Glycosciences

Applications Verbascose (CAS# 546-62-3) is an α-galactooligosaccharide with immunomodulatory activity in mouse macrophage RAW264.7 cells.
References Dai, Z.; et al.: J. Agric. Food. Chem., 66, 9070 (2018);

Inhibitor of viral, bacterial and animal sialidase

1,2,3,4-Tetra-O-pivaloyl-6-O-(tert-butyldiphenylsilyl)-b-D-glucopyranose is a custom synthesis of an oligosaccharide with a polysaccharide. The carbohydrate is modified with fluorination and methylation. This product has high purity and is synthesized using click chemistry. Monosaccharides are attached to the sugar backbone in order to form complex carbohydrates. This product can be used as a synthetic sugar or in the production of other oligosaccharides.

Fructosazine is a natural compound that is found in the bark of the fructus quinquefoliae tree. It has been shown to have antimicrobial properties when it reacts with hydrochloric acid. Fructosazine inhibits the growth of bacteria by reacting with their cell walls and interfering with their metabolism. Fructosazine may also have physiological effects, such as reducing blood pressure and body weight gain, which are not fully understood. The reaction mechanism for fructosazine is not yet known, but it may be due to its reactive nature. More research needs to be done on this compound before we can understand its full potential.

6'-O-Acetylpaniculoside II is an oligosaccharide that contains a methylated saccharide. It has CAS No. 836-50-4 and Click modification, which is a chemical reaction between the glycone of a saccharide and an electrophile. 6'-O-Acetylpaniculoside II is also a glycosylation product of a polysaccharide and it can be custom synthesized to produce high purity carbohydrates. This compound is fluorinated for complex carbohydrate chemistry.

Lactonamycin is a linker that contains an oxygenated functional group. It can be found in some active natural products and has been synthesized in the laboratory. Lactonamycin is used as a model system for biosynthesis, where it was shown to efficiently produce glycosidic bonds when supplied with carbon sources such as glucose. The biological properties of Lactonamycin include its ability to inhibit microbial infection and inflammation, which may be due to its hydroxy group.

Phosphatidyl inositol-10mg/ml solution in chloroform:methanol(4:1) is a carbohydrate that is a complex carbohydrate. It is synthesized by the modification of the phosphatidyl inositol molecule with fluorination and methylation. The CAS number for this compound is 91228-52-5. This product can be custom synthesized as per customer's requirements. It has a high purity and excellent quality, and is available at competitive prices.

6-Epi-castanospermine is a nitro compound that is synthesized by the allylic oxidation of castanospermine. It has been shown to inhibit glycosidases and glycosidase inhibitors in vitro, including those from the families of α-amylase, α-L-arabinofuranosidases, β-hexosaminidases, α-glucuronidases, and phytases. 6-Epi-castanospermine has also been used as an intermediate for the synthesis of chiral polyhydroxylated compounds. The 13C NMR spectrum of this compound was found to be diagnostic for its structural assignment.

Trehalose is a naturally occurring disaccharide found in many organisms.Its role in nature is as versatile as its applications in the laboratory. Trehalose is synthesized by cells in response to stress and helps retaining the cellular integrity under tough conditions: An important function of Trehalose is to stabilize protein structures and to prevent proteins from their degradation. Researchers use Trehalosefor instance as a carbon source in selective microbiological media, as desiccation protectant and for cryoprotection.

Produced from high maltose syrup by treatment with transglucosidase

Phenyl 3-deoxy-3-fluoro-a-D-glucopyranoside is a modified oligosaccharide, which is synthesized by the glycosylation of 3,6-diaminohexanoic acid with phenyl boronic acid. This compound is also known as an anti-tuberculosis drug. It has been shown to inhibit bacterial growth by binding to DNA dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch clamp technique on human erythrocytes. Phenyl 3-deoxy-3-fluoro-a-D-glucopyranoside also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX1 secretion system protein) and inhibits cell growth in culture.

This beta-cyclodextrin (β-CD) derivative is a functionalized cyclic oligosaccharide composed of seven glucose units, characterized by a hydrophilic exterior and a lipophilic cavity (bigger than α-CD and smaller than γ-CDs), which allows it to encapsulate various guest molecules. This structural feature facilitates its use in multiple applications, including pharmaceuticals, food enhancement, and cosmetics. In the pharmaceutical industry, it enhances the solubility and stability of poorly water-soluble drugs, improving their bioavailability and efficacy while also masking unpleasant tastes. The food sector utilizes it as a stabilizer for flavors, colors, and nutrients, extending shelf life by protecting sensitive ingredients from degradation. In cosmetics, it serves as a complexing agent for fragrances and active components, ensuring their stability and controlled release. Its use expands to many other fields, including nanotechnology for drug delivery systems, environmental remediation for extracting organic pollutants, textiles for slow-release fragrances, and analytical chemistry for chiral separation.

