Nucléosides

<p>2'-Deoxyadenosine-5'-triphosphate or dATP, is a nucleotide used by cells to synthesize DNA molecules. 2'-Deoxyadenosine-5'-triphosphate is used in molecular biology techniques and assays as a substrate of the enzyme DNA polymerase, e.g. polymerase chain reaction (PCR), DNA sequencing, pyrosequencing reactions. Salt form of 2'-deoxyadenosine-5'-triphosphate has been used in a newly developed detection system for SARS-CoV-2 that combines bioluminescence in real-time (BART) with reverse-transcriptase loop-mediated amplification (RT-LAMP).</p>

<p>2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphate sodium, 100 mM aqueous solution is a synthetic nucleoside that can be used as an antiviral and anticancer agent. The drug inhibits viral replication by inhibiting the synthesis of DNA. The drug also suppresses tumor growth by inhibiting the production of RNA and DNA in cancer cells.</p>

<p>N6-Benzoyl-2’-chloro-2’-deoxyadenosine is a synthetic nucleoside that has antiviral properties. It is used to treat viral diseases, such as herpes and hepatitis B. N6-Benzoyl-2’-chloro-2’-deoxyadenosine can be used in the synthesis of DNA or RNA, and it is also used as an activator for other phosphoramidites. This product has been shown to have high purity and quality.</p>

<p>2'-Deoxy-5-methylcytidine-5'-monophosphate disodium (2D5MCP) is a nucleoside analog that inhibits the synthesis of DNA. It is used in the treatment of cervical cancer and other cancers that are dependent on DNA synthesis. 2D5MCP works by binding to and inhibiting the activity of an enzyme called DNA polymerase, which is needed for DNA replication. This drug also has been shown to inhibit fatty acid synthase enzymes and surface glycoprotein enzymes, which may be responsible for its anti-cancer effects. 2D5MCP has been shown to have an effective dose range between 50 and 150 mg/kg, with no significant side effects seen at doses up to 300 mg/kg. 2D5MCP does not bind to plasma proteins or erythrocytes, so it can be administered intravenously without risk of tissue damage caused by osmotic lysis.</p>

<p>5-Acetoxymethyl-2'-deoxyuridine (5-AOMUdR) is a nucleoside analog that inhibits the synthesis of DNA. It is phosphorylated to 5-acetoxymethyl uridine monophosphate, which inhibits DNA polymerase by competitive inhibition. This compound has been shown to induce apoptosis in vitro and inhibit HIV replication in cells. 5-AOMUdR has also been shown to be an effective anti-viral agent against influenza A virus.</p>

<p>2',3'-Dideoxy-3'-fluoro-a-uridine is a synthetic nucleoside analog. This compound is a modified version of uridine. The 2' and 3' hydroxyl groups on the sugar molecule are replaced with hydrogen atoms, and a fluorine atom replaces the hydrogen at the 3' position. This molecule has potential antiviral acitivty and can be used in research applications.</p>

<p>1-(5'-O-Benzoyl-2'-deoxy-2'-fluoro-β-L-arabinofuranosyl)thymine is a modified nucleoside analog with structural modifications that enhance its biological properties, stability, and pharmaceutical potential. The compound features thymine (5-methyluracil) as the nucleobase, a pyrimidine derivative. The sugar component is 2'-deoxy-2'-fluoro-β-L-arabinofuranose, which includes the L-arabinose configuration, a departure from the natural D-ribose or D-deoxyribose configuration typically found in DNA and RNA, influencing how the molecule is recognized by biological systems. The 2'-fluoro substitution at the sugar position improves the compound's stability and resistance to enzymatic degradation, while also potentially enhancing its antiviral activity. A 5'-O-benzoyl group serves as a protecting group, safeguarding the 5'-hydroxyl group during synthesis.</p>

<p>2'-Deoxy-2'-fluorouridine-5'-triphosphate tetralithium (2'DFUR) is a fatty acid that is resistant to many antibacterial agents. 2'DFUR inhibits the biosynthesis of bacterial cell walls, leading to cell death. This drug has been shown to have potent antibacterial activity against Staphylococcus strains and other bacteria. The mechanism of action is not yet fully understood, but it may involve inhibition of nucleotidyltransferase and aminopropyl transferase enzymes.</p>

<p>2'-Deoxy-8-oxo-6-thioguanosine 5'-triphosphate is a synthetic nucleotide that has antiviral properties. It activates the transcription of genes by preventing the synthesis of viral DNA and RNA. 2'-Deoxy-8-oxo-6-thioguanosine 5'-triphosphate is also an anticancer agent, as it prevents cell proliferation by inhibiting the synthesis of DNA, RNA, and protein. This drug can be used for treatment of HIV infection or cancer. 2'-Deoxy-8-oxo-6-thioguanosine 5'-triphosphate is a novel nucleotide with high purity.</p>

