Nucléotides

<p>5'-O-DMT-thymidine-3'-succinyl CPG 2000 Å is a synthetic nucleoside that contains an acetyl group at the 5' position. The succinyl group has been added to the 3' position of the nucleoside and is bonded to a carrier molecule (2000 Å). This product is used as an activator in DNA synthesis, it also has antiviral and anticancer activities.</p>

<p>Guanylyl-3',5'-guanosine ammonium salt is a novel antiviral agent that has high antiviral activity against influenza A virus. It is a guanine derivative which has been modified to include an aminopropyl group and an ammonium cation. This compound also acts as an activator for deoxyribonucleosides, nucleotides, and ribonucleosides. Guanylyl-3',5'-guanosine ammonium salt may be used in the manufacture of DNA, RNA, and phosphoramidites. This compound also has anticancer effects by inhibiting the proliferation of tumor cells and inducing apoptosis.</p>

<p>2',3',5'-Tri-O-acetyl-8-bromoguanosine is a synthetic nucleoside analog that inhibits the growth of tumor cells. It has been shown to inhibit the progression of prostate cancer and cervical cancer by binding to guanosine, preventing its conversion into ATP. This compound also prevents proliferation in hek293 and glioblastoma cells. The mechanism of action may be due to oxidative phosphite formation, which causes DNA damage and subsequent apoptosis.</p>

<p>Universal sulfonate donor for in vivo sulfonation by sulfotransferases</p>

<p>5′-O-DMT-LNA N-Bz 5-Me cytidine is a protected LNA cytidine nucleoside.</p>

<p>3'-Deoxycytidine-5'-triphosphate is a modified nucleoside that is the precursor for DNA synthesis. It is an activator of deoxyribonucleoside triphosphates, which are needed in the production of DNA. 3'-Deoxycytidine-5'-triphosphate has been shown to be active against cancer cells and antiviral agents. This chemical also inhibits viral RNA synthesis by blocking the conversion of ribonucleotides to deoxyribonucleotides. 3'-Deoxycytidine-5'-triphosphate is novel and high purity, with a CAS number 69383-05-7.</p>

<p>2-Chloroadenosine 5'-monophosphate triethylamine salt is a phosphoramidite that has anticancer and antiviral activities. It is synthesized by reacting 2-chloroadenosine with triethylamine. This product has a novel chemical structure and it can be used as an activator for the synthesis of modified DNA, RNA, and other nucleosides. It is also used in the manufacture of deoxyribonucleosides, ribonucleosides, and other nucleotides.</p>

<p>N6-Acetyl-2'-deoxyadenosine is an antiviral and anticancer nucleoside. It is a novel modified nucleoside that has been synthesized with a high degree of purity. N6-Acetyl-2'-deoxyadenosine is active against HIV, Hepatitis C, and other viruses, as well as cancer cells. It also inhibits the activity of bacterial DNA gyrase and topoisomerase IV, which are enzymes that maintain the integrity of bacterial DNA. N6-Acetyl-2'-deoxyadenosine has a phosphoramidite structure and is synthesized from 2'-deoxyribonucleosides.</p>

<p>Abacavir 5'-phosphate is a nucleoside analog that inhibits the replication of the herpes virus by covalently binding to the viral DNA polymerase and blocking its ability to polymerize dNTPs. Abacavir 5'-phosphate's anti-viral potency has been shown in vivo using a model with herpes simplex virus, and it has been shown to inhibit viral replication in cell culture. The drug also reacts with cellular components such as proteins, lipids, and nucleic acids, which may lead to drug reactions. Abacavir 5'-phosphate is chemically stable, so it can be subjected to analytical methods without degradation. It is an analog of zidovudine (AZT).</p>

<p>2'-O-Methyluridine-5'-monophosphate triethylammonium salt is a modified nucleoside analogue that is an antiviral agent. It inhibits viral replication by acting as an inhibitor of RNA synthesis and DNA polymerase, which are necessary for the virus to replicate. This compound also has anticancer activity and can be used as a chemotherapeutic agent. 2'-O-Methyluridine-5'-monophosphate triethylammonium salt is synthesized from uracil, phosphoramidite, and triethylamine. It has high purity and high quality with a CAS number of 67624-43-5.</p>

