Antiparasitaires
Les antiparasitaires sont des composés conçus pour traiter et prévenir les infections parasitaires en inhibant la croissance et la survie des parasites. Cette catégorie comprend une gamme d'agents antiparasitaires destinés exclusivement à un usage en laboratoire et non à la consommation humaine. Ces produits sont essentiels à des fins de recherche, permettant aux scientifiques d'étudier les cycles de vie des parasites, les mécanismes d'action et le développement de la résistance. L'utilisation d'antiparasitaires en laboratoire aide à la découverte et à l'optimisation de nouveaux traitements pour les maladies parasitaires, contribuant aux avancées en parasitologie médicale et vétérinaire. Les chercheurs comptent sur ces produits pour améliorer leur compréhension des infections parasitaires et développer des thérapies plus efficaces.
704 produits trouvés pour "Antiparasitaires"
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Diethyl Isobutylmalonate
CAS :Produit contrôlé<p>Applications Diethyl Isobutylmalonate is used as a reagent in the synthesis of quinoline-based zinc metallo-aminopeptidase inhibitors which have antimalarial activity.<br>References Flipo, M., et al.: Bioorg. Med. Chem. Lett., 13, 2659 (2003)<br></p>Formule :C11H20O4Couleur et forme :NeatMasse moléculaire :216.275-Nitro-1H-quinolin-2-one
CAS :Produit contrôlé<p>Applications 5-Nitro-1H-quinolin-2-one is used in the synthetic preparation of novel antileishmanial agents for Leishmania donovani promastigotes.<br>References Paloque, L., et al.: Europ. J. Med. Chem., 54, 75 (2012);<br></p>Formule :C9H6N2O3Couleur et forme :NeatMasse moléculaire :190.163-Chloro-N-(3-methoxyphenyl)propanamide
CAS :Produit contrôlé<p>Applications 3-Chloro-N-(3-methoxyphenyl)propanamide acts as an inhibitor towards DOXP-reductoisomerase (DXR), a primary target for antimalarial drugs.<br>References Bodill, T. et al.: Bioorg. Med. Chem., 21, 4332 (2013);<br></p>Formule :C10H12ClNO2Couleur et forme :NeatMasse moléculaire :213.6623-Des(methoxyimino)-23-hydroxy Moxidectin O-TBS
CAS :Produit contrôléFormule :C42H66O8SiCouleur et forme :NeatMasse moléculaire :727.054-(Aminomethyl)-cyclohexanone Hydrochloride
CAS :Produit contrôlé<p>Applications 4-(Aminomethyl)-cyclohexanone Hydrochloride is used to prepare dispiro-1,2,4-trioxolanes with antimalarial activities. It is also used to synthesize aminopyrimidines as SYK inhibitors useful in the treatment of SYK-mediated diseases.<br>References Tang, Y., et al.: Bioorg. Med. Chem. Lett., 17, 1260 (2007); Altman, M., et al.: PCT Int. Appl. (2011), WO 2011075515 A1 20110623<br></p>Formule :C7H13NO·HClCouleur et forme :NeatMasse moléculaire :127.18 + 36.463-Aminopropionitrile (Stabilized with K2CO3)
CAS :Produit contrôléFormule :C3H6N2Couleur et forme :NeatMasse moléculaire :70.09Pseurotin A
CAS :Produit contrôlé<p>Applications Pseurotin A shows antiparasitic and anticancer activity. It exhibits inhibition towards IgE (immunoglobin E) production.<br>References Martinez-Luis, S. et al.: Nat. Prod. Comm., 7, 165 (2012); Bioorg. Med. Chem. Lett., 19, 1457 (2009);<br></p>Formule :C22H25NO8Couleur et forme :NeatMasse moléculaire :431.444-Methoxy-6-(2-phenylethyl)-2H-pyran-2-one
CAS :Produit contrôlé<p>Applications 4-Methoxy-6-(2-phenylethyl)-2H-pyran-2-one is a Kawain (K145490) derivative that is known to exhibit antimalarial and antituberculosis activities. 4-Methoxy-6-(2-phenylethyl)-2H-pyran-2-one has been identified as a lead compound for the dual treatment of malaria and leishmaniasis.<br>References McCracken, S.T., et al.: Bioorg. Med. Chem., 20, 1482 (2012); Elzaawely, A.A.. et al.: Food. Chem., 103, 486 (2007); Xuan, T.D., et al.: J. Natural. Med., 62, 188 (2008);<br></p>Formule :C14H14O3Couleur et forme :NeatMasse moléculaire :230.262'-O-(2-Methoxyethyl)-5-methylcytidine (~90%)