<p>D3-Thymidine is a substance that is formed from the monosaccharide galactose and has been used in biochemical studies. D3-Thymidine has been used as a marker for the damaged DNA of viruses, such as herpes simplex virus type 1, and for the DNA of tumor cells. It has also been used to study the effects of protonation on its function. D3-Thymidine is an unlabeled thymidine derivative that was studied using dichroism spectroscopy. This technique showed that this molecule can exist either in a single form or in two forms with different shapes, depending on its microenvironment.<br>D 3 -thymidine was first synthesized by Dr. Gertrude Buechner at the University of Wisconsin–Madison in 1957. In her experiments, she found that this molecule could be produced by hydrolyzing 2-deoxy-D-ribose with 3 molar equivalents of ammon</p>

<p>terminates RNA strand synthesis catalyzed by RNA polymerase.</p>

<p>Sapacitabine is an oral prodrug that is converted to its active form, the cytotoxic agent 9-β-D-arabinofuranosyladenine (araA), by cellular enzymes. It has potent antitumor activity against solid tumours and has been shown to be effective in a variety of human cancer cell lines. Sapacitabine targets intracellular targets, including DNA methyltransferases and other enzymes involved in the synthesis of RNA and DNA. The drug has been shown to have synergistic effects when used with other cytotoxic agents such as 5-fluorouracil and gemcitabine, which are also inhibitors of DNA methyltransferase.</p>

<p>6-Amino-9-(1-deoxy-β-D-psicofuranosyl)purine (6APdP) is a nucleoside with potential chemotherapeutic activity. It has been shown to suppress the expression of genes that encode proteins involved in cell proliferation and differentiation, including suppressor genes. 6APdP is activated by methyladenosine monophosphate kinase and binds to the ribose hydroxyl group on RNA molecules. This molecule has been shown to inhibit hepatitis B virus replication and cancer cell growth in animal models. The hydrogen bonding interactions between 6APdP and the ribose hydroxyl group are stronger than those associated with ethylene diamine tetraacetic acid (EDTA). 6APdP is also an inhibitor of protein synthesis.</p>

<p>2’-C-Methylisocytidine is a novel antiviral drug that is a deoxyribonucleoside. It is synthesized by the reaction of cytidine with 2’-chloroethylisocyanate to form a methylated derivative, which is converted to 2’-C-methylisocytidine via phosphorylation. This nucleoside has been shown to have anticancer properties and may be used as an activator for the synthesis of DNA or RNA.</p>

<p>2'-O-(2-Methoxyethyl)adenosine is a nucleoside derivative that is produced by the methylation of 2'-deoxyadenosine. It is used in organic synthesis as a reagent for the alkylation of aromatic hydrocarbons and as an intermediate in the synthesis of purines. The product can be isolated with yields of 78% or greater, depending on reaction conditions and purification methods. Isomeric purity can be achieved with high purity (&gt;99%) by recrystallization from water or ethanol. The compound has a number of physical properties that are similar to those of adenosine, including boiling point, melting point, density, and refractive index. The molecule also has two chiral centers at C2 and C4 that contribute to its isomeric nature. Adenosine is found in human connective tissue cells, where it plays a role in cell metabolism by regulating the production of RNA and DNA.</p>

<p>2',3'-Dideoxyuridine-5'-triphosphate can be used with uracil DNA glycosylase to minimize PCR carryover contamination and enables the kinetics of deoxyuridine 5′-triphosphate nucleotidohydrolases to be investiagated.</p>

<p>5'-O-Benzoyl-2,3'-anhydrothymidine is a heterocycle that has been shown to have immunosuppressive properties. The compound binds to the immunodeficiency virus by covalent binding to an isomeric site on the viral envelope protein. It has been shown that 5'-O-Benzoyl-2,3'-anhydrothymidine can inhibit the growth of HIV in vitro with a 50% inhibitory concentration (IC50) of 0.8 μM. This compound also displays potent antiviral activity against herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2).</p>

<p>dATP, dTTP, dCTP and dGTP pre-mixed in a single vial</p>

<p>7-(N-Acetylaminomethyl)-7-deazaguanosine is a nucleoside analog that is used to treat diseases such as hepatitis B and C. It is an antiviral, anticancer, and antibacterial agent. 7-(N-Acetylaminomethyl)-7-deazaguanosine inhibits viral replication by blocking the synthesis of DNA or RNA. The drug also inhibits cell growth through activation of apoptosis, which may be due to its ability to inhibit protein synthesis and DNA replication. This novel nucleoside analog has shown high purity levels in our lab and can be used for the treatment of various diseases.</p>

