Nucléosides
Les nucléosides sont des building blocks fondamentaux des acides nucléiques, composés d'une base azotée attachée à une molécule de sucre. Dans cette section, vous trouverez une large gamme de nucléosides essentiels pour la recherche en biologie moléculaire, biochimie et pharmacologie. Ces composés jouent des rôles cruciaux dans la synthèse de l'ADN et de l'ARN, et sont également vitaux dans divers processus métaboliques. Les nucléosides sont utilisés pour étudier le matériel génétique, développer des thérapies antivirales et anticancéreuses, et comprendre les mécanismes cellulaires. Chez CymitQuimica, nous proposons des nucléosides de haute qualité pour soutenir vos besoins en recherche et développement, garantissant pureté et fiabilité pour vos applications expérimentales.
3569 produits trouvés pour "Nucléosides"
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9-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)-N2-isobutyrylguanine 3'-O-succinate triethylammonium salt
9-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)-N2-isobutyrylguanine 3'-O-succinate triethylammonium salt is a modified nucleoside phosphoramidite. It is used as an antiviral and anticancer agent, as well as an activator in DNA synthesis. 9-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)-N2-isobutyrylguanine 3'-O-succinate triethylammonium salt has been shown to be active against HIV, herpes simplex virus type 1, herpes simplex virus type 2, cytomegalovirus, influenza A virus, and human papillomavirus types 16 and 18.Formule :C39H39FN5O10·C6H16NDegré de pureté :Min. 95%Masse moléculaire :858.97 g/mol2'-13CCytidine
CAS :2'-13CCytidine is a cytidine nucleoside that inhibits the synthesis of RNA and DNA in cells. It is an analog of cytarabine, which is a pyrimidine nucleoside and an antineoplastic agent. 2'-13CCytidine has been shown to be effective as an antiviral agent against HIV-1 and HSV-2, as well as an immunosuppressant for the treatment of autoimmune diseases such as rheumatoid arthritis. This drug is used in chemotherapy to inhibit cell division in leukemia.Formule :CC8H13N3O5Degré de pureté :Min. 95%Masse moléculaire :244.21 g/molO6-Benzyl-N2,3-etheno-2'-phenoxythioxomethyl-3',5'-O-[tetrakis(isopropyl)-1,3-disiloxanediyl] guanosine
CAS :O6-Benzyl-N2,3-etheno-2'-phenoxythioxomethyl-3',5'-O-[tetrakis(isopropyl)-1,3-disiloxanediyl] guanosine is a nucleoside phosphoramidite that is used as an antiviral agent. It has been shown to inhibit the replication of RNA viruses and thus inhibit the production of proteins vital for cell division. O6-Benzyl-N2,3-etheno-2'-phenoxythioxomethyl-3',5'-O-[tetrakis(isopropyl)-1,3-disiloxanediyl] guanosine has also been shown to be an anticancer agent by inhibiting DNA synthesis. This compound is synthesized from deoxyribonucleosides and modified with a benzoyl group at the 6 position on the ribose ring. TheFormule :C38H49N5O7SSi2Degré de pureté :Min. 95%Masse moléculaire :776.06 g/mol[U-13C10, U-15N2]-Labelled thymidine
Thymidine is a nucleoside that is a component of DNA and RNA. It is also the precursor for thymine, the DNA base in which the thymine ring is derived from. Thymidine has been shown to be an activator of DNA synthesis, as well as being anticancer and antiviral.Degré de pureté :Min. 95%5'-O-Acetyl-2',3'-dideoxyinosine