CAS :Produit contrôléFormule :C13H21N3O6Degré de pureté :~90%Couleur et forme :NeatMasse moléculaire :315.324,4'-Dimethyldiphenylamine
CAS :Produit contrôlé<p>Applications 4,4'-Dimethyldiphenylamine is a reagent used in the comparative studies of the analgesic and anti-inflammatory properties of N-phenylanthranilic acids and mefenamic acid, and the anti parasitic activities of some substituted diphenylamines.<br>References Izard-Verchere, C., et al.: Chimica Therapeutica, 6, 346 (1971)<br></p>Formule :C14H15NCouleur et forme :NeatMasse moléculaire :197.282-Hydroxy-1-methyl-9,10-anthracenedione
CAS :Produit contrôléFormule :C15H10O3Couleur et forme :NeatMasse moléculaire :238.242,5-Diacetoxy-2,5-dihydrofuran (Mixture of Isomers) (>90%)
CAS :Produit contrôlé<p>Applications 2,5-Diacetoxy-2,5-dihydrofuran is used as a reagent to synthesize Mexicanin H, a biologically active sesquiterpene lactone that exhibits antiparasitic activity against Trypanosoma cruzi (a parasite that causes Chagas disease)<br>References Jimenez-Ortiz, V., et al.: Parasitology, 91, 170 (2005); Romo, J., et al.: Tetrahedron Lett., No vol. given, 1029 (1966)<br></p>Formule :C8H10O5Degré de pureté :>90%Couleur et forme :NeatMasse moléculaire :186.16PBD-5,11-dione
CAS :Produit contrôlé<p>Applications PBD-5,11-dione (cas# 18877-34-4) is a useful research chemical.<br></p>Formule :C12H12N2O2Couleur et forme :NeatMasse moléculaire :216.243-[(Dimethylamino)methyl]-2-hexanone
CAS :Produit contrôléFormule :C9H19NOCouleur et forme :ColourlessMasse moléculaire :157.25Benzenebutanoic Acid Ethyl Ester
CAS :Produit contrôlé<p>Applications Benzenebutanoic Acid Ethyl Ester is used in the synthesis of thiazolium salts with potent antimalarial activity. Also used in the preparation of novel lactate dehydrogenase A inhibitors. This compound is suitable for lactate dehydrogenase (LDH) related research.<br>References Hamze, A. et al.: J. Med. Chem., 48, 3639 (2005); Ward, R. et al.: J. Med. Chem., 55, 3285 (2012);<br></p>Formule :C12H16O2Couleur et forme :NeatMasse moléculaire :192.25Tizoxanide - 98%
CAS :<p>Anti-parasitic; pyruvate ferredoxin oxidoreductase inhibitor</p>Formule :C10H7N3O4SDegré de pureté :Min. 95%Masse moléculaire :265.01573Oxfendazole
CAS :<p>Oxfendazole is a benzimidazole anthelmintic with action on microtubule formation in parasitic worms and is used for treating gastrointestinal parasites in livestock.</p>Formule :C15H13N3O3SDegré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :315.35 g/molAmoscanate
CAS :<p>Amoscanate is an antischistosomal agent, which is a synthetic compound with a broad spectrum of activity against parasitic infections. Its mode of action involves the disruption of parasite metabolism and structure, ultimately leading to the elimination of schistosomes. Schistosomes are trematode worms responsible for schistosomiasis, a significant parasitic disease affecting millions of people worldwide.</p>Formule :C13H9N3O2SDegré de pureté :Min. 95%Masse moléculaire :271.3 g/molIvermectin
CAS :<p>Naturally produced by the soil bacterium Streptomyces avermitili, it is clinically used in the treatment of parasitosis in both humans and animals. Ivermectin is commercially available as a mixture of 80% 22, 23-dihydroavermectin B1a and 20% 22, 23-dihydroavermectin B1b. In 2020, Ivermectin indicated that it was a good antiviral agent in the treatment of SARS-CoV-2 and a new mechanism of action has been suggested. Ivermectin would act on importin α/β heterodimer and affect nuclear transport and the translocation of viral proteins.</p>Formule :C48H74O14Degré de pureté :85%MinMasse moléculaire :875.1 g/mol4′-O-De(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-O-demethylavermectin A1a
CAS :<p>4′-O-De(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-O-demethylavermectin A1a is a semi-synthetic derivative of avermectin, which is a naturally occurring compound isolated from the fermentation broth of the soil bacterium *Streptomyces avermitilis*. This compound exhibits potent antiparasitic activity by targeting the glutamate-gated chloride channels in the nervous systems of parasitic organisms. By binding and activating these channels, it increases the permeability of the cell membrane to chloride ions, resulting in paralysis and death of the parasite.</p>Formule :C41H60O11Degré de pureté :Min. 95%Masse moléculaire :728.91 g/molPF 1022A
CAS :<p>PF 1022A is a cyclooctadepsipeptide, which is a type of cyclic peptide composed of amino acids and hydroxy acids. It is derived from the fermentation products of the fungus *Mycelia sterilia*, a member of the *Rosellinia* genus. Its mode of action involves disrupting glutamate-gated chloride channels in parasitic nematodes, which leads to paralysis and eventual death of the parasite.</p>Formule :C52H76N4O12Degré de pureté :Min. 95%Masse moléculaire :949.18 g/molHalofuginone
CAS :<p>Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.</p>Formule :C16H17BrClN3O3Degré de pureté :99.53%Couleur et forme :Off-White SolidMasse moléculaire :414.68Satranidazole
CAS :<p>Satranidazole is an antimicrobial agent that falls under the category of synthetic nitroimidazoles. It is derived from chemical synthesis and is designed to combat infections caused by specific organisms. The mode of action involves the reduction of the nitro group within the organism, creating reactive intermediates that disrupt DNA synthesis and lead to cell death. This mode of action is notably effective against protozoal infections and anaerobic bacterial infections.</p>Formule :C8H11N5O5SDegré de pureté :Min. 95%Masse moléculaire :289.27 g/molICA
CAS :<p>ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) is a SK channel inhibitor and exhibits antileishmanial activity (IC50: 2.1 µM).</p>Formule :C13H10N4SDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :254.31Piperaquine
CAS :<p>Piperaquine is a bisquinoline antimalarial compound and a companion compound to artemisinin.</p>Formule :C29H32Cl2N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :535.51BPH-715
CAS :<p>BPH-715 inhibits the liver-stage growth of P. falciparum with an IC50 of 10 μM for P. falciparum exoerythrocytic forms in HepG2 cells.</p>Formule :C17H31NO7P2Degré de pureté :98.91%Couleur et forme :SolidMasse moléculaire :423.38Quinfamide
CAS :<p>Quinfamide is a compound with the potential to treat tropical parasitic infections such as Amoebiasis and Helminthiasis.</p>Formule :C16H13Cl2NO4Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :354.18Halofuginone hydrobromide
CAS :<p>Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.</p>Formule :C16H17BrClN3O3·HBrDegré de pureté :97.01% - 99.73%Couleur et forme :SolidMasse moléculaire :495.59Antimalarial agent 26
CAS :<p>Antimalarial agent 26, a derivative of 1,4-naphthoquinones, demonstrates antimalarial properties through oral administration.</p>Formule :C20H22N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.41Antiparasitic agent-18
CAS :<p>Antiparasitic agent-18 (compound 3a) exhibits potent and selective antiprotozoal activity, demonstrating effective inhibition of T.</p>Formule :C25H21N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :435.48Antimalarial agent 19
CAS :<p>Compound 6e, an antimalarial, targets P. falciparum K1 (EC50 0.3 µM) and P. berghei (EC50 15.3 µM); has high solubility and stability.</p>Formule :C22H33Cl2N5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :470.5Antimalarial agent 24