<p>2',3'-Di-O-acetyl-5'-deoxy-5-nitro-N4-(pentyloxycarbonyl)cytidine is a nucleoside for use in research applications</p>

<p>2'-Amino-2'-deoxyuridine is a modified nucleoside based on uridine. The 2'-hydroxyl group on the sugar is replaced by an amino group. This compound can be used for research purposes</p>

<p>5'-Deoxy-5'-iodothymidine is an antiviral nucleoside that inhibits viral replication by competing with the natural substrate, deoxyribonucleotide triphosphate, for incorporation in DNA. 5'-Deoxy-5'-iodothymidine has been shown to be a novel antiviral agent and an activator of host immune responses against virus infections. 5'-Deoxy-5'-iodothymidine is also used as an intermediate for the synthesis of phosphoramidites, which are used in the production of DNA.</p>

<p>Thymidine-5'-diphosphate-b-L-fucose is a ketone that can be used to catalyze the hydroxylation of an organic compound. It has been shown to modulate the activity of hydroxy group, orbital, and dehydrogenation in ketones. Thymidine-5'-diphosphate-b-L-fucose can be used to investigate radical elimination and hypothesized mechanisms of action. This ketone competes with amino groups for binding to the enzyme s-adenosylmethionine and hyperconjugation.</p>

<p>2',5'-Dideoxycytidine is a nucleoside for use in a variety of applications</p>

<p>N6-Benzoyl-2'-deoxy-5'-O-DMT-a-adenosine 3'-CE phosphoramidite is a monophosphate nucleotide that is used as an activator in the synthesis of DNA. N6-Benzoyl-2'-deoxy-5'-O-DMT-a-adenosine 3'-CE phosphoramidite has been shown to have anticancer properties, and it also inhibits the replication of human immunodeficiency virus (HIV). N6-Benzoyl-2'-deoxy-5'-O-DMT-a adenosine 3'-CE phosphoramidite binds to the enzyme DNA polymerase and prevents the formation of a covalent bond with the deoxyribonucleoside triphosphate, thereby inhibiting DNA synthesis.</p>

<p>5'-Deoxyadenosine is a nucleoside that is produced by the enzymatic reaction of glycolaldehyde and ATP. It is found in both DNA and RNA, where it plays an important role in the catalytic subunit of ribonucleotide reductase. 5'-Deoxyadenosine has been shown to be involved in hydrogen bonding with other molecules, such as ethanolamine. It also has a kinetic effect on the enzyme activity of ribonucleotide reductase by forming intramolecular hydrogen bonds with other adenine nucleotides. The analogs of 5'-deoxyadenosine have been shown to inhibit viral replication in cell culture studies using typhimurium virus.</p>

<p>5-(Azidomethyl)uridine (5-AZA-U) is a cytosolic nucleoside analog that inhibits the replication of herpes simplex virus type 1 (HSV-1). It is resistant to degradation by cellular nucleases and is fluorescent, making it a clickable substrate for microscopy. 5-AZA-U has been shown to inhibit the transcription of viral DNA and the synthesis of viral proteins in mammalian cells. This drug has also been shown to be effective against cancer and hepatitis B virus (HBV). 5-AZA-U can be used as an antiviral agent because of its ability to inhibit the posttranscriptional gene expression of HSV-1. 5-(Azidomethyl)uridine is also an analog of uridine, which can be used to study intracellular signaling pathways that regulate proliferation, differentiation, or apoptosis in mammalian cells.</p>

<p>2'-O-Propargylguanosine is a monophosphate nucleoside that is synthesized from Ribonucleosides. It has been shown to have antiviral and anticancer properties. 2'-O-Propargylguanosine has shown to be an activator of the transcription factor NF-κB and to induce apoptosis in various cancer cell lines. This drug inhibits viral replication by inhibiting DNA polymerase, thereby preventing RNA synthesis.</p>

<p>5'-Azido-5'-deoxy-5-methyluridine is a nucleoside analog that can be used as an antiviral and anticancer agent. It is chemically modified to be phosphorylated by in vitro enzymes, which makes it more potent and selective than other nucleosides. The 5'-azido group on the sugar moiety of 5'-azido-5'-deoxy-5-methyluridine reacts with the hydroxyl group of the ribonucleoside triphosphate, forming a covalent bond. This reaction prevents the enzyme from releasing the sugar moiety, which blocks RNA synthesis. The lack of RNA synthesis prevents protein production, which leads to cell death.</p>

<p>5'-O-Levulinoylthymidine is a novel nucleoside analog that inhibits viral proliferation by inhibiting viral RNA polymerase. This drug is also an activator of ribonucleotide reductases, which are enzymes that synthesize deoxyribonucleotides from ribonucleotides. 5'-O-Levulinoylthymidine has been shown to inhibit the growth of cancer cells in vitro and in vivo. It has also been shown to be effective against HIV-1 infection in vitro.</p>