Methyl 6-O-tert-butyldimethylsilyl-2,3,4-tri-O-pivaloyl-a-D-mannopyranoside is a synthetic glycosylation agent that can be used for the synthesis of complex carbohydrates. This product has been fluorinated and saccharide modified. Methyl 6-O-tert-butyldimethylsilyl-2,3,4-tri-O-pivaloyl-aDmannopyranoside is available in CAS number: 5756782.

Paracetamol glucoside is a prodrug that is hydrolyzed in vivo to paracetamol. It has an inhibitory effect on the uptake of photosynthetic pigments, and has been shown to have a chronic exposure inhibitory effect on the activity of enzymes such as catalase, peroxidase, and glutathione reductase. The uptake and toxic effects of paracetamol glucoside have been studied in vitro and also in vivo. In vitro studies have shown that animals are less sensitive to the toxicity of this compound than humans.

Chitin forms the tough fibrous exoskeletons of insects, crustaceans and other arthropods, and, in addition to its presence in some fungi, it occurs in at least one alga. The structure of chitin is similar to that of cellulose but with glucose replaced with N-acetyl-D-glucosaminyl units linked β-D-(1,4) in a linear chain. Chitin is normally produced from the shells of lobster, crab or shrimp.

(2R, 3S, 4R, 5S) -2- Butyl-3, 4, 5- piperidinetriol is a custom synthesis of a fluorinated saccharide. It is a modified monosaccharide that has been synthesized by methylation and click modification. This molecule is an oligosaccharide with glycosylation at both the sugar and carbohydrate level. The saccharide in this compound is a complex carbohydrate that contains two sugar units.

2-Acetamido-1,3,6-tri-O-benzyl-2-deoxy-b-D-glucopyranoside is a synthetic monosaccharide that can be modified to the desired structures. It is used as a building block for the synthesis of polysaccharides and oligosaccharides. It is also used as an intermediate in the preparation of saccharides. 2 - Acetamido - 1,3,6 - tri - O - benzyl - 2 - deoxy - b - D - glucopyranoside is available in high purity and custom synthesis.

Phenyl 4-deoxy-4-fluoro-a-D-glucopyranoside is a custom synthesis that can be modified with fluorination, methylation, monosaccharide and oligosaccharide. It has CAS No. and is a polysaccharide. Phenyl 4-deoxy-4-fluoro-a-D-glucopyranoside is a sugar that is glycosylated and complexed with carbohydrates.

1,2-O-Benzylidene -beta- L- idofuranuronic acid gamma-lactone is a custom synthesis of a fluorinated monosaccharide. The modification of the sugar is accomplished by methylation and click chemistry. The monosaccharide can be used as a building block for oligosaccharides and polysaccharides. It is also used as an intermediate in the glycosylation process that produces complex carbohydrates.

3-Deoxy-D-gluconic acid is a chemical compound that has the chemical structure of C6H12O6. It is a white crystalline solid that can be found in nature as a reaction product of glucose and oxygen. 3-Deoxy-D-gluconic acid can also be synthesized by reacting D-glucose with nitrous acid or sulfur dioxide. 3-Deoxy-D-gluconic acid is an organic acid and has been shown to inhibit the growth of filamentous fungi by acting on their glycosidic bonds. This chemical compound has not been shown to have any adverse health effects in humans, although it may cause irritation if it comes into contact with skin or eyes.

Bearberry has been used for centuries to treat various disorders of the urinary tract and prostate. The active ingredient in bearberry is a flavonol glycoside called arbutin, which is converted to hydroquinone during metabolism. As an antioxidant, hydroquinone inhibits the oxidation of LDL cholesterol and may reduce the risk of atherosclerosis. Hydroquinone has also been shown to have anti-inflammatory properties in rat liver microsomes and tissue culture, inhibiting prostaglandin synthesis by blocking cyclooxygenase activity. In vitro, bearberry extracts have been shown to inhibit bacterial growth on agar plates with pH levels from 4-7 and at concentrations between 0.1-1%. It was found that bearberry extracts were most effective against Pseudomonas aeruginosa strains, with MIC values ranging from 2-4 mg/mL. Bearberry extract was observed to be more effective than ampicillin against these strains in a chromatographic assay.

