Glycosciences

a-D-Lactose 1-phosphate barium salt is a modification of a D-lactose monosaccharide. It is a complex carbohydrate that has been synthesized using the polyol method. The CAS number for this product is 103404-65-5. This product is available in high purity and the molecular weight of this compound is 576. a-D-Lactose 1-phosphate barium salt can be used as an ingredient in pharmaceuticals, food products, and cosmetics. It has been shown to have anticariogenic activities and may be used as a substitute for sucrose in food products.

L-Threonic acid-1,4-lactone is a nutrient solution for mammalian tissue. It is a coenzyme that acts as an intermediate in the conversion of dehydroascorbic acid to erythronate and participates in the synthesis of 4-hydroxycinnamic acid from 4-hydroxyphenylpyruvic acid. L-Threonic acid-1,4-lactone has been shown to inhibit the replication of human immunodeficiency virus (HIV) in vitro. The physiological levels of L-Threonic acid-1,4-lactone are not yet known, but it has been shown to have inhibitory properties on HIV infection at concentrations that do not affect cellular metabolism or induce reactive oxygen species production. L-Threonic acid-1,4-lactone also has been shown to prevent hepatic steatosis and fatty liver disease by inhibiting lipid accumulation via its ability to

Chiral synthon; used to synthesise analgoues of natural products

Fructodecasaccharide is a methylated, custom-synthesized oligosaccharide that is a polysaccharide with the molecular formula C10H17O11. Fructodecasaccharide is a complex carbohydrate that consists of a monosaccharide and two disaccharides. It has been modified to include fluorine atoms in the glycosidic linkages between the sugar residues. This modification can alter the physical properties of fructodecasaccharide, such as increasing its solubility and stabilizing its structure. Fructodecasaccharide is used in many industries as a high-purity, synthetic product for use in medical applications, including pharmaceuticals and cosmetics.

Candesartan N-glucuronide is a metabolite of candesartan. It is produced by human UDP-glucuronosyltransferase, which belongs to the subfamily of uridine diphosphate (UDP)-glucuronosyltransferases. Candesartan N-glucuronide inhibits angiotensin II receptor type 1 (AT1) and has minimal effects on angiotensin II receptor type 2 (AT2). Candesartan N-glucuronide binds to the AT1 receptor and blocks its activation by angiotensin II. This binding inhibits the uptake of sodium ions into cells and causes an increase in potassium ion secretion, leading to vasodilation. Candesartan N-glucuronide also induces the expression of cytochrome P450 3A5, which results in increased metabolism of drugs such as paclitaxel.

Alpha-cyclodextrin (α-CD) derivative with a hydrophilic exterior and lipophilic cavity (smaller than β-CDs and γ-CDs) to allocate certain guest molecules. This structural characteristic enables applications in molecular encapsulation, solubility enhancement, and stabilization across multiple industries. In pharmaceuticals, it serves as a drug delivery vehicle, enhancing the bioavailability and stability of active ingredients. The food industry utilizes it as a stabilizer for flavors, colors, and nutrients, as well as a functional ingredient for its effects on lipid metabolism. In cosmetics, it acts as a complex agent for fragrances and active components. Its applications extend to analytical chemistry for chiral separation and to materials science for developing smart materials and nanosystems.

Fucogalactan (GFS) is a polysaccharide isolated and purified from the brown seaweed Undaria pinnatifida. The polysaccharide is a sulphated galactose containing fucan. Fucogalactan is currently under investigation for possible therapeutic indications including anti-inflammatory properties, immuno- modulating activities, inhibition of tumor growth, stem cell replentishment, antiviral activity, dementia and ulcer healing.Fucoidan ≥ 75 %
The image was kindly provided by Prof Mike Guiry from Cork who runs ‘The Seaweed Site’.