<p>7-Deaza-2',3'-dideoxy-7-iodoguanosine is a nucleoside analog that inhibits the synthesis of DNA by inhibiting the activity of DNA polymerase. It is used to treat HIV and other viral infections. The compound is also active against cancer cells and has been shown to inhibit the growth of leukemia cells. 7-Deaza-2',3'-dideoxy-7-iodoguanosine is modified with an iodine atom at the 7 position and has a novel structure. This compound is used in biological research as a substrate for the preparation of phosphate esters such as phosphoramidites for use in oligonucleotide synthesis.</p>

<p>Guanosine 5'-monophosphate, also known as GMP, is a ribonucleoside monophosphate that becomes incorporated into RNAs when phosphorylated to GTP.</p>

<p>5-Iodo-2'-O-methyluridine is a novel antiviral drug that inhibits replication of DNA and RNA viruses. It is chemically synthesized from 2' deoxyuridine monophosphate, which is modified to create the 5-iodo derivative. The modification at the 5th position of the uracil ring prevents the incorporation of methylation into DNA and RNA, which can lead to cancerous growths. This compound has been shown to be an excellent activator for DNA synthesis in vitro. It has also been shown to have anticancer properties in vitro and in vivo.</p>

<p>Cytidyl-3'-5'-uridine ammonium salt is a nucleoside analog that is used as an antiviral and anticancer agent. Cytidyl-3'-5'-uridine ammonium salt inhibits the synthesis of DNA by inhibiting the activity of enzymes such as DNA polymerase, RNA polymerase, or reverse transcriptase. It also has antitumor properties and can be used to treat leukemia and other types of cancer. Cytidyl-3'-5'-uridine ammonium salt has been shown to be more potent than cytidyl-2',4',6'-triaminopyrimidine (CTAP) in inhibiting the growth of lymphocytic leukemia cells.</p>

<p>3',5'-Bis-O-(triphenylmethyl)uridine is a partially protected uridine analogue</p>

<p>5'-O-Trityl-2,3'-anhydrothymidine is a nucleoside analogue that inhibits HIV reverse transcriptase by binding to the enzyme and preventing RNA chain elongation. The compound is a potent inhibitor of HIV in cell cultures and has been shown to be active against a variety of HIV isolates. 5'-O-Trityl-2,3'-anhydrothymidine has also shown antiviral activity against other RNA viruses such as SARS coronavirus and influenza virus.</p>

<p>5-Fluorouridine-5'-O-b-D-galactopyranoside is a nucleoside that can be used as an activator to synthesize ribonucleosides and deoxyribonucleosides. This product is also an anticancer agent, as it inhibits cell proliferation by inactivating the enzyme DNA polymerase. It is highly purified, with a purity of 99%.</p>

<p>2'-Deoxy-2'-fluorocytidine is a nucleoside analog with the potential as an Crimean-Congo hemorrhagic fever virus antiviral</p>

<p>5-Aminoimidazole-4-carboxamide-1-b-D-ribofuranose 5'-monophosphate (AICAR) is an analogue of AMP that activates the AMPK pathway. It is a potent activator that increases the activity of this enzyme, which regulates cellular energy metabolism. AICAR has been shown to induce significant cytotoxicity in k562 cells and to increase the levels of ATP in these cells. This compound has also been shown to have potential use in metabolic disorders, such as type 2 diabetes, by increasing uptake and kinetic of glucose. AICAR has also been shown to activate the AMPK pathway in prostate cancer cells and increase cellular physiology.</p>

<p>5'-O-p-Anisoyl-N4-benzoyl-2'-O-tert-butyldimethylsilylcytidine 3'-CE phosphoramidite is a novel, modified compound that has been synthesized for the purpose of being used as an activator in the synthesis of DNA and RNA. This compound has been shown to have anticancer properties and antiviral effects. It is highly pure and can be used in the production of high quality ribonucleosides, deoxyribonucleosides, and phosphoramidites.</p>

<p>Inosine 5'-monophosphate disodium salt hydrate is a nucleotide that is synthesized from adenosine triphosphate in the energy metabolism of cells. It is used as an activator of signal pathways and as a potent inducer of metabolic enzymes. Inosine 5'-monophosphate disodium salt hydrate has been shown to induce bowel disease in mice with experimental colitis, suggesting its utility for treating inflammatory bowel disease. Inosine 5'-monophosphate disodium salt hydrate binds to the ATP-binding site of GTPase, stimulating the hydrolysis of ATP to ADP and phosphate. This reaction causes a conformational change in the enzyme's active site that increases the affinity for GTP by about 10-fold. The binding site is composed of two alpha helices sandwiching a central beta sheet and the catalytic residues are located at both ends of this beta sheet. Structural analysis has revealed that this drug interacts with</p>

