Antifongiques
Les antifongiques sont des composés spécialement conçus pour arrêter, prévenir et éliminer la croissance des champignons. Dans cette catégorie, vous trouverez une large variété d'agents antifongiques essentiels pour la recherche et les applications thérapeutiques. Ces composés sont cruciaux pour traiter les infections fongiques et prévenir leur récurrence, ce qui en fait des outils vitaux tant dans les domaines médical qu'agricole. Les chercheurs et les professionnels de la santé peuvent explorer de nombreux antifongiques pour comprendre leurs mécanismes, optimiser leur efficacité et développer de nouveaux traitements pour combattre les souches de champignons résistantes. La vaste sélection d'antifongiques soutient les avancées continues dans la recherche sur les champignons et le développement de thérapies antifongiques efficaces.
904 produits trouvés pour "Antifongiques"
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Antifungal agent 42
Antifungal 42 blocks biofilm formation and inhibits C.albicans' CYP51.Formule :C22H20Cl2N4Se2Couleur et forme :SolidMasse moléculaire :569.25Griseofulvic Acid
CAS :Griseofulvic Acid ((±)-Griseofulvic acid) is a metabolite of the antifungal agent Griseofulvin. It induces protein aggregation and tubulin polymerization in cell-free assays.Formule :C16H15ClO6Masse moléculaire :338.74Succinate dehydrogenase-IN-8
CAS :Succinate dehydrogenase-IN-8 (compound i19) is a potent inhibitor of succinate dehydrogenase (SDH). This indanoyl amino acid derivative demonstrates strong antifungal activity in vitro against Rhizoctonia solani (EC50 = 0.1843 mg/L), Botrytis cinerea (EC50 = 0.4829 mg/L), and Sclerotinia sclerotiorum (EC50 = 0.1349 mg/L).Formule :C22H19Cl2F2N5O2Couleur et forme :SolidMasse moléculaire :494.32Antifungal agent 16
Antifungal agent 16 has antimicrobial activity comparable to that of ciprofloxacin and has higher antifungal activity than fluconazole.Formule :C27H21N5O2SCouleur et forme :SolidMasse moléculaire :479.55Antifungal agent 40
Antifungal agent 40 blocks C. albicans CYP51 in pocket II, hindering lanosterol demethylase and biofilm growth.Formule :C22H20Cl2N4SeCouleur et forme :SolidMasse moléculaire :490.29Chitin synthase inhibitor 11
Potent CHS inhibitor with an IC50 of 0.10 mM; exhibits broad-spectrum antifungal properties.Formule :C24H24N4O8Couleur et forme :SolidMasse moléculaire :496.47WQ3810 TFA
<p>WQ3810 TFA is an orally available fluoroquinolone with antimicrobial activity against Mycobacterium tuberculosis and inhibits the DNA rotamase activity of</p>Formule :C24H23F6N5O5Degré de pureté :99.52%Couleur et forme :SoildMasse moléculaire :575.46Antifungal agent 19
Antifungal agent 19 shows the potent antifungal activity ( EC 50 = 0.72 μM).Formule :C19H18F4O2Couleur et forme :SolidMasse moléculaire :354.34PKR-IN-1
CAS :PKR-IN-1 (Compound 5s) is a pyruvate kinase (PK) inhibitor with antifungal properties, exhibiting an EC50 of 0.21 μg/mL against Rhizoctonia solani (R. solani).Formule :C9HCl5N4OS2Couleur et forme :SolidMasse moléculaire :422.525CDA-IN-4
CAS :CDA-IN-4 (compound VS-24) is an inhibitor of chitin deacetylase (CDA). At a concentration of 100 μg/mL, CDA-IN-4 provides a protective effect of 61.2% against rice blast disease.Formule :C10H9BrN4O2SCouleur et forme :SolidMasse moléculaire :329.17Antifungal agent 39
CAS :Antifungal agent 39 (Compound 9h) is a broad-spectrum antifungal agent.Formule :C23H22ClN3O5Couleur et forme :SolidMasse moléculaire :455.89Fosmanogepix
