Glycosciences

<p>3-Deoxy-L-threo-2-hexulosaric acid is a sugar that is modified by the addition of a fluorine atom to one of its hydroxyl groups. 3-Deoxy-L-threo-2-hexulosaric acid is used in the synthesis of complex carbohydrates and oligosaccharides. It is also used in the modification of saccharides, sugars, and polysaccharides. 3-Deoxy-L-threo-2-hexulosaric acid can be custom synthesized according to your specifications. It can be synthesized with high purity at our labs.</p>

<p>2,3:4,5-Di-O-isopropylidene-1,6-di-O-benzyl-D-myo-inositol is a complex carbohydrate and a sugar. It is an oligosaccharide with two monosaccharides and a glycosidic linkage. It has been modified by methylation, fluorination and Click chemistry. This compound has been custom synthesized for high purity.</p>

<p>GDP-D-mannose is a natural mannosyl donor and substrate for mannosyltransferases that catalyses mannosylation, for instance during the synthesis of the trimannoside core of complex, high-mannose or hybrid N-glycans. GDP-D-mannose is widely used in (chemo)enzymatic synthesis of oligosaccharides and its biosynthesis occurs from glucose-6-phosphate over several steps. GDP-D-mannose consists of a D-mannose unit, α-glycosydically linked to the nucleotide guanosine diphosphate (GDP). Examples of this important reaction would be the transfer of mannosyl moieties onto the dolichol-P-P-GlcNAc2 precursor of N-glycans in the endoplasmatic reticulum, with release of GDP, or the mannosylation reactions during GPI-anchor (bio)synthesis. GDP-D-mannose has also been used for the in vitro synthesis of b-mannan oligosaccharides.</p>

<p>UDP-a-D-galactose disodium salt is a nucleotide sugar that is used in the synthesis of oligosaccharides. It is also used to identify mammalian cells that express UDP-galactose:quinone oxidoreductase, which are responsible for synthesizing the sugar. It is a building block of the influenza virus and has been shown to inhibit viral growth by interfering with RNA synthesis. This compound can be synthesized using solid-phase synthesis or multienzyme strategy.</p>

<p>3,4-O-Isopropylidene-D-arabinose is a synthetic compound that has been used as an active analogue for the study of nucleophile reactions. 3,4-O-Isopropylidene-D-arabinose undergoes nucleophilic addition with potassium azide to form a thiazolidine intermediate. The stereospecificity of this reaction was shown by the chemists and biochemists who synthesized it. It has also been shown to react with an anion in a similar manner. This chemical is used in the synthesis of d-arabinose, which can be used for the production of other compounds.</p>

<p>A fucan sulphate found in brown marine algae (Phaeophyta-typically Fucus serratus, Ascophyllum nodosum, Pelvitiata canaliculata (illustrated) and Macrocystis pyrifyra) and has been shown to have anticoagulant activity. The main constituents are α-1,4 and α-1,2 linked L-fucose sulphates although galactose also occurs and there are many variations of the basic structure found in different species of Phaeophyta.<br>The image was kindly provided by Prof Mike Guiry from Cork who runs ‘The Seaweed Site’.</p>

<p>a-Acetobromo-D-xylose is an oligosaccharide sugar used in glycosylation and polysaccharide modifications. It is synthesized by the fluorination of xylose with acetic acid, bromine, and a base. The product is purified by vacuum distillation and recrystallization. In addition to its use as a carbohydrate, this product can be modified using methylation or click chemistry to create derivatives.</p>

<p>Potential prebiotic oligosaccharides made from agar by enzymatic hydrolysis</p>

<p>2-Acetamido-2-deoxy-4-O-(b-D-galactopyranosyl)-D-glucopyranose LacNAc isomer. This compound has been shown to inhibit pro-inflammatory cytokines in human bronchial epithelial cell lines, which may be helpful in treating inflammatory conditions. The compound can be analyzed using high-performance liquid chromatography (HPLC), which separates molecules based on their chemical properties. The acid residues present in the molecule make it an ideal target for antibodies and polymer-based drug delivery systems. In host cells, this compound is involved in various biological processes related to cell adhesion and signaling.</p>

