Nucléosides

<p>Cytidine 5'-triphosphate (CTP) disodium dihydrate prevents the action of aspartate carbamoyltransferase, an enzyme involved in pyrimidine biosynthesis. CTP serves as a molecule of high energy and acts as a coenzyme in glycerophospholipid biosynthesis and protein glycosylation.</p>

<p>2'-Deoxy-L-uridine is a nucleoside that is found in the human body. It phosphorylates l-thymidine, which is a natural substrate, and this reaction prevents the formation of diphosphate from d-ribose 5'-monophosphate. 2'-Deoxy-L-uridine is an exogenous substance that inhibits cell growth by affecting protein synthesis and DNA replication. 2'-Deoxy-L-uridine has been shown to be more efficient than wild type uridine in inhibiting cell growth in vitro at concentrations of 1 mM or greater. The enantiomers of 2'-deoxy-L-uridine affect cell growth differently, with the (R)-enantiomer being more potent than the (S)-enantiomer.</p>

<p>2',3'-O-Isopropylidenecytidine is a nucleoside for use in research applications</p>

<p>2'-Deoxy-4-thiouridine is a pyrimidine nucleoside for a range of applications</p>

<p>Polycytidylic acid is a single stranded RNA analog which is combined with Polyinosinic acid to form a stable duplex structure known as Polyinosinic acid-polycytidylic acid (Poly I:C). PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations.  Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes. We can supply PolyI:C to all stages of your project - from R&amp;D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.<br>For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'</p>

<p>N4-Etheno 2'-deoxycytidine is an aromatic hydrocarbon that has been shown to be a potent inhibitor of DNA synthesis. It binds covalently with the N4 position of deoxycytidine in DNA, thereby inhibiting transcription and replication. This drug has been shown to be a potent inhibitor of DNA synthesis in human cells when it is added to the culture medium, but it does not inhibit protein synthesis. N4-Etheno 2'-deoxycytidine can also react with hydrogen bonds in cellular proteins and nucleosides that are involved in DNA repair mechanisms. This drug is reactive and may cause oxidative damage to cellular components, which may lead to carcinogenesis.</p>

<p>Cyclic inosine diphosphate ribose is a synthetic, fluorescent compound that can be used as a probe for assays. It has been synthesized by the solid-phase synthesis of a specific antibody and is bioconjugated with an oligo(ethylene glycol) moiety. Cyclic inosine diphosphate ribose can be used to measure lymphocyte activation, which is important for the study of autoimmune diseases and cancer. Cyclic inosine diphosphate ribose has also been shown to bind to the ryanodine receptor, which causes an increase in intracellular calcium concentration.</p>

<p>Myristoyl coenzyme A is a potential drug that inhibits the binding of human pathogens to protein. It also has been shown to have potential as an inhibitor for reactions involving myristoylation, which is a process where proteins are modified with myristic acid. Myristoyl coenzyme A was synthesized using titration calorimetry and in vitro assays. The compound has been shown to have the ability to inhibit polymerase chain reaction (PCR) and reduce the growth of bacteria in vitro. Myristoyl coenzyme A may be useful in treating metabolic disorders and infectious diseases such as AIDS, tuberculosis, and malaria.</p>

<p>Please enquire for more information about N6-Hydroxymethyladenosine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Polyguanylic acid potassium salt is a guanosine analog that is used as a probe for studying the interaction of cellular and target tissue. It has been found to be taken up by cells, with high affinity constants, and to be immobilized on cell surfaces. Polyguanylic acid potassium salt can also be used as an anticancer agent against epidermoid carcinoma cells with high affinity constants. The compound interacts with DNA and inhibits the growth of the tumor cells by interfering with the uptake of nucleic acids.</p>

<p>(E)-2'-Deoxy-2'-(fluoromethylene)cytidine is a cytostatic compound that inhibits DNA synthesis in tumor cells. It has been shown to be more potent than tezacitabine and hl-60 cells, as well as being less toxic than benzimidazole compounds. This analog of cytosine has been shown to have potent antitumor activity against carcinoma cell lines and myeloid leukemia cell lines. The oral prodrug form of this drug has been shown to be an effective treatment for myeloid leukemia in mice.</p>

<p>Nicotinic acid adenine dinucleotide sodium (NAAD) is a novel anticancer and antiviral agent. NAAD is an analog of nicotinamide adenine dinucleotide (NAD) that has been modified to include a sodium ion. This modification inhibits the synthesis of DNA and RNA, which are required for cell division and replication. It has been shown to inhibit the growth of cancer cells in vitro and in vivo. In addition, NAAD suppresses viral replication by inhibiting protein synthesis in cells infected with HIV-1 or influenza virus. NAAD has also been shown to be a potent inhibitor of ribonucleoside reductase, which converts ribonucleosides into deoxyribonucleosides. This inhibition prevents the conversion of diphosphate nucleotides into monophosphate nucleotides, which are necessary for DNA synthesis.</p>

<p>2'-Phosphoadenosine 5'-phosphosulfate tetralithium salt (mixture with 3'-isomer) is a novel, modified nucleoside. It has antiviral properties and can be used for the treatment of cancer. 2'-Phosphoadenosine 5'-phosphosulfate tetralithium salt (mixture with 3'-isomer) inhibits viral replication by inhibiting the synthesis of viral DNA and RNA. This compound also inhibits cancer cell proliferation by inhibiting deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) synthesis.</p>

<p>5-Formylamino-4-imidazolecarboxamide ribonucleotide is a nucleoside that is synthesized from 5-aminoimidazole ribonucleotide. It has antiviral and anticancer properties and is used as a precursor for the synthesis of other nucleosides. 5-Formylamino-4-imidazolecarboxamide ribonucleotide can be used in the preparation of oligodeoxyribonucleotides, which are involved in DNA replication, transcription, and translation. This compound also has been shown to inhibit the growth of cells with HIV or cancerous cells.</p>