CAS :<p>Compound 24 (Compound 7), an in vitro antimalarial agent, demonstrates inhibitory activity against the Plasmodium falciparum W2 strain with an IC50 of 0.81 μM</p>Formule :C20H16N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :344.37Antimalarial agent 29
CAS :<p>Compound 29 (also known as Compound 16) is an antimalarial agent that demonstrates inhibition of the P.</p>Formule :C18H10ClF3N2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :346.73Antileishmanial agent-14
CAS :<p>Antileishmanial agent-14, a sulfuretin analog, exhibits potential activity against Leishmania donovani promastigotes (IC 50 = 4.1 μM) and inhibits infection by</p>Formule :C23H26ClNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :431.91Insecticidal agent 2
CAS :<p>Insecticidal agent 2 (example 2) is an effective pesticide that significantly inhibits pest growth [1].</p>Formule :C16H8ClF7N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.69Antileishmanial agent-15
CAS :<p>Antileishmanial agent-15 (compound 13c) exhibits potent activity against L.</p>Formule :C28H39N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :509.64Epsiprantel
CAS :<p>Epsiprantel is an orally active antiparasitic drug that inhibits various tapeworms, including Echinococcus granulosus (granular echinococcus), in dogs.</p>Formule :C20H26N2O2Degré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :326.43CRK12-IN-2
CAS :<p>CRK12-IN-2, a potent CRK12 inhibitor, has EC50 of 3.2 nM for T. congolense and 0.08 nM for T. vivax; treats trypanosomiasis in animals.</p>Formule :C23H33F2N5O3S2Degré de pureté :99.26% - 99.70%Couleur et forme :SolidMasse moléculaire :529.67Symetine
CAS :<p>Symetine（L 16726） is a small molecule compound with antiparasitic activity that can be used to study amoebic liver abscesses in guinea pigs.</p>Formule :C30H48N2O2Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :468.71(Rac)-ACT-451840
CAS :<p>(Rac)-ACT-451840 is an isomer of ACT-451840 exhibiting antimalarial activity against Plasmodium falciparum NF54.</p>Formule :C47H54N6O3Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :750.97Chalcone 4 hydrate
CAS :<p>Chalcone 4 hydrate, an anti-parasite compound, inhibits the growth of Theileria and Babesia.</p>Formule :C16H15ClO4Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :306.74Phosphodiesterase-IN-1
CAS :<p>Phosphodiesterase-IN-1 (Compound 7), a phosphodiesterase (PDE) inhibitor, exhibits anti-Plasmodium and antiproliferative activities. It effectively inhibits P. falciparum (strain 3D7) with an IC 50 value of 0.64 μM [1].</p>Formule :C15H15FN4OCouleur et forme :SolidMasse moléculaire :286.3MMV006833
CAS :<p>MMV006833 is an inhibitor of Plasmodium falciparum. It targets the lipid transfer protein PfSTART1, inhibiting the ring-stage development of Plasmodium falciparum.</p>Formule :C19H27ClN2O4SCouleur et forme :SolidMasse moléculaire :414.95Topoisomerase II inhibitor 16
CAS :<p>Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of trypanosomal topoisomerase II, possessing the</p>Formule :C19H12F4N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :416.33SQ109
CAS :<p>SQ109 (NSC-722041) is an effective inhibitor of the trypomastigote form of the parasite (IC50 = 50 nM). SQ109 is an antitubercular agent and targets MmpL3.</p>Formule :C22H38N2Degré de pureté :99.70% - 99.91%Couleur et forme :SolidMasse moléculaire :330.55Antitrypanosomal agent 2
CAS :<p>Antitrypanosomal agent 2 shows potent and specific antiparasite activities against Trypanosoma brucei.</p>Formule :C17H13N5O3Degré de pureté :99.2%Couleur et forme :SolidMasse moléculaire :335.32Artelinic acid
