Antiparasitaires
Les antiparasitaires sont des composés conçus pour traiter et prévenir les infections parasitaires en inhibant la croissance et la survie des parasites. Cette catégorie comprend une gamme d'agents antiparasitaires destinés exclusivement à un usage en laboratoire et non à la consommation humaine. Ces produits sont essentiels à des fins de recherche, permettant aux scientifiques d'étudier les cycles de vie des parasites, les mécanismes d'action et le développement de la résistance. L'utilisation d'antiparasitaires en laboratoire aide à la découverte et à l'optimisation de nouveaux traitements pour les maladies parasitaires, contribuant aux avancées en parasitologie médicale et vétérinaire. Les chercheurs comptent sur ces produits pour améliorer leur compréhension des infections parasitaires et développer des thérapies plus efficaces.
704 produits trouvés pour "Antiparasitaires"
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Antimalarial agent 30
CAS :<p>Antimalarial agent 30 has anti-Plasmodium berghei liver stage parasite activity and antimalarial activity for the study of malarial infections.</p>Formule :C18H11F3N2Degré de pureté :99.83% - 99.90%Couleur et forme :SolidMasse moléculaire :312.29Brotianide
CAS :<p>Brotianide (BAY-VA4059) has anthelmintic activity and is highly potent against liver fluke and gastric fluke infestations and can be used to treat acute,</p>Formule :C15H10Br2ClNO2SDegré de pureté :97.44% - 98.12%Couleur et forme :SolidMasse moléculaire :463.57JCP174
CAS :<p>JCP174 is a depalmitoylase inhibitor that enhances Toxoplasma host-cell invasion by targeting TgPPT1.</p>Formule :C12H12ClNO3Degré de pureté :97.05%Couleur et forme :SolidMasse moléculaire :253.68Allopurinol riboside
CAS :<p>Allopurinol riboside, an allopurinol metabolite, inhibits purine nucleoside phosphorylase in parasites with a Ki of 277 μM.</p>Formule :C10H12N4O5Degré de pureté :99.46% - 99.73%Couleur et forme :SolidMasse moléculaire :268.23UCT943
CAS :<p>UCT943 is an inhibitor of Plasmodium falciparum PI4K (IC50 = 23 nM).</p>Formule :C22H20F3N5ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :427.42AP-C5
CAS :<p>AP-C5 inhibits cGKII with a Pic50 of 7.2, useful in diarrheal disease research.</p>Formule :C16H13N5Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :275.31DDD85646
CAS :<p>DDD85646 is an inhibitor of T. brucei N-myristoyltransferase with a Ki of 1.44 nM, an IC50 of 2 nM and an EC50 of 2 nM. The IC50 of hNMT is 4 nM.</p>Formule :C21H24Cl2N6O2SDegré de pureté :97.8% - 99.76%Couleur et forme :SolidMasse moléculaire :495.43Myrrhterpenoid O
CAS :<p>Unfortunately, you did not provide the description of the chemical compound that needs to be rewritten.</p>Formule :C16H20O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :260.33Propamidine
CAS :<p>Propamidine acts as a covalent inhibitor of TMPRSS2 and exhibits antibacterial properties. [1]</p>Formule :C17H20N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :312.37UCB7362
CAS :<p>UCB7362 (GLXC-26743) is an orally available and potent plasmepsin X (PMX) inhibitor with anti-malarial activity.UCB7362 inhibits parasite reproduction.</p>Formule :C25H26ClN5O3Degré de pureté :97.67%Couleur et forme :SolidMasse moléculaire :479.96Antileishmanial agent-16
CAS :<p>Antileishmanial agent-16 (compound 14c), an anti-Leishmania agent, exhibits potent activity against Leishmania major promastigotes (IC50 = 0.59 µM) and</p>Formule :C27H37N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :495.61Antileishmanial agent-17