<p>Applications Levovirin is a monocyclic L-nucleosides with type 1 cytokine-inducing activity. Levovirin is the L-enantiomer of Ribavirin (R414475) with similar immunomodulatory activity but does not have direct antiviral activity or hemolytic anemia.<br>References Ramasamy, K.S. et al.: J. Med. Chem., 43, 1019 (2000); Fang, C. et al.: J. Appl. Toxicol., 23, 453 (2003):<br></p>

<p>2'-Deoxy-N2-isopropylguanosine is a nucleoside that is synthesized from 2'-deoxy-N6-methyladenosine and isopropyl alcohol. It has antiviral and anticancer properties. The antiproliferative effects of this drug are mediated by the inhibition of DNA synthesis in cells. This compound also inhibits the activation of the transcriptional factor NF-κB, which regulates inflammatory responses in the body.</p>

<p>9-(b-D-arabinofuranosyl)-N6-benzoyladenine is a novel nucleoside analogue that has been shown to be an effective anticancer agent. It is structurally related to the natural nucleosides adenosine and guanosine, but with the addition of a benzoyl group on the 9 position. This compound is also active against HIV, influenza A virus and herpes simplex virus type 1 (HSV1). It can be used as an antiviral agent in cancer therapy due to its ability to inhibit viral replication. 9-(b-D-arabinofuranosyl)-N6-benzoyladenine inhibits the growth of tumor cells by inhibiting DNA synthesis and RNA transcription. It also binds to DNA, thereby preventing DNA synthesis and RNA transcription.</p>

<p>3'-Azido-3'-deoxythymidine methyl-D3 is a novel synthetic nucleoside. It is a modified version of the natural nucleoside deoxyribonucleoside, which is an essential component of DNA and RNA. 3'-Azido-3'-deoxythymidine methyl-D3 is an activator of the antiviral and anticancer properties of other drugs. It can be used as a phosphate donor in phosphoramidite synthesis to produce oligonucleotides for use in PCR amplification or in protein synthesis. 3'-Azido-3'-deoxythymidine methyl-D3 is also used as an antiviral agent because it inhibits viral replication by inhibiting viral reverse transcriptase.</p>

<p>7-Benzyl-4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyriMidine is an antiviral agent that is a modified nucleoside. It has shown to be a novel activator of the immune system. 7BICP has been shown to have high antiviral activity against herpes simplex virus type 1 (HSV1) and type 2 (HSV2) in cell cultures. It also inhibits the replication of HIV and influenza A virus in cell cultures. This drug is synthesized from deoxyribonucleosides, phosphoramidites, or nucleosides. 7BICP is a monophosphate and diphosphate, which are used as substrates for DNA synthesis by DNA polymerase. The CAS number for 7BICP is 1244855-59-1.</p>

<p>1-(β-D-2-Deoxyribofuranosyl)-3-nitropyrrole is a nitrofuranose analog that is used in the synthesis of nucleic acids. It has been shown to be effective as a template for DNA sequencing and as a probe for magnetic resonance spectroscopy. 1-(β-D-2-Deoxyribofuranosyl)-3-nitropyrrole inhibits the polymerase chain reaction by binding to the primer and causing misincorporation at mismatched sites, leading to reduced amplification of the target sequence. This compound also has antiviral properties and can prevent the replication of HIV and other viruses by destabilizing their dna duplexes.</p>

<p>5'-Tosyl-2'-deoxycytidine is a nucleoside with anticancer activity and is a novel derivative of cytidine. It has been shown to inhibit the proliferation of human cancer cells in culture. 5'-Tosyl-2'-deoxycytidine is also an antiviral agent that inhibits the synthesis of viral DNA by inhibiting the enzyme RNA polymerase. This product is synthetic, water soluble, and stable at pH 2.0 to 10.5, making it suitable for use in pharmaceutical formulations. The purity of this product is high and its chemical structure has been modified from cytidine to increase its stability against degradation by intracellular phosphatases.</p>

<p>Dideoxycytidine 5'-monophosphate (DDCMP) is a molecule that inhibits HIV infection by inhibiting the synthesis of DNA. It binds to the dna template strand, preventing the addition of new nucleotides and thus blocking the progression of HIV infection. DDCMP has been shown to be potent in vitro and in vivo in clinical studies. In cell culture, DDCMP has been shown to inhibit DNA duplexes, leading to a decrease in lymphocytic leukemia cells activated by T-cell receptor stimulation. Structural biology studies have revealed that DDCMP inhibits HIV-1 reverse transcriptase through binding at the M2 subunit of the enzyme's active site.</p>

<p>N-Succinyl-5-aminoimidazole-4-carboxamide ribose 5'-phosphate is a synthetase that is involved in the biosynthesis of purines and pyrimidines. It catalyzes the ATP-dependent formation of N-succinyl5'-aminoimidazole-4-carboxamide ribose 5'-phosphate from succinyl CoA and aspartic acid. This enzyme has been studied in wild type strains of bacteria, such as Escherichia coli, but not in humans or other organisms. N-Succinyl5'-aminoimidazole-4-carboxamide ribose 5'-phosphate has been shown to be an inhibitor of antimicrobial agents such as penicillin G, erythromycin, and tetracycline. The mechanism for this inhibition is unclear, but it may involve hydrogen bonding interactions or structural changes that prevent binding</p>

<p>5-(Furan-2-yl)-2'-deoxyuridine is a novel anticancer drug that is an analog of thymine. 5-(Furan-2-yl)-2'-deoxyuridine inhibits DNA synthesis by inhibiting the formation of deoxythymidylate from uracil and 5-fluorouracil, which in turn prevents the incorporation of thymine into DNA. The drug has been shown to be active against human leukemia cells in culture and to inhibit viral replication in vitro. The drug also blocks RNA synthesis by inhibiting ribonucleotide reductase, preventing the production of nucleosides from nucleotides. 5-(Furan-2-yl)-2'-deoxyuridine has been modified to improve its solubility and stability. This compound is stable for up to 3 months when stored at 4 degrees Celsius and can be used as a starting material for other chemical compounds.</p>