CAS :<p>Artelinic acid is an artemisinin analog with antimalarial activity and is used for the treatment of multi-drug resistant strains of Plasmodium falciparum.</p>Formule :C23H30O7Degré de pureté :97.49% - 97.69%Couleur et forme :SolidMasse moléculaire :418.48Bithionol sulfoxide
CAS :<p>Bithionol sulfoxide (Bithionoloxide) is a compound with inhibitory effects against parasites, inhibiting Fasciola hepatica and Schistosoma mansoni.</p>Formule :C12H6Cl4O3SDegré de pureté :98.76%Couleur et forme :Off White To Tinch Pink Crystalline PowderMasse moléculaire :372.05Rufigallol
CAS :<p>Rufigallol, an anthraquinone with six OH groups, induces DLC and fluoresces when aggregated, showing antimalarial effects with vitamin C and ketones.</p>Formule :C14H8O8Degré de pureté :98.92% - 99.27%Couleur et forme :SolidMasse moléculaire :304.21Antimalarial agent 30
CAS :<p>Antimalarial agent 30 has anti-Plasmodium berghei liver stage parasite activity and antimalarial activity for the study of malarial infections.</p>Formule :C18H11F3N2Degré de pureté :99.83% - 99.90%Couleur et forme :SolidMasse moléculaire :312.29Brotianide
CAS :<p>Brotianide (BAY-VA4059) has anthelmintic activity and is highly potent against liver fluke and gastric fluke infestations and can be used to treat acute,</p>Formule :C15H10Br2ClNO2SDegré de pureté :97.44% - 98.12%Couleur et forme :SolidMasse moléculaire :463.57JCP174
CAS :<p>JCP174 is a depalmitoylase inhibitor that enhances Toxoplasma host-cell invasion by targeting TgPPT1.</p>Formule :C12H12ClNO3Degré de pureté :97.05%Couleur et forme :SolidMasse moléculaire :253.68Allopurinol riboside
CAS :<p>Allopurinol riboside, an allopurinol metabolite, inhibits purine nucleoside phosphorylase in parasites with a Ki of 277 μM.</p>Formule :C10H12N4O5Degré de pureté :99.46% - 99.73%Couleur et forme :SolidMasse moléculaire :268.23UCT943
CAS :<p>UCT943 is an inhibitor of Plasmodium falciparum PI4K (IC50 = 23 nM).</p>Formule :C22H20F3N5ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :427.42AP-C5
CAS :<p>AP-C5 inhibits cGKII with a Pic50 of 7.2, useful in diarrheal disease research.</p>Formule :C16H13N5Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :275.31DDD85646
CAS :<p>DDD85646 is an inhibitor of T. brucei N-myristoyltransferase with a Ki of 1.44 nM, an IC50 of 2 nM and an EC50 of 2 nM. The IC50 of hNMT is 4 nM.</p>Formule :C21H24Cl2N6O2SDegré de pureté :97.8% - 99.76%Couleur et forme :SolidMasse moléculaire :495.43Myrrhterpenoid O
CAS :<p>Unfortunately, you did not provide the description of the chemical compound that needs to be rewritten.</p>Formule :C16H20O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :260.33Propamidine
CAS :<p>Propamidine acts as a covalent inhibitor of TMPRSS2 and exhibits antibacterial properties. [1]</p>Formule :C17H20N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :312.37UCB7362
CAS :<p>UCB7362 (GLXC-26743) is an orally available and potent plasmepsin X (PMX) inhibitor with anti-malarial activity.UCB7362 inhibits parasite reproduction.</p>Formule :C25H26ClN5O3Degré de pureté :97.67%Couleur et forme :SolidMasse moléculaire :479.96Antileishmanial agent-16
CAS :<p>Antileishmanial agent-16 (compound 14c), an anti-Leishmania agent, exhibits potent activity against Leishmania major promastigotes (IC50 = 0.59 µM) and</p>Formule :C27H37N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :495.61Antileishmanial agent-17
CAS :<p>Antileishmanial agent-17, a coumarin hybrid, exhibits potent antileishmanial activity (IC50 <0.78 μM) while proving non-toxic to normal VERO cells.</p>Formule :C27H37N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :511.61SID 26681509
CAS :<p>SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).</p>Formule :C27H33N5O5SDegré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :539.65FIKK9.1-IN-1
