Étalons pharmaceutiques

Applications 2-Bromo-4-fluoroacetophenone (cas# 1006-39-9) is a compound useful in organic synthesis.

Impurity Atorvastatin 2-Hydroxy Lactone
Stability Hygroscopic
Applications A metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.

Applications 3-Deoxy-D-ribo-hexono-1,4-lactone, is a building block used in synthesis of various compounds.

Stability Hygroscopic
Applications A metabolite of Mosapride (M731000).
References Chen, H., et al.: J. Pharm. Biomed. Anal., 40, 142 (2006), Pedraglio, S., et al.: J. Pharm. Biomed. Anal., 44, 665 (2007), Christopher, L., et al.: Drug Metab. Dispos., 36, 1341 (2008), Curran, M., et al.: Drugs, 68, 981 (2008),

Applications (S)-1-Amino-3-chloro-2-propanol Hydrochloride is used in biological studies as an orally active male antifertility agent which is mediated by an effect on epididymal and vas deferens sperm.
References Coppola, J. A., et al.: Contraception, 9, 459 (1974);

Stability Hygroscopic
Applications Atorvastatin (A791750) impurity.
References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996);

Applications Dihydronaftazone-d4 O-β-D-Glucuronide is labelled Dihydronaftazone O-β-D-Glucuronide (D450330) which is a metabolite of Naftazone (N359270) which is a novel anti-anflammatory agent as well as an anti-proliferative agent due to its 1,2-napthoquinone substructure.
References Marrero-Ponce, Y. et al.: Eur. J. Med. Chem., 46, 5736 (2011)

Applications 2',5'-Dideoxyuridine (cas# 35959-50-3) is a useful research chemical.

Applications (+)-Pinanediol-2-O-(hydrogen Sulfate) is a reactant used in studies on formation of organosulfates from reactive uptake of monoterpene oxides on neutral and acidic sulfate particles.
References Iinuma, Y., et al.: Phys. Chem. Chem. Phys., 11, 7985 (2009);

Applications Aluminum Glycinate is an antacid which is used in the treatment of peptic ulceration. It is used in the development of a transdermal hydrogel patch for ferulic acid to treat skin damage induced by UV radiation.
References Rice, M., et al.: Am. J. Gastroenterol., 25, 74 (1956); Bai, J., et al.: Pak. J. Pharm Sci., 27, 369 (2014);

Applications 1-​(6-​Amino-​9H-​purin-​2-​yl)​-1H-​pyrazole-​4-​carboxylic Acid Ethyl Ester is an intermediate in synthesizing 1-(6-Amino-9H-purin-2-yl)-N-methyl-1H-pyrazole-4-carboxamide (A629440), it is used in the synthetic preparation of regadenoson and intermediates by using cyclocondensation, amidation and condensation as the key steps.
References Chai, J.; et al.: Faming Zhuanli Shenqing. 14pp.Patent 2015 CODEN:CNXXEV

Applications 7-Ethoxy-4-methylcoumarin (cas# 87-05-8) is a useful research chemical.