<p>Used in synthetic organic chemistry and natural product synthesis. Induces apoptosis by inhibiting the synthesis and increasing the efflux of glutathione. It is used for synthesis of optically active dipyrrolyl alkanols from pyrroles on the surface of montmorillonite KSF clay.</p>

<p>Di-O-isopropylidene psicose is a synthetic sugar that is a modification of the natural compound, psicose. It can be used for the synthesis of oligosaccharides, polysaccharides and other complex carbohydrates. Di-O-isopropylidene psicose can be methylated and glycosylated to form other sugar derivatives or fluorinated to form fluoroquinolones. This sugar has been shown to have high purity and stability under a wide range of conditions.</p>

<p>Dextran sulfate sodium salt is a water-soluble polymer that is used as a drug carrier and has many applications in the pharmaceutical industry. It is an oligosaccharide with an average molecular weight of 9,000 to 16,000 Daltons. Dextran sulfate sodium salt can be used for the treatment of cavities, especially those that are infected or in which there is a risk of infection. It can also be used for intubation and has been shown to be effective at reducing allergic reactions by blocking the release of histamine by mast cells. Dextran sulfate sodium salt also has kinetic properties and can be used to study enzymatic reactions. This polymer is not toxic because it cannot be absorbed through the skin or gastrointestinal tract.</p>

<p>(2R, 3R, 4R) -3, 4- Difluoro- 1- (phenylmethyl) - 2- pyrrolidinemethanol is a synthetic compound that has been modified to contain fluoro substituents. It is an intermediate for the synthesis of oligosaccharides and complex carbohydrates. This compound can be used in click chemistry or glycosylation reactions. The purity of this compound is greater than 99% and it has not been tested on animals.</p>

<p>1-Azido-1-deoxy-2-C-hydroxymethyl-2,3-O-isopropylidene -D-glucitol is a synthetic monosaccharide that can be used for glycosylation, methylation, and click modification. It is a complex carbohydrate with an Oligosaccharide structure. 1-Azido -1-deoxy -2 -C -hydroxymethyl -2,3 -O -isopropylidene D glucitol has been fluorinated. This compound is a sugar that has been modified with a Click modification. It is a sugar that has been synthesized and custom synthesized by high purity.</p>

<p>(2S, 3R, 4R) -3-Benzyloxy-1-butyl-4-(hydroxymethyl)-N-methyl-2-azetidinecarboxylic acid methyl ester is a modification of an oligosaccharide. This product is custom synthesized and has a high purity. It is a methylated carbohydrate that contains a fluorinated saccharide.</p>

<p>N-Acetyl D-mannosamine (ManNAc) is an aldohexose (2-acetamido-2-deoxymannose) in which the axial hydroxyl group at position 2 is replaced by a N-acetyl group (Collins, 2006). It has been reported that N-acetyl D-mannosamine supplementation, may provide novel means to break the link between obesity and hypertension (Peng, 2019). N-Acetyl-D-mannosamine and N-acetyl-D-glucosamine are the essential precursors of sialic acid, the specific monomer of polysialic acid, a bacterial pathogenic determinant, for example, Escherichia coli K1 uses both amino sugars as carbon sources. It has been reported that ManNAc can be used as a treatment for hereditary inclusion body myopathy, an adult-onset, progressive neuromuscular disorder and also for renal disorders involving proteinuria and hematuria due to podocytopathy and/or segmental splitting of the glomerular basement membrane (Galeano, 2007).</p>

<p>Ribulose 5-phosphate sodium is a chemical that can be used to inhibit the enzyme ribulose phosphate reductase. Ribulose 5-phosphate sodium has been shown to inhibit glycolaldehyde production in the chloroplasts of plants, effectively reducing the amount of carbon dioxide produced. This chemical has also been shown to have an inhibitory effect on other enzymes involved in carbon fixation and assimilation. The effectiveness of this chemical is dependent on the specific plant species and environmental conditions.</p>