CAS :<p>FIKK9.1-IN-1 (Compound 1), an antimalarial agent (IC50: 2.68 μg/mL), serves as a FIKK9.1 inhibitor by interacting with the ATP-binding residues within FIKK9.1,</p>Formule :C22H22N2SeDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :393.38ELQ-596
CAS :<p>ELQ-596, a quinolone derivative, exhibits antimicrobial activity against several protozoan parasites, including the intraerythrocytic parasites Plasmodium and Babesia. ELQ-596 attenuates babesiosis in immunosuppressed mice [1].</p>Formule :C24H17ClF3NO3Couleur et forme :SolidMasse moléculaire :459.84Fervenulin
CAS :<p>Fervenulin, from Streptomyces sp. CMU-MH021, halts egg hatch (MIC: 30 μg/mL) and kills J2 larvae (MIC: 120 μg/mL) of M. incognita.</p>Formule :C7H7N5O2Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :193.16Z-Pro-Pro-CHO
CAS :<p>Z-Pro-Pro-CHO acts as a prolyl oligopeptidase inhibitor with half-maximal inhibitory concentrations (IC50) of 0.16 μM for human prolyl oligopeptidase and 0.01</p>Formule :C18H22N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :330.38BTG 502
CAS :<p>BTG 502 is an alkylamide insecticide that binds to voltage-gated sodium channels, antagonising the activation of sodium channels by Batrachotoxin (BTX).</p>Formule :C21H24BrNODegré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :386.33EDI048
CAS :<p>EDI048, also known as compound 1.16, is an orally active inhibitor of Cryptosporidium PI4K, utilized in the study of cryptosporidiosis [1].</p>Formule :C25H21ClN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.91OfChi-h-IN-2
CAS :<p>OfChi-h-IN-2 (compound TQ19) is a potent inhibitor of OfChi-h, exhibiting a K i of 0.33 μM, and significantly impairs the growth and development of Ostrinia</p>Formule :C25H28ClN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :481.98Eugenitin
CAS :<p>Eugenitin, a polyketide from Mycoleptodiscus indicus, exhibits inhibitory activity against Leishmania major with an LD50 of 39.9 μM and demonstrates low</p>Formule :C12H12O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :220.22Antileishmanial agent-23
CAS :<p>Antileishmanial agent-23 (compound G1/9), a potent and selective trypanothione reductase (TR) inhibitor, exhibits an IC50 of 2.24 ± 0.52 μM.</p>Formule :C20H17N3O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :427.5Phylloflavan
CAS :<p>Phylloflavan, an antileishmanial compound, exhibits an intracellular half maximal effective concentration (EC50) of 3.2 nM in RAW 264.7 cells and inhibits the</p>Formule :C26H26O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.48MMV688533
CAS :<p>MMV688533 has antimalarial activity.</p>Formule :C24H15F6N5O2Degré de pureté :99.12%Couleur et forme :SoildMasse moléculaire :519.4Dehydroemetine
CAS :<p>Dehydroemetine, a synthetic emetine, treats amoebic infections and leishmaniasis, and resists metronidazole amoebiosis.</p>Formule :C29H38N2O4Degré de pureté :98.68% - 99.68%Couleur et forme :SolidMasse moléculaire :478.62ZY-19489
CAS :<p>ZY-19489: Antimalarial, potential single-dose cure, FDA orphan drug status.</p>Formule :C24H32FN9Degré de pureté :>99.99%Couleur et forme :SoildMasse moléculaire :465.57GSK3186899
CAS :<p>GSK3186899 is an inhibitor of Cdc2-related kinase 12 with an EC50 of 1.4 μM for L. donovani.</p>Formule :C19H28F3N7O3SDegré de pureté :98.35% - 99.61%Couleur et forme :SolidMasse moléculaire :491.53CWHM-1552
CAS :<p>CWHM-1552 is an effective Plasmodium falciparum inhibitor. For the 3D7 and Dd2 strains, the IC50s are 51 nM and 53 nM.</p>Formule :C22H27F2N3ODegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :387.47Ac-Atovaquone
CAS :<p>Ac-Atovaquone, an ester-acetylated derivative of atovaquone, acts as a potent inhibitor of cytochrome bc1 (cytochrome bc1). This compound shows potential for use in malaria research.</p>Formule :C24H21ClO4Couleur et forme :SolidMasse moléculaire :408.87WR-27653
