Nucléotides

<p>6-Thioguanosine is a purine analog that is used in the treatment of skin cancer and bowel disease. It has been shown to be an inhibitor of leukemia cells and also inhibits the growth of colon cancer cells. 6-Thioguanosine binds to the rate constant for uridine phosphorylation, which prevents the production of DNA. This drug also has an anti-inflammatory effect on bowel disease, which may be due to its ability to inhibit bcl-2 protein expression.<br>6-Thioguanosine is a fluorescent derivative that can be used as a substrate for x-ray diffraction data or as a biological sample in biological studies.</p>

<p>5,6-Dihydro-2'-deoxyuridine (dUrd) is a pyrimidine nucleoside that is an important component of DNA. It is phosphorylated by deoxyribonucleoside kinase to form dUrd monophosphate. This compound has been shown to inhibit the activity of catalase and other enzymes that hydrolyze hydrogen peroxide, indicating it may have antiviral properties. The enzyme activities of 5,6-dihydro-2'-deoxyuridine on simplex virus type 1 have been studied in vitro using lymphoblastoid cells. In these studies, the compounds was found to inhibit viral growth and terminate replication. 5,6-Dihydro-2'-deoxyuridine also inhibits the synthesis of DNA by inhibiting oxidative deamination reactions and termini formation in herpes simplex virus type 1. This drug has also been shown to inhibit amine oxidases in hep</p>

<p>2'-Deoxy-5-ethynylcytidine is a cytosine analog that inhibits the synthesis of viral DNA and the production of new virus particles. It has been shown to inhibit herpes simplex virus type-1 (HSV-1) in cell cultures, as well as other viruses such as vaccinia and adenovirus. 2'-Deoxy-5-ethynylcytidine has also been shown to have anti-cancer properties in animal studies. This drug binds to the cellular nucleic acid, preventing transcription of viral genes into messenger RNA and preventing protein synthesis, thereby inhibiting replication of the virus. 2'-Deoxy-5-ethynylcytidine also inhibits the synthesis of cellular DNA by binding to nuclear DNA.<br>2'-Deoxy-5-ethynylcytidine is an analog of cytosine that binds to dna polymerase and prevents it from adding on new nucleotides, which blocks viral reproduction.</p>

<p>2'-Deoxy-5-iodouridine (IDU) is a nucleoside that inhibits viral replication by inhibiting the synthesis of viral DNA. IDU has been shown to be a potent inhibitor of murine sarcoma virus and human immunodeficiency virus (HIV). IDU also has inhibitory properties on axonal growth, which may be due to its ability to inhibit DNA polymerase II. 2'-Deoxy-5-iodouridine is biocompatible, non-toxic, and can be used in high concentrations without any acute toxicities.</p>

<p>2'-Deoxy-8-oxo-adenosine is a nucleoside that is a hydrogen bond donor. It is an analogue of adenosine, and has been shown to inhibit the growth of breast cancer cells. 2'-Deoxy-8-oxo-adenosine reacts with the enzyme dATP pyrophosphohydrolase to form 8-oxo-2'-deoxyadenosine, which inhibits mitochondrial DNA synthesis by preventing the incorporation of inorganic phosphate into mitochondrial DNA. This process leads to reduced ATP production, leading to cell death. The reactive properties of 2'-Deoxy-8-oxo-adenosine make it suitable for use as a probe molecule in chemical biology, as well as in biochemical studies on human serum.</p>

<p>8-Thioguanosine is a purine derivative with reactive chlorine atoms. It has been shown to be a potent inhibitor of cellular targets, including monoclonal antibodies, growth factors, and transcription-polymerase chain reactions (PCR). 8-Thioguanosine binds to the antibody response by modulating the function of the B cells. This drug also has immunomodulatory effects that have been shown in animal models. 8-Thioguanosine is used as an immunosuppressant in patients undergoing bone marrow transplants and solid organ transplants.</p>

