Hormones

<p>Stability Temperature Sensitive<br>Applications Anabolic steroid. Androgen.Controlled substance.<br>References Schanzer, W., et al.: Clin. Chem., 42, 1001 (1996), Kicman, A., et al.: Br. J. Pharmacol., 154, 502 (2008), Fragkaki, A., et al.: Steroids, 74, 172 (2009),<br></p>

<p>Applications Labelled Androgen. It has been used as an androgenic agent. Controlled substance (anabolic steroid).<br>References Bichet, N., et al.: Toxicol. Appl. Pharmacol., 106, 509 (1990), Gustafson, D., et al.: Toxicol. Sci., 53, 245 (2000), Copple, B., et al.: Toxicol. Sci., 77, 172 (2004), Takashima, K., et al.: Life Sci., 78, 2787 (2006),<br></p>

<p>Applications Androstenediol 3-Acetate is an intermediate in the synthesis of Pregnenolone (P712200) which is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens.<br>References Stastna, E., et al.: Steroids., 75, 721 (2010);<br></p>

<p>Applications (R,S)-Equol is a human urinary metabolite of the soy isoflavones Daidzein (D103500).<br>References Heinonen, S., et al.: Anal. Biochem., 274, 211 (1999), Setchell, K., et al.: J. Nutr., 132, 3577 (2002), Thigpen, J., et al.: Comp. Med., 53, 607 (2003), Yee, S., et al.: Food Chem. Toxicol., 46, 2713 (2008),<br></p>

<p>Applications Abiraterone Ethyl Ether is an impurity of Abiraterone (A108490), a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.<br>References Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389(2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005)<br></p>

<p>Applications epi Dienogest, is metabolite of Dienogest (D441870), a derivative of 19-Nortestosterone, that in combination with estrogencan acts as oral contraceptive.<br>References Hubner, M., et al.: Arzneim.-Forsch., 30, 401 (1980), Spona, J., et al.: Contraception, 56, 185 (1997), Foster, R.H., et al.: Drugs, 56, 825 (1998),<br></p>

<p>Human Hepcidin peptide hormone product also know as LEAP-1 (liver-expressed antimicrobial peptide), where the disulfides are formed by random oxidation. Hepcidin is a peptide hormone that is synthesized in the liver and is an important regulator of iron homeostasis. Through binding to ferroportin Hepcidin prevents the exportation of iron thus reducing the amount of circulating iron. Furthermore through inflammatory cytokine induction Hepcidin leads to the internalization and degradation of ferroportin thus further reducing the amount of iron in circulation. This in turn make conditions unfavourable to invading pathogens. This demonstrates Hepcidin's ability as an anti-microbial peptide. This antimicrobial behaviour can be used in research into the elimination of pathogens but also in combatting diseases where iron dysregulation is prevalant.</p>

Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR).

Expression System: E. coli<br>Length: 59-83, Full Length of Mature Protein<br>Activity: Not Tested

Expression system: E. coli<br>Length: 71-132, Partial<br>Activity: Not Tested

CGRP induces vasodilation.

Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile.

Adiponectin Protein, Feline, Recombinant is expressed in E.

Adiponectin Protein, Bovine, Recombinant (His) is expressed in yeast with N-6xHis tag.

Expression System: E. coli<br>Length: 24-51, Ghrelin<br>Activity: Not Tested

Expression System: E. coli<br>Length: 90-84, Hepcidin-25<br>Activity: Not Tested

Meteorin-like/METRNL Protein, Rat, Recombinant (His) is expressed in E.

Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of

Plays an important role in growth control.