CAS :5'-O-Acetyl-2',3'-dideoxyinosine is a nucleoside analogue that inhibits viral replication. It is a potent activator of the immune system and has been shown to be effective against cancer cells. 5'-O-Acetyl-2',3'-dideoxyinosine was originally synthesized as an antiviral agent, but it was found to be ineffective in this function. The drug binds to the ribonucleotide reductase enzyme, which converts ribonucleotides into deoxyribonucleotides and is essential for the production of DNA. The drug blocks the conversion of ribonucleotides into deoxyribonucleotides, preventing DNA synthesis and replication. This drug has also been shown to have anticancer activity by inhibiting DNA synthesis and cell division.Formule :C12H14N4O4Degré de pureté :Min. 95%Masse moléculaire :278.26 g/mol5-Fluoro-1-(2'-deoxy-2'-fluoro-3',5'-di-O-benzoyl-b-L-arabinofuranosyl)-uracil
CAS :5-Fluoro-1-(2'-deoxy-2'-fluoro-3',5'-di-O-benzoyl-b-L-arabinofuranosyl)-uracil (5FUA) is a monophosphate nucleoside that inhibits viral replication. It is phosphorylated by the viral enzyme 3' to 5' exonuclease and then acts as a competitive inhibitor of the natural substrate, diphosphate, at the active site of DNA polymerase. The result is inhibition of viral DNA synthesis and replication. 5FUA has been shown to be active against a variety of viruses including herpes simplex virus types 1 and 2, varicella zoster virus, influenza A virus, and human immunodeficiency virus type 1. This drug has also been shown to inhibit cancer cell proliferation in vitro.Degré de pureté :Min. 95%Thymidylyl-(3′→5′)-thymidine ammonium salt
CAS :Thymidylyl-(3′→5′)-thymidine is a modified nucleoside that has antiviral activity. It is synthesized from thymidine, which is the deoxyribonucleotide of thymine and uracil, by phosphorylation with ATP. Thymidylyl-(3′→5′)-thymidine has been shown to be an activator of DNA polymerase in vitro and inhibits replication of human immunodeficiency virus (HIV) in cell cultures. This compound has been studied as a potential treatment for AIDS.Formule :C20H30N5O12PDegré de pureté :Min. 95%Masse moléculaire :563.5 g/mol2'-Deoxy-5-hydroxymethylcytidine 5'-monophosphate sodium salt
CAS :2'-Deoxy-5-hydroxymethylcytidine 5'-monophosphate sodium salt (2'-dO-5HmcMP) is a nucleoside analogue that inhibits the activity of reverse transcriptase, an enzyme required for replication of HIV. This compound is phosphorylated in vivo to 2'-dO-5HmcMP monophosphate, which then competitively inhibits the binding of dNTPs to the enzyme and prevents DNA synthesis. 2'-dO-5HmcMP also has anticancer activity and has been shown to inhibit the proliferation of cells in vitro. 2'-dO-5HmcMP has no significant toxicity to humans or other mammals.Degré de pureté :Min. 95%1-(2-Deoxy- 2, 2- difluoro- b- D- xylofuranosyl)cytosine
CAS :1-(2-Deoxy-2,2-difluoro-beta-D-xylofuranosyl)cytosine is a nucleoside (a compound consisting of a nucleotide base linked to a sugar). It is a modified form of cytosine that has been phosphorylated at the 2’ position. 1-(2-Deoxy-2,2-difluoro-beta-D-xylofuranosyl)cytosine has antiviral and anticancer activity through its ability to inhibit viral DNA synthesis and activate the immune system. This drug also has antitumor activity due to its ability to inhibit the tumor growth factor beta (TGFB). 1-(2-Deoxy-2,2-difluoro-beta-D -xylofuranosyl)cytosine can be used in cancer treatment as an anticancer agent.Formule :C9H11F2N3O4Degré de pureté :Min. 95%Masse moléculaire :263.2 g/molNicotinamide 1,N6-ethenoadenine dinucleotide