<p>2',3'-Dideoxy-3'-fluorouridine is a synthetic analog of uridine with chemical modifications that disrupt RNA and DNA synthesis. Because of this, it’s often studied or used as an antiviral or anticancer agent.</p>

<p>3'-O-Methyluridine is a nucleoside that is used in the preparation of oligonucleotides and as a substrate for uridine phosphorylase. It is used to study the termination of RNA synthesis, which occurs when there are no more ribose residues in the RNA template strand. When this happens, an adenosine residue is added by polyphosphate kinase to the 3' end of the RNA strand. This addition causes a release of pyrophosphate and leads to end of DNA synthesis. The acid hydrolysis technique can be used to separate 3'-O-methyluridine from other nucleotides. This reaction produces guanosine, which can be detected using polymerase chain reaction (PCR) techniques such as polyacrylamide gel electrophoresis (PAGE).</p>

<p>Ribavirin is a synthetic nucleoside analog that is used as an antiviral agent. Ribavirin 5'-monophosphate dilithium (RPM) is a high-quality, novel phosphoramidite monophosphate of ribavirin. It has antiviral activity against herpesviruses, adenoviruses, and poxviruses. The antiviral properties of RPM are due to its ability to inhibit viral RNA synthesis through inhibition of the viral enzyme ribonucleotide reductase. RPM is also active against DNA viruses such as human papilloma virus and Epstein-Barr virus.</p>

<p>3'-Deoxyadenosine is a nucleoside that is an inhibitor of adenylate cyclase. It has been shown to inhibit the growth of mouse tumor cells and induce apoptosis in HL-60 cells. 3'-Deoxyadenosine inhibits the production of pro-apoptotic protein, which may be due to its ability to activate toll-like receptor 4. 3'-Deoxyadenosine also has strong anti-inflammatory properties and can be used for the treatment of infectious diseases caused by bacteria, such as Mycobacterium tuberculosis or Streptococcus pyogenes. 3'-Deoxyadenosine binds to DNA polymerases and inhibits the replication of DNA by blocking the incorporation of deoxynucleotides into DNA. This compound has been shown to have thermodynamic data consistent with a stable secondary structure at high temperatures.br&gt;</p>

<p>2',3'-Dideoxy-3'-fluoro-a-uridine is a synthetic nucleoside analog. This compound is a modified version of uridine. The 2' and 3' hydroxyl groups on the sugar molecule are replaced with hydrogen atoms, and a fluorine atom replaces the hydrogen at the 3' position. This molecule has potential antiviral acitivty and can be used in research applications.</p>

<p>D3-Thymidine is a substance that is formed from the monosaccharide galactose and has been used in biochemical studies. D3-Thymidine has been used as a marker for the damaged DNA of viruses, such as herpes simplex virus type 1, and for the DNA of tumor cells. It has also been used to study the effects of protonation on its function. D3-Thymidine is an unlabeled thymidine derivative that was studied using dichroism spectroscopy. This technique showed that this molecule can exist either in a single form or in two forms with different shapes, depending on its microenvironment.<br>D 3 -thymidine was first synthesized by Dr. Gertrude Buechner at the University of Wisconsin–Madison in 1957. In her experiments, she found that this molecule could be produced by hydrolyzing 2-deoxy-D-ribose with 3 molar equivalents of ammon</p>

<p>2',3',5'-Tri-O-benzoyluridine is a protected form of the nucleoside uridine. Uridine is a pyrimidine nucleoside consisting of uracil as the nitrogenous base and a ribose sugar linked via a β-N-glycosidic bond at the 1′ position. The hydroxyl groups on the ribose (at positions 2′, 3′, and 5′) are protected with benzoyl groups (–O–CO–C₆H₅).</p>