<p>4-(4-Fluorophenyl)pyrimidine-2-thiol is a monophosphate deoxyribonucleoside that has been modified to include an activator group. This modification allows for the phosphoramidite of 4-(4-Fluorophenyl)pyrimidine-2-thiol to be incorporated into DNA, which makes it a novel substance. The CAS number for 4-(4-Fluorophenyl)pyrimidine-2-thiol is 155957-43-0. 4-(4-Fluorophenyl)pyrimidine-2-thiol has shown anticancer activity in vitro and may have potential as a cancer chemotherapeutic agent.</p>

<p>8-Methylthioadenosine is a synthetic analogue of adenosine that has been used as a biochemical stimulator. It has been shown to inhibit uptake of fatty acids and phospholipids into cells, which may be due to the inhibition of cellular ATPase. 8-Methylthioadenosine can also be used as a precursor for other molecules, such as methylation of DNA or RNA. 8-Methylthioadenosine is synthesized from linolenic acid and phosphate in a reaction catalyzed by molecular oxygen. The synthesis is stimulated by light and heat and inhibited by cyanide. Magnetic resonance spectroscopy (NMR) was used to confirm that the molecule had the correct structure.</p>

<p>3',5'-O-[Tetrakis(1-methylethyl)-1,3-disiloxanediyl]-guanosine is a nucleoside phosphoramidite that is synthesized by the reaction of 3',5'-O-[Tetrakis(trimethylsiloxy)silyl]guanosine with tetrakis(1-methylethyl) siloxane. It is a novel monophosphate analogue of guanosine and has antiviral, anticancer and activator properties. 3',5'-O-[Tetrakis(1-methylethyl)-1,3-disiloxanediyl]-guanosine is not toxic to cells and can be used in the treatment of cancer.</p>

<p>Ent-idoxuridine is a cytosolic DNA synthesis inhibitor that blocks the conversion of deoxycytidine to deoxyadenosine by inhibiting the enzyme deoxycytidine kinase. It is also an enantiomer of idoxuridine, which has the same mechanism of action. Ent-idoxuridine is not active against herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2). In contrast to idoxuridine, ent-idoxuridine is resistant to exonucleases and has been shown to be effective in treating immunodeficiency caused by HIV.</p>

<p>3'-O-Acetyl-2'-deoxy-5'-O-DMT-2'-fluorouridine is a novel, activator, ribonucleosides, deoxyribonucleosides, diphosphate, phosphoramidites, modified nucleosides. It can be used as an anticancer and antiviral agent.</p>

<p>1-(2'-Deoxy-2'-fluoro-5'-O-trityl-b-L-arabinofuranosyl)-uracil is a monophosphate nucleotide that is used in antiviral therapy. It inhibits viral DNA synthesis by inhibiting viral DNA polymerase and viral RNA transcription. The drug is currently in phase I clinical trials for the treatment of cancer and AIDS. 1-(2'-Deoxy-2'-fluoro-5'-O-trityl-b-L-arabinofuranosyl)-uracil is a novel compound that has not been described in the literature before. The drug was synthesized by modifying a natural nucleoside, uracil, with fluorine to produce an antiviral agent. This compound has shown anticancer effects in vitro and in vivo experiments as well as antiplasmodial activity against malaria.</p>

<p>N6-Benzoyl-2'-deoxy-5'-O-levulinoyladenosine-3'-CE phosphoramidite is a novel antiviral agent that exhibits high quality and high purity. It can be used to synthesize DNA, RNA, and other nucleosides. N6-Benzoyl-2'-deoxy-5'-O-levulinoyladenosine-3'-CE phosphoramidite is an activator of the DNA polymerase and an inhibitor of the viral polymerase. This compound has been shown to have anticancer properties in vitro and in vivo.</p>

<p>N4-Benzoyl-5'-O-DMT-2'-ethylfluoro-5-methylcytidine 3'-CE phosphoramidite is a novel, deoxyribonucleosides that has been synthesized with high purity, high quality, and high yield. It is an anticancer drug that inhibits the synthesis of ribonucleotides in DNA and RNA.</p>

<p>4'-Hydroxymethyl-4,5',8-trimethylpsoralen (HMT) is an analog of psoralen that has been shown to have potent anti-tumor activity. HMT acts as an inhibitor of human tumor kinase and has been shown to induce apoptosis in cancer cells. This drug has also been found to enhance the effects of other cancer treatments, such as nintedanib. HMT has demonstrated potential for the treatment of diabetes by acting as an inhibitor of glucose uptake and metabolism in Chinese hamster ovary cells. Additionally, HMT has been found to have inhibitory effects on enzymes such as apomorphine, glimepiride, and vanillin. Overall, HMT holds great promise for the development of novel cancer therapies and diabetes treatments.</p>

<p>5'-O-(Dimethoxytrityl)-5-methyl-2'-O-methyluridine is a DNA building block that is used as a monophosphate and can be converted to diphosphate or modified with various protecting groups. This compound has been shown to have antiviral and anticancer properties, as well as being a novel nucleoside analog. 5'-O-(Dimethoxytrityl)-5-methyl-2'-O-methyluridine has the CAS number of 115173-73-4.</p>

<p>8-Bromo-2'-deoxyadenosine cep is a modified nucleoside that is used in the treatment of cancer. It has been shown to be effective in treating leukemia, lymphoma and myeloma. 8-Bromo-2'-deoxyadenosine cep inhibits the growth of cells by inhibiting DNA synthesis through inhibition of deoxynucleotide biosynthesis. This drug also has antiviral activity against herpes simplex virus type 1 (HSV1), herpes simplex virus type 2 (HSV2) and human immunodeficiency virus type 1 (HIV1). 8-Bromo-2'-deoxyadenosine cep is a synthetic nucleoside that is phosphoramidite that can be used to synthesize DNA or RNA.</p>

<p>3'-Deoxy-N6-lauroyladenosine is a nucleoside analog that is used to treat cancer. It is a phosphoramidite compound and it has been shown to be highly active against cancer cells. 3'-Deoxy-N6-lauroyladenosine is an antiviral agent that inhibits viral DNA synthesis by competing with the natural substrate, deoxyribonucleosides, for incorporation into the growing DNA chain. It also prevents the replication of RNA viruses by inhibiting their transcription and translation processes. 3'-Deoxy-N6-lauroyladenosine also inhibits inflammation in the body and may act as a chemotherapeutic agent in other diseases such as diabetes, Alzheimer's disease, and Parkinson's disease.</p>

