Nucléosides
Les nucléosides sont des building blocks fondamentaux des acides nucléiques, composés d'une base azotée attachée à une molécule de sucre. Dans cette section, vous trouverez une large gamme de nucléosides essentiels pour la recherche en biologie moléculaire, biochimie et pharmacologie. Ces composés jouent des rôles cruciaux dans la synthèse de l'ADN et de l'ARN, et sont également vitaux dans divers processus métaboliques. Les nucléosides sont utilisés pour étudier le matériel génétique, développer des thérapies antivirales et anticancéreuses, et comprendre les mécanismes cellulaires. Chez CymitQuimica, nous proposons des nucléosides de haute qualité pour soutenir vos besoins en recherche et développement, garantissant pureté et fiabilité pour vos applications expérimentales.
3569 produits trouvés pour "Nucléosides"
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2'-O-tert-Butyldimethylsilyl-5-methyluridine
CAS :2'-O-tert-Butyldimethylsilyl-5-methyluridine is a monophosphate of 5-methyluridine. It is an analog of uracil and has been used as an antiviral agent, as well as for the prevention of colorectal cancer. 2'-O-tert-Butyldimethylsilyl-5-methyluridine is also known to be a potent activator of the ribonucleotide reductase enzyme, which may contribute to its anticancer effects. This compound has a high purity and quality, making it easy to use in various applications.Formule :C16H28N2O6SiDegré de pureté :Min. 95%Masse moléculaire :372.49 g/molBiotin-11-deoxyuridine-5'-triphosphate, triethylammonium salt - 1 mM aqueous solution
CAS :Biotin-11-deoxyuridine-5'-triphosphate, triethylammonium salt (Biotin-11-dUTP) is a nucleotide analog that is used as a fluorescent substrate for detection of DNA. It is nonradioactive and can be detected in aqueous solution. Biotin-11-dUTP binds to the 3' end of a DNA strand and becomes incorporated into the newly synthesized DNA strand during DNA replication. The incorporation of Biotin-11-dUTP into the newly synthesized strand causes an increase in fluorescence intensity, which can be detected by chemiluminescence. This nucleotide analog has been shown to have high sensitivity for detecting low levels of dsDNA in diploid cells and can be used for detection of bacterial strain, such as Salmonella enterica serovar Typhimurium.Formule :C34H56N7O18P3SDegré de pureté :Min. 95%Masse moléculaire :975.83 g/mol2'-Deoxy-5'-O-DMT-2-thio-N4-toluoylthymidine 3'-CE phosphoramidite
CAS :2'-Deoxy-5'-O-DMT-2-thio-N4-toluoylthymidine 3'-CE phosphoramidite is a novel nucleoside analogue with anticancer activity. It has been shown to inhibit the proliferation of human colon cancer cells in vitro, and inhibits the growth of HIV in cultured T-cells. In addition, this compound was found to be active against herpes virus. 2'-Deoxy-5'-O-DMT-2-thio-N4-toluoylthymidine 3'-CE phosphoramidite is a nucleoside analogue with ribonucleosides at the 2' and 5' positions, while the 4' position is modified by an acetyl group. This modification prevents incorporation into DNA or RNA, and so prevents viral replication.Formule :C48H56N5O7PSDegré de pureté :Min. 95%Masse moléculaire :878.05 g/mol3'-O-DMT-thymidine 3'-succinyl CPG 1000 Å
3'-O-DMT-thymidine 3'-succinyl CPG 1000 Å is a monophosphate nucleoside that is used in the synthesis of DNA. It is an antiviral and anticancer drug that inhibits viral replication by competing with natural diphosphate nucleosides. 3'-O-DMT-thymidine 3'-succinyl CPG 1000 Å also has shown to be effective against leukemia cells in vitro and has been shown to inhibit angiogenesis, which may be due to its ability to inhibit the proliferation of endothelial cells.Degré de pureté :Min. 95%4-Chloro-5-aminopyrimidine
CAS :4-Chloro-5-aminopyrimidine (4CAP) is an inhibitor of the enzyme purine nucleoside phosphorylase, which is involved in the synthesis of purines and pyrimidines. 4CAP has potent inhibitory activity with a Ki value of 0.06 μM, which is comparable to that of zebularine. 4CAP has also been shown to have antiinflammatory properties in lung tissue. The molecular modeling studies show that 4CAP binds to the hydroxyl group on the enzyme and prevents it from forming a covalent bond with its substrate. This causes a decrease in the rate of reaction time for the enzyme, resulting in decreased production of purines and pyrimidines.