CAS :Fosmanogepix (APX001) is a broad-spectrum oral antifungal that targets Gwt1 enzyme, transforming into active APX001A in the body.Formule :C22H21N4O6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.40CDA-IN-3
CAS :CDA-IN-3 (NCDI) is a chitin deacetylase (CDA) inhibitor with antiparasitic properties. It disrupts chitin metabolism in nematodes, increasing ROS levels within these organisms and causing cellular damage. CDA-IN-3 significantly inhibits all developmental stages of Caenorhabditis elegans and can be utilized in research focused on anti-infective applications.Formule :C16H27N3O3S2Couleur et forme :SolidMasse moléculaire :373.534Antifungal agent 43
Antifungal agent 43 inhibits biofilms with low toxicity to human cancer cells.Formule :C24H26N4Se2Couleur et forme :SolidMasse moléculaire :528.41Antifungal agent 17
Antifungal agent 17 showed good antifungal activity against B. cinerea (EC50: 2.86 μg/mL).Formule :C18H16Br2O2Couleur et forme :SolidMasse moléculaire :424.13Antifungal agent 28
Antifungal 28 disrupts Candida, hits fluconazole-resistant strains, and inhibits biofilms.Formule :C22H29N5OSCouleur et forme :SolidMasse moléculaire :411.56Hyalodendrin
CAS :Hyalodendrin ((+)-Hyalodendrin) acts as a fungal growth inhibitor, specifically targeting wood decay fungi. It exhibits low phytotoxicity and possesses an acute toxicity (LD50) level of 75 mg/kg in mice.Formule :C14H16N2O3S2Couleur et forme :SolidMasse moléculaire :324.42SDH-IN-25
CAS :<p>SDH-IN-25 is an SDH inhibitor with an IC50 of 4.82 mg/L, demonstrating broad-spectrum and potent antifungal activity. By binding to SDH amino acid residues (TRP173, TYR58, and ARG43), it mimics the action mode of the commercial fungicide flutolanil. SDH-IN-25 induces changes in hyphal morphology, disrupts respiratory metabolism by binding to complex II, generates reactive oxygen species (ROS), and affects mitochondrial membrane potential (MMP) in hyphae. This compound is utilized in agricultural disease control research.</p>Formule :C19H15BrCl2N2O4Couleur et forme :SolidMasse moléculaire :486.143Antifungal agent 11
<p>Antifungal agent 11 has a good antifungal effect.</p>Formule :C21H19F2N7O3S2Couleur et forme :SolidMasse moléculaire :519.55GW461484A
CAS :GW461484A is a small molecule inhibitor targeting Candida albicans Yck2, exhibiting an IC50 of 0.11 µM. It has a MIC80 of 12.5 µM against C. albicans. GW461484A shows potential for research into fungal diseases, including drug-resistant Candida infections.Formule :C19H14FN3Couleur et forme :SolidMasse moléculaire :303.333Chitin synthase inhibitor 12
Chitin synthase inhibitor 12: potent CHS blocker (IC50: 0.16 mM), broad-spectrum antifungal, effective against resistant strains. Useful in IFI research.Formule :C23H21ClFN3O5Couleur et forme :SolidMasse moléculaire :473.88ATPase-IN-5
CAS :<p>ATPase-IN-5 (Compound 11) is an antifungal Pma1p (H+ -ATPase) inhibitor (IC50 = 12.7 μM) that inhibits the growth of Candida albicans and Saccharomyces cerevisiae.</p>Formule :C10H10N4O3SDegré de pureté :99.19%Couleur et forme :SolidMasse moléculaire :266.28Chitin synthase inhibitor 7
Compound 9c, a chitin synthase inhibitor, has an IC50 of 0.37 nM and is useful for studying fungal infections.Formule :C24H25N3O5Couleur et forme :SolidMasse moléculaire :435.47Antifungal agent 100
CAS :Antifungal agent 100 (compound 3i) demonstrates notable antifungal activity, exhibiting an EC 50 of 0.33 mg/L against S. sclerotiorum. It also possesses an IC 50 value of 0.63 mg/mL targeting the Succinate dehydrogenase (SDH) of the same organism [1].Formule :C23H21N3O4SCouleur et forme :SolidMasse moléculaire :435.5Ethaboxam
