Glycosciences

<p>Applications Coumarin 307 is a suitable candidate for use as a laser dye.<br></p>

<p>Applications trans-4-Hydroxy-2-hexenal-5,5,6,6,6-d5 Dimethyl Acetal (CAS# 1219806-40-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications sn-Glycerol 3-Phosphate Bis(cyclohexylammonium) Salt is a standard used for measuring the level of glycerol-3-phosphate produced by the hydrolysis of phosphatidic acid. Glycerol 3-phosphate (G3P) is an important intermediate of carbohydrate and lipid metabolic pathways.<br>References Morita, S., et al.: J. Lipid Res., 50, 1945 (2009); Feesner, W., et al.: Angewandte Chemie, 106, 217 (1994)<br></p>

<p>Stability Hygroscopic<br>Applications 4-O-α-D-Mannopyranosyl-D-mannose is used in the preparation of immunostimulants, useful as materials for foods as well.<br>References Imamura, L., et al.: Biol. Pharm. Bull., 17, 596 (1994), ,Perrin, S., et al.: J. Appl. Microbiol., 90, 859 (2001), Olano-Martin, E., et al.: J. Appl. Microbiol., 93, 505 (2002), Gibson, G., et al.: J. Food Sci., 69, 141 (2004),<br></p>

<p>Applications 5-(4-Hydroxyphenyl)-5-phenyl-d5-hydantoin-15N2 (CAS# 369656-71-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tri-p-tolylamine-15N (CAS# 311761-87-2) is a useful isotopically labeled research compound. This compound has been used in structural studies relating to photoconductivity of various polymers.<br>References Kesling, B., et.al., J Labelled Compd Rad., 43,1059-1068,(2000);<br></p>

<p>Applications 2-Acetamido-4,6-O-benzylidene-2-deoxy-beta-D-glucopyranosyl Azide 168397-51-1 (cas# 168397-51-1) is a useful research chemical.<br></p>

<p>Applications 5-Azido-6-(tert-butyldimethylsilyl)-2,3-O-isopropylidene L-Gulono-1,4-lactone (cas# 118464-49-6) is a compound useful in organic synthesis.<br></p>

<p>Applications D-Mannose-6-O-sulphate Sodium Salt (cas# 204575-08-6) was a product of esterase-catalyzed regioselective deacylation and acid-catalyzed rearrangement from per-acetylated derivatives.<br>References Horrobin, T., et al.: J. Chem. Soc. Perkin 1, 1069 (1998)<br></p>

<p>Applications p-Nitrophenyl 2-Acetamido-2-deoxy-(4-O-2-acetamido-2-deoxy-β-D-_x000D_glucopyranosyl)-α-D-galactopyranoside is a compound useful in organic synthesis.<br>References Medina, M. et al.: Cancer Res. 59,1061-1070, (1999)<br></p>

<p>Applications D-Glucosamine-2-N-sulfate sodium salt (cas# 38899-05-7) is a useful research chemical.<br></p>

<p>Applications D-Gentiobiose is incorporated in the chemical structure of Crocin (C794945); a natural carotenoid derived from the flowers crocus and gardenia, that has been shown to be a potent antioxidant. Also shown to have an antiproliferative action against cancer cells in vitro. Possible antidepressant properties.<br>References Zheng, Y. Q., et al.: Brain Res., 1138, 86 (2006); Hosseinzadeh, H., et al.: PTR, 24 (5), 726 (2010); Ochiai, T., et al.: Biochim. Biophys. Acta., 1770(4), 578 (2006)<br></p>

<p>Applications Derivative of Neuraminic Acid<br>References Oetke, C., et al.: J. Biol. Chem., 277, 6688 (2002),<br></p>

<p>Applications 3-Acetamido-3-deoxy-D-glucose (cas# 14086-88-5) is a compound useful in organic synthesis.<br></p>

<p>Applications β-D-Glucosamine Pentaacetate is an N-acetylglucosamine derivative that has been shown to promote hyaluronic acid production.<br>References Bastida, A., et al.: Biotechnol. Bioeng., 58, 486 (1998), Mong, T., et al.: Chem. Biochem., 4, 835 (2003), Mogensen, J., et al.: Biochemistry, 44, 1719 (2005), Schulz, T.,Schumacher, U. and Prehm, P. Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP. The Journal of Biological Chemisty 282(29), 20999-21004 (2007).<br></p>