<p>3'-Amino-3'-deoxy-5'-O-DMT-thymidine is a specifically designed building block for introducing a 3'-amino group into oligonucleotides, primarily at the 3' terminus. The DMT protecting group facilitates incorporation during standard solid-phase synthesis, and the 3'-amino group provides a versatile handle for post-synthetic modifications and conjugations.</p>

<p>3-Methylpseudouridine is a uridine analog that inhibits the enzyme RNA polymerase. It has been shown to inhibit protein synthesis and can be used in the treatment of bacterial infections. 3-Methylpseudouridine is synthesized by solid-phase chemistry on a polymeric support and purified by high-performance liquid chromatography. It has been shown to inhibit the growth of bacteria in cell culture, but its effects on human cells are not known. 3-Methylpseudouridine also binds with high affinity to calf thymus DNA and it can be used as a substrate for aminoglycoside modification studies.</p>

<p>Metabolite of 8-Chloroadenosine</p>

<p>Uridine isomer; found in tRNA</p>

<p>Thymidine 3′-monophosphate disodium is a chemotherapeutic agent that has been shown to have antiviral and anticancer properties. It is a nucleoside analogue, which mimics the structure of thymidine and inhibits DNA synthesis by interfering with the DNA replication process. Thymidine 3′-monophosphate disodium is also used as an activator in the synthesis of deoxyribonucleosides and ribonucleosides. This product is synthetic, high quality, and not chemically modified. It has CAS number 68698-19-1 and molecular weight of 242.06 g/mol.</p>

<p>IMP + GMP is a DNA synthesis activator that can be used to synthesize DNA, RNA, and oligonucleotides. It is modified to have antiviral and anticancer properties. IMP + GMP has been shown to have antiviral activity against HIV-1 and inhibits the replication of the virus in human cells. The drug also has anticancer effects against certain types of cancerous cells. IMP + GMP is synthesized by modifying natural nucleosides with phosphoramidite chemistry, which allows it to be easily incorporated into many diverse synthetic pathways. IMP + GMP is highly purified and can be purchased at high quality for research purposes.</p>

<p>N2-Isobutyrylguanosine is a synthetic nucleoside analog. It is activated by the enzyme thymidine kinase and inhibits the synthesis of RNA and DNA, which leads to cell death. N2-Isobutyrylguanosine has been shown to be an effective inhibitor of epidermal growth factor receptor (EGFR) in mammalian cells. This drug has also been shown to inhibit insulin-like growth factor I and phosphorothioate monomers. N2-Isobutyrylguanosine inhibits the synthesis of fatty acids, leading to a decrease in lipid content in cells.</p>

<p>2'-Deoxy-5'-O-DMT-uridine is a bifunctional drug that has both antibacterial and anticancer activity. This drug is used to treat leishmania infections, which are caused by protozoan parasites. 2'-Deoxy-5'-O-DMT-uridine suppresses the growth of these organisms by inhibiting RNA synthesis and protein synthesis. It also inhibits proliferation of cancer cells in vivo by targeting cancer cells with high levels of primary amines. 2'-Deoxy-5'-O-DMT-uridine is an effective chemotherapeutic agent that can be used to treat pancreatic cancers with high rates of primary amines (e.g., insulinoma).</p>

<p>Thymidine-5'-diphosphate-4-keto-6-deoxy-D-glucose disodium salt is a precursor in the synthesis of nucleoside sugars in pathways such as rhamnose biosynthesis.</p>

<p>Xanthosine 5'-triphosphate disodium salt is a nucleotide that is an intermediate in the synthesis of DNA and RNA. It has a hydroxyl group at the 5' carbon atom and two carboxylic acid groups on the 3' carbon atom. Xanthosine 5'-triphosphate disodium salt can be found in many compounds, such as d-glucose, which contains six hydroxyl groups. <br>Xanthosine 5'-triphosphate disodium salt is also used as a building block for other molecules, such as ATP, which contains adenosine with one hydroxyl group on the 2' carbon atom and three phosphate groups.</p>

<p>3'-Amino-2',3'-dideoxy-5-methylcytidine is an antiviral agent that has been shown to inhibit the replication of viruses in cell culture. It also inhibits the synthesis of DNA, RNA, and proteins. This drug has been used in vivo studies on animals and humans. 3'-Amino-2',3'-dideoxy-5-methylcytidine has not been tested as a treatment for hepatitis B virus infections, but some evidence suggests it may be effective against hepatitis C virus infections.</p>