CAS :Ethaboxam is a β-tubulin inhibitor and antifungal agent used against oomycete pathogens.Formule :C14H16N4OS2Degré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :320.43Antifungal agent 134
CAS :Antifungalagent 134 (Compound B13) is an antifungal agent effective against Botrytis cinerea, Alternaria solani, Fusarium graminearum, Rhizoctonia solani, Colletotrichum orbiculare, and Alternaria alternata with EC50 values of 3.24, 1.89, 1.70, 0.36, 4.27, and 1.50 μg/mL, respectively. It disrupts the fungal cell membranes and mitochondria, leading to substantial accumulation of reactive oxygen species (ROS). Additionally, Antifungalagent 134 exhibits significant herbicidal activity on field weeds such as Amaranthus retroflexus L and Abutilon theophrasti Medicus, and is applicable in crop disease and field weed research.Formule :C18H12F4N2O4Couleur et forme :SolidMasse moléculaire :396.29Pyriofenone
CAS :Pyriofenone (IKF-309) is an aryl phenyl ketone fungicide predominantly used to control powdery mildew on crops such as cereals, rice, fruit trees, and vegetables. It exhibits moderate efficacy against rice blast disease. Pyriofenone functions through prevention, residue activity, treatment, rainfastness, translaminar action, and fumigation.Formule :C18H20ClNO5Couleur et forme :SolidMasse moléculaire :365.81Antifungal agent 13
CAS :Antifungal agent 13 demonstrates significant antifungal activity against Sclerotinia sclerotiorum, achieving an EC50 of 1.25 mg/L.Formule :C21H16ClF3N4OCouleur et forme :SolidMasse moléculaire :432.83Complex III-IN-1
Complex III-IN-1 inhibits complex III, has antifungal properties, and an EC50 of 18.53 mg/L against S. sclerotiorum.Formule :C14H20ClNO2S2Couleur et forme :SolidMasse moléculaire :333.9HDAC-IN-87
CAS :HDAC-IN-87 (Compound XII6) is a non-selective HDAC inhibitor with pIC50 values of 6.9 for HDAC4 and 5.8 for HDAC6. It exhibits fungicidal activity against P. sorghi and P. pachyrhizi. The acute oral LD50 in both male and female rats is greater than 500 mg/kg.Formule :C13H7F5N4O2SCouleur et forme :SolidMasse moléculaire :378.277CYP51-IN-7
CAS :CYP51-IN-7 (compound 1g) is an analogue of Fluconazole and serves as an effective antifungal agent. It exhibits inhibitory activity against Microsporum gypseum and Candida albicans, with MIC80 values of 62.5 ng/mL and 250 ng/mL, respectively.Formule :C21H21ClF2N4OMasse moléculaire :418.87AnCDA-IN-1
CAS :AnCDA-IN-1 (Compound J075-4187) is an inhibitor of chitin deacetylase (CDA) exhibiting antifungal properties. It possesses an IC50 of 4.24 μM against A. nidulans AnCDA. The compound demonstrates a minimum inhibitory concentration (MIC) of 260 μg/mL and a minimum fungicidal concentration (MFC) of 520 μg/mL for food spoilage fungi and plant pathogenic fungi. AnCDA-IN-1 is applicable for research in the antifungal domain.Formule :C16H13ClN4O2Couleur et forme :SolidMasse moléculaire :328.753Complex III-IN-2
Complex III-IN-2 inhibits complex III, with antifungal EC50: 29.31 mg/L vs R. solani, 29.98 mg/L vs S. sclerotiorum.Formule :C15H21ClN2O2SCouleur et forme :SolidMasse moléculaire :328.86Chitin synthase inhibitor 5
Calpain Inhibitor-2, lipophilic, inhibits calpain; shows anti-proliferative effects on melanoma, PC-3 cells; blocks 80% DU-145 cell invasion.Formule :C23H22BrN3O5Couleur et forme :SolidMasse moléculaire :500.34Chitin synthase inhibitor 6
Compound 9b inhibits CHS with an IC50 of 0.21 mM; it's a broad-spectrum antifungal, effective against resistant strains.Formule :C24H25N3O6Couleur et forme :SolidMasse moléculaire :451.47Antifungal agent 25