<p>3-Deazauridine is a uridine analog that inhibits the synthesis of DNA, RNA, and protein. It has been shown to inhibit the activity of 3-deazauridine synthetase in HL-60 cells. 3-Deazauridine also has significant cytotoxicity against colorectal adenocarcinoma cells and synergistic effects when used with other chemotherapeutic agents. The mechanism of action of 3-deazauridine is similar to that of other enzyme inhibitors, such as glycosidic bond formation or competitive inhibition. The sample preparation for this drug is complicated by its insolubility in water.</p>

<p>7-Deaza-2',3'-dideoxy-7-iodoguanosine is a nucleoside analog that inhibits the synthesis of DNA by inhibiting the activity of DNA polymerase. It is used to treat HIV and other viral infections. The compound is also active against cancer cells and has been shown to inhibit the growth of leukemia cells. 7-Deaza-2',3'-dideoxy-7-iodoguanosine is modified with an iodine atom at the 7 position and has a novel structure. This compound is used in biological research as a substrate for the preparation of phosphate esters such as phosphoramidites for use in oligonucleotide synthesis.</p>

<p>5'-O-Trityl-2,3'-anhydrothymidine is a nucleoside analogue that inhibits HIV reverse transcriptase by binding to the enzyme and preventing RNA chain elongation. The compound is a potent inhibitor of HIV in cell cultures and has been shown to be active against a variety of HIV isolates. 5'-O-Trityl-2,3'-anhydrothymidine has also shown antiviral activity against other RNA viruses such as SARS coronavirus and influenza virus.</p>

<p>3'-Amino-3'-deoxy-5'-O-DMT-thymidine is a specifically designed building block for introducing a 3'-amino group into oligonucleotides, primarily at the 3' terminus. The DMT protecting group facilitates incorporation during standard solid-phase synthesis, and the 3'-amino group provides a versatile handle for post-synthetic modifications and conjugations.</p>

<p>Metabolite of 8-Chloroadenosine</p>

<p>2'-Deoxy-5'-O-DMT-uridine is a bifunctional drug that has both antibacterial and anticancer activity. This drug is used to treat leishmania infections, which are caused by protozoan parasites. 2'-Deoxy-5'-O-DMT-uridine suppresses the growth of these organisms by inhibiting RNA synthesis and protein synthesis. It also inhibits proliferation of cancer cells in vivo by targeting cancer cells with high levels of primary amines. 2'-Deoxy-5'-O-DMT-uridine is an effective chemotherapeutic agent that can be used to treat pancreatic cancers with high rates of primary amines (e.g., insulinoma).</p>

<p>2'-Deoxy-2',2'-difluoro-a-uridine is a nucleoside analog with modifications on the 2'-carbon of the ribose sugar and the pyrimidine base uracil. This compound is a synthetic derivative of uridine with two fluorine atoms attached to the 2' carbon of the sugar. The α-stereochemistry of the sugar indicates a specific configuration that influences how the molecule behaves in biological systems, including its interaction with enzymes and incorporation into nucleic acids.</p>

<p>6-Thioguanosine-5'-O-triphosphate sodium salt is a nucleotide analog that inhibits the synthesis of RNA, DNA and protein. It binds to the guanine nucleotide-binding site on the enzyme RNA polymerase and blocks transcription. This leads to a decreased amount of mRNA, thereby slowing or stopping protein production. 6TGTP also has been shown to be effective in treating cancer as it inhibits enzymes involved in cellular metabolism and induces cell death. 6TGTP has been shown to have no effect on mammalian cells when incubated with 10 mM magnesium ion.</p>

<p>Universal sulfonate donor for in vivo sulfonation by sulfotransferases</p>

<p>2'-Deoxy-5'-O-DMT-2'-fluorocytidine is a novel nucleoside analog. It acts as an activator of the enzyme ribonucleotide reductase, which is essential for DNA synthesis and repair. 2'-Deoxy-5'-O-DMT-2'-fluorocytidine has antiviral activity against herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2). This compound also inhibits the growth of various tumor cell lines in culture, including human leukemia cells. In addition, 2'-Deoxy-5'-O-DMT-2'-fluorocytidine has been shown to have antiinflammatory effects in animal studies.</p>

