, 609 (1990); Kanao, M. et al.: J. Med. Chem., 25, 1358 (1982);

Applications N-Isopropyl-3,4-dimethyl-2,6-dinitroaniline is a dinitro herbicides.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chen, Y., et al.: Green Chemistry, 15, 91 (2013)

Applications Fluorescent Brightener KSN (cas# 5242-49-9) is a useful research chemical.

Applications 7-Chlorokynurenic acid is an NMDA receptor antagonist and inhibitor of EAAT.

Applications 3-trans-Hydroxy Norcotinine (cas# 1292911-83-1) is a compound useful in organic synthesis.

Applications A reactant used in the preparation of Liraglutide, a GLP-1R agonist.

Applications ((2R,5S)-5-(4-Amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate is an impurity of Emtricitabine (E525000), a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).
References FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. InfecSchinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: . Dis., 182, 599 (2000)

Applications Isopropyl Phenyl Phosphate-d7 is the isotope labelled analog of Isopropyl Phenyl Phosphate (I873050); a polymer plasticizer for controlled release pesticide formulations. Isopropyl Phenyl Phosphate is also used as an antiwear and fireproofing agent.
References Asrar, J., et al.: PCT Int. Appl. WO 2002021913 A2 20020321. Mar 21, 2002; Placek, D.G., et al.: PCT Int. Appl. WO 9616143 A1 19960530. May 30, 1996; Beacham, H.H., et al.: Eur. Pat. Appl. EP 2601 A1 19790627. Jun 27, 1979

Applications A metabolite of Ranolazine (R122500).

Stability Light Sensitive
Applications (1R,​3S)​-3-​(2,​2-​Dichloroethenyl)​-​2,​2-​dimethylcyclopropanecarboxam​ide is a useful research chemical.

Applications rac cis-Paroxetine N-Methyl is an impurity formed in the synthesis Paroxetine (P205750) related compounds.
References Gangula, S., et al.: Syn. Commun., 42, 3344 (2012);

Applications 17β-Hydroxy Exemestane 17-O-β-D-Glucuronide is the glucuronidated conjugate of the hydroxy metabolite of Exemestane (E957000).
References Sun, D. et al.: Pharmacogen. Genom., 20, 575 (2010);

Applications 4'-(Imidazol-1-yl)acetophenone (cas# 10041-06-2) is a useful research chemical.

Applications (R)-8-Hydroxy-3-methyl-1,2,3,4-tetrahydrobenz[a]anthracene-7,12-dione (cas# 681001-30-9) is a compound useful in organic synthesis.

Applications 4-(5-Bromothiophen-2-yl)benzonitrile (CAS# 415718-60-4) is a useful research chemical compound.

Applications 7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-[(carboxymethoxy)imino]acetyl]amino]-cefixime is a cefixime impurity. Cefixime (C242800) is an orally active, third generation cephalosporin antibiotic.
References Kamimura, T., et al.: Antimicrob. Agents Chemother., 25, 98 (1984),Yamanaka, H., et al.: J. Antibiot., 38, 1738 (1985), Guay, D.R.P., et al.: Antimicrob. Agents Chemother., 30, 485 (1986),

Applications Oleoyl-L-carnitine-d3 is labelled Oleoyl-L-carnitine (O526700, HCl salt), a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Oleoyl-L-carnitine can be diagnostic for a number of ß-oxidation defects.
References Adams, S., et al.: J. Nutrition, 139, 1073 (2009); Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)

Applications Estradiol 6-N3-Adenine is a depurinating adduct that is created by the interaction of specific metabolites of estrogens in the body with DNA. Unfortunately, these adducts are endogeneous initiators of various human cancers, such as breast & prostate.
References Yang, L., et al.: Prostate, 69, 41 (2009); Zahid, M., et al.: Chem. Res. Toxicol., 19, 164 (2006); Zhang, Y., et al.: Metabol. Clin. Exp., 56, 887 (2007)

Applications Lactosyl-C18-sphingosine has been found to have a strong interaction with HIV-1 Gp120.
References McReynolds, K.D., et. al.: Bioconjugate Chem., 10, 1021 (1999)

Applications N-Methyl(p-tosyl)carbamic Acid Methyl Ester is a methyl ester derivative of N-[(arylsulfonyl)methyl]carbamates that display intramolecular shielding.
References Van der Werf, S. et al.: Rec. Trav. Chim. Pays-Bas, 89, 423 (1970);