CAS :<p>WR-27653 (RC-12), a derivative of Catechol, demonstrates significant activity against hypnozoites in the Plasmodium cynomolgi-Rhesus monkey (Macaca mulatta) model, which is considered the gold standard. Additionally, WR-27653 exhibits antimalarial properties.</p>Formule :C20H36BrN3O2Couleur et forme :SolidMasse moléculaire :430.423PFK-IN-1
CAS :<p>PFK-IN-1 (compound 1) is an inhibitor of 6-phosphofructo-1-kinase (PFK), demonstrating IC50 values of 0.41 and 0.23 μM against T. brucei and T. cruzi PFK, respectively, and an ED50 of 15.18 μg/mL for T. brucei. The compound has a half-life of 9.7 minutes in rat liver microsomes and 408 minutes in mouse liver microsomes.</p>Formule :C18H15Cl2N3O4SCouleur et forme :SolidMasse moléculaire :440.3Ipronidazole
CAS :<p>Ipronidazole (RO-71554) is an orally effective antiprotozoal agent used to prevent and ameliorate histomoniasis in turkeys, commonly referred to as blackhead disease.</p>Formule :C7H11N3O2Couleur et forme :SolidMasse moléculaire :169.18Arohynapene B
CAS :<p>Arohynapene B is an anticoccidial compound that inhibits the growth of Eimeria parasites.</p>Formule :C18H22O3Couleur et forme :SolidMasse moléculaire :286.366NEU-1017
CAS :<p>NEU-1017 serves as a broad-spectrum antiparasitic compound, effectively inhibiting T. brucei, L. major, and P. falciparum with EC50 values of 210 nM, 240 nM, and 3 nM, respectively.</p>Formule :C33H31ClFN5O3SCouleur et forme :SolidMasse moléculaire :632.147SLU-10906
CAS :<p>SLU-10906 (Compound 63) is an orally active inhibitor of Cryptosporidium. It demonstrates activity against the parasite in cell-based infection models with an EC50 of 0.19 μM and exhibits no cytotoxicity. SLU-10906 is a promising candidate for research in cryptosporidiosis.</p>Formule :C22H21BFN5O2Couleur et forme :SolidMasse moléculaire :417.244SPB07935
CAS :<p>SPB07935 inhibits plasmepsin II in the malaria-causing parasite Plasmodium falciparum and serves as an antimalarial agent. It affects the life cycle of P. falciparum, hindering the growth of the parasite's FcB1 and 3D7 strains, with IC50 values of 8 μM and 4.7 μM, respectively.</p>Formule :C22H15N5O4S2Couleur et forme :SolidMasse moléculaire :477.516Menoctone
CAS :<p>Menoctone is an orally effective antimalarial agent that inhibits blood-induced rodent malaria. It enhances the antimalarial effects of chloroquine or quinine, making it useful for malaria research.</p>Formule :C24H32O3Couleur et forme :SolidMasse moléculaire :368.51Insecticidal agent 16
CAS :<p>Insecticidal agent 16 (compound A21) exhibits insecticidal activity against Plutella xylostella, with LC50 values of 1.2 and 13.2 µg/mL respectively.</p>Formule :C21H13Cl2F6N5O2SCouleur et forme :SolidMasse moléculaire :584.32Antimalarial agent 48
CAS :<p>Antimalarial agent 48 (Compound 15a) is a triazine compound with antimalarial activity, showing effectiveness against Plasmodium falciparum K1 and Plasmodium falciparum FCR3 with IC50 values of 280 and 290 nM, respectively. It holds promise for research in the field of anti-infective treatments.</p>Formule :C19H14F3N11Couleur et forme :SolidMasse moléculaire :453.383MMV03
CAS :<p>MMV03 is an antimalarial compound effective against Plasmodium falciparum, with an EC50 of 0.6 μM.</p>Formule :C19H14N4OSCouleur et forme :SolidMasse moléculaire :346.406Antimalarial agent 44
<p>Antimalarial agent 44 (Compound 3) is an antiparasitic agent effective against malaria. It exhibits good permeability in MDCK-MDR1 cell monolayers and has a high clearance rate in mouse liver microsomes.</p>Formule :C37H37N5O7Couleur et forme :SolidMasse moléculaire :663.72MED6-189