<p>10umol is approx 5mg.2'-O-(2-Methoxyethyl)guanosine 5'-monophosphate is a novel nucleoside phosphorylated on the 5' position</p>

<p>2'-Deoxyinosine-5'-triphosphate sodium is a nucleoside that is used as an antiviral, anticancer and novel drug. It inhibits viral replication by inhibiting DNA synthesis in the cell. 2'-Deoxyinosine-5'-triphosphate sodium binds to viral RNA polymerase, preventing the enzyme from creating new DNA strands. This prevents the virus from replicating and spreading to other cells in the body. 2'-Deoxyinosine-5'-triphosphate sodium has been shown to inhibit cancer growth by binding to DNA, which prevents it from dividing and creating new cells. This drug also has antiviral activity against HIV and Herpes Simplex Virus Type 1 (HSV1). 2'-Deoxyinosine-5'-triphosphate sodium is typically used as a buffer solution for peptide synthesis or as a chemical intermediate for various organic syntheses.</p>

<p>Please enquire for more information about 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4-nitro-1H-indole including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2',3'-Di-O-benzoyl-N6-benzoyl-L-adenosine (DBBA) is a modified nucleoside with anticancer, antiviral, and synthetic properties. It can be used as a building block for the synthesis of DNA, RNA, or other nucleotide analogues. DBBA has shown activity against certain cancer cells and has been found to inhibit the replication of HIV and herpes simplex virus type 1 in cell culture. DBBA is also known as 2',3'-Dibenzoyl-N6-benzoyladenosine.</p>

<p>2',3'-Dehydro-5'-O-tritylthymidine is an anticancer compound, which is a novel nucleoside phosphoramidite. It is synthesized from thymidine in two steps: first, the 2',3'-dideoxyribose phosphate moiety is prepared by reacting 2',3'-dideoxyribose with chloroacetic acid in the presence of triethylamine, followed by reaction with trityl chloride to form the 5' position of the thymidine. 2',3'-Dehydro-5'-O-tritylthymidine has been shown to inhibit DNA synthesis and antiviral activity.</p>

<p>2'-Deoxy-5-methyl-isocytidine is an analog of cytidine that is used in the synthesis of oligodeoxynucleotides. It has shown to be complementary to dsDNA and to inhibit hepatitis B virus replication in cell culture. 2'-Deoxy-5-methyl-isocytidine is synthesized by solid phase chemistry on a polystyrene support with monomers, depyrimidination, and purification by column chromatography. The chemical stability of this compound has been shown by its ability to withstand heating at 100°C for 10 minutes without decomposition.</p>

<p>7-Deaza-2'-deoxyguanosine-5'-triphosphate sodium salt is a cytosolic small molecule that inhibits the activity of telomerase, an enzyme involved in the replication of chromosomes. It also has inhibitory effects on kinase domains and may be used to treat cancer. 7-Deaza-2'-deoxyguanosine-5'-triphosphate sodium salt binds to human mitochondrial DNA and inhibits gene transcription by hybridizing with it. This results in the inhibition of dopamine production, which can be helpful for treating Parkinson's disease. 7-Deaza-2'-deoxyguanosine-5'-triphosphate sodium salt is structurally similar to 2'-deoxyadenosine 5'-triphosphate (dATP) and can be incorporated into DNA by phosphorylation to form a covalent bond that disrupts the dATP/ATP ratio. This causes cellular energy production to decrease and</p>

<p>Guanosine-2'(&amp;3')-monophosphate disodium salt (mixed isomers) is a synthetic nucleoside with antiviral and anticancer properties. It has been shown to activate the transcription of DNA in vitro by binding to the promoter region, resulting in higher levels of RNA synthesis. Guanosine-2'(&amp;3')-monophosphate disodium salt (mixed isomers) has been shown to inhibit the replication of viruses, such as herpes simplex virus type 1 (HSV-1), and it may have potential use in cancer therapy. The drug is also used as a precursor for other antiviral drugs and antibiotics. Guanosine-2'(&amp;3')-monophosphate disodium salt (mixed isomers) is available in high purity, high quality, and at low cost.</p>