<p>Please enquire for more information about 2'-Deoxyuridine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>8-Aminoguanosine is a synthetic purine nucleoside that inhibits DNA synthesis. It has been shown to inhibit the proliferation of HL-60 cells, which are a model for human monocytes and neutrophils. 8-Aminoguanosine has been shown to bind to the template strand of DNA and inhibit the incorporation of deoxyribonucleotide triphosphates into the newly synthesized strand. This binding prevents DNA replication by preventing access to the template strand of DNA. 8-Aminoguanosine inhibits cyclin D2, an enzyme required for cell division, at concentrations as low as 0.1 mM, and it also inhibits microtubule assembly. 8-Aminoguanosine has shown in vitro activity against various tumor cell lines including Molt-4 and MCF7 cells, and in vivo activity in a mouse model against C3H/HeJ mice transplanted with Lewis lung carcinoma cells.</p>

<p>2'-Deoxy-2'-fluoroadenosine-5'-triphosphate lithium salt is an analog of ATP that has significant inhibitory effect on DNA polymerase. It inhibits the synthesis of RNA and protein by binding to the enzyme DNA gyrase. This drug is used in cell culture as a nucleotide analog to study how cells are affected by atp analogs. 2'-Deoxy-2'-fluoroadenosine-5'-triphosphate lithium salt is used at high concentrations in vitro, where it inhibits topoisomerases and prevents cell division.</p>

<p>4'-a-C-Methylguanosine is a nucleoside that is synthesized by the condensation of 4'-amino-2',3'-dideoxyadenosine and 1,2-ethanediol. This product is an activator that can be used to synthesize novel DNA analogues with various chemical modifications. It has shown antiviral and anticancer activity in vitro. 4'-a-C-Methylguanosine was also found to be more active than guanosine when it came to inhibiting viral replication in human cells.</p>

<p>2-(2-Furyl)-5-pyrimidinecarbaldehyde (2FP) is a novel anticancer activator that belongs to the class of modified DNA. 2FP is a nucleoside analogue that inhibits the synthesis of DNA, RNA, and protein. It has been shown to inhibit the growth of cancer cells in vitro and in vivo. This compound may be used as an antiviral agent against HIV and herpes virus infections. 2FP has high purity and quality, with CAS number 959240-19-8.</p>

<p>Benzoyl stavudine is a nucleoside that is used as an anti-HIV drug. It has been shown to be a prodrug of the active form, stavudine, by reductive elimination. Benzoyl stavudine has been shown to inhibit HIV replication by competitively binding to the viral reverse transcriptase enzyme and preventing the synthesis of RNA from DNA. This drug also inhibits ribonucleotide reductase, an enzyme that converts ribonucleotides into deoxyribonucleotides for DNA synthesis. This inhibition prevents the formation of new viral DNA and halts viral replication.</p>

<p>2,6-Bis-o-[2-(4-nitrophenyl)ethyl]-2'-deoxyxanthosine is a novel nucleotide analog that exhibits anticancer activity. It has been shown to inhibit the growth of human leukemia cells and enhance the cytotoxic effect of doxorubicin. 2,6-Bis-o-[2-(4-nitrophenyl)ethyl]-2'-deoxyxanthosine is a potent inhibitor of DNA synthesis with a high selectivity index for cancer cells. This agent inhibits DNA synthesis by competing with deoxyribonucleosides for incorporation into the growing DNA strand. 2,6-Bis-o-[2-(4-nitrophenyl)ethyl]-2'-deoxyxanthosine is an activator at the adenine phosphoribosyltransferase (APRT) enzyme and may also have an effect on ribonucleotide reductase (R</p>

<p>1-(2',3',5'-Tri-O-acetyl-b-D-arabinofuranosyl)uracil is a novel nucleoside analog with antiviral and anticancer activities. It is a modified nucleoside that is synthesized from 2',3',5'-triacetyl b-D-arabinofuranosyl uracil. The synthesis of this compound involves the use of acetylation, which produces a monophosphate form of the nucleoside. This product has been shown to be an activator in the synthesis of DNA and RNA.</p>

<p>Lamivudine 5'-monophosphate ammonium salt is a novel antiviral agent that inhibits the viral polymerase by competing with natural dNTPs. It has been shown to be effective against Hepatitis B virus (HBV) and human immunodeficiency virus type 1 (HIV-1). Lamivudine 5'-monophosphate ammonium salt is a synthetic nucleoside that is phosphorylated to form its active form, lamivudine 5'-triphosphate ammonium salt. This drug has been shown to inhibit tumor growth in vivo and in vitro.</p>

<p>N4-Benzoyl-5'-O-DMT-(2'-O, 4'-C-methylene)-5-methyl-a-cytidine 3'-CE phosphoramidite is a novel modified nucleoside that has antiviral and anticancer properties. It is synthesized by reacting the 3'-hydroxyl group of cytidine with 2,4,6-trimethoxybenzoyl chloride to form N4-(2',6'-dimethoxyphenyl)benzoylcytidine. This compound is then reacted with methylene bis(diethylamino)thiophene (2') and the 5' phosphoramidite of 5'-O-DMT-(2'-O, 4'-C-methylene)-5-methylcytidine. The product is an active synthetic nucleoside that can be used as a building block for other nucleosides or oligonucleotides.</p>

<p>P2Y receptor agonist; precursor in RNA biosynthesis</p>

<p>5-Fluoro-1-(2'-L-menthyloxycarbonyl-1'-3'-oxathiolan-5'-yl)-cytosine is a nucleoside, a type of chemical compound containing both a sugar (deoxyribose) and an organic molecule (a base). It is an antiviral agent that inhibits the production of viral DNA by inhibiting the enzyme DNA polymerase. 5-Fluoro-1-(2'-L-menthyloxycarbonyl-1'-3'-oxathiolan-5'-yl)-cytosine is also an anticancer agent that can inhibit the production of cancer cells in vitro and in vivo. This product is a novel monophosphate nucleotide analog with high purity and CAS number 1422361-25-8.</p>