CAS :<p>MED6-189, an analog of kalihinol, disrupts the apicoplast functions and vesicular transport in the malignant malaria parasite (P. falciparum, IC50 < 50 nM). The compound specifically targets the apicoplast, which is a non-photosynthetic plastid essential for isoprenoid synthesis, found in most apicomplexan parasites.</p>Formule :C17H26N2OCouleur et forme :SolidMasse moléculaire :274.40Isazofos
CAS :<p>Isazofos is a broad-spectrum organophosphate insecticide and nematicide effective in controlling a variety of lawn pests, such as nematodes (Radopholus similis). It also demonstrates efficacy in managing rice gall midge.</p>Formule :C9H17ClN3O3PSCouleur et forme :SolidMasse moléculaire :313.74PfCLK3-IN-1
<p>PfCLK3-IN-1 (Compound 4) serves as a covalent inhibitor of the malaria parasite CLK3 (Pf CLK3) under alkaline conditions, with a pEC50 of 7.1. It inhibits the maturation of gametocytes during the sexual stage of the parasite, thereby hindering transmission. Additionally, PfCLK3-IN-1 effectively suppresses the Dd2-B2 clone of the malaria parasite, exhibiting an IC50 of 239.5 nM.</p>Formule :C28H27ClN4O4Couleur et forme :SolidMasse moléculaire :518.99PIQ-2
CAS :<p>PIQ-2 (compound 54) serves as an antiprotozoal agent, displaying potent activity against IP. falciparum 3D7 and B. divergens Rouen, with IC50 values of 9.4 nM and 1.6 nM, respectively.</p>Formule :C23H21F3N4O3Couleur et forme :SolidMasse moléculaire :458.43Ferrocene
CAS :<p>Ferrocene, a crucial structural core in bioorganometallic chemistry, is renowned for its intrinsic stability, excellent oxygen reduction capabilities, and low toxicity. It also exhibits antimalarial and anticancer properties.</p>Formule :C10H10FeCouleur et forme :SolidMasse moléculaire :186.03Erythromycin B
CAS :<p>Erythromycin B exhibits antimalarial activity by effectively inhibiting the asexual growth of Plasmodium falciparum.</p>Formule :C37H67NO12Couleur et forme :SolidMasse moléculaire :717.93SAL-0010042
CAS :<p>SAL-0010042 is an inhibitor of Plasmodium phosphodiesterase β (PDEβ), effectively blocking the hydrolysis of cAMP and cGMP in gametocytes with an IC50 of 48.9 nM, thereby activating PKG and inhibiting the growth and development of Plasmodium (IC50s for 3D7 and Dd2 are 142 nM and 218 nM, respectively). It also inhibits hPDE5 and hPDE6 with IC50 values of 632 nM and 73 nM, respectively.</p>Formule :C15H15FN4OCouleur et forme :SolidMasse moléculaire :286.304DNA crosslinker 6
CAS :<p>DNA crosslinker 6 (compound 1) is an anti-mitotic agent known for its strong binding affinity to AT-DNA and inhibition of AT-hook 1 binding to DNA (IC50=0.03 µM). Additionally, it exhibits anti-protozoal activity, effectively inhibiting T. brucei with an EC50 of 0.83 µM.</p>Formule :C19H21N7OCouleur et forme :SolidMasse moléculaire :363.42Etofamide
CAS :<p>Etofamide, an antimicrobial agent, exhibits an IC50 of 5.96 mg/L against amoebae.</p>Formule :C19H20Cl2N2O5Couleur et forme :SolidMasse moléculaire :427.28LN002
CAS :<p>LN002 is an orally active inhibitor of Cryptosporidium oxidase, utilized for research in cryptosporidiosis.</p>Formule :C22H15N7Couleur et forme :SolidMasse moléculaire :377.40VNI
CAS :<p>VNI is an effective inhibitor of CYP51. It suppresses sterol synthesis in Trypanosoma cruzi, exhibiting anti-Trypanosoma cruzi activity.</p>Formule :C26H19Cl2N5O2Couleur et forme :SolidMasse moléculaire :504.372-Phenazinamine,N,5-bis(4-chlorophenyl)-3,5-dihydro-3-[(1-methylethyl)imino]-
CAS :Formule :C27H22Cl2N4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.3964Insecticidal agent 6
CAS :<p>Compound Im (Insecticidal agent 6) is a potent inhibitor of insect ryanodine receptors (RyRs), exhibiting an EC50 of 0.6308 µM against S.</p>Formule :C19H14BrCl2N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :527.16
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