Formule :C4H4ClN3Degré de pureté :Min. 95%Masse moléculaire :129.55 g/mol3'-Azido-3'-deoxy-5'-O-tritylthymidine
CAS :An intermediate in the production of Zidovudine, the FDA approved medication for treatment of AIDS.Formule :C29H27N5O4Degré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :509.56 g/mol5'-O-DMT-thymidine-3'-lcaa-CPG
5'-O-DMT-thymidine-3'-lcaa-CPG is a nucleoside, ribonucleoside, and diphosphate that inhibits viral DNA synthesis. It is a novel compound with antiviral properties that has been shown to inhibit the replication of human cytomegalovirus (HCMV) and herpes simplex type 1 virus. 5'-O-DMT-thymidine-3'-lcaa-CPG also functions as an anticancer agent by inhibiting DNA synthesis in tumor cells. This nucleoside analog is phosphoramidite, which can be used for the preparation of modified oligonucleotides. 5'-O-DMT-thymidine-3'-lcaa-CPG has high purity and high quality.Degré de pureté :Min. 95%Couleur et forme :Powder2',3'-Dideoxyguanosine-5'-triphosphate
CAS :2',3'-Dideoxyguanosine-5'-triphosphate (ddGTP) is a nucleotide analog that inhibits the formation of DNA and RNA, which are important for protein synthesis. It is used in clinical studies to assess prognosis and to evaluate drug elimination. ddGTP has been shown to inhibit mitochondrial membrane potential, decrease mitochondrial superoxide, and inhibit cancer growth. It also prevents allergic reactions by preventing the release of histamine. The use of probiotic bacteria containing ddGTP may help in the treatment of inflammatory bowel disease.Formule :C10H14N5O6PDegré de pureté :Min. 95%Masse moléculaire :331.22 g/mol5'-O-DMT-N2-isopropylphenoxyacetyl-2'-O-(2-methoxyethyl)guanosine 3'-O succinate TEA salt
5'-O-DMT-N2-isopropylphenoxyacetyl-2'-O-(2-methoxyethyl)guanosine 3'-O succinate TEA salt is a modified nucleoside with anticancer activity. It is a diphosphate that can be used for the synthesis of DNA and RNA. This product is synthesized by the reaction of 5'-O-dimethoxytritylthymidine (5'-DMTT), 2'-O-(2-methoxyethyl)hydroxylamine hydrochloride, and succinic anhydride in the presence of triethylamine. The product is purified by column chromatography, followed by recrystallization from hot acetonitrile. CAS No.: 102972-73-0Formule :C49H52N5O13·C6H16NDegré de pureté :Min. 95%Masse moléculaire :1,021.16 g/mol5’-Deoxy-5’-iodouridine
CAS :5’-Deoxy-5’-iodouridine (5DIU) is an antiviral agent that inhibits the synthesis of DNA by interfering with the enzyme thymidine kinase, which converts thymine to uracil. It is used in the treatment of cutaneous herpes simplex virus infections. 5DIU has been shown to inhibit viral replication and yield in vitro. The drug showed no significant toxicity in mice, rats, or hamsters. In addition, it has been observed that 5DIU does not interfere with human cell growth, which may be due to its lack of activity against a wide range of human enzymes.Degré de pureté :Min. 95%Gemcitabine 5'-elaidate
CAS :Gemcitabine 5'-elaidate is an analog of gemcitabine that has hydrophobic properties. It has been shown to be active against solid tumours, including lung cancer. In a study on murine xenografts, gemcitabine 5'-elaidate was found to have the same degree of efficacy as gemcitabine in reducing tumour growth and increasing survival time. Gemcitabine 5'-elaidate also has good antitumour activity against infectious diseases such as HIV and malaria, which may be due to its ability to bind to the epidermal growth factor receptor (EGFR) on the surface of cells. This binding prevents EGFR from initiating cellular signaling.
Formule :C27H43F2N3O5Degré de pureté :Min. 95%Masse moléculaire :527.66 g/molAMP PNP tetralithium salt
CAS :Non-hydrolyzable AMP analog
Formule :C10H13Li4N6O12P3Degré de pureté :Min. 95%Masse moléculaire :529.93 g/mol5-Amino-1-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)-imidazole-4-carboxamide
CAS :5-Amino-1-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)-imidazole-4-carboxamide (AICAR) is a high purity novel nucleotide analog that has been shown to be an activator of AMPK. AICAR can act as a substitute for ATP, the molecule that drives cellular energy production. AICAR has been shown to inhibit tumor growth and induce apoptosis in cancer cells. This compound also inhibits viral RNA replication by competitively binding to the enzyme polymerase, which is essential for viral replication.