CAS :<p>Antileishmanial agent-17, a coumarin hybrid, exhibits potent antileishmanial activity (IC50 <0.78 μM) while proving non-toxic to normal VERO cells.</p>Formule :C27H37N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :511.61SID 26681509
CAS :<p>SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).</p>Formule :C27H33N5O5SDegré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :539.65FIKK9.1-IN-1
CAS :<p>FIKK9.1-IN-1 (Compound 1), an antimalarial agent (IC50: 2.68 μg/mL), serves as a FIKK9.1 inhibitor by interacting with the ATP-binding residues within FIKK9.1,</p>Formule :C22H22N2SeDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :393.38ELQ-596
CAS :<p>ELQ-596, a quinolone derivative, exhibits antimicrobial activity against several protozoan parasites, including the intraerythrocytic parasites Plasmodium and Babesia. ELQ-596 attenuates babesiosis in immunosuppressed mice [1].</p>Formule :C24H17ClF3NO3Couleur et forme :SolidMasse moléculaire :459.84Fervenulin
CAS :<p>Fervenulin, from Streptomyces sp. CMU-MH021, halts egg hatch (MIC: 30 μg/mL) and kills J2 larvae (MIC: 120 μg/mL) of M. incognita.</p>Formule :C7H7N5O2Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :193.16Z-Pro-Pro-CHO
CAS :<p>Z-Pro-Pro-CHO acts as a prolyl oligopeptidase inhibitor with half-maximal inhibitory concentrations (IC50) of 0.16 μM for human prolyl oligopeptidase and 0.01</p>Formule :C18H22N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :330.38BTG 502
CAS :<p>BTG 502 is an alkylamide insecticide that binds to voltage-gated sodium channels, antagonising the activation of sodium channels by Batrachotoxin (BTX).</p>Formule :C21H24BrNODegré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :386.33EDI048
CAS :<p>EDI048, also known as compound 1.16, is an orally active inhibitor of Cryptosporidium PI4K, utilized in the study of cryptosporidiosis [1].</p>Formule :C25H21ClN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.91OfChi-h-IN-2
CAS :<p>OfChi-h-IN-2 (compound TQ19) is a potent inhibitor of OfChi-h, exhibiting a K i of 0.33 μM, and significantly impairs the growth and development of Ostrinia</p>Formule :C25H28ClN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :481.98Eugenitin
CAS :<p>Eugenitin, a polyketide from Mycoleptodiscus indicus, exhibits inhibitory activity against Leishmania major with an LD50 of 39.9 μM and demonstrates low</p>Formule :C12H12O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :220.22Antileishmanial agent-23
CAS :<p>Antileishmanial agent-23 (compound G1/9), a potent and selective trypanothione reductase (TR) inhibitor, exhibits an IC50 of 2.24 ± 0.52 μM.</p>Formule :C20H17N3O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :427.5Phylloflavan
CAS :<p>Phylloflavan, an antileishmanial compound, exhibits an intracellular half maximal effective concentration (EC50) of 3.2 nM in RAW 264.7 cells and inhibits the</p>Formule :C26H26O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.48MMV688533
CAS :<p>MMV688533 has antimalarial activity.</p>Formule :C24H15F6N5O2Degré de pureté :99.12%Couleur et forme :SoildMasse moléculaire :519.4Dehydroemetine
CAS :<p>Dehydroemetine, a synthetic emetine, treats amoebic infections and leishmaniasis, and resists metronidazole amoebiosis.</p>Formule :C29H38N2O4Degré de pureté :98.68% - 99.68%Couleur et forme :SolidMasse moléculaire :478.62ZY-19489
CAS :<p>ZY-19489: Antimalarial, potential single-dose cure, FDA orphan drug status.</p>Formule :C24H32FN9Degré de pureté :>99.99%Couleur et forme :SoildMasse moléculaire :465.57GSK3186899
CAS :<p>GSK3186899 is an inhibitor of Cdc2-related kinase 12 with an EC50 of 1.4 μM for L. donovani.</p>Formule :C19H28F3N7O3SDegré de pureté :98.35% - 99.61%Couleur et forme :SolidMasse moléculaire :491.53CWHM-1552
