Étalons pharmaceutiques

Applications Asomate is an organoarsenic fungicide used for various agricultural goods. Research has shown that arsenic pollution manifested permanently and extensively when asomate was used continuously in apple orchard.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zhao, Z.Y., et al.: Xuanyi. Xueboa., 34, 117 (2007); Kim, N., et al.: Food. Sci. Biotechnol., 14, 554 (2005);

Applications (S)-7,8-Dihydroxy Efavirenz is a metabolite of (S)-Efavirenz (E425000); a nonnucleoside HIV-1 reverse transcriptase inhibitor.
References Young, S. D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995); Deng, Y., et al.: J. Sep. Sci., 38, 1529 (2015)

Stability Hygroscopic
Applications 25-​Cyclohexyl-​4'-​O-​de(2,​6-​dideoxy-​3-​O-​methyl-​α-​L-​arabino-​hexopyranosyl)​-​5-​demethoxy-​25-​de(1-​methylpropyl)​-​5-​oxo-avermectin A1a is an intermediate in synthesizing 22,23-Didehydro Selamectin (D439445), an impurity of Selamectin (S247990) which is a topical parasiticide. Selamectin (S247990) is also used as a veterinary antihelminithic agent on animals.
References Eshar, D., et al.: J. Am. Veterin. Med. Association., 241, 1056 (2012); Geis-Asteggiante, L., et al.: J. Chromatograph., 1258, 43 (2012)

Applications 14,15-Epoxy-25-des(dimethylbutenyl)-25-(1,3-dimethyl-2,3-epoxybutnyl) Moxidectin is a by-product during the synthesis of 3,4-Epoxy-moxidectin (E589045), which is derived from the parent compound Moxidectin (M744800), a macrocyclic lactone and semisynthetic derivative of nemadectin. Moxidectin is a parasiticide used for the prevention and control of heartworm and intestinal worms. Moxidectin is found in veterinary medicine used to treat animals such as dogs, cats, horses, cattle and sheep.Also, it is one of the impurities of Moxidectin under stress conditions.
References Bisset, S.A. et al.: New Zeal. Vet. J., 40, 97 (1992); Monahan, C.M. et al.: Vet. Parasitol., 63, 225 (1996); Glickman, L.T. et al.: Int. J. Appl. Res. Vet. Med., 3, 49 (2005); Awasthi, A., et al.: Anal. Bioanal. Chem., 404, 2203-2222 (2012)

Applications 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic Acid Methyl Ester is an imidazodiaepine derivative and an impurity of Midazolam (M343000), an anesthetic, anticonvulsant, sedative and hypotic agent.

Applications Nucleosides as antiviral agent for the treatment of influenza; broad-spectrum inhibitor of viruses in the Flaviviridae family.
References Sidwell, R.W., et al.: Appl. Microbiol., 22, 797 (1971), Allen, B., et al.: J. Med. Che,., 18, 721 (1976),

Applications (1S,αS)-trans-Cypermethrin is an impurity in the synthesis of θ-Cypermethrin which a synthetic pyrethroid used as an insecticide in large-scale commercial agricultural applications as well as in consumer products for domestic purposes. It behaves as a fast-acting neurotoxin in insects. Cypermethrin can exhibit a toxic effect on the reproductive system.
References Hu, J., et al.: J. Appl. Toxicol., 33, 576 (2011); Singh, A., et al.: Neurobiol. Aging., 33, 404 (2012); Amer, S., et al.: J. Mut. Res., 155, 135 (1985)

Stability No Data Availableg
Applications (1S,αS)-trans-Cypermethrin is an impurity in the synthesis of θ-Cypermethrin which a synthetic pyrethroid used as an insecticide in large-scale commercial agricultural applications as well as in consumer products for domestic purposes. It behaves as a fast-acting neurotoxin in insects. Cypermethrin can exhibit a toxic effect on the reproductive system.
References Hu, J., et al.: J. Appl. Toxicol., 33, 576 (2011); Singh, A., et al.: Neurobiol. Aging., 33, 404 (2012); Amer, S., et al.: J. Mut. Res., 155, 135 (1985)

Applications Phosphoric Acid Tris(3-​methylphenyl) Esteris a human urinary organophosphate flame retardant metabolite. It is also used to study properties of supercooled liquids.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Schindler, B., et al.: J. Chromat. B, 877, 375 (2009); Heuberger, G., et al.: J. Phys. Chem., 100, 15255 (1996); Blochowicz, T., et al.: J. Chem. Phys., 118, 7544 (2003)

Stability Hygroscopic
Applications 3,​3',​3''-​(2,​4,​6-​boroxintriyl)​tris-Pyridine Hydrochloride is a compound useful in organic synthesis.

Impurity Atorvastatin lactam phenanthrene calcium salt impurity
Applications Atorvastatin (A791750) impurity. A stable Atorvastatin formulation.

Applications 1,1'-((3,3',5,5'-Tetramethyl-[1,1'-biphenyl]-4,4'-diyl)bis(oxy))bis(propan-2-one) is an intermediate in the synthesis of Mexiletine Dimer (M340805), which is an impurity compound of Mexiletine (M340800), an antiarrhythmic (class IB).
References Singh, E.M., et al.: Br. J. Pharmacol., 44, 1 (1972); Scott, K.N., et al.: Drug Metab. Dispos., 1, 506 (1973); Chew, C.Y.C., et al.: Drugs, 17, 161 (1979); Abounassif, M.A., et al.: Anal. Profiles Drug Subs., 20, 433 (1991);

Applications A metabolite of Varenicline. Metabolite M5.
References Dow, J., et al.: Drug Metab. Dispos., 22, 738 (1994), Toide, K., et al.: Biochem. Pharmacol., 67, 1269 (2004), Coe, J., et al.: J. Med. Chem., 48, 3474 (2005), Doll, R., et al.: Br. J. Cancer, 92, 426 (2005),

Applications N-Guanyl-S-Methyl-Isothiourea Hydroiodide is a reactant used in the synthesis of novel compounds that may be used as HIV entry inhibitors.
References Wilkinson, R. et al.: Antimicrob. Agents Chemother., 55, 255 (2011);

Applications Δ6-Gestodene, is an impurity of Gestodene (G368250), an orally active gestogen with progesterone-like profile of activity. Used in combination with estrogen as oral contraceptive.
References Duesterberg, B., et al.: Contraception, 24, 673 (1981); Duesterberg, B., et al.: Seroids, 43, 43 (1984); Losert, W., et al.: Arzneim.-Forsch., 35, 459 (1985);