Formule :C15H20N4O8Degré de pureté :Min. 95%Masse moléculaire :384.34 g/mol5-Fluoro-1-(2'-deoxy-2'-fluoro-5'-O-trityl-b-L-lyxofuranosyl)-uracil
5-Fluoro-1-(2'-deoxy-2'-fluoro-5'-O-trityl-b-L-lyxofuranosyl)-uracil is a phosphoramidite, activator, and synthetic nucleoside that has been modified to contain fluorine atoms. 5-Fluoro-1-(2'-deoxy-2'-fluoro-5'-O-trityl-b-L-lyxofuranosyl)-uracil is an antiviral agent that was developed for the treatment of HIV/AIDS and cancer. It inhibits the synthesis of DNA by inhibiting the enzyme ribonucleotide reductase. This drug also has anticancer properties because it inhibits the synthesis of DNA in tumor cells and activates apoptosis, causing cell death.Degré de pureté :Min. 95%2-Amino-4-(thien-2-yl)pyrimidine
CAS :2-Amino-4-(thien-2-yl)pyrimidine is a bioavailable, water soluble antiallergy drug. 2-Amino-4-(thien-2-yl)pyrimidine has been shown to be effective against allergic asthma and other allergic diseases. It is thought to work by blocking the release of histamine from mast cells, thereby preventing the production of inflammatory prostaglandins and leukotrienes. This drug also blocks the response to allergies by inhibiting the release of IgE antibodies that bind to allergens. The therapeutic effect of 2-amino-4-(thien-2-yl)pyrimidine is repeatable and it does not cause any adverse effects on potassium or carbonate metabolism.Formule :C8H7N3SDegré de pureté :Min. 95%Masse moléculaire :177.23 g/mol1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)uracil 3'-CE phosphoramidite
CAS :1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)uracil 3'-CE phosphoramidite is a novel nucleoside monophosphate that has been modified with fluorine at the 2' position and a deoxyribose sugar. 1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)uracil 3'-CE phosphoramidite may be useful for antiviral treatment, as it can inhibit human immunodeficiency virus type 1 (HIV1) replication in vitro by inhibiting HIV1 reverse transcriptase. This drug also has anticancer properties, which may be due to its ability to inhibit DNA synthesis or promote apoptosis.Formule :C39H46FN4O8PDegré de pureté :Min. 95%Couleur et forme :White To Off-White SolidMasse moléculaire :748.8 g/mol1-(2',3'-Dideoxy-2',3'-didehydro-2'-fluoro-5'-O-trityl-b-L-ribofuranosyl)-uracil
1-(2',3'-Dideoxy-2',3'-didehydro-2'-fluoro-5'-O-trityl-b-L-ribofuranosyl)-uracil is a synthetic nucleoside that is activated by phosphorylation. This nucleoside is an antiviral and anticancer agent, and has been shown to be active against HIV, cytomegalovirus, herpes simplex virus type 1, and lymphocytic leukemia cells. It has also been shown to have anti-inflammatory properties. The compound is a monophosphate and diphosphate, which are more potent than the corresponding ribonucleosides. 1-(2',3'-Dideoxy-2',3'-didehydro-2'-fluoro-5'-O-trityl-b-L-ribofuranosyl)-uracil has CAS number 26582, high purity, high quality.Formule :C28H23FN2O4Degré de pureté :Min. 95%Masse moléculaire :470.49 g/mol2',3'-Dideoxyadenosine-5'-triphosphate lithium
CAS :2',3'-Dideoxyadenosine-5'-triphosphate lithium salt is a nucleoside for use in research applicationsFormule :C10H16N5O11P3•Li3Degré de pureté :Min. 95%Couleur et forme :Clear liquid.Masse moléculaire :496 g/mol2,6-Diamino-9-(2'-deoxy-2'-fluoro-b-D-arabinofuranosyl)purine
CAS :2,6-Diamino-9-(2'-deoxy-2'-fluoro-b-D-arabinofuranosyl)purine is a synthetic purine nucleoside analog. The fluorine substitution and sugar modification allow it to mimic natural nucleosides but disrupt DNA or RNA synthesis when incorporated. The fluorine makes the molecule more chemically stable and can influence how enzymes interact with it. Like other nucleoside analogs, it has the potential to act as a chain terminator or inhibit key enzymes like polymerases or reverse transcriptases.Formule :C10H13FN6O3Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :284.25 g/molAcetoacetyl coenzyme A trisodium salt tetrahydrate
CAS :Acetoacetyl coenzyme A trisodium salt tetrahydrate is a novel antiviral agent that inhibits the synthesis of viral DNA and RNA. Acetoacetyl CoA has been shown to inhibit the replication of HIV, HSV-1 and HSV-2, influenza virus, and cytomegalovirus (CMV). The mechanism of action is not yet known but may be related to its ability to activate cellular DNA polymerase β. Acetoacetyl CoA also has a high purity and quality, as well as being modified for use in phosphoramidites.Formule :C25H37N7Na3O18P3S·4H2ODegré de pureté :Min. 96 Area-%Couleur et forme :PowderMasse moléculaire :989.62 g/mol