Polysorbate 20 is a sodium salt of polyoxyethylene sorbitan monolaurate, which is a biocompatible polymer. It is used as an emulsifier in pharmaceuticals, foods, cosmetics, and other personal care products. Polysorbate 20 has been shown to be effective against the production of proprotein convertase subtilisin/kexin type 9 (PCSK9), a protein that regulates the levels of low-density lipoprotein cholesterol (LDL-C) in the blood. This drug has also been shown to enhance the production of monoclonal antibodies by human serum cells. Polysorbate 20 can be used for cell lysis and biological sample handling due to its ability to dissolve proteins, including biological samples such as tissue sections or blood smears.

Ribulose 5-phosphate sodium is a chemical that can be used to inhibit the enzyme ribulose phosphate reductase. Ribulose 5-phosphate sodium has been shown to inhibit glycolaldehyde production in the chloroplasts of plants, effectively reducing the amount of carbon dioxide produced. This chemical has also been shown to have an inhibitory effect on other enzymes involved in carbon fixation and assimilation. The effectiveness of this chemical is dependent on the specific plant species and environmental conditions.

Silodosin O-beta-D-glucuronide is a metabolite of silodosin, a drug used to treat benign prostatic hyperplasia. It is the glucuronide conjugate of silodosin and its presence in plasma can be quantified by high performance liquid chromatography (HPLC). The solvents used in HPLC are acetonitrile and ammonium formate. The chromatographic separation is achieved with a mobile phase consisting of an organic solvent (acetonitrile) and an ion pairing agent (ammonium formate) that interacts with the analyte and forms an ion pair. The sensitivity of HPLC for this analyte can be improved by using deuterated solvents.

Pectins are regarded as linear chains of α-1,4-linked D-galacturonic acid, a homogalacturonan (pectic acid). In the products of commerce, the degree of methylation has a vital influence on the properties of pectin, especially the solubility and gel forming characteristics.

6-Deoxy-6-iodo-a-cyclodextrin is a cavity-forming agent that is used in the treatment of dental cavities. It has been shown to be effective against Streptococcus mutans and is less toxic than other cavity treatments. 6-Deoxy-6-iodo-a-cyclodextrin also has phosphorescence and can be used as a fluorescent tracer. This molecule has been shown to form complexes with 3-bromoquinoline, which are good substrates for cyclodextrin synthesis. In addition, it reacts with 6-bromo2 naphthol to form a complex that includes an electron donor and an electron acceptor. The complex absorbs light at wavelengths of 400 nm or more and emits light at wavelengths of 500 nm or less, making it useful for luminescent imaging systems.

S-(-)-Perillyl alcohol glucoside is a glycoconjugate that has been shown to inhibit β-glucosidase and pancreatic lipase. It is used in the treatment of cancers, such as colorectal cancer, by inhibiting glucose uptake into cells. S-(-)-Perillyl alcohol glucoside may also have anticancer effects by inhibiting glucose transporters and caspases.

Lewis B tetrasaccharide-sp-biotin is a high purity, custom synthesis of saccharides. The saccharide is modified with a Click modification and fluorination. Glycosylation, methylation, and other modifications are also present in this product. Lewis B tetrasaccharide-sp-biotin is used in research for the glycosylation of proteins and to study carbohydrate binding proteins.

Cholesterol b-D-glucoside is a modified cholesterol that has been fluorinated and methylated. It is a complex carbohydrate that can be used in the synthesis of oligosaccharides and monosaccharides. Cholesterol b-D-glucoside is soluble in water, alcohols, and ethers and is insoluble in chloroform. The CAS number for Cholesterol b-D-glucoside 7073-61-2. This product is available for custom synthesis, which means it can be made to order with the specifications you need.

Digalactosyl diglyceride is a lipid that is found in the wax of plants. It has been shown to have anti-inflammatory properties and can be used as a nonsteroidal anti-inflammatory drug. Digalactosyl diglyceride binds to nuclear DNA and inhibits fatty acid synthesis, which leads to membrane destabilization.