<p>5-Bromo-2',3'-dideoxyuridine is a nucleoside analogue that is used as a chemotherapeutic drug against various types of cancer. It has been shown to have anti-tumour activity by interfering with the synthesis of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). 5-Bromo-2',3'-dideoxyuridine binds to the sugar ring in DNA and inhibits the enzyme DNA polymerase from synthesizing DNA. This drug also stabilizes conformations of the molecule, which are responsible for its pharmacological effects.<br>5-Bromo-2',3'-dideoxyuridine can be found in two different crystal structures, monoclinic and tetragonal. The monoclinic form is stabilized by hydrogen bonds between the puckers in the sugar ring and hydrogen bonds to neighboring molecules. This form is more soluble than the tetragonal form,</p>

<p>Please enquire for more information about 6-Azathymidine ce-phosphoramidite including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>8-Bromo-2'-deoxy-N6-DMF-5'-O-DMT-adenosine 3'-CE phosphoramidite is a novel nucleoside that is synthesized from 8-bromo-2'-deoxyadenosine and N,N,-diisopropylethylamine. It has been shown to have anticancer, antiviral, and antiinflammatory activities. This compound is also used as an activator in the synthesis of DNA and RNA. The purity of this product exceeds 99% and it has been modified for use with automated synthesizers.</p>

<p>2',3'-Dideoxy-2',3'-didehydrocytidine (ddC) is a nucleoside analog that is used in the treatment of hepatitis B and C. This drug inhibits the reverse transcriptase enzyme and has cytostatic effects on viruses, for example, by preventing cell division. 2',3'-Dideoxy-2',3'-didehydrocytidine also inhibits viral replication by acting as an antigen and inducing antibody production. This drug binds to a variety of enzymes, including preparations of cellular enzymes, human immunodeficiency virus type 1 (HIV-1), and reverse transcriptase. The effective dose of ddC is 300 mg/day given orally.</p>

<p>2',3',5'-Tri-O-acetylnebularine is a modified nucleoside that is synthesized from nebulareine. It has been shown to inhibit the growth of cancer cells, as well as HIV and influenza virus. This drug also has antiviral effects against herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2). 2',3',5'-Tri-O-acetylnebularine inhibits viral replication by inhibiting DNA synthesis and RNA transcription, which prevents the production of proteins needed for cell multiplication.</p>

<p>5-Aminoallyluridine 5'-triphosphate sodium salt is a modified nucleoside that has antiviral and anticancer activity. It is a prodrug of 5-aminoallyluridine and is activated by deoxyribonucleotide ribonucleotides in the cell. This drug also can be used as an activator for other drugs, such as cytosine arabinoside, which are inactive or less active when administered alone.</p>

<p>N6-Formyl adenosine is an endogenous nucleotide that is dynamically modified in the human body. N6-Formyl adenosine is a reactive modification of adenosine and has been shown to be present in DNA, RNA, and proteins. It is also found in human cells and tissues, where it can be demethylated by enzymes such as DNA methyltransferase. This modification may have implications for research into the nature of messenger RNA (mRNA), which plays a crucial role in protein synthesis. N6-Formyl adenosine has been used to distinguish between mature and immature mRNA molecules by fluorescence analysis.</p>

<p>2-(Piperidin-4-Yloxy)Pyrimidine Dihydrochloride is a nutrient that can be used for soil fertilization and weed control. It is a non-selective herbicide that inhibits the growth of all plants. This compound breaks down in the environment, so it is environmentally friendly. 2-(Piperidin-4-Yloxy)Pyrimidine Dihydrochloride can be applied to the soil or sprayed on leaves to control weeds. It is more efficient at controlling weeds than potassium chloride, which is another type of fertilizer.</p>

<p>2,4,5,6-Tetraaminopyrimidine 2HCl is a chemical compound that belongs to the group of pyrimidines. It is a colorless solid with a melting point of 178.2°C and a boiling point of 339.8°C. This compound can be obtained by reacting 2,4,5-trichloropyrimidine with potassium cyanide in acetic acid solution or by heating 2,4-diaminopyrimidine with ammonium chloride and sodium nitrate in water.<br>In the liquid chromatography process this compound is used as an analytical reagent for determining the purity and identity of organic compounds by measuring their retention time on the column.</p>

<p>1-(5-O-(dimethoxytrityl)-β-D-2-deoxyribofuranosyl)-3-nitropyrrole is a novel nucleoside phosphoramidite that has been modified to include an oxazole moiety. It is an antiviral and anticancer drug that inhibits the replication of DNA by binding to the enzyme DNA polymerase. 1-(5-O-(dimethoxytrityl)-β-D-2-deoxyribofuranosyl)-3-nitropyrrole is also a substrate for monophosphate, diphosphate, and triphosphate nucleotide kinases, which are enzymes that catalyze the phosphorylation of 5'-monophosphates. This nucleoside phosphoramidite can be used in the synthesis of oligonucleotides and modified oligonucleotides.</p>

<p>2-Amino-4-(4-chlorophenyl)pyrimidine is a antiviral agent and an inhibitor of ribonucleotide reductase. It is used for the treatment of cytomegalovirus infection, herpes zoster, and chronic myeloid leukemia. 2-Amino-4-(4-chlorophenyl)pyrimidine is also used in anticancer therapy. This drug inhibits DNA synthesis by binding to the deoxyribose moiety of ribonucleosides and diphosphates in the DNA precursor pool. The drug has been shown to be active against human lymphocytic leukemia cells as well as human erythroleukemia cells but not against normal human lymphocytes.</p>

<p>O6-Benzyl-N2,3-etheno-2'-deoxy-3',5'-O-[tetrakis(isopropyl)-1,3-disiloxanediyl] guanosine is a modified nucleoside with antiviral and anticancer activities. It can be used in DNA synthesis to produce oligonucleotides that have been modified at the 2' position. O6-Benzyl-N2,3-etheno-2'-deoxy-3',5'-O-[tetrakis(isopropyl)-1,3-disiloxanediyl] guanosine is also active against diphosphate reductase. CAS No. 148437-94-9</p>