<p>Applications 4-Acetamidophenyl β-D-Glucuronic Acid Methyl Ester is an intermediate to synthesize Acetaminophen (A161220) metabolites (1).<br>References (1) Burgess, S., et al.: Anal. Biochem., 312, 228 (2003)<br></p>

<p>Applications 5alpha-Pregnan-11beta,17alpha,21-triol-3,20-dione-1,2,4,5-d4 (CAS# 252976-11-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Nitrophenyl 2-Acetamido-2-deoxy-4-O-α-L-fucopyranosyl)-β-D-glucopyranoside (cas# 259143-52-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Nitrobenzonitrile-d4 (CAS# 1219795-50-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Used in the synthesis of novel bis(D-mannose) compounds.<br>References Holman, G.D., et al.: Carbohydrate Res., 135, 337 (1985),<br></p>

<p>Applications Isolevoglucosenone (cas# 307991-08-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Fucoidan is a polysaccharide composed predominantly of sulfated fucose.<br></p>

<p>Applications Benzyl 2-Acetamido-2-deoxy-4-O-(β-D-galactopyranosyl)-β-_x000D_D-glucopyranoside (cas# 53167-38-7 ) is a compound useful in organic synthesis.<br>References Ohmae, M., et al.: ChemBioChem., 8, 1710 (2007),<br></p>

<p>Applications L-Glucose is the enantiomer of D-Glucose (G595000), a naturally occurring carbohydrate used in an abundance of cellular processes. L-Glucose is a synthetic sugar used in the formation of L-Glucose Pentaacetate (G596510), a potential therapeutic agent regarding type II diabetes. In addition, L-glucose can be used as a colon cleansing agent for before a colonoscopy procedure.<br>References Malaisse, W. et al.: Int. J. Mol. Med., 2, 383 (1998); Raymer, G. et al.: Gastrointest. Endosc., 58, 30 (2003); Wang, R., et al.: J. Mol. Catal. B. Enz., 56, 131 (2009),<br></p>

<p>Applications 1,8-Octanedioic-d12 Acid (CAS# 169397-99-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-O-β-D-Mannopyranosyl-D-glucopyranoside (cas# 29276-55-9) is a compound useful in organic synthesis.<br></p>

<p>Applications An inhibitor of peptic hydrolysis and stomach acidity. Used as an anti-ulcerative.<br>References Mayberr, J.F., et al.: Brit. J. Clin. Pract., 32, 291 (1978); Brogden, R.N., et al.: Drugs, 27, 194 (1984);<br></p>

<p>Applications Isotope labelled D-galactose (G155250), A C-4 epimer of Glucose (G595000) found in milk and sugar beets as well as being synthesized by the body. Potential use in oral therapy for nephrotic syndrome in focal and segmental glomerulosclerosis.<br>References De Smet, E. et al.: Nephrol. Dial. Transplant., 24, 2938 (2009); Kivele, R. et al.: Carb. Pol., 85, 645 (2011);<br></p>

<p>Stability Hygroscopic<br>Applications Methylprotodioscin is a steroidal saponin compound found in a number of plant species. It is known to be the active component of the herbal aphrodisiac plant Tribulus terrestris. It has also shown to produce significant increases in the levels of the hormonal levels in animal studies.<br>References Gauthaman, K., et al.: Inter. J. Phytother. Phytopharm., 15, 44 (2008); Ganzera, M., et al.: J. Pharmac. Sci., 90(11), 1752 (2001);<br></p>

<p>Applications Isomaltopentaose, is an isomalto-oligosaccharides (IMO) compound, used as functional food ingredients.<br>References Hu, Y., et al.: Lett. App. Microbio., 57, 108 (2013);<br></p>

<p>Applications 3,5-Dimethyl-d6-cyclohexanone-3,4,4,5-d4 (mixture of isomers) (CAS# 1219804-55-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl-2,2,2-d3-malonic Acid (CAS# 70907-93-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Oligosaccharide which participates in cell adhesion between bacterial and eukaryotic cells<br>References Perret, S., et al.: Biochem. J., 389, 325 (2005), Marotte, K., et al.: ChemMedChem., 2, 1328 (2007),<br></p>

<p>Applications DL-Arabinose, is a building block of polysaccharide (CCPa-1) from fungus Coprinus comatus Gray, which has potential application as natural antitumor agent with immunomodulatory activity. Arabinose is also used as a culture medium for certain bacteria.<br>References Xiao-Gang, J., et al.: Int. J. Bio. Macromol., 58, 349 (2013);<br></p>