CAS :<p>CWHM-1552 is an effective Plasmodium falciparum inhibitor. For the 3D7 and Dd2 strains, the IC50s are 51 nM and 53 nM.</p>Formule :C22H27F2N3ODegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :387.47Ac-Atovaquone
CAS :<p>Ac-Atovaquone, an ester-acetylated derivative of atovaquone, acts as a potent inhibitor of cytochrome bc1 (cytochrome bc1). This compound shows potential for use in malaria research.</p>Formule :C24H21ClO4Couleur et forme :SolidMasse moléculaire :408.87WR-27653
CAS :<p>WR-27653 (RC-12), a derivative of Catechol, demonstrates significant activity against hypnozoites in the Plasmodium cynomolgi-Rhesus monkey (Macaca mulatta) model, which is considered the gold standard. Additionally, WR-27653 exhibits antimalarial properties.</p>Formule :C20H36BrN3O2Couleur et forme :SolidMasse moléculaire :430.423PFK-IN-1
CAS :<p>PFK-IN-1 (compound 1) is an inhibitor of 6-phosphofructo-1-kinase (PFK), demonstrating IC50 values of 0.41 and 0.23 μM against T. brucei and T. cruzi PFK, respectively, and an ED50 of 15.18 μg/mL for T. brucei. The compound has a half-life of 9.7 minutes in rat liver microsomes and 408 minutes in mouse liver microsomes.</p>Formule :C18H15Cl2N3O4SCouleur et forme :SolidMasse moléculaire :440.3Ipronidazole
CAS :<p>Ipronidazole (RO-71554) is an orally effective antiprotozoal agent used to prevent and ameliorate histomoniasis in turkeys, commonly referred to as blackhead disease.</p>Formule :C7H11N3O2Couleur et forme :SolidMasse moléculaire :169.18Arohynapene B
CAS :<p>Arohynapene B is an anticoccidial compound that inhibits the growth of Eimeria parasites.</p>Formule :C18H22O3Couleur et forme :SolidMasse moléculaire :286.366NEU-1017
CAS :<p>NEU-1017 serves as a broad-spectrum antiparasitic compound, effectively inhibiting T. brucei, L. major, and P. falciparum with EC50 values of 210 nM, 240 nM, and 3 nM, respectively.</p>Formule :C33H31ClFN5O3SCouleur et forme :SolidMasse moléculaire :632.147SLU-10906
CAS :<p>SLU-10906 (Compound 63) is an orally active inhibitor of Cryptosporidium. It demonstrates activity against the parasite in cell-based infection models with an EC50 of 0.19 μM and exhibits no cytotoxicity. SLU-10906 is a promising candidate for research in cryptosporidiosis.</p>Formule :C22H21BFN5O2Couleur et forme :SolidMasse moléculaire :417.244SPB07935
CAS :<p>SPB07935 inhibits plasmepsin II in the malaria-causing parasite Plasmodium falciparum and serves as an antimalarial agent. It affects the life cycle of P. falciparum, hindering the growth of the parasite's FcB1 and 3D7 strains, with IC50 values of 8 μM and 4.7 μM, respectively.</p>Formule :C22H15N5O4S2Couleur et forme :SolidMasse moléculaire :477.516Menoctone
CAS :<p>Menoctone is an orally effective antimalarial agent that inhibits blood-induced rodent malaria. It enhances the antimalarial effects of chloroquine or quinine, making it useful for malaria research.</p>Formule :C24H32O3Couleur et forme :SolidMasse moléculaire :368.51Insecticidal agent 16
CAS :<p>Insecticidal agent 16 (compound A21) exhibits insecticidal activity against Plutella xylostella, with LC50 values of 1.2 and 13.2 µg/mL respectively.</p>Formule :C21H13Cl2F6N5O2SCouleur et forme :SolidMasse moléculaire :584.32Antimalarial agent 48
CAS :<p>Antimalarial agent 48 (Compound 15a) is a triazine compound with antimalarial activity, showing effectiveness against Plasmodium falciparum K1 and Plasmodium falciparum FCR3 with IC50 values of 280 and 290 nM, respectively. It holds promise for research in the field of anti-infective treatments.</p>Formule :C19H14F3N11Couleur et forme :SolidMasse moléculaire :453.383MMV03