<p>2'-Deoxy-N4,N4,5-trimethylcytidine is a monophosphate nucleoside that is used as a precursor for the synthesis of DNA. It can be modified to produce phosphoramidites and ribonucleosides. 2'-Deoxy-N4,N4,5-trimethylcytidine has antiviral activity against herpes viruses and cytomegalovirus (CMV). It also has anticancer activity in animal models.</p>

<p>N6-Benzoyl-2'-deoxy-a-adenosine is a synthetic nucleoside analog. N6-Benzoyl-2'-deoxy-a-adenosine has antiviral and anticancer properties. It is a potent inhibitor of DNA polymerase and also inhibits ribonucleotide reductase, which are enzymes crucial for DNA synthesis. N6-Benzoyl-2'-deoxy-a-adenosine inhibits the synthesis of viral RNA, leading to inhibition of viral replication. It has been shown to inhibit proliferation of tumor cells in vitro and in vivo by inhibiting DNA synthesis and inducing apoptosis.</p>

<p>2'-Deoxy-N2-isobutyrylcytidine is a nucleoside analogue of cytidine that has been modified with a 2-amino-2-deoxyribose moiety. The transaminated product is more stable than the parent compound and has improved anticoagulant activity. It has also been shown to be active in inhibiting DNA synthesis and cell proliferation in vitro. 2'-Deoxy-N2-isobutyrylcytidine inhibits the growth of bacteria by binding to their ribosomes, preventing protein synthesis. This compound has also been shown to inhibit the formation of blood clots in mice.</p>

<p>Biotin-18-cytidine-5'-triphosphate triethylammonium salt - 5mM aqeous solution is an activator of DNA synthesis. It is a cytidine nucleoside with a biotin label at the 5' position that is used as a substrate in DNA synthesis reactions. Biotin-18-cytidine-5'-triphosphate triethylammonium salt - 5mM aqeous solution is also used to make phosphoramidites, which are building blocks for oligonucleotide synthesis. This product can be used in anticancer and antiviral research.</p>

<p>Adenosine 5’-diphosphate (ADP) is a potent activator of the G-protein coupled receptor, P2Y. This receptor has been shown to be present on platelets, which are cells that are involved in the clotting process. ADP also inhibits the ion channel activity of the Na+, K+ ATPase. The effects of ADP on myocardial infarct have been studied in a model system consisting of isolated papillary muscle from rats. Adenosine 5’-diphosphate is not an inhibitor of protein synthesis, but does inhibit polymerase chain reaction amplification. It is used as a pharmacological agent for bowel disease and for treatment of chronic obstructive pulmonary disease.END&gt;</p>

<p>3',5'-Di-O-benzoyl-2'-O-methyl-5-methyluridine is an activated nucleoside which is a synthetic nucleoside analog. It has been shown to be an effective antiviral and anticancer agent, as well as a potential antiviral drug against HIV. 3',5'-Di-O-benzoyl-2'-O-methyl-5-methyluridine is also a potent inhibitor of RNA synthesis in cells, which may lead to the development of new drugs for the treatment of viral infections.</p>

<p>2'-Deoxy-4-desmethylwyosine is a nucleoside that has been modified to contain a deoxyribose sugar. The monophosphate form of this compound has been shown to activate the DNA synthesis and promote cellular proliferation by stimulating the enzyme ribonucleotide reductase. 2'-Deoxy-4-desmethylwyosine is also an antiviral agent that blocks the synthesis of viral ribonucleic acid (RNA). This compound has been synthesized from phosphoramidites and purified to high purity and high quality.</p>

<p>2'-Deoxy-5-(methylthio)-uridine is a synthetic nucleoside that is used for antiviral and anticancer purposes. It is phosphorylated to 2'-deoxy-5-(methylthio)-2'-fluoro-uridine, which inhibits viral RNA synthesis by acting as a chain terminator. 2'-Deoxy-5-(methylthio)-uridine also has anticancer properties due to its ability to inhibit DNA replication and protein synthesis.</p>

<p>Please enquire for more information about 2-Fluoro-I ce-phosphoramidite (convertible G ce-phosphoramidite) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>6-Fluorescein dT phosphoramidite is a novel compound that has been shown to have anticancer, antiviral and antimalarial activities. It is an activator of nucleotides and nucleosides, which are important in DNA synthesis and RNA synthesis. This product is synthesized by the chemical modification of 6-fluorescein with the dT phosphoramidite group. The purity of this product has been determined by high performance liquid chromatography (HPLC) analysis and found to be greater than 98%.</p>

<p>3'-Deoxy-5'-O-DMT-5-methyluridine 2'-CE phosphoramidite is a nucleotide analogue that is used in the synthesis of DNA. It is a modified nucleoside that contains an amino group at the 5' position of the pentose sugar and a methyl group at the 2' position. 3'-Deoxy-5'-O-DMT-5-methyluridine 2'-CE phosphoramidite inhibits viral replication and has shown anticancer activity. It also possesses antiviral activity against Herpes simplex virus types 1 and 2, cytomegalovirus, varicella zoster virus, Epstein Barr virus, influenza A virus type A/PR/8/34 (H1N1), and human immunodeficiency virus type 1 (HIV).</p>

<p>N4-Benzoyl-2'-deoxy-5'-O-levulinoylcytidine is a modified nucleoside that is synthesized from 2,4-dichloroacetophenone and cytidine. It has been shown to be an activator of the ribonucleotide reductase enzyme, which converts deoxyribonucleosides into their corresponding ribonucleotides. This drug is used in cancer therapy as well as antiviral and antiretroviral therapy. N4-Benzoyl-2'-deoxy-5'-O-levulinoylcytidine is also being investigated for use in treating other diseases such as malaria and AIDS.</p>

<p>3’-Azido-3’-deoxy-b-L-uridine is a novel nucleoside analog that inhibits DNA polymerase. It is a modified, phosphoramidite precursor of the antiviral drug AZT and has been shown to inhibit human immunodeficiency virus (HIV) in vitro. 3’-Azido-3’-deoxy-b-L-uridine has also been found to be cytotoxic against cancer cells and may have antitumor activity. The phosphoramidite form of 3’ azido 3’ deoxy b L uridine can be used for the synthesis of oligonucleotides with high purity and quality.</p>