<p>Applications Useful substrate for the rapid colorimetric assay of N-Acetyl-beta-glucosaminidase in human urine.<br>References Muruhn, D.: Clin. Chim. Acta, 73, 453 (1976)<br></p>

<p>Applications Antigen which binds to endothelial adhesion molecule, E-selectin.<br>References Fukushima, K., et al.: Cancer Research, 44, 5279 (1984), Zein, N., et al.: Science, 240, 1198 (1988), Phillips, M.L., et al.: Science, 250, 1130 (1990), Walz, G., et al.: P.N.A.S. U.S.A., 88, 6224 (1991), Walker, S., et al.: P.N.A.S. U.S.A., 89, 4608 (1992)<br></p>

<p>Applications Ethyl-alpha-13C-benzene (CAS# 287399-32-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Inhibition of β-glucosidase.<br>References Barkley, M.D., et al.: Biochemistry, 14, 1700 (1975), Gonzalez, J.B., Biotechnol. Lett., 4, 369 (1982)<br></p>

<p>Applications 1,6-Anhydro-3,4-O-isopropylidene-2-tosyl-β-D-galactopyranose is used in the HPLC detection and evaluation of chiral compounds with a laser-based chiroptical detector.<br>References Reitsma, B., et al.: J. Chromatogr., 362, 353 (1986), Lloyd, D., et al.: Anal. Chem., 61, 1238 (1989),<br></p>

<p>Applications 2-Acetamido-2-deoxy-D-mannono-1,4-lactone (cas# 28876-37-1) is a compound useful in organic synthesis.<br></p>

<p>Applications α-D-Mannose 1-Phosphate is used in the synthesis of non-natural mannoglucans by α-glucan phosphorylase-catalyzed enzymatic copolymerization;Also, it is derived from D-Mannose (M168000), which is a carbohydrate that is important in the glycosylation of molecules in a variety of cellular processes. It is involved in N and O glycosylation of bovine why protein products, used in infant formulas. It is also responsible for the O-glycosylation of the T helper cell-derived cytokine interlukin-17A, an important cell-signaling molecule.<br>References Baba, R., et al.: Carbohydr. Polym., 151, 1034-1039 (2016); van Leeuwen, S. et al.: J. Agri. Food Chem., 60, 12553 (2012); Geoghegan, K. et al.: Prot. Express. Purif., 87, 27 (2013);<br></p>

<p>Applications Thiogdigalactosideis an inhibitor of galectin 1 which has an essential role in high-fat diet induced obesity development.<br>References Mukherjee, R. et al.: Int. J. Obes., 39, 1349 (2015);<br></p>

<p>Applications N-Methoxy-N-methyl-β-D-glucopyranosylamine is used in the synthesis of 6-α-D-Glucopyranosyl Maltotriose (G419100), which is the sugar composition of sake.<br>References Giri, N.Y., et al.: Arch. Biochem. Biophysics, 145, 505 (1971)<br></p>

<p>Applications L-Mannose (cas# 10030-80-5) is a compound useful in organic synthesis.<br></p>

<p>Applications (8S-cis)-8-Acetyl-10-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione is an tert-butyldiphenylsilyl protected degredation product of Doxorubicin (D194500), an anthracycline antibiotic related to the rhodomycins.<br>References Matsumoto, T., et al.: Chem. Pharma. Bull., 34, 4613 (1986);<br></p>

<p>Applications It is produced by microorganism fermentation of glucose in a fermentation culture medium without adding calcium carbonate.<br>References Ostrowski, S., et al.: Science, 305, 71 (2004), Vavilin, D., et al.: Biochim. Biophys. Acta, 1708, 91 (2005), Fletcher, J., et al.: Anal. Chem., 79, 2199 (2007), Weissleder, R., et al.: Nature, 452, 580 (2008),<br></p>

<p>Applications 2-O-(α-D-Glucopyranosyl)-D-galactose (cas# 7368-73-2) is a compound useful in organic synthesis.<br>References Gent, P.A., et al.: J. Chem. Soc., 1, 1446 (1974)<br></p>

<p>Applications n-Hexane-1,1,1,2,2,3,3-d7 (CAS# 32740-31-1) is a useful isotopically labeled research compound.<br></p>

<p>Stability Hygroscopic<br>Applications Benzyl 3’-Sulfo-β-D-lactoside Sodium Salt (cas# 431898-95-2) is a compound useful in organic synthesis.<br></p>