Antifungal agent 25: broad-spectrum, stable in vivo, effective against Candida albicans, including fluconazole-resistant strains.Couleur et forme :SolidBenzohydroxamic acid
CAS :Benzohydroxamic acid (BHA) is a chitin deacetylase (CDA) inhibitor with notable antifungal properties. It displays Ki values of 8.31 μM against Verticillium dahliae CDA and 9.83 μM against Puccinia striiformis f. sp. tritici CDA. BHA can restore the defense responses in infected host plants by upregulating the expression of defense-related genes, thereby reducing fungal growth and proliferation within the plants. It is applicable in the research of agricultural fungal diseases, such as cotton wilt and wheat stripe rust, caused by pathogens like Verticillium dahliae and Puccinia striiformis.Formule :C7H7NO2Couleur et forme :SolidMasse moléculaire :137.136Wikstrol A
CAS :Wikstrol A: antifungal, anti-mitotic, anti-HIV agent with various IC50/MDC values (67.8-131 µM) and deforms P. oryzae mycelia.Formule :C30H22O10Couleur et forme :SolidMasse moléculaire :542.49Antibacterial agent 188
CAS :Compound 2d (Antibacterial agent 188) serves as an antibacterial agent that suppresses the activity of dermatophytes [1].Formule :C12H10N4SCouleur et forme :SolidMasse moléculaire :242.3Chitin synthase inhibitor 9
CHS inhibitor 9: a broad-spectrum antifungal for studying fungal infections.Formule :C24H25N3O6Couleur et forme :SolidMasse moléculaire :451.47FDU-PB-22
CAS :FDU-PB-22, a novel synthetic cannabinoid, undergoes rapid metabolism in human liver microsomes (HLM) with a half-life of 12.4 minutes.Formule :C26H18FNO2Couleur et forme :SolidMasse moléculaire :395.43EGFR-IN-133
CAS :EGFR-IN-133 (Compound 24) serves as an inhibitor targeting various mutations of the EGFR, including the wild type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with respective IC50 values of 0.1, 0.044, 0.036, 0.04, and 0.054 nM. The compound exhibits favorable pharmacokinetic properties and high oral bioavailability.Formule :C27H29F2N7O3Couleur et forme :SolidMasse moléculaire :537.56(Z)-Lanoconazole
<p>(Z)-Lanoconazole, an imidazole antifungal for dermatophytosis and onychomycosis, inhibits fungal ergosterol production.</p>Formule :C14H10ClN3S2Couleur et forme :SolidMasse moléculaire :319.83(3R,6S)-Bassiatin
CAS :(3R,6S)-Bassiatin represents the enantiomeric form of the fungal metabolite known as bassiatin.Formule :C15H19NO3Masse moléculaire :261.32Chitin synthase inhibitor 8
Chitin synthase inhibitor 8 is a chitin synthase (CHS) inhibitor with broad-spectrum antifungal effects that can be used in studies related to fungal infectionsFormule :C23H23N3O5Couleur et forme :SolidMasse moléculaire :421.45A25822B
CAS :A25822B is an antifungal agent.Formule :C28H45NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :411.66Antifungal agent 12
Antifungal agent 12 is a new fluconazole-like compound that exhibits good antifungal effects.Formule :C20H16F3N7O2S2Couleur et forme :SolidMasse moléculaire :507.51D75-4590
CAS :<p>D75-4590, a β-1,6-Glucan synthetase inhibitor, combats fungal infections by targeting cell walls.</p>Formule :C21H27N5Degré de pureté :98.56% - 98.85%Couleur et forme :SolidMasse moléculaire :349.474-Hydroxyvoriconazole
CAS :<p>Metabolite of voriconazole; sterol 14?-demethylase inhibitor</p>Degré de pureté :Min. 95%Rhizocticin A
CAS :Rhizocticin A is a potential inhibitor of threonine synthase.Formule :C11H22N5O6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.3