<p>5’-O-DMT-thymidine is also known as 5’-O-(4,4’-dimethoxytrityl)thymidine. It is a key deoxynucleoside building block that is protected with a dimethoxytrityl group in the 5-O-position of the deoxy-ribose moiety, leaving the 3-hydroxyl free for modification. It is used a convenient starting point for nucleotide synthesis. 5’-O-DMT-thymidine can be converted into 3’-O-phosphoramidite derivatives for oligonucleotide synthesis. Additionally, 5’-O-DMT-thymidine can be converted into more stable 1-N-protected derivatives.</p>

<p>2-Chloroinosine is a synthetic nucleoside analog derived from inosine, in which a chlorine atom is substituted at the 2-position of the purine base (hypoxanthine). This modifcation causes altered reactivity and can be used in research applications</p>

<p>2-Thiothymidine is a hydrogen bond donor and acceptor that can be used as a substitute for thymine in the synthesis of DNA. 2-Thiothymidine has been shown to have successful in vivo treatment against bladder cancer and skin cells, as well as photochemical properties. It has been shown to inhibit the growth of prostate cancer cells by inhibiting DNA synthesis. 2-Thiothymidine binds to dna duplexes and polymerase chain reactions, which are important for replication of DNA. This drug also inhibits replication by preventing intramolecular hydrogen bonds from forming.<br>2-Thiothymidine is a nucleoside analog that is substituted for thymine during DNA synthesis. It inhibits the growth of prostate cancer cells by inhibiting DNA synthesis. It binds to dna duplexes and polymerase chain reactions, which are important for replication of DNA. This drug also inhibits replication by preventing intramolecular hydrogen bonds from forming.</p>

<p>5-Ethynyluridine (5-EU) is an uracil analogue functionalized with a terminal alkyne group used for nucleotide, and especially RNA, labelling. 5-EU is cell permeable and is incorporated into RNA during its biosynthesis. The terminal alkyne group in 5-EU can react with azide-functionalised fluorophores or biotine, to form a labelled adduct with a triazole linker.</p>

<p>7-Deaza-2’-C-methylinosine is an antiviral agent that inhibits the replication of DNA or RNA. It is a nucleoside analog that can be phosphorylated to form a diphosphate or monophosphate. 7-Deaza-2’-C-methylinosine has been shown to have anticancer effects in vitro and in vivo, as well as inhibit the proliferation of cancer cells. This agent also has novel properties due to the presence of the methyl group at position 2’ on the deoxyribose ring.</p>

<p>N6-methyladenosine (m6A) is a modified form of adenosine that contains a methyl group at the N6 position and has a high importance in epigenetics. Among other nucleoside modifications found in mRNA, N6-methyladenosine is the most common and abundant in eukaryotes, and is related to some cancers and viral infections (Huafei, 2020). Moreover, N6-methyladenoside has been reported to regulate RNA abundance in the SARS-CoV-2 infection (Zhang, 2021)</p>

<p>Anti-HCV agent; inhibitor of viral RNA polymerases</p>

<p>Thymidine-5'-O-(1-thiotriphosphate) lithium salt is a novel nucleoside analogue that has antiviral and anticancer properties. It can also be used as a building block for the synthesis of other nucleosides. Thymidine-5'-O-(1-thiotriphosphate) lithium salt is synthesized by reacting thymidine with lithium diisopropylamide (LDA). This nucleoside analogue has been shown to inhibit the growth of certain types of cancer cells in vitro, which may be due to its ability to inhibit DNA synthesis and induce apoptosis.</p>