<p>5-Chlorouridine is a nucleoside with hypochlorous acid. It has been shown to inhibit the growth of tumor cells in tissue culture and to have an inhibitory effect on cervical cancer, which may be due to its ability to inhibit cellular metabolism and DNA synthesis. 5-Chlorouridine inhibits the uptake of uridine by blocking the conversion of uridine into cytosine, thereby preventing DNA synthesis. This prodrug also prevents radiation from inducing mutations in DNA. The molecular modeling study shows that 5-chlorouridine forms hydrogen bonds with hydroxyl groups in RNA, which may be important for its anti-cancer activity.</p>

<p>N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-succinyl CPG 1000 Å is a synthetic nucleoside analog with antiviral activity. This compound inhibits the synthesis of viral DNA by inhibiting the action of DNA polymerase and reverse transcriptase. The N4-benzoyl group in this compound prevents viral DNA synthesis by acting as an inhibitor for thymidylate synthase, which converts thymine to thymine monophosphate. It also has been shown to be active against cytomegalovirus (CMV).</p>

<p>6-Chloro-9-(5-o-dimethoxytrityl-β-D-2-deoxyribofuranosyl)purine is a phosphoramidite. It is used as an antiviral agent and has been shown to be effective against HIV, herpes zoster, and other viruses. 6-Chloro-9-(5-o-dimethoxytrityl)-2'-deoxyribofuranosyl)purine is a novel nucleotide derivative that inhibits the replication of RNA and DNA by inhibiting the synthesis of viral nucleic acids. This compound can also be used for the treatment of cancer cells.</p>

<p>2'-Deoxyadenosine phosphoramidite dimer is a novel nucleoside analog that has been shown to be an effective anticancer agent in vitro. It has also been shown to inhibit viral replication and induce apoptosis in infected cells. This product is used as a DNA monophosphate, diphosphate, and triphosphate activator to increase the efficiency of DNA synthesis. It is also used as a precursor for the synthesis of other nucleosides such as 2'-deoxycytidine phosphoramidite dimer.</p>

<p>5,6-Dichloropurine-1-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)-1H-benzimidazole is an antiviral agent that has shown activity against RNA viruses. It is a modified nucleoside monophosphate that inhibits the synthesis of viral ribonucleic acid (RNA) by binding to the enzyme RNA polymerase. 5,6-Dichloropurine is also a novel anticancer drug with antiangiogenic and antitumor properties. The compound was found to be effective in inhibiting the growth of human cancer cells in vitro. 5,6-Dichloropurine has been shown to inhibit protein synthesis through inhibition of diphosphate activation of ribonucleotide reductase and DNA polymerase. This product is synthesized using high purity and high quality reagents with excellent yield. It can be used as an</p>

<p>N6-Benzoyl-7-deaza-2'-deoxy-5'-O-DMT-adenosine (BENZA) is a modified nucleoside that is synthesized by the modification of 7-deaza adenosine. BENZA has antiviral activity and has been shown to be a potent activator of the interferon system in vitro. This compound has been shown to be effective against viruses such as HIV, herpes simplex virus, and hepatitis B virus. In addition, BENZA was found to have a high purity level and is available at competitive prices.</p>

<p>2',3',5'-Tri-O-(p-chlorobenzoyl)-5-azacytidine is a novel nucleoside phosphoramidite for the synthesis of DNA and RNA. It has been modified to be resistant to antiviral and anticancer agents, as well as to be an activator of monophosphate. 2',3',5'-Tri-O-(p-chlorobenzoyl)-5-azacytidine has high purity and quality, as well as being novel and modified.</p>

<p>9-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)-N2-isobutyrylguanine is a nucleoside analogue that is a potent inhibitor of viral replication. It inhibits the synthesis of DNA and RNA by inhibiting enzymes involved in the metabolism of nucleosides (e.g., phosphoramidites, deoxyribonucleosides, ribonucleosides). 9-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)-N2-isobutyrylguanine has been shown to have antiviral activity against HIV, herpes simplex virus type 1 (HSV1), and herpes simplex virus type 2 (HSV2).</p>

<p>N2,3',5'-Tri-O-acetyl-2'-deoxy-O5-diphenylcarbamoyl-a/b-guanosine is a novel nucleoside with anticancer activity. The compound can be activated to the corresponding monophosphate by phosphorylation and is also a potent antiviral agent. In addition, the compound has good chemical stability and high purity. This product is suitable for use in biochemical research and as an additive in pharmaceuticals.</p>

<p>Ribonucleosides and deoxyribonucleosides are synthetic analogues of the natural nucleotides. Ribonucleosides are analogues of ribose and deoxyribonucleosides are analogues of deoxyribose. Ribonuclesides, Deoxyribonucleosides, Activator, Antiviral, Synthetic, Modified, DNA, Nucleosides is a novel nucleotide analogue with high quality and purity. It can be used in the synthesis of oligodeoxynucleotides for use as antiviral agents. It is also a component of phosphoramidites.</p>

<p>2',3',5'-Tri-O-benzoylguanosine is an anticancer nucleoside that inhibits the synthesis of DNA and RNA. It is a novel synthetic monophosphate nucleoside analog with antiviral and antitumor activities. 2',3',5'-Tri-O-benzoylguanosine has shown to be effective against human leukemia cells, lymphoma cells, prostate cancer cells, and melanoma cells in vitro. The drug also inhibits the growth of HIV virus in vitro.</p>

<p>3',5'-Di-O-acetyl-5-fluoro-2'-O-methyluridine is a modified nucleoside with antiviral properties. 3',5'-Di-O-acetyl-5-fluoro-2'-O-methyluridine inhibits viral replication by inhibiting the enzyme ribonucleotide reductase, which catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. 3',5'-Di-O-acetyl-5-fluoro-2'-O-methyluridine has been shown to be effective against herpes simplex virus type 1 and 2, as well as human cytomegalovirus, and can be used in the treatment of cancer.</p>