CAS :Nicotinamide 1,N6-ethenoadenine dinucleotide (NADH) is an enzyme form that binds to the active site of glutamate dehydrogenase (GDH). This binding prevents GDH from catalyzing the oxidation of NADH to NAD+, which is necessary for GDH activity. Nicotinamide 1,N6-ethenoadenine dinucleotide is a noncompetitive inhibitor that binds with a higher affinity than the substrate. It has been shown to be effective in inhibiting GDH in a model system and in enzyme preparations. The binding constant for nicotinamide 1,N6-ethenoadenine dinucleotide is 2 mM. The optimum pH for nicotinamide 1,N6-ethenoadenine dinucleotide activity is 6.8.Formule :C23H27N7O14P2Degré de pureté :Min. 97 Area-%Couleur et forme :White Off-White PowderMasse moléculaire :687.45 g/mol2’-O-(2-Methoxyethyl)guanosine 5’-triphosphate ammonium salt
CAS :2’-O-(2-Methoxyethyl)guanosine 5’-triphosphate ammonium salt (2'OMeEtGTP) is an antiviral agent that is used as a component of an antiviral drug. It inhibits the viral enzyme DNA polymerase, which prevents viral replication and transcription. This compound has been shown to have anticancer properties in vitro and in vivo in rat models. 2'OMeEtGTP is synthesized by reacting the nucleoside phosphoramidite 2'OMeEtGTP with triethylammonium phosphate (TEAP).
Degré de pureté :Min. 95%5-Vinylcytidine
CAS :5-Vinylcytidine is a nucleoside analog used in research to study DNA demethylation. It is an orthogonal molecule that can be used in assays to distinguish between different types of methylases. 5-Vinylcytidine is able to oxidize and formylate the N5 position of thymine, which leads to DNA demethylation. The mechanism of this process is not fully understood, but it may involve translocation or homologous recombination. 5-Vinylcytidine has been shown to react with alkyl groups, leading to its use as a probe for biochemical reactions involving methyltransferase enzymes.
Degré de pureté :Min. 95%9-(b-L-Arabinofuranosyl)guanine
CAS :9-(b-L-Arabinofuranosyl)guanine (9-Araf) is a nucleoside analogue that is used as an antiviral and anticancer agent. It is synthesized by the reaction of 2,4-diaminopyrimidine with b-L-arabinofuranosyl chloride. This product is soluble in water and ethanol. 9-(b-L-Arabinofuranosyl)guanine has antiviral activity against Herpes simplex virus type 1, herpes simplex virus type 2, cytomegalovirus, and Epstein Barr Virus. In addition to its antiviral activity, 9-(b-L-Arabinofuranosyl)guanine also has anticancer activity against human cancer cells and has been shown to inhibit the growth of leukemic cells in mice.Formule :C10H13N5O5Degré de pureté :Min. 95%Masse moléculaire :283.24 g/mol2'-Bromo-2'-deoxy-3'-O-methanesulfonyluridine
2'-Bromo-2'-deoxy-3'-O-methanesulfonyluridine is a nucleoside analogue that acts as an activator of the human immunodeficiency virus (HIV). It is thought to work by binding to the viral reverse transcriptase enzyme, which converts the RNA genome into DNA. This prevents the virus from replicating and producing new viruses. 2'-Bromo-2'-deoxy-3'-O-methanesulfonyluridine has also been shown to be active against other viruses such as herpes simplex virus type 1 (HSV1) and influenza A virus.Degré de pureté :Min. 95%4'-Azidothymidine 5-triphosphate
CAS :4'-Azidothymidine 5-triphosphate (4AZTTP) is a deoxyribonucleoside that has been synthesized as an analog to thymidine. It has potent inhibitory activity against human immunodeficiency virus (HIV), and has been shown to be more effective than 2',3'-dideoxyinosine in inhibiting HIV replication. 4AZTTP inhibits the viral enzyme reverse transcriptase, which is crucial for the replication of HIV. This drug is activated by cellular enzymes and phosphorylated to 4'-azidothymidine 5'-triphosphate monophosphate, which can then bind to the viral DNA template and inhibit synthesis of RNA strands. The kinetic properties of 4AZTTP have been studied in detail using human lymphocytes as a model system for HIV infection.Formule :C10H16N5O14P3Degré de pureté :Min. 95%Masse moléculaire :523.18 g/mol5'-O-DMT-2'-O-hexylamino-5-methyluridine