Salicylic acid D-glucuronide is the major metabolite of aspirin, which is formed by hydrolysis of acetylsalicylic acid. It has been demonstrated to have anti-inflammatory and analgesic effects. Salicylic acid D-glucuronide is excreted in urine and can be detected in human serum. The formation rate of this metabolite varies with the individual's age, sex, and kidney function.
Salicylic acid D-glucuronide can be formed in vitro using hydrochloric acid and acetylsalicylic acid as substrates. This reaction is catalyzed by the enzyme uridine diphosphate glucuronyltransferase (UGT). Salicylic acid D-glucuronide has been shown to form covalent adducts with hydroxyl groups from other molecules in vivo and in vitro, including proteins (e.g., albumin) and DNA bases (e.g.,

Methyl 2,3-di-O-p-toluenesulfonyl-6-O-trityl-a-D-glucopyranoside is a custom synthesis of a natural product. It is an analogue of the disaccharide sucrose (CAS No. 69649-64-5). Methyl 2,3-di-O-p-toluenesulfonyl 6-[(trityloxy)methyl]-a-(1,2:4,5)-D glucopyranoside reacts with fluoride ion to form methyl 2,3 di -O - p - toluenesulfonyl 6-[(trityloxy)methyl]-a-(1,2:4,5)-D glucopyranoside fluoride ion. The monosaccharides are linked by glycosyl bonds and can be modified by different reactions such as oxidation or reduction. The saccharide can be modified

Diethylstilbestrol (DES) is an endogenous substance that has been shown to be a potent estrogen. It is metabolized in the body to form stilbestrol glucuronide, which is excreted in the urine. Radiolabeling studies have shown that DES has a chemical structure similar to estradiol, although its pharmacologic effects are not as potent. Diethylstilbestrol glucuronide can be used for the diagnosis of cancer and other diseases by using nuclear medicine techniques such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT). Studies have also demonstrated that DES can induce erythropoietic protoporphyria in animals.

3,5-Dideoxy-N-(1-hexyl)-3,5-imino-D-xylopentitol is a synthetic monosaccharide that is used in the production of complex carbohydrates. It can be modified with fluorination and methylation to produce 3,5-dideoxy-N-(1-hexyl)-3,5-[(2-[(2,6-difluoro phenoxy)methyl]phenyl]imino)D-xylopentitol. The compound has been shown to have antiviral properties and has been used in the synthesis of glycosaminoglycans.

Dextran sulphate is a dextran derivative whose ulcer (colitis) -causing properties were first reported in hamsters and extrapolated a few years later to mice and rats. The exact mechanisms through which dextran sulphate induces intestinal inflammation are unclear but may be the result of direct damage of the monolayer of epithelial cells in the colon, leading to the crossing of intestinal contents (for e.g. commensal bacteria and their products) into underlying tissue and therefore induction of inflammation.  The dextran sulphate sodium-induced ulceration model in laboratory animals has some advantages when compared to other animal models of colitis due to its simplicity and similarities to human inflammatory bowel disease. 
MW is in the range of 40,000Da

Starch consists of two polysaccharides, amylose and amylopectin and represents approximately 20-25% of the total polysaccharide content in starch. Amylose molecules consist of single mostly unbranched chains of 500-20,000 α-(1->4)-D-glucose residues dependent on source (e.g. wheat, rice, potato, tapioca, etc). Amylose can form an extended shape (hydrodynamic radius 7-22 nm) but generally tends to wind up into a rather stiff left-handed single helix or form even stiffer parallel left-handed double helical junction zones. Hydrogen bonding between aligned chains causes retrogradation and releases some of the bound water (syneresis). The aligned chains may then form double stranded crystallites that are resistant to amylases. These possess extensive inter- and intra-strand hydrogen bonding, resulting in a fairly hydrophobic structure of low solubility. The amylose content of starches is thus the major cause of resistant starch formation.

Varenicline N-glucoside is a modification of varenicline, which is an antagonist of the nicotinic acetylcholine receptor. This compound has been synthesized using custom synthesis and glycosylation to obtain high purity. It has been methylated and fluorinated in order to remove any impurities. Varenicline N-glucoside is a carbohydrate with a molecular weight of 581.5 g/mol, consisting of one monosaccharide and one disaccharide. It also contains a complex carbohydrate with an oligosaccharide chain that is composed of glycosylation and saccharide units. The CAS number for this compound is 873302-31-9.

Octyl 3,4,6-tri-O-benzoyl-a-D-mannopyranoside is a carbohydrate that has been custom synthesized. It has a molecular weight of 614.4 g/mol and the chemical formula C30H50O8. This compound is an oligosaccharide with a polysaccharide backbone. Octyl 3,4,6-tri-O-benzoyl-a-D-mannopyranoside is soluble in water and ethanol, but insoluble in hexane or ether. It has CAS No. 19308-45-3 and can be modified by methylation or glycosylation. The molecule contains three sugar residues that have been linked through glycosidic bonds to form a triose sugar (a sugar containing three carbon atoms). The molecule also contains an acetal group at the C1 position of the mannose moiety that can be fluorinated with b