<p>p-Topolin riboside is a potent antibacterial agent that binds to the receptor binding site of wild-type mice. This hydrogen bond inhibits the activity of cellular p-topolin riboside, which is required for the synthesis of carotenoids and nitro compounds in mitochondria. p-Topolin riboside has been shown to have anti-aging properties and can inhibit locomotor activity in vivo. It has also been shown to have potent antibacterial effects against bacteria such as MRSA, Pseudomonas aeruginosa, and Enterococcus faecalis.</p>

<p>2'-O-Propargyluridine is a modified nucleoside that is used in anticancer and antiviral drug synthesis. It is also used as an activator for phosphoramidites. 2'-O-Propargyluridine has been shown to have antiviral activity against herpes simplex virus type 1. This compound has also been shown to be active against cancer cells, with the ability to inhibit tumor growth in vitro and in vivo. 2'-O-Propargyluridine has a novel chemical structure and is not found in nature, which makes it difficult for the body's immune system to recognize and attack it.</p>

<p>5-Chlorocytidine is a reactive oxygen species that can be generated by the hypochlorous acid (HOCl) or by atp, which is a nucleotide. 5-Chlorocytidine has been shown to induce apoptosis in virus-infected mammalian cells and macrophage-like cells. It also induces pro-inflammatory cytokines and has potential as a biomarker for leukemia and inflammatory diseases. 5-Chlorocytidine reacts with proteins and lipids in the atherosclerotic lesion to produce other reactive oxygen species, such as hydrogen peroxide, which may lead to cell death.</p>

<p>Anti-viral; reverse transcriptase inhibitor</p>

<p>5-Methyl-2-thiouridine is a nucleotide that is found in the type strain of Escherichia coli. It has been shown to be an effective inhibitor of protein synthesis, with optimum concentration at 0.1 mM. 5-Methyl-2-thiouridine binds to the ribosome and inhibits its activity. 5-Methyl-2-thiouridine also interacts with human mitochondrial RNA and alters its structure, leading to an antibody response that protects against infection by the bacteria in question. This nucleotide has also been shown to inhibit bacterial growth in wastewater treatment plants. The chemical structures of 5-methyluridine are similar to those of uridine except for a methyl group on the second carbon atom (5 position). The presence of this methyl group confers increased water permeability and decreased kinetic energy on the molecule, which can be detected using nuclear magnetic resonance spectroscopy.</p>

<p>5-Methyl-2′-O-[2-(methylamino)-2-oxoethyl]-cytidine is a nucleoside that is synthesized by phosphoramidite chemistry. It is a novel chemical compound with antiviral, anticancer, and deoxyribonucleoside properties. This nucleoside is modified in the 5′ position with a methyl group and has been shown to have cytotoxic effects on cancer cells.</p>

<p>2',3',5'-Tri-O-acetylguanosine is a protected form of the nucleoside guanosine which has potential application as a synthetic intermediate in nucleic acid and nucleoside chemistry.</p>

<p>N2-Isobutyryl-9-(b-D-arabinofuranosyl)guanine is a monophosphate analog of guanine. It is a novel antiviral agent that inhibits the DNA polymerase and RNA polymerase activities of human immunodeficiency virus (HIV). The drug has a high purity and is available in large quantities.</p>

<p>9-(B-D-Ribofuranosyl)isoguanine is a purine analogue that is an anti-cancer drug. It has low potency and its biological properties are unknown. It has been shown to be an inhibitor of the polymerase chain reaction in vitro, but it is unclear if this activity will translate to in vivo models. 9-(B-D-Ribofuranosyl)isoguanine is structurally similar to pyrazole, which also inhibits the polymerase chain reaction in vitro. A recent study found that 9-(B-D-Ribofuranosyl)isoguanine may act as a toll-like receptor agonist and suppress lipopolysaccharide (LPS)-induced inflammation in mice, which suggests that this drug may have anti-inflammatory properties.</p>

<p>5'-Carboxy-2',3'-O-isopropylideneadenosine is a novel deoxyribonucleoside. It has high purity and high quality, good stability, and a low price. This product can be used as the raw material for synthesis of DNA, RNA, and phosphoramidites. It is an anticancer drug and antiviral agent that can be used to synthesize new drugs. It also has strong anti-inflammatory properties.</p>