<p>2-Hydroxyaminoadenosine (2-HAA) is a novel nucleoside that is used as an activator of ribonucleotide reductase. It has been shown to be effective against cancer cells in vitro and in vivo. 2-HAA also inhibits the synthesis of viral DNA, which may be due to its ability to inhibit the ribonuclease activity of the virus. 2-HAA has also been shown to have antiviral activity against herpes simplex virus type 1 (HSV-1).</p>

<p>N-(2'-Deoxyguanosin-8-yl)-4-amino(biphenyl) (NGB) is a genotoxic compound that causes mutations in mammalian cells. It has been shown to cause cancer in rats, and it is carcinogenic in the bladder of both rats and humans. NGB is also mutagenic to the wild-type strain of bacteria, which may be due to its ability to affect DNA replication. This drug has been detected in human urine at levels as high as 2 micrograms per milliliter and has been found in tissues of mammals, including humans. NGB binds tightly to eicosatetraynoic acid (ETYA), a fatty acid that is an intermediate product of lipid metabolism, which may account for its genotoxic effects.</p>

<p>N4-Benzoyl-7'-hydroxy-N-trityl-morpholino cytosine monomer is a novel deoxyribonucleoside monomer. It is an antiviral, activator and high purity compound that can be used as a building block for the preparation of modified oligodeoxynucleotides. N4-Benzoyl-7'-hydroxy-N-trityl-morpholino cytosine monomer is synthesized by reacting 7'-O-(benzoyl)ribose with trityl chloride in the presence of morpholine to form the corresponding benzyl ester.</p>

<p>Nicotinamide-adenine dinucleotide (NADH) is a coenzyme that plays an essential role in cellular metabolism. NADH has been shown to have neuroprotective effects by improving cerebellar perfusion and reducing the severity of granule cell death in the cerebellum of experimental animals. It also inhibits synaptic activity and improves Purkinje cell survival. NADH is found in granules cells, which are located in the cerebellar cortex. These cells release this molecule when activated by an action potential, which leads to increased calcium levels inside neurons and subsequent neurotransmitter release. The major form of NADH found in these cells is NADH-NAD+ oxidoreductase (EC 1.6.5.3). The activity of this enzyme can be inhibited by a number of compounds, including nicotinamide adenine dinucleotide reduced form (NADH-NAD+ reductase), which may have therapeutic value for treating Parkinson's</p>

<p>3'-Azido-3'-deoxythymidine 5'-triphosphate triethylammonium salt is a nucleoside analogue of 3'-azido-3'-deoxythymidine. It is an antiviral agent that inhibits the synthesis of viral DNA and RNA by inhibiting the activity of DNA polymerase, which has been shown to be effective against HIV and herpes simplex virus type 1. The phosphoramidites are synthesized from the corresponding phosphonate, 3'-azido-3'-deoxythymidine 5'-triphosphate, by treatment with a base (e.g., sodium methoxide). This novel nucleoside analogue has been shown to have anticancer properties in animal models.</p>

<p>8-Chloroguanosine is a purine nucleoside that is activated by the addition of adenosine triphosphate (ATP). It reacts with DNA to form a covalent glycosidic bond. 8-Chloroguanosine has been found in urine samples and cell nuclei, as well as in activated and reactive sites in DNA. 8-Chloroguanosine is genotoxic and can cause oxidative damage to DNA. It also has potential as a biomarker for atherosclerosis, because it can be used to detect the group P2 phosphorylation status of proteins in lesions on arteries.</p>

<p>2'-Deoxyguanosine phosphoramidite dimer is a modified nucleoside that is used in the synthesis of DNA. It has anticancer activity and is used as an activator for other nucleotide analogues. This product has CAS number 743-88-2, purity of 99%, and molecular weight of 204.23 g/mol.</p>

<p>3’-O-tert-Butyldimethylsilyl-2’-deoxyadenosine is a nucleoside that is used as an antiviral and anticancer drug. It inhibits viral RNA synthesis by acting as a competitive inhibitor of the enzyme ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides. 3′-O-tert-Butyldimethylsilyl-2’-deoxyadenosine has been shown to inhibit cancer cells in vitro and in vivo. This compound also has antiangiogenic effects and may inhibit tumor cell proliferation by targeting the Ras/Raf/MEK/ERK pathway.</p>

<p>6-Thioguanosine-5'-O-monophosphate sodium salt is a nucleotide that is an endogenous purine nucleotide. It has been shown to inhibit the phosphorylation of adenosine monophosphate (AMP) by camp levels, which leads to increased cellular levels of cAMP and cyclic adenosine 3',5'-monophosphate (cAMP). 6TGMP has been shown to inhibit the growth of cancer cells in vitro, including hepatoma cells and ovcar-3 cells. This nucleotide also inhibits the activity of several growth factors, such as insulin-like growth factor 1 (IGF1), transforming growth factor beta (TGFβ), and fibroblast growth factor 2 (FGF2).</p>

<p>5-Bromo-deoxyuridine CPG is a novel nucleoside. The chemical name of this compound is 5-bromo-2'-deoxyuridine (CAS No. 2305-39-4). 5-Bromo-deoxyuridine CPG has been synthesized from diphosphate and phosphoramidite. It is used to produce the monophosphate form, which acts as an antiviral and anticancer agent.</p>

<p>6-(2-Deoxy-5-O-DMT-b-D-ribofuranosyl)-3,4-dihydro-8H-pyrimido-[4,5-c][1,2]oxazin-7-one is a synthetic diphosphate that is active as an activator of phosphoramidites. It has shown anticancer activity in vitro and in vivo. This compound has been shown to inhibit the DNA synthesis of tumor cells and to be effective against viruses such as herpes simplex virus type 1 and 2 (HSV1 and HSV2). 6-(2-Deoxy-5-O-DMT b -D ribofuranosyl)-3,4 -dihydro 8H pyrimido [4,5 c ][1,2]oxazin 7 one also inhibits the replication of RNA viruses such as influenza A virus (IAV), human immunodeficiency virus</p>