<p>Chondroitin disaccharide 6S sodium salt is a synthetic, fluorinated, oligosaccharide that has been custom synthesized and glycosylated. It is a sugar-based compound with a high purity and excellent solubility in water. It was synthesized by click modification of the sugar monomer with an amine group at the reducing end. The chondroitin disaccharide 6S sodium salt was further modified with methylation to yield a product with a higher purity.</p>

<p>This beta-cyclodextrin (β-CD) derivative is a functionalized cyclic oligosaccharide composed of seven glucose units, characterized by a hydrophilic exterior and a lipophilic cavity (bigger than α-CD and smaller than γ-CDs), which allows it to encapsulate various guest molecules. This structural feature facilitates its use in multiple applications, including pharmaceuticals, food enhancement, and cosmetics. In the pharmaceutical industry, it enhances the solubility and stability of poorly water-soluble drugs, improving their bioavailability and efficacy while also masking unpleasant tastes. The food sector utilizes it as a stabilizer for flavors, colors, and nutrients, extending shelf life by protecting sensitive ingredients from degradation. In cosmetics, it serves as a complexing agent for fragrances and active components, ensuring their stability and controlled release. Its use expands to many other fields, including nanotechnology for drug delivery systems, environmental remediation for extracting organic pollutants, textiles for slow-release fragrances, and analytical chemistry for chiral separation.</p>

<p>Reference compound for metabolites of the pentosephosphate pathway</p>

<p>In water, hydroxypropyl cellulose forms liquid crystals with many mesophases depending on concentration. These mesophases include isotropic, anisotropic, nematic and cholesteric, the latter resulting in many colors such as violet, green and red. Pharmaceutical applications include treatments for medical conditions such as dry eye syndrome (keratoconjunctivitis sicca), recurrent corneal erosions, decreased corneal sensitivity, exposure and neuroparalytic keratitis. It is also used as a binder in tablets. Hydroxypropylcellulose is also used as a thickener, a binder and emulsion stabiliser in foods with E number E463.  HPC is used as a support matrix for DNA separations by capillary and microchip electrophoresis.</p>

<p>Applications N,N-[Iminobis(trimethylene)]bis-D-gluconamide (cas# 86303-20-0) is a compound useful in organic synthesis.<br></p>

<p>Methyl D-arabinofuranoside is an antimycobacterial agent that inhibits the synthesis of mycolic acids, which are important components of the cell wall of Mycobacterium tuberculosis. Methyl D-arabinofuranoside has been shown to be active against drug-resistant strains and has been well tolerated by animals. This compound can be synthesized from 2,4-dichlorophenylacetic acid and arabinose in two steps. The first step involves a three-component condensation reaction with sodium hydroxide, hydrochloric acid, and 2,4-dichlorophenylacetic acid. The second step is a nucleophilic attack on the pyran ring of methyl D-arabinofuranoside with hypophosphorous acid. Methyl D-arabinofuranoside can also be prepared by reacting sodium nitrosobenzene with sodium benzene sulfinate in alcoholic solution</p>

<p>Please enquire for more information about 1,5-α-L-Arabinooctaose including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>4-Deoxy-D-glucose is a sugar that is synthesized by the condensation of two molecules of erythrose. It has been shown to be an efficient donor substrate for nucleophilic attack, which can lead to the synthesis of glycosides and other natural products. 4-Deoxy-D-glucose is also a competitive inhibitor of uridine diphosphate (UDP) glucose, which is an enzyme involved in the biosynthesis of UDP sugars and glycoproteins. The concentration of 4-deoxy-D-glucose affects its catalytic mechanism, as it acts as a competitive inhibitor at high concentrations. Molecular modeling has revealed that this molecule adopts a chair conformation with significant solvent exposure.</p>

<p>4-Glucopyranosylmannose is a disaccharide compound, which is a synthetic carbohydrate derived from the enzymatic or chemical glycosylation processes. It consists of glucose and mannose units linked through a glycosidic bond. The compound is sourced through advanced synthetic methodologies involving specific glycosyltransferases or chemical catalysts that facilitate the precise attachment of these sugar moieties.</p>

