Antimicrobiens

<p>Dolutegravir sodium is an HIV integrase strand transfer inhibitor with action on HIV integrase to block viral replication and is used for treating HIV/AIDS in combination with other antiretroviral medications.</p>

<p>9’-Deoxy-8’,8’-dihydroxyherbicidin is a specialized compound, classified as an antibacterial agent and secondary metabolite, which is naturally derived from microbial sources, specifically certain strains of actinomycetes. These microorganisms are prolific producers of bioactive secondary metabolites, including antibiotics and herbicidins, which exhibit diverse biological activities.</p>

<p>Adefovir is an antiviral drug that is used for the treatment of hepatitis B infections. This drug works by blocking the enzyme reverse transcriptase, therefore preventing the replication of the virus in the body.</p>

<p>Herbicidin H is a naturally occurring microbial herbicide, which is derived from specific strains of soil-borne bacteria. This compound is primarily isolated from Streptomyces species, known for their prolific production of various bioactive secondary metabolites. The mode of action of Herbicidin H involves the disruption of essential cellular processes within plant cells, particularly affecting nucleic acid synthesis. This disruption leads to impaired growth and eventual plant death, making it a potent agent against a range of undesirable plant species.</p>

<p>A derivative of azithromycin, used as an antibiotic</p>

<p>This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>Santonin is a terpenoid compound with action as an anthelmintic by paralyzing parasitic worms and is used for expelling intestinal worms.</p>

<p>2-Methyl-4-isothiazolin-3-one is a biocidal agent, which is a synthetic compound derived from isothiazolinone chemistry. Its primary mode of action involves the inhibition of microbial cell growth by disrupting essential enzyme systems within the cells, leading to cell death. This compound is often supplied as a 50% aqueous solution, facilitating its integration into different mediums.</p>

<p>Ribavirin is a guanosine nucleoside analog with broad-spectrum antiviral properties. Ribavirin gets phosphorylated to ribavirin triphosphate in cells and competes with natural nucleotides for incorporation in a nascent RNA chain, thus interfering with RNA synthesis by inhibiting viral RNA polymerases. Ribavirin is also an inhibitor of inosinate dehydrogenase (IMP), which is involved in the biosynthesis of GTP.</p>

<p>2-[(2-Amino-6-oxo-3H-purin-9-yl)methoxy]ethyl (2S)-2-aminopropanoate is a nucleotide analog, a synthetic compound designed to mimic the structure of natural nucleotides incorporated into DNA. It is derived from chemical synthesis to specifically interfere with viral DNA replication. The compound acts by selectively inhibiting viral DNA polymerase, an enzyme essential for the replication of viral genetic material. This inhibition effectively halts the proliferation of the virus, rendering it unable to reproduce within the host cell.</p>

<p>Gentamicin B is an aminoglycoside antibiotic, which is derived from the bacterium Micromonospora. This derivative exhibits its mode of action by binding to the 30S subunit of the bacterial ribosome, disrupting protein synthesis. As a result, it causes misreading of mRNA, ultimately leading to cell death, thereby exhibiting bactericidal effects.</p>

<p>Oxiconazole is an anti-fungal agent that is used for the treatment of various dermatophyte infections. It can be used to treat athlete’s foot, ringworm and jock itch. This drug inhibits ergosterol biosynthesis and acts to destabilize the fungal cytochrome enzyme P450 51. Additionally, this drug has shown to inhibit DNA synthesis and suppress concentrations of ATP.</p>

<p>Fengycin A analogue is an antifungal lipopeptide, which is a cyclic compound derived from microbial sources, specifically produced by Bacillus subtilis strains. It functions primarily by disrupting the cell membranes of pathogenic fungi, leading to altered membrane permeability and subsequent cell death. The unique structure of fengycin allows it to interact with membrane lipids, compromising membrane integrity and inhibiting fungal growth.</p>

<p>Carbomycin is a macrolide antibiotic, which is derived from the bacterium Streptomyces halstedii. This antibiotic functions by binding to the 50S ribosomal subunit, thereby inhibiting bacterial protein synthesis. Through this mechanism, carbomycin effectively disrupts the growth and replication of susceptible bacterial strains, making it a potent tool in combating bacterial infections.</p>

<p>Cefditoren acid sodium is an antibacterial agent that belongs to the class of third-generation cephalosporins, which is derived from Acremonium fungus and produced through chemical synthesis. This compound acts by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. It achieves this by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall. The interruption of peptidoglycan synthesis in the cell wall is crucial for maintaining bacterial cell integrity, and its inhibition results in the bactericidal activity of cefditoren acid sodium. It is effective against a range of Gram-positive and Gram-negative bacteria. The key applications of this compound include the treatment of bacterial infections such as respiratory tract infections, skin infections, and other conditions caused by susceptible bacteria. Its spectrum of activity and pharmacokinetic properties make it suitable for situations where third-generation cephalosporins are indicated. Understanding the specific interaction with PBPs and the resistance mechanisms is crucial for optimizing its clinical use and managing antibiotic resistance.</p>

<p>Ampicillin is a β-lactam antibiotic with a broad spectrum of activity against Gram-positive and Gram-negative bacteria. It is used in the treatment of bacterial infections, including those caused by methicillin-resistant Staphylococcus aureus (MRSA), Streptococcus pneumoniae, and Listeria monocytogenes. Ampicillin binds to penicillin-binding proteins in the bacterial cell wall by competitive inhibition. It prevents the formation of an antibiotic-inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division.</p>

<p>Cefatrizine is a broad-spectrum antibiotic, which is a semisynthetic cephalosporin derived from cephalosporin C, a natural product originating from the fungus Acremonium chrysogenum. It exerts its mode of action through the inhibition of bacterial cell wall synthesis, a critical component for bacterial growth and replication. Specifically, cefatrizine targets and binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, leading to the inhibition of peptidoglycan synthesis. This disruption results in cell lysis and ultimately bacterial cell death.</p>

<p>Amphotericin B is a macrocycle antibiotic with very potent antifungal effects and resistance very rarely occurs. Amphotericin B is a polyene antifungal that binds to fungal cell membrane, i.e., ergosterol disrupts the membrane permeability leading to leakage of intracellular components. It is often used as an alternative therapy for leishmaniasis and to treat severe mycoses including: systemic Candida, Cryptococcus, blastomycosis, and histoplasmosis.</p>

<p>Cidofovir is an anti-viral agent that is used to treat Cytomegalovirus (CMV) retinitis in patients with AIDS. This drug suppresses CMV replication by inhibiting viral DNA synthesis.</p>