<p>Applications A useful glycopeptide intermediate.<br></p>

<p>Applications 2-(Acetylamino)-2-deoxy-D-glucopyranose 3,4,6-Triacetate (cas# 34051-43-9) is a compound useful in organic synthesis.<br></p>

<p>Gala1-3(Fuca1-2)Galb1-3GlcNAc</p>

<p>7-Xylosyl-10-deacetyltaxol is a plant chemical that is found in the needles of the Taxus cuspidata tree. This compound has been shown to inhibit prostate cancer cells and has been clinically used as an adjuvant agent for cancer treatment. 7-Xylosyl-10-deacetyltaxol binds to prostate cancer cells and inhibits their growth, which may be due to its ability to inhibit cell cycle progression at the G2/M phase transition. It also has a strong inhibitory effect on test samples from human prostate cancer cells. In addition, it inhibits enzyme activities that are involved in the biosynthesis of membrane lipids, such as phospholipase A2, arachidonate 12-lipoxygenase, and cyclooxygenase 2. 7-Xylosyl-10-deacetyltaxol also inhibits enzyme activities in cell culture that are involved in the synthesis of carbon</p>

<p>8-Methoxycarbonyloctyl 2-deoxy-4,6-O-(4-methoxybenzylidene)-2-phthalimido-b-D-glucopyranoside is a sugar that is found in plants. It can be used as a custom synthesis for pharmaceutical purposes. The CAS number of this product is 359436-88-7 and it has a purity of &gt;99%.</p>

<p>1,4-β-D-Glucosyl-D-mannobiose is a specialized carbohydrate substrate, which is derived from complex polysaccharides typically found in plant cell walls. It acts as a substrate for endo-1,4-β-mannanase, an enzyme that cleaves specific glycosidic bonds within mannans. This substrate facilitates the investigation of enzymatic activity by allowing the measurement of endo-1,4-β-mannanase efficiency and specificity under controlled conditions.In biochemical enzyme assays, 1,4-β-D-Glucosyl-D-mannobiose serves as a critical component for quantifying mannanase activity. It enables researchers to study the enzyme's role in various biological processes, including polysaccharide degradation. Additionally, this product is invaluable in in vitro diagnostic analyses where precise enzyme activity assessment is crucial for understanding pathological states or the functionality of industrial enzyme preparations. Its applications extend to biotechnology research, where it aids in the formulation of enzyme-based solutions and optimization of enzymatic reactions in diverse biological and industrial contexts.</p>

<p>Benzyl 2-acetamido-4,6-O-benzylidene-2-deoxy-3-O-(b-D-galactopyranosyl)-a-D-galactopyranoside is a methylated and fluorinated monosaccharide. It is used in the synthesis of complex carbohydrates and oligosaccharides. The modification of this compound can be done with click chemistry, which is a process that allows for the rapid assembly of molecules on surfaces. This product has been shown to have high purity, making it suitable for use in research or production.</p>

<p>2-Acetamido-1,4-imino-1,2,4-trideoxy-L-arabinitol is a competitive inhibitor of the enzyme arabinitol dehydrogenase. This compound has been shown to be an enantiomer of 1,4-imino-1,2,4-trideoxyglucitol and inhibits the growth of Mycobacterium tuberculosis in vitro assays. 2AITDG also has inhibitory properties against macrophage cells and noncompetitive inhibitors against glycoprotein glycoconjugates. 2AITDG binds to endoplasmic reticulum chaperones such as BiP/Grp78 to inhibit protein folding and cellular proliferation. It may also inhibit protein synthesis by binding to ribosomes or blocking the activity of factors involved in transcription and translation.</p>

<p>5-Azido-5-deoxy-2,3-O-isopropylidene-D-lyxono-1,4-lactone is a synthetic monosaccharide. It is used in the synthesis of glycosylated saccharides and oligosaccharides. This product can be custom synthesized at high purity.</p>

<p>Allyl 4,6-O-benzylidene-b-D-glucopyranoside is a custom synthesis molecule that can be modified to suit your needs. It has been used in the synthesis of oligosaccharides and polysaccharides. Allyl 4,6-O-benzylidene-b-D-glucopyranoside is a high purity product that has been fluorinated with allyl bromide and benzoyl chloride. This product is a monosaccharide and sugar that can be synthesized from a variety of raw materials.</p>

<p>A modified heparin disaccharide</p>

<p>Benzyl N-acetyl-6-O-benzyl-a-D-muramic acid methyl ester is a synthetic glycosylation that is custom synthesized for the purpose of modifying glycoproteins. This compound can be used to add a fluorinated sugar to the glycan chain, which can help increase the drug's bioavailability. The synthesis of this compound is achieved through a click modification reaction.</p>