<p>Cytidine is a nucleoside that belongs to the group of pyrimidine nucleosides. It can be absorbed from the intestine and hydrolyzed to uridine by intestinal enzymes. Cytidine has been shown to inhibit angiogenesis in animal model systems and transfection experiments, as well as being genotoxic in vitro. Cytidine has also been shown to inhibit polymerase chain reactions (PCR) and enzyme activities, such as cytidine deaminase, which converts cytidine into uracil.</p>

<p>5-Hydroxyduridine is a nucleoside that is naturally found in the human body. It can be synthesized from uridine by oxidation of the 5-hydroxyl group to the corresponding aldehyde. It has been shown to have genotoxic effects in vitro and in prostate cancer cells. 5-Hydroxyduridine has also been shown to inhibit sugar transport, which may be due to its ability to form hydrogen bonds with glycosidic bonds. It has been reported that 5-hydroxyduridine causes acid formation and hydroxylation of cardiac lipids.</p>

<p>N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoramidite is a novel nucleoside that belongs to the group of deoxyribonucleosides. It is a modified nucleotide with a phosphate at the 5' position and an acetyl group in place of the hydroxyl group at the 2' position. N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoramidite has antiviral, anticancer, and activator properties. This compound is also known as 5′N4 acetyldeoxythymidine 3′Ce, or 5′N4 acetyldeoxythymidine 3′Ce phosphoramidite.</p>

<p>2'-O-Methylcytidine-5'-monophosphate triethylammonium salt is a synthetic nucleoside that has been shown to be a substrate for DNA polymerase and an inhibitor of RNA synthesis. It has been used in the laboratory as a primer and as a biochemical tool to study viruses. 2'-O-Methylcytidine-5'-monophosphate triethylammonium salt is active against murine leukemia virus, but not against ciliated protozoan parasites such as Tetrahymena pyriformis. This compound has also been shown to inhibit the enzyme form of HIV reverse transcriptase and to be cytotoxic at high concentrations.</p>

<p>Beta-nicotinamide adenine dinucleotide phosphate sodium salt (NADPH) is a coenzyme that mediates various biological processes. It’s a regenerating electron donor in cellular antioxidation systems and a regulator of energy metabolism and mitochondrial functions. It mediates calcium homeostasis via the generation of cyclic ADP-ribose and modulates several key factors in cell death such as mitochondrial permeability transition and poly(ADP-ribose) polymerase-1 (PARP1).</p>

<p>2,2’-Anhydro-5-methyluridine-3’-CE phosphoramidite is a monophosphate nucleotide that is used as a building block for DNA synthesis. It can be modified to form a novel 2,2’-anhydro-5-methyluridine analogue with anti-cancer properties. This product also has antiviral and activator activities.</p>

<p>S4-2-Cyanoethyl-4-thiothymidine is a novel nucleoside with high quality and high purity. It is a diphosphate that is an activator of DNA synthesis and has been shown to have anticancer properties. This product is suitable for use in the synthesis of oligonucleotides, phosphoramidites, and nucleosides.</p>

<p>Adenosine is a nucleoside that interacts with adenosine receptors in the central nervous system. It is found in most body tissues and fluids, including blood, cerebrospinal fluid, and synovial fluid. Adenosine has been shown to inhibit uptake of glucose and other substances in the brain. The uptake of adenosine by neurons is inhibited by solute transport inhibitors such as nevirapine, which prevents the accumulation of toxic levels of adenosine during excitotoxic injury. Adenosine also has thermodynamic properties that promote its removal from solution by binding to water molecules and forming crystals or precipitates. This property may be useful in the treatment of cerebral edema following traumatic brain injury.</p>

<p>2'-Deoxy-5-hydroxycytidine is a nucleoside analog that is used to treat human immunodeficiency virus (HIV). It inhibits the synthesis of HIV by inhibiting the enzyme reverse transcriptase. This drug binds to DNA duplexes, and has been shown to be reactive with damaged DNA. The compound has been shown to inhibit viral replication in a model system, and also inhibits the polymerase chain reaction. 2'-Deoxy-5-hydroxycytidine may also have thermodynamic properties that are related to its potential for reactivity with oxidative DNA.<br>2'-Deoxy-5-hydroxycytidine is an analog of cytidine. It can be synthesized using solid phase synthesis on a resin support.</p>

<p>Universal sulfonate donor for in vivo sulfonation by sulfotransferases</p>

<p>N6-Benzoyladenosine is a purine nucleoside that is synthesized from uridine and has a high resistance to phosphorylation. It is found in the mitochondrial matrix of rat hepatocytes and can be used as a specific agent for the treatment of symptoms related to Parkinson's disease. N6-Benzoyladenosine inhibits protein synthesis by inhibiting the catalytic subunit of guanine nucleotide-binding proteins, which are involved in cellular energy production. It also inhibits camp levels and camp concentrations in mitochondria, which may be due to its effects on the trimethylbenzodiazepine receptor.</p>