CAS :<p>MMV03 is an antimalarial compound effective against Plasmodium falciparum, with an EC50 of 0.6 μM.</p>Formule :C19H14N4OSCouleur et forme :SolidMasse moléculaire :346.406Antimalarial agent 44
<p>Antimalarial agent 44 (Compound 3) is an antiparasitic agent effective against malaria. It exhibits good permeability in MDCK-MDR1 cell monolayers and has a high clearance rate in mouse liver microsomes.</p>Formule :C37H37N5O7Couleur et forme :SolidMasse moléculaire :663.72MED6-189
CAS :<p>MED6-189, an analog of kalihinol, disrupts the apicoplast functions and vesicular transport in the malignant malaria parasite (P. falciparum, IC50 < 50 nM). The compound specifically targets the apicoplast, which is a non-photosynthetic plastid essential for isoprenoid synthesis, found in most apicomplexan parasites.</p>Formule :C17H26N2OCouleur et forme :SolidMasse moléculaire :274.40Isazofos
CAS :<p>Isazofos is a broad-spectrum organophosphate insecticide and nematicide effective in controlling a variety of lawn pests, such as nematodes (Radopholus similis). It also demonstrates efficacy in managing rice gall midge.</p>Formule :C9H17ClN3O3PSCouleur et forme :SolidMasse moléculaire :313.74PfCLK3-IN-1
<p>PfCLK3-IN-1 (Compound 4) serves as a covalent inhibitor of the malaria parasite CLK3 (Pf CLK3) under alkaline conditions, with a pEC50 of 7.1. It inhibits the maturation of gametocytes during the sexual stage of the parasite, thereby hindering transmission. Additionally, PfCLK3-IN-1 effectively suppresses the Dd2-B2 clone of the malaria parasite, exhibiting an IC50 of 239.5 nM.</p>Formule :C28H27ClN4O4Couleur et forme :SolidMasse moléculaire :518.99PIQ-2
CAS :<p>PIQ-2 (compound 54) serves as an antiprotozoal agent, displaying potent activity against IP. falciparum 3D7 and B. divergens Rouen, with IC50 values of 9.4 nM and 1.6 nM, respectively.</p>Formule :C23H21F3N4O3Couleur et forme :SolidMasse moléculaire :458.43Ferrocene
CAS :<p>Ferrocene, a crucial structural core in bioorganometallic chemistry, is renowned for its intrinsic stability, excellent oxygen reduction capabilities, and low toxicity. It also exhibits antimalarial and anticancer properties.</p>Formule :C10H10FeCouleur et forme :SolidMasse moléculaire :186.03Erythromycin B
CAS :<p>Erythromycin B exhibits antimalarial activity by effectively inhibiting the asexual growth of Plasmodium falciparum.</p>Formule :C37H67NO12Couleur et forme :SolidMasse moléculaire :717.93SAL-0010042
CAS :<p>SAL-0010042 is an inhibitor of Plasmodium phosphodiesterase β (PDEβ), effectively blocking the hydrolysis of cAMP and cGMP in gametocytes with an IC50 of 48.9 nM, thereby activating PKG and inhibiting the growth and development of Plasmodium (IC50s for 3D7 and Dd2 are 142 nM and 218 nM, respectively). It also inhibits hPDE5 and hPDE6 with IC50 values of 632 nM and 73 nM, respectively.</p>Formule :C15H15FN4OCouleur et forme :SolidMasse moléculaire :286.304DNA crosslinker 6
CAS :<p>DNA crosslinker 6 (compound 1) is an anti-mitotic agent known for its strong binding affinity to AT-DNA and inhibition of AT-hook 1 binding to DNA (IC50=0.03 µM). Additionally, it exhibits anti-protozoal activity, effectively inhibiting T. brucei with an EC50 of 0.83 µM.</p>Formule :C19H21N7OCouleur et forme :SolidMasse moléculaire :363.42Etofamide
CAS :<p>Etofamide, an antimicrobial agent, exhibits an IC50 of 5.96 mg/L against amoebae.</p>Formule :C19H20Cl2N2O5Couleur et forme :SolidMasse moléculaire :427.28
