Antiparasitaires

<p>Primaquine is an antimalarial agent with action on Plasmodium hypnozoites in the liver and is used for preventing relapses of malaria caused by Plasmodium vivax and Plasmodium ovale.</p>

<p>Benznidazole is an antiprotozoal agent and is used for the treatment of Chagas disease. It generates free radicals that damage the DNA and other cellular components of the parasite.</p>

<p>Inhibits methionine aminopeptidase-2; anti-angiogenic; antibiotic</p>

<p>Hexadecylphosphocholine, better known as miltefosine, belongs to the group of phospholipids. The long alkyl chain and a polar group of a molecule proved to be essential for antitumor activity, especially to cure breast cancer cells. The apoptotic process takes place in the plasma membrane, where molecules are inserted and then influence signaling pathways. Moreover, during preclinical studies hexadecylphosphocholine (He-PC) found to be highly effective in inhibiting the growth of chemically induced rat mammary carcinomas, and even a high percentage of the tumors regressed completely. The He-PC has many more applications such as antifungal agent, antiprotozoal drug, protein kinase inhibitor or immunomodulator. Even though miltefosine was originally developed in the 1980s as an anti-cancer agent, new studies have demonstrated activity against Leishmania parasites and neoplastic cells, and due to broad spectrum of antimicrobial effects, it is recommended as a first line treatment for free-living amebae infections.</p>

<p>Triclabendazole is a benzimidazole anthelmintic with action on liver flukes by disrupting their microtubule formation and is used for treating fascioliasis in humans and animals.</p>

<p>Mebendazole is a benzimidazole anthelmintic with action on microtubule formation in parasitic worms and is used for treating intestinal worm infections like threadworms and roundworms.</p>

<p>Fenbendazole is a benzimidazole anthelmintic with action on microtubule formation in parasites and is used for treating gastrointestinal parasites in animals.</p>

<p>N-Desethyl Amodiaquine-d5 DiHCl is a deuterated compound of N-Desethyl Amodiaquine DiHCl. N-Desethyl Amodiaquine DiHCl has a CAS number of 79352-78-6. N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent,is the major biologically active Amodiaquine metabolite .</p>

<p>Tafenoquine (WR 238605) is an antimalarial prophylactic agent with schizonticidal activity, useful in hemolytic anemia research.</p>

<p>Primaquine is an antimalarial compound and a gametocytocide, clearing liver schizonts and dormant forms of Plasmodium vivax.</p>

<p>DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.</p>

<p>(+)-Isopulegol is a monoterpenoid from Mentha canadensis L.</p>

<p>Applications Farnesal is a reagent in the synthesis of farnesylpyrophosphate analogues which acts as bisubstrate inhibitors of protein farnesyltransferase and has antiparasitics properties.<br>References Duez, S. et al.: Bioorg. Med. Chem., 18, 543 (2010);<br></p>

<p>Applications Antimalarial agent. The compound showed antimalarial activity similar to that of Chloroquine.<br>References Desjardins, R., et al.: Antimicrob. Agents Chemother., 16, 710 (1979), McKie, J., et al.: J. Med. Chem., 41, 1367 (1998), Gozalbes, R., et al.: J. Pharm. Pharmacol., 52, 111 (1999), Marrero-Ponce, Y., et al.: Bioorg. Med. Chem., 13, 1293 (2005),<br></p>

<p>Applications 5-Amino-1-(1,1-dimethylethyl)-3-[(3-methylphenyl)methyl]-1H-pyrazole-4-carbonitrile is an derivative in the synthesis of small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by toxoplasma gondii.<br>References Lourido, S., et al.: J. Med. Chem., 56, 3068 (2013);<br></p>

<p>Applications Methyl 2-​((1R,​3R,​4''S,​5R,​5'S,​7R)​-​dispiro[adamantane-​2,​3'-​[1,​2,​4]​trioxolane-​5',​1''-​cyclohexan]​-​4''-​yl)​acetate is an intermediate for the synthesis of Arterolane p-Toluenesulfonic Acid (A614161), which is an antimalaria agent.<br>References Valecha, N., et al.: Clin Infect Dis. 55, 663 (2012); Patil, C. Y., et al.: Ann Med Health Sci Res. 4, 466 (2014)<br></p>

<p>Applications A substituted imidazolothiazole derivative as possible antiparasitic agents.<br>References Sarasin, J., et al.: Helv. Chim. Acta, 7, 713 (1924),<br></p>

<p>Applications (±)-2-(2,4-Dichlorophenyl)-2-hydroxyethylamine is an intermediate in the synthesis of Aminoazabenzimidazoles, a novel class of orally active antimalarial agent.<br>References Hameed, P., et al.: J. Med. Chem., 57, 5702 (2014);<br></p>

<p>Applications cis-Dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2''-tricyclo[3.3.1.13,7]decane]-4-acetic Acid is an intermediate for the synthesis of Arterolane p-Toluenesulfonic Acid (A614161), which is an antimalaria agent.<br>References Valecha, N., et al.: Clin Infect Dis. 55, 663 (2012); Patil, C. Y., et al.: Ann Med Health Sci Res. 4, 466 (2014)<br></p>

<p>Applications N-(2-Indol-3-ylethyl)-succinamic Acid Methyl Ester is an intermediate in the synthesis of Canthin-6-one (C175635), which is used as an anticancer agent compromising cancer cells showing multi-drug resistance. Also used in the synthesis of β-carbolinium compounds as antimalarial agents.<br>References Murakami, C. et al.: Bioorg. Med. Chem., 12, 4963 (2004); Takasu, K. et al.: Chem. Pharm. Bull., 53, 653 (2005);<br></p>