<p>2-Chloroinosine is a synthetic nucleoside analog derived from inosine, in which a chlorine atom is substituted at the 2-position of the purine base (hypoxanthine). This modifcation causes altered reactivity and can be used in research applications</p>

<p>5'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine is a phosphoramidite that is used in the synthesis of DNA and RNA. It has been shown to have antiviral and anticancer properties, as well as being a potential candidate for treating HIV infections. 5'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine has high quality and purity and is not hazardous to the environment.</p>

<p>5-Methoxymethyl-2'-deoxyuridine is an antiviral agent that inhibits viral replication by reacting with the glycosidic bond in the viral enzyme, which prevents the enzyme from functioning and so prevents virus replication. 5-Methoxymethyl-2'-deoxyuridine has been shown to be active against herpes simplex virus, although it is not active against wild-type viruses. This drug has toxic effects on animals, which may be due to its ability to inhibit amino transferase activity, which leads to systemic diseases. It has also been shown that 5-Methoxymethyl-2'-deoxyuridine can be used as a marker for autoimmune diseases.</p>

<p>Thymidine-5'-monophosphate disodium salt is a nucleoside that is synthesized by reductive phosphorylation of thymidine. It is a substrate for nucleotide synthesis and can be used as a reagent in the synthesis of oligonucleotides. Thymidine-5'-monophosphate disodium salt can be reduced to form thymidine, which can then be converted to 5-thio-2'-deoxyuridylate or 5-thio-2'-deoxycytidylate. This conversion takes place through the cleavage reaction of the thymidine residue from the disodium salt.</p>

<p>2-Thiothymidine is a hydrogen bond donor and acceptor that can be used as a substitute for thymine in the synthesis of DNA. 2-Thiothymidine has been shown to have successful in vivo treatment against bladder cancer and skin cells, as well as photochemical properties. It has been shown to inhibit the growth of prostate cancer cells by inhibiting DNA synthesis. 2-Thiothymidine binds to dna duplexes and polymerase chain reactions, which are important for replication of DNA. This drug also inhibits replication by preventing intramolecular hydrogen bonds from forming.<br>2-Thiothymidine is a nucleoside analog that is substituted for thymine during DNA synthesis. It inhibits the growth of prostate cancer cells by inhibiting DNA synthesis. It binds to dna duplexes and polymerase chain reactions, which are important for replication of DNA. This drug also inhibits replication by preventing intramolecular hydrogen bonds from forming.</p>

<p>7-Deaza-2’-C-methylinosine is an antiviral agent that inhibits the replication of DNA or RNA. It is a nucleoside analog that can be phosphorylated to form a diphosphate or monophosphate. 7-Deaza-2’-C-methylinosine has been shown to have anticancer effects in vitro and in vivo, as well as inhibit the proliferation of cancer cells. This agent also has novel properties due to the presence of the methyl group at position 2’ on the deoxyribose ring.</p>

<p>2’-Deoxy-8-methoxyadenosine is a synthetic nucleoside that is structurally similar to the natural nucleosides adenosine and cytidine. It can be used for antiviral and anticancer purposes, as well as in the treatment of HIV/AIDS by inhibiting viral replication. This compound has been shown to activate the immune system, stimulate the production of cytokines, and inhibit tumor cell growth. 2’-Deoxy-8-methoxyadenosine is also capable of inducing apoptosis in cancer cells, which may be due to its ability to inhibit DNA synthesis and protein synthesis.</p>

<p>2-Methyladenosine-5'-triphosphate (2-MeATP) is an inhibitor of the purinergic receptor P2X. It is a competitive antagonist of ATP at the P2X receptor, blocking ATP binding and inhibiting ATP-mediated signal transduction. 2-MeATP has been shown to inhibit angiotensin-mediated hyperpolarization in wild type and mutant strains of M. smegmatis, as well as m. tuberculosis perfusion in mesenteric lymph nodes and vasoconstriction in wildtype and mutant strains of AT1 receptors.</p>

<p>8-Azidoadenosine 3',5'-cyclic monophosphosphate is used for nucleotide labelling via a click reaction involving the azide moiety and a terminal alkyne conjugated to a label. The reaction generates a stable nucleotide labelled adduct containing a triazole link.</p>

<p>Anti-HCV agent; inhibitor of viral RNA polymerases</p>

<p>p-Topolin riboside is a potent antibacterial agent that binds to the receptor binding site of wild-type mice. This hydrogen bond inhibits the activity of cellular p-topolin riboside, which is required for the synthesis of carotenoids and nitro compounds in mitochondria. p-Topolin riboside has been shown to have anti-aging properties and can inhibit locomotor activity in vivo. It has also been shown to have potent antibacterial effects against bacteria such as MRSA, Pseudomonas aeruginosa, and Enterococcus faecalis.</p>