<p>2-Acetamido-2-deoxy-4-O-(b-D-galactopyranosyl)-D-mannopyranose is a disaccharide with the chemical formula C8H14N2O6. It has a glycosidic bond between two acetamides and a sequence of three sugars. It is also known as n-acetyl-d-mannosamine, or NAM. 2-Acetamido-2-deoxy-4-O-(b-D-galactopyranosyl)-D-mannopyranose is an important building block in the synthesis of glycoproteins. This molecule's carbohydrate structure confers it with properties that are similar to other monosaccharides.</p>

<p>2-Acetamido-3-O-acetyl-2-deoxy-D-glucopyranose is a methylated, acetylated, and fluorinated sugar that is used in the synthesis of glycosides. It is a polysaccharide with an Oligosaccharide and saccharide with Click modification that can be modified to suit your needs. The carbohydrate has high purity and can be synthesized from custom molecules. It can be synthesized from carbohydrates or sugars. This product is made synthetically for research purposes only, not for human consumption.</p>

<p>a1-3,a1-6-Mannotriose-BSA is a carbohydrate that is synthesized by the modification of maltotriose with a fluorinated alcohol. It is an oligosaccharide made up of three glucose units linked together in a 1,3 configuration and one glucose unit linked together in a 1,6 configuration. The molecular weight of this carbohydrate is 793 Daltons. This product has been shown to be high purity and custom synthesis for use in research.</p>

<p>Tetra-O-acetyl-3-O-benzyl-a-D-mannopyranose is a modification of mannose. It is a complex carbohydrate that belongs to the class of oligosaccharides and has CAS No. 65827-58-9. The molecular weight of this compound is 462.76 g/mol. Tetra-O-acetyl-3-O-benzyl mannopyranose is synthesized for use as an analytical reagent to study the glycosylation and methylation reactions in carbohydrates, as well as for use in diagnostic kits for the detection of penicillinase and erythromycin resistance genes. This product has high purity, custom synthesis, and can be used as a monosaccharide or polysaccharide sugar in glycosylation reactions. Tetra O acetyl 3 O benzyl mannopyranose can also be fluorinated</p>

<p>L-Noviose is a glycopeptide antibiotic that has been modified to increase its stability and bioavailability. The modifications have led to an increase in the activity of L-Noviose against gram-negative bacteria, including strains resistant to other antibiotics. This drug also inhibits bacterial biosynthesis by binding to the 30S ribosomal subunit and preventing the initiation of protein synthesis. L-Noviose is used clinically for the treatment of infections caused by Actinomyces, Enterobacter, Erysipelothrix, Haemophilus, Klebsiella, Proteus mirabilis, Pseudomonas aeruginosa and Staphylococcus aureus. The biological function of L-Noviose is to inhibit bacterial protein synthesis by binding to the 30S ribosomal subunit.</p>

<p>4-O-(b-D-Galactopyranosyl)-D-glucosamine HCl is a synthetic, water soluble, non-digestible oligosaccharide. It has regulatory effects on the utilisation of glucose and lacto-n-neotetraose by various cells in vitro. This compound also inhibits the development of intestinal pathogens in humans and elucidates their sequence specificity. 4-O-(b-D-Galactopyranosyl)-D-glucosamine HCl is used to study the role of this molecule in infant nutrition.</p>

<p>2-O-Acetyl-3,4,6-tri-O-benzyl-a-D-mannopyranosyl trichloroacetimidate is a complex carbohydrate that can be modified. It can be synthesized by Methylation, Glycosylation, Carbohydrate, Click modification and fluorination of 2-(2'-deoxyribofuranosyl)propionic acid. This product has CAS No. 108869-64-3 and a purity of greater than 98%.</p>

<p>This is a gene product that belongs to the family of histone proteins. It is a bacterial enzyme that participates in the biosynthesis of glycan, which plays an important role in bacterial pathogenicity and antigen expression. The 2-acetamido-2-deoxy-D-galactopyranose diphospho undecaprenyl (AGDP) has been shown to inhibit cancer cells by inhibiting histone protein acetylation. This inhibits DNA methylation, which may lead to tumorigenesis. Structural studies have also shown that AGDP binds to bacterial enzyme with high affinity and specificity, suggesting that it could be used as a potential antibacterial agent.</p>