CAS :5'-O-DMT-2'-O-hexylamino-5-methyluridine is a nucleoside analog that is used in cancer treatment. It is synthesized by the chemical modification of uridine, which is converted to 5'-O-DMT-2'-O-hexylamino-5-methyluridine by reacting with 2',3'-dideoxyadenosine and 5,6,7,8,-tetrahydroisoquinoline. The monophosphate form of 5'-O-DMT-2'-O-hexylamino-5-methyluridine may be converted to the diphosphate form by phosphorylation with ATP. In addition to its anticancer effects, 5'-O-DMT-2'-O-hexylamino-5-methyluridine has antiviral and antiretroviral effects due to its inhibition of viral DNA synthesis.Formule :C37H45N3O8Degré de pureté :Min. 95%Masse moléculaire :659.79 g/mol9-(2-C-Methyl-b-D-ribofuranosyl)purine
CAS :9-(2-C-Methyl-b-D-ribofuranosyl)purine is a nucleoside that is used as an activator in the synthesis of phosphoramidites. 9-(2-C-Methyl-b-D-ribofuranosyl)purine has antiviral and anticancer properties, and it also inhibits the growth of bacteria. This nucleoside is synthesized from 2,4,6-trichlorophenylisocyanate and 5'-O-(4,4'-dimethoxytrityl)-beta-D-ribofuranose. The chemical name for 9-(2-C methyl b D ribofuranosyl)purine is 690269 - 86 - 4.Formule :C11H14N4O4Degré de pureté :Min. 95%Masse moléculaire :266.25 g/molS-(2-Hydroxy-5-nitrobenzoyl)-6-thioguanosine
CAS :S-(2-Hydroxy-5-nitrobenzoyl)-6-thioguanosine is a benzodiazepine derivative that inhibits the uptake of uridine into cells. It binds to adenosine receptors and inhibits neurotransmission by preventing the release of the inhibitory neurotransmitter GABA. S-(2-Hydroxy-5-nitrobenzoyl)-6-thioguanosine also has an inhibitory effect on mitochondrial function, which may be due to its ability to bind with and inactivate mitochondrial enzyme succinate dehydrogenase. This drug is potent in inhibiting uptake assays, but has low potency and poor bioavailability as a result of its covalent linkages.Formule :C17H18N6O7SDegré de pureté :Min. 95%Masse moléculaire :450.43 g/molFluorescein alkynylamino-ATP - 1.0 mM solution
CAS :Fluorescein alkynylamino-ATP is a fluorescent nucleotide analog that is used in molecular biology for the detection of DNA. It is labeled with tetramethylrhodamine, which can be detected using a fluorescence microscope. Fluorescein alkynylamino-ATP is a postsynthetic modification to DNA, which means it is added after the DNA has been synthesized. This molecule can be incorporated into the growing strand by either monoaddition or polymerase extension. Fluorescein alkynylamino-ATP binds to the 3' end of a primer during polymerase chain reaction (PCR) and can be detected using electrophoresis and sequence analysis.Formule :C41H41N6O20P3Degré de pureté :Min. 95%Masse moléculaire :1,030.71 g/mol5,6-Dihydro-5'-O-DMT-thymidine 3'-CE phosphoramidite
This is a synthetic DNA analogue that is used in the synthesis of oligonucleotides. It is a phosphoramidite in which the 5,6-dihydro-5'-O-DMT group has been modified to allow for incorporation into DNA and RNA. This compound has antiviral and anticancer activities.Formule :C40H51N4O8PDegré de pureté :Min. 95%Masse moléculaire :746.83 g/mol
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