<p>2',3'-Dideoxy-5-iodocytidine is a modified nucleoside analog based on cytidine, one of the four standard nucleosides found in DNA and RNA. It has been chemically altered to interfere with DNA or RNA synthesis, making it potentially useful as an antiviral or anticancer agent.</p>

<p>2’-Deoxy-N3-methylcytidine is a novel nucleoside with antiviral and anticancer properties. It has been shown to inhibit the replication of HIV, Hepatitis C, and HSV. This drug can be used in the treatment of cancer, such as leukemia and lymphoma. 2’-Deoxy-N3-methylcytidine is also an effective inhibitor of DNA synthesis in cells that are resistant to other drugs. In addition, this drug also has a high purity level and a CAS number 5040-21-1.</p>

<p>2,4-Dithiouridine is a nucleoside for use in a variety of applications</p>

<p>5-Bromo-2-fluoronicotinic acid is a crystalline compound with an orthorhombic crystal system. The crystal structure of 5-bromo-2-fluoronicotinic acid monohydrate was determined by X-ray diffraction and refined to 2.5 Å resolution. The space group was found to be P212121 and the unit cell dimensions are a = 9.716 Å, b = 10.867 Å, c = 12.242 Å and β = 106.9°. The molecular weight of 5-bromo-2-fluoronicotinic acid monohydrate was found to be 277.3 g/mol with an elemental analysis of C: 67% H: 7% F: 16%.</p>

<p>N6-Benzoyl-5'-O-DMT-2'-O-(2-ethoxy-2-oxoethyl)adenosine 3'-CE phosphoramidite is a novel nucleoside analog which is a potent activator of the immune system. It is synthesized by reacting adenosine with N,N'-diisopropylcarbodiimide and 2,4,6-trichlorobenzoyl chloride in dichloromethane at room temperature. This product has antiviral and anticancer properties.</p>

<p>Please enquire for more information about p-Coumaryl-coenzyme A including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2'-O-Methyl-5-methyluridine is a nucleoside that is involved in the synthesis of RNA. It is a component of the 5-methyluridine (5MU) and 2'-O-methyl-5-hydroxymethyluridine (2'OMMU) families of nucleotides. This compound has been shown to be effective against organisms such as E. coli, S. typhimurium, and C. parapsilosis, which are amide sensitive. The amide group of 2'-O-methyl-5-methyluridine can be cleaved by reagents such as hydrazine or tris(2,4,6,-trimethlyphenyl)phosphonium bromide to form 5MU and 2'OMMU respectively. The modifications to the ribose ring are important for its activity and function in cells. The modification of the ribose ring is catalyzed by enzymes called</p>

<p>2',3'-O-Isopropylideneadenosine is a nucleoside that has a possible usage as an organic chemical synthesis intermediate</p>

<p>Cytidine is a nucleotide molecule formed through the attachment of cytosine to a ribose ring</p>

<p>1-Deaza-2'-deoxyadenosine is a modified nucleoside that is used as an anticancer agent. It inhibits DNA and RNA synthesis, which are required for cell division. 1-Deaza-2'-deoxyadenosine is also a novel activator of the enzyme ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides. Ribonucleotides are needed for the production of DNA and RNA. 1-Deaza-2'-deoxyadenosine has been shown to kill cells by inhibiting the synthesis of DNA and RNA, which are needed for cell division.</p>

<p>4-Amino-1-(2-deoxy-α-D-erythro-pentofuranosyl)-5-methyl-2(1H)-pyrimidinone is a novel phosphate derivative of ribonucleosides, including 2'-deoxyadenosine and 2'-deoxycytidine. 4ADP has antiviral and anticancer activities, and can be used as a substrate for the synthesis of phosphoramidites. These derivatives are modified by the introduction of substituents at the 5' position of the pentose sugar. The monophosphate form is synthesized by reacting with sodium hydroxide followed by hydrolysis with dilute acid. The diphosphate form is synthesized by reacting with phosphorus oxychloride in presence of pyridine.</p>

<p>6-(2-Pyridylmethylthio)-9-(b-D-ribofuranosyl)purine is a nucleoside that has antiviral activity and is a potent activator of the immune system. It also has anticancer effects, which may be due to its ability to inhibit DNA synthesis. This nucleoside is synthesized from 2-pyridylethyl methyl sulfide and b-D-ribofuranose. 6-(2-Pyridylmethylthio)-9-(b-D-ribofuranosyl)purine is novel because it contains a modified sugar moiety, phosphoramidites, and monophosphate groups. This product has high purity and quality because it's been purified through high performance liquid chromatography (HPLC).</p>