Applications 3-Acetyl-1-Boc-pyrrolidine is a boc protected reagent that is used for selective inhibitors of H. influenzae TrmD that mimic tRNA interaction by inducing TrmD lid domain ordering.
References Hill, P.J., et al.: J. Med. Chem., 56, 7278 (2013);

Applications 6-Methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide is an intermediate of Dorzolamide Hydrochloride (D535100), a carbonic anhydrase inhibitor. Antiglaucoma agent.
References Jiang, X., et. al.: Yingyong Huagong, 36, 1215 (2007); Lippa, E.A., et al.: Ophthalmology, 98, 308 (1991); Wang, R.-F., et al.: Arch. Ophthalmol., 109, 1297 (1991); Whikehart, D., et al.: J. Ocul. Pharmacol., 7, 195 (1991); Sjoquist, B., et al.: Drug Metab. Dispos., 26, 745 (1998)

Stability Hygroscopic
Applications A metabolite of Venlafaxine.

Applications Intermediate for the preparation of Naratriptan and other indole sulfonamide derivatives.

Applications 21-O-Acetyl Allo-3α-tetrahydro Cortisol 3-(2’,3’,4’-Tri-O-acetyl)-β-D-Glucuronide methyl ester is a Cortisol derivative. A potential corticoid metabolite. a
References Okihara, R. et al.; Chem. Pharm. Bull. 58, 344 (2010); Hosoda, H. et al.; Chem. Pharm. Bull. 32, 4023 (1984)

Applications Α labelled metabolite of Tamoxifen (T006000).
References Sun, D., et al.: Breast Cancer Res., 8(4), (2006), Zheng, Y., et al.: Drug Metab. Dispos., 35, 1942 (2007),

Applications Mycophenolic Acid Carboxybutoxy Ether Dimethyl Ester is a metabolite of Mycophenolic Acid (M831500).
References Wieland, E., et al.: Clin. Biochem., 33, 107 (2000), Shipkova, M., et al.: Ther. Drug Monit., 25, 1 (2003),

Applications Used in the preparation of triazole antifungal agents.

Applications 1- tert-Butyl-3-[4-phenoxy-2,5-di(propan-2 -yl)phenyl]thiourea is an isomer of Diafenthiuron (D310550), an insecticide.
References Delbeke, F., et al.: Entomophaga, 42, 349 (1997); Mezcua, M., et al.: Anal. Chem., 81, 913 (2009);

Applications 14,15-Epoxy-moxidectin is a by-product during the synthesis of 3,4-Epoxy-moxidectin (E589045), which is derived from the parent compound Moxidectin (M744800), a macrocyclic lactone and semisynthetic derivative of nemadectin. Moxidectin is a parasiticide used for the prevention and control of heartworm and intestinal worms. Moxidectin is found in veterinary medicine used to treat animals such as dogs, cats, horses, cattle and sheep.Also, it is one of the impurities of Moxidectin under stress conditions.
References Bisset, S.A. et al.: New Zeal. Vet. J., 40, 97 (1992); Monahan, C.M. et al.: Vet. Parasitol., 63, 225 (1996); Glickman, L.T. et al.: Int. J. Appl. Res. Vet. Med., 3, 49 (2005); Awasthi, A., et al.: Anal. Bioanal. Chem., 404, 2203-2222 (2012)

Applications 5α-Dihydrocortisol 21-Tetrahydro-2H-pyran-2-yl is an intermediate in the synthesis of Allo-3α-tetrahydro Cortisol 3-O-β-D-Glucuronide Sodium Salt-d7 (A548512), which is a metabolite of Cortisol (H714615) in human plasma.
References Ikegawa, S. et al.: Anal. Chem., 81, 10124 (2009); Kornel, L. et al.: J. Steroid. Biochem., 13, 751 (1980); Kornel, L. et al.: J. Steroid Biochem., 6, 1267 (1975);

Applications 2,4,5-Trichlorophenoxyacetic Acid Isobutyl Ester is a component in herbicide formulation used in the protection of crops.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Noble, A. et al.: Pest. Sci., 28, 203 (1990);

Applications 4-Hydroxybenzoyl Chloride is used in preparation of lysine sulfonamides as HIV-protease inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Stranix, B., et al.: Bioorg. Med. Chem. Lett., 16, 3459 (2006);