Propofol et Impuretés

Impurity Propofol EP Impurity E; Propofol USP Related Compound A
Applications Dipropofol (Propofol EP Impurity E) is a dimeric derivative of Propofol (P829750). Dipropofol is an antibacterial agent with strong activity againts Gram-positive bacteria. Dipropofol also displays antioxidant and radical scavenging activity. Propofol USP Related Compound A.
References Ogata, M. et al.: Chem. Pharm. Bull., 53, 344 (2005); Ogata, M. et al.: Biol. Pharmac. Bull., 30, 1565 (2007);

Impurity Propofol EP Impurity B
Applications 2-Isopropenyl-6-isopropylphenol (Propofol EP Impurity B) is an alkylphenol derivative with anesthetic activity.
References James, R. et al.: J. Med. Chem., 23, 1350 (1980);

Impurity Propofol EP Impurity J
Applications 2,6-Diisopropyl-1,4-benzoquinone (Propofol EP Impurity J) is a Propofol (P829750) impurity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References McMahon, R., et al.: J. Med. Chem., 22, 1100 (1979), Mamada, K., et al.: Drug Metab. Dispos., 14, 509 (1986),

Applications Propofol is an anesthetic used in veterinary medicine. Neuroprotective & Neuroresearch Products
References Glen, J.B., and Hunter, S.C.: Brit. J. Anaesth., 56, 617 (1984), Kohnen, S.L., et al.: Nitric Oxide, 8, 170 (2003)

Applications Labelled Propofol β-D-Glucuronide (P829780). Propofol β-D-Glucuronide is a metabolite of Propofol (P829750), an anesthetic used in veterinary medicine.
References Fujiwara, R., et al.: Drug Metab. Dispos., 35, 747 (2007), Soars, M., et al.: J. Pharmacol. Toxicol. Methods, 47, 161 (2002),

Impurity Propofol EP Impurity N
Applications Propofol 4-Carboxylic Acid (Propofol EP Impurity N) is a related compound of Propofol (P829750), as an antioxidant.
References Bahri, M., et al.: Biophys. Chem., 129, 82 (2007), Foti, M., et al.: J. Pharm. Pharmacol., 59, 1673 (2007), Gutierrez, M., et al.: Life Sci., 72, 2337 (2003),

Impurity Propofol EP Impurity O
Applications 2-Isopropyl-6-propylphenol (Propofol EP Impurity O).

Applications Propofol-d14 is the labeled analogue of Propofol (P829750), an anesthetic used in veterinary medicine.
References Glen, J.B., and Hunter, S.C.: Brit. J. Anaesth., 56, 617 (1984); Kohnen, S.L., et al.: Nitric Oxide, 8, 170 (2003)

Impurity Propofol EP Impurity F
Stability Light Sensitive
Applications 3-Isopropylphenol (Propofol EP Impurity F) is an impurity of Propofol (P829750).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bahri, M., et al.: Biophys. Chem., 129, 82 (2007), Foti, M., et al.: J. Pharm. Pharmacol., 59, 1673 (2007), Vasileiou, I., et al.: Eur. J. Pharmacol., 605, 1 (2009),

Impurity Propofol EP Impurity H
Applications 4-Isopropylphenol (Propofol EP Impurity H) is an impurity of Propofol (P829750).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bahri, M., et al.: Biophys. Chem., 129, 82 (2007), Foti, M., et al.: J. Pharm. Pharmacol., 59, 1673 (2007), Vasileiou, I., et al.: Eur. J. Pharmacol., 605, 1 (2009),

Impurity Propofol EP Impurity G; Propofol USP Related Compound C
Applications Propofol Isopropyl Ether (Propofol EP Impurity G; Propofol USP Related Compound C) is an isopropyl ether derivative of the anesthetic Propofol (P829750).

Applications Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate is an antioxidant that is used in polyethylene.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Blazquez-Blazquez, Enrique. et al., ACS Omega. 16, 9055-9063(2020);

Applications Labelled Propofol β-D-Glucuronide methyl ester (P829810). Propofol β-D-Glucuronide methyl ester is a precursor to metabolite Propofol β-D-Glucuronide (P829780).

Impurity Propofol EP Impurity L
Applications 2,2-Dimethyl-4-isopropyl-1,3-benzodioxole (Propofol EP Impurity L).

Applications 3,5-Di-tert-butyl-4-hydroxyphenylpropionic Acid acts as a new oxazole-pyrone antimicrobial agent. Inhibits electron transport in complex 1 of the respiratory chain. HIV-1 inihibitor.
References Kunze, B. et al.: J. Antibiot., 45, 1549 (1992); Yashuharu, I. et al.: Tetrahedron Lett., 37, 2997 (1996);

2-Isopropyl-6-propylphenol is a reactive alkylating agent that reacts with proteins and enzymes. It binds to the hydroxyl group of a protein target, which modifies the activity of the target molecule by introducing a new functional group. 2-Isopropyl-6-propylphenol has been shown to bind to the active site of several enzymes, including human serum albumin and cytochrome P450 reductase. The binding constants for these targets have been determined computationally using an algorithm based on quantum chemical calculations. These values are in good agreement with experimental data obtained from titration calorimetry experiments at different temperatures.

Applications A metabolite of Propofol.
References Davies, M., et al.: Biochem. J., 257, 603 (1989), Eriksson, O., et al.: Biochem. Pharmacol., 44, 391 (1992), Bryson, H., et al.: Drugs, 50, 513, (1995), Raoof, A., et al.: Eur. J. Clin. Pharmacol., 50, 91 (1996)

Impurity Propofol EP Impurity C
Applications 2-Isopropylphenol (Propofol EP Impurity C) is an impurity of Propofol (P829750).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bahri, M., et al.: Biophys. Chem., 129, 82 (2007), Foti, M., et al.: J. Pharm. Pharmacol., 59, 1673 (2007), Vasileiou, I., et al.: Eur. J. Pharmacol., 605, 1 (2009),