<p>2'-Deoxy-5-fluorouridine-5'-triphosphate sodium salt - 100 mM solution in water is a nucleotide analog that inhibits the synthesis of RNA. It is used for the treatment of cancer. This agent binds to DNA and prevents the formation of RNA by inhibiting the enzyme ribonucleotide reductase. 2'-Deoxy-5-fluorouridine-5'-triphosphate sodium salt - 100 mM solution in water also has a perchloric acid component, which may be responsible for its haematopoietic effects.</p>

<p>Please enquire for more information about 2’-Deoxy-N2-DMF-2’-fluoroguanosine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>7-Deaza-2'-deoxy-7-ethynyladenosine is a fluorescent analog of adenosine that has been synthesized to be used as an antimicrobial agent. This compound has shown to be effective against both Gram-positive and Gram-negative bacteria, including methicillin resistant Staphylococcus aureus and Escherichia coli. 7DDAE is also able to inhibit the growth of fungus and yeast, such as Candida albicans. This drug has been shown to have no cytotoxic effects on mammalian cells at concentrations up to 50 μM. 7DDAE has been found to be very photostable in solution, which means it does not degrade when exposed to light.</p>

<p>Nucleobase functionalised deoxynucleoside</p>

<p>5-(Carboxyhydroxymethyl)uridine methyl ester is a modified form of uridine that is used in biochemical reactions. It is found in the ovary, where it interacts with acidic environments to produce the corresponding hydroxymethyl derivatives. The hydroxymethyl derivatives are then converted to the corresponding 5-carboxy-hydroxymethyl derivatives by conjugates and modifications, which can be analyzed using various assays. 5-(Carboxyhydroxymethyl)uridine methyl ester has also been shown to have epigenetic effects on cellular activity and cancer.</p>

<p>N2-DMF-5'-O-DMT-2'-O-methylguanosine is a novel nucleoside analog that has antiviral, anticancer and immunomodulating properties. It is synthesized from 2′,3′-dideoxyadenosine 5′-monophosphate by the condensation of 2,6-dimethylaniline with methylguanosine 5′-monophosphate and 5,6-dimethylaniline. The modification of the guanine base in N2-DMF-5'-O-DMT-2'-O-methylguanosine to an O6 -methyl group results in increased affinity for the ribonucleotide reductase enzyme (RNR) and inhibition of DNA synthesis.</p>

<p>2',3'-O-Isopropylideneadenosine is a nucleoside that has a possible usage as an organic chemical synthesis intermediate</p>

<p>5-Methylcytidine is a nucleoside that is found in DNA and RNA. It is used in structural biology to probe the structure of DNA. 5-Methylcytidine binds to the enzyme methyl transferase, which catalyzes the transfer of a methyl group from S-adenosylmethionine to produce 5-methyluridine. This reaction occurs in long-term toxicity studies using primary cells, such as lymphocytes and fibroblasts. 5-Methylcytidine has been shown to inhibit tumour growth in mice by binding to nuclear dna polymerase and blocking transcription. The binding site for this drug on the polymerase is located at the same site as that for nucleoside analogues like azidothymidine (AZT) and zidovudine (AZT).</p>

<p>5-Iodocytidine is a nucleoside analogue that has been shown to possess potent antitumor activity. It is also used as a fluorescent probe for detection of uridine in biological samples. 5-Iodocytidine is structurally similar to uridine, which allows it to be taken up by cells and incorporated into RNA. This analog can also be detected with antibody response, as well as with the use of a fluorescence microscope. 5-Iodocytidine may have the potential to treat infectious diseases and autoimmune diseases because it binds to response elements on DNA and activates gene transcription.</p>

<p>Polyinosinic acid-polycytidylic acid (Poly I:C), an agonist of TLR3 toll-like receptors, is a synthetic double-stranded RNA analog, consisting of polyinosinic acid (poly I) paired with polycytidylic acid (poly C), forming a stable duplex structure. PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations.  Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes. We can supply PolyI:C to all stages of your project - from R&amp;D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.<br>For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'</p>

<p>Polyinosinic acid is a single stranded RNA analog which is combined with polycytidylic acid (poly C) to form a stable duplex structure known as Polyinosinic acid-polycytidylic acid (Poly I:C). PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations.  Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes. We can supply PolyI:C to all stages of your project - from R&amp;D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.<br>For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'</p>