<p>D-ribulose-5-phosphate sodium is a nucleotide sugar that is one of the ribonucleotides, which are fundamental components of RNA. D-ribulose 5-phosphate sodium has been shown to be an intermediate in the metabolism of ribulose and catalyzes the oxidation of d-arabinose. This enzyme also catalyses the synthesis of fatty acids and participates in reactions involving glycerolipids and phospholipids. The reaction mechanism involves a double displacement with simultaneous attack by a water molecule on C2' and C3'. When deuterium is present, it affects the rate of these reactions in a way that depends on the orientation of the substrate to the enzyme.</p>

<p>2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-a-D-galactopyranose is a fluorinated complex carbohydrate that has been modified by methylation and acetylation. This product is a custom synthesis that has not been previously described in the scientific literature. It is synthesized from 2, 3, 4, 6 tetraacetyl alpha D galactopyranoside and 2 deoxy alpha D galactopyranose. The chemical properties of this compound are similar to those of other complex carbohydrates such as glycogen and heparin.</p>

<p>1,5-α-L-Arabinohexaose is a carbohydrate. It is a nonreducing sugar that can be found in plants. 1,5-α-L-Arabinohexaose has an optimum pH of 5 and an ethanol concentration of 0.02%. The enzyme form of 1,5-α-L-Arabinohexaose is α-(1→6)-glycosidase. This enzyme hydrolyzes the α-(1→6) glycosidic bond between two glucose residues in a polysaccharide chain to produce β-(1→4) bonds. It also hydrolyzes the β-(1→4) glycosidic bond between two galactose residues to produce β-(1→2) bonds and oxidizes the terminal carbon atom to produce aldehyde products.<br>A structural analysis of this carbohydrate was conducted using marine microorganisms and it was found that they contain galacturonic acid and sugar residues</p>

<p>Difucosyl-para-lacto-N-hexaose III is a custom synthesis. It is an oligosaccharide that belongs to the class of polysaccharides. It has a molecular weight of 1,000 Da and contains two monosaccharides: difucose and para-lactohexose. This product can be modified with fluorination or click chemistry. Difucosyl-para-lacto-N-hexaose III has a purity of &gt; 98% and CAS No., which is 93794-37-5.</p>

<p>3'-a-Sialyl-N-acetyllactosamine sodium salt is a high purity, custom synthesis sugar. It has been modified with fluorination, glycosylation, and methylation to provide the desired properties. This product is also available in other forms such as monosaccharide and saccharide. 3'-a-Sialyl-N-acetyllactosamine sodium salt can be used in various applications including Click modification, fluoroamination, glycosylation, carbonylation and methylation. CAS No. 350697-53-9</p>

<p>D-Xylulose 5-phosphate sodium salt is a synthetic monosaccharide that can be used in the synthesis of oligosaccharides, polysaccharides, and complex carbohydrates. It is also used in glycosylation reactions. D-Xylulose 5-phosphate sodium salt has been fluorinated to provide better stability and solubility. The compound has a molecular weight of 206.06 g/mol and a CAS number of 105931-44-0. This product is available for custom synthesis upon request.</p>

<p>1,2,3,5-Tetra-O-acetyl-β-D-ribofuranose is a sugar that has been acetylated at the hydroxyl group. It has biological properties that are similar to those of 1,2,3,5-tetraacetyl-β-D-ribofuranose. This compound is an analog of 1,2,3,5-tetraacetyl-β-D-ribofuranose and can be used as a model system for studying the effects of acetylation on the properties of this molecule. Acetylation at the hydroxyl group in sugars can lead to low energy (chemical) properties. The acetylated form of this compound reacts with trifluoromethanesulfonic acid to give tetrafluoroethylene and ammonium sulfate in a model reaction solution. 1,2,3,5-Tetraacetyl β</p>

<p>Decyl D-glucopyranoside is a sodium salt of decyl D-glucopyranoside that is used as a detergent additive in cleaning compositions. Decyl D-glucopyranoside has shown antimicrobial activity against both Gram-positive and Gram-negative bacteria, including methicillin resistant Staphylococcus aureus (MRSA) and Clostridium perfringens. Decyl D-glucopyranoside has also been shown to have chemical stability at high temperatures, making it useful in the manufacture of lacrimal gland preparations and cationic surfactants.</p>