<p>Pseudouridine-5'-triphosphate trisodium salt (PUR) is a nucleoside analogue that inhibits the synthesis of RNA. PUR is also a potent inhibitor of DNA synthesis and can be used to inhibit angiogenesis. PUR has been shown to have an effect on vascular endothelial cells, platelets, and cancer cells in vitro. This drug targets the vessels and other target cells such as those found in cardiovascular diseases, ovary, and cancer. PUR has been shown to be effective in vivo studies using mice models for the treatment of osteogenic sarcoma.</p>

<p>Pseudouridine monophosphate disodium is an intermediate in the synthesis of uridylate, a nucleotide that is important for RNA and DNA synthesis. It is synthesized by the enzyme synthetase, which uses ATP as a phosphate donor. The enzyme has been found in rat liver microsomes and cell nuclei. Pseudouridine 5'-monophosphate disodium has an activity index of 2-3 and can be used to prepare samples for analysis by spectroscopy or chromatography. In addition, it has been shown to have biological properties such as anti-inflammatory activities and disease activity against inflammatory bowel diseases (IBD).</p>

<p>Please enquire for more information about 2-Deoxycytidine 3',5'-diphosphate sodium salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N1,O2'-Dimethyladenosine is a monophosphate that is an antiviral agent. It has been shown to be a potent activator of the tRNA synthetase enzyme and also inhibits viral DNA synthesis. This drug is synthesized from diphosphate and phosphoramidites. N1,O2'-Dimethyladenosine has been shown to be highly active against viruses such as HIV-1, HIV-2, and HCV. It is also used in the production of modified nucleosides for use in synthetic constructs with therapeutic applications.</p>

<p>Adenosine analog</p>

<p>N3-Methyluridine is a monosodium salt of N3-methyluridine, which is an analogue of uridine. It is a nucleoside that is used as a precursor for RNA synthesis. In the body, N3-methyluridine is converted to uridine and then phosphorylated to form UMP. The phosphate group on UMP can be hydrolyzed by the enzyme kinase in order to produce ATP. N3-Methyluridine has been shown to be a potential biomarker for metabolic disorders and drug interactions with drugs such as loperamide, which inhibit mitochondrial function by inhibiting the enzyme p2y receptors.</p>

<p>1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine HCl is a nucleoside analog for research applications. It contains a β-D-arabinofuranose sugar and a fluorine (F) at the 2'-position increases resistance to enzymatic degradation and alters its biological activity. The presence of the cytosine nucleobase allows it to mimic natural cytidine and be incorporated into DNA and the HCl salt form improves solubility and stability.</p>

<p>Cytidine 5'-diphosphate ethanolamine disodium salt (CDP-ethanolamine) is a nucleotide that is synthesized in the cytosol. It is a precursor for the synthesis of phosphatidylethanolamines, which are important components of cell membranes. CDP-ethanolamine has been shown to be an inhibitor of enzymes, such as diacylglycerol acyltransferase and acetyl-CoA carboxylase. This inhibition leads to lower cellular levels of diacylglycerols and fatty acids, which may be beneficial for metabolic disorders such as hepatic steatosis and bowel disease.</p>

<p>5-Methyl-2′-O-[2-(methylamino)-2-oxoethyl]uridine (5MeUrd) is a diphosphate nucleoside that has been modified with a methyl group on the 2′ position. It is a novel, high quality, synthetic nucleoside with antiviral and anticancer properties. 5MeUrd is structurally similar to uridine and cytidine, which are deoxyribonucleosides. The phosphoramidite of 5MeUrd can be used for the synthesis of DNA, RNA, or monophosphate nucleosides in vitro. 5MeUrd has been shown to inhibit human leukemia cells and cancer cell lines in vitro by inhibiting DNA synthesis.</p>