Antimicrobiens

<p>Anti-viral; NS3/4A protease inhibitor_x000D_</p>

<p>Oleandomycin phosphate is a macrolide antibiotic with action on bacterial protein synthesis inhibition and is used for treating respiratory tract infections and as a veterinary antibiotic.</p>

<p>STAADIUM™ GalactoZide I is a targeted inhibitor for β-galactosidase producing bacteria. The antibacterial activity of STAADIUM™ GalactoZide I is triggered by the enzyme β-galactosidase which is produced by E.coli (EHEC), thermophilic lactic acid bacteria, and other coliform bacteria. STAADIUM™ GalactoZide I can help to selectively inhibit the growth of E. coli in complex bacterial cultures and can be useful in microbiome studies, food control, environmental safety, hygiene, and clinical diagnostics. GalactoZide I has a slightly lower inhibitory activity on coliforms compared to STAADIUM™ GalactoZide II but has a higher compatibility with pH indicators, e.g. neutral red and H2S staining.</p>

<p>Ceftaroline fosamil acetate hydrate is a fifth-generation cephalosporin antibiotic with action against gram-positive bacteria, including MRSA and is used for treating bacterial skin infections and community-acquired pneumonia.</p>

<p>Anti-fungal; glucan synthase inhibitor</p>

<p>Antibiotic; binds bacterial ribosomes to inhibit protein synthesis</p>

<p>Naturally produced by the soil bacterium Streptomyces avermitili, it is clinically used in the treatment of parasitosis in both humans and animals. Ivermectin is commercially available as a mixture of 80% 22, 23-dihydroavermectin B1a and 20% 22, 23-dihydroavermectin B1b. In 2020, Ivermectin indicated that it was a good antiviral agent in the treatment of SARS-CoV-2 and a new mechanism of action has been suggested. Ivermectin would act on importin α/β heterodimer and affect nuclear transport and the translocation of viral proteins.</p>

<p>Hexadecylphosphocholine, better known as miltefosine, belongs to the group of phospholipids. The long alkyl chain and a polar group of a molecule proved to be essential for antitumor activity, especially to cure breast cancer cells. The apoptotic process takes place in the plasma membrane, where molecules are inserted and then influence signaling pathways. Moreover, during preclinical studies hexadecylphosphocholine (He-PC) found to be highly effective in inhibiting the growth of chemically induced rat mammary carcinomas, and even a high percentage of the tumors regressed completely. The He-PC has many more applications such as antifungal agent, antiprotozoal drug, protein kinase inhibitor or immunomodulator. Even though miltefosine was originally developed in the 1980s as an anti-cancer agent, new studies have demonstrated activity against Leishmania parasites and neoplastic cells, and due to broad spectrum of antimicrobial effects, it is recommended as a first line treatment for free-living amebae infections.</p>

<p>Colistin sodium methanesulfonate is an antibiotic, which is a derivative of polymyxin E sourced from the bacterium Paenibacillus polymyxa. Its mode of action involves disrupting the bacterial cell membrane by interacting with lipopolysaccharides and phospholipids, leading to cell death.</p>

<p>**Ivermectin 8α-hydroperoxide** is a derivative of the antiparasitic agent ivermectin, which is synthesized through chemical modification. Ivermectin originally derives from the fermentation products of the bacterium *Streptomyces avermitilis*. The modification to form 8α-hydroperoxide involves the addition of a hydroperoxide group, potentially altering its biological properties.</p>

<p>Sarafloxacin hydrochloride is a fluoroquinolone antibiotic with action on bacterial DNA gyrase and topoisomerase IV and is used for treating bacterial infections in veterinary medicine.</p>

<p>Difloxacin is a bactericidal, broad-spectrum, fluroquinolone antibiotic which is active against both Gram-positive and Gram-negative bacteria. By interfering with the bacterial enzyme DNA gyrase, which is necessary for the upkeep and synthesis of bacterial DNA, it causes an antibacterial impact. It is used for the treatment of many bacterial infections including skin infections.</p>

<p>Fluconazole is an antifungal drug used to treat a wide range of fungal infections. Fluconazole is a cytochrome demethylase system inhibitor that acts by interfering with β-glucan biosynthesis. It has been shown to be effective in treating candidemia, a life-threatening form of candidiasis caused by the fungus Candida albicans. Fluconazole seems to be more effective than amphotericin B in treating some isolates of C. albicans, making it a valuable tool in the fight against this deadly fungal infection, although due to the increase of antimicrobial resistance, fluconazole has been studied in combination with other drugs (e.g. farnesol).</p>

<p>Efavirenz is a non-nucleoside-based reverse transcriptase inhibitor (NNRTI) of the reverse transcriptase of HIV-1. It inhibits the viral enzyme reverse transcriptase by binding to its active site. In certain cell culture assays, Efavirenz showed great efficiency when inhibiting wild-type HIV-1 replication. In the treatment of HIV, Efavirenz has been studied in combination with Emtricitabine and Tenofovir disoproxil fumarate for ease of administration in some clinical studies. Recent in vitro cell studies indicated Efavirenz is a potential treatment for pancreatic, prostate and triple-negative breast cancers due to its cytotoxicity against cancer cells.Efavirenz is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>Kanamycin B is a broad spectrum antibiotic active against both gram-positive and gram-negative bacteria, often used to treat eye infections. Compared to Kanamycin A, it exhibits stronger interaction with the acidic phospholipids.</p>

<p>Anhydro chlortetracycline HCl is an antibiotic and is used for the treatment of bacterial infections. It binds to the 30S ribosomal subunit, inhibiting protein synthesis</p>

<p>Ketolide; binds bacterial ribosomes and inhibits translation</p>

<p>Mezlocillin sodium is a sodium salt form of mezlocillin with similar action and applications as mezlocillin.</p>

<p>Metronidazole is a nitroimidazole antibiotic with action on anaerobic bacteria and protozoa by disrupting DNA synthesis and is used for treating infections like bacterial vaginosis, trichomoniasis, and certain parasitic infections.</p>

<p>Inhibitor of protein synthesis; glycylcycline class</p>