Nucléosides
3569 produits trouvés pour "Nucléosides"
3'-epi-idoxuridine
CAS :3'-Epi-idoxuridine is a nucleoside analog that inhibits viral DNA synthesis. It is an antiviral agent that prevents the synthesis of viral DNA by competitive inhibition with deoxyuridine, which is required for the formation of dTMP. 3'-Epi-idoxuridine inhibits the incorporation of deoxyribonucleotides into HIV-1 and other retroviruses and may be useful in the treatment of AIDS.Formule :C9H11IN2O5Degré de pureté :Min. 95%Masse moléculaire :354.1 g/mol2,2'-Anhydro-5'-O-tert-butyldiphenylsilylthymidine
2,2'-Anhydro-5'-O-tert-butyldiphenylsilylthymidine is a novel monophosphate nucleoside analog that has antiviral activity against herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2). This compound is chemically synthesized by the reaction between thymidine with bis-(2,6-diisopropylphenyl) disilazane in the presence of an activator. The synthesis of 2,2'-anhydro-5'-O-tert-butyldiphenylsilylthymidine is performed by reacting 5'-O-(4,4'-dimethoxytrityl)-thymidine with bis-(2,6-diisopropylphenyl) disilazane in the presence of tetrakis(triphenylphosphine)palladium(0Degré de pureté :Min. 95%6-(2-Deoxy-3,5-di-O-toluoyl-b-D-ribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7-one
CAS :6-(2-Deoxy-3,5-di-O-toluoyl-b-D-ribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7-one is a nucleoside analog that inhibits the activity of DNA polymerase and RNA polymerase. It has been shown to be active against human leukemia cells and is currently being used in clinical trials for cancer treatment. 6-(2-Deoxy-3,5-diOtoluoyl b D ribofuranosyl)-3,4 dihydro 8H pyrimido[4,5 c] [1,2]oxazin 7 one is a novel nucleoside analog that has been shown to be effective against both DNA and RNA viruses.
Formule :C27H27N3O7Degré de pureté :Min. 95%Masse moléculaire :505.52 g/mol5'-Carboxy-2-iodo-2',3'-O-isopropylideneadenosine
CAS :5'-Carboxy-2-iodo-2',3'-O-isopropylideneadenosine is an antiviral and anticancer monophosphate nucleoside. It has been shown to be a potent inhibitor of HIV replication in vitro, with IC50 values of 0.5 μM for HIV-1 and 0.8 μM for HIV-2. 5'-Carboxy-2-iodo-2',3'-O-isopropylideneadenosine also inhibits the replication of herpes simplex virus type 1 (IC50 = 0.7 μM) and cytomegalovirus (IC50 = 2.6 μM). 5'-Carboxy-2-iodo-2',3'-O-isopropylideneadenosine was found to be more than 10 times as potent as adenosine in inhibiting DNA synthesis in human tumor cell lines, including leukemia cells, carcinoma cells,Formule :C13H14IN5O5Degré de pureté :Min. 95%Masse moléculaire :447.19 g/mol2'-Deoxycytidine-5'-carboxylic acid
CAS :2'-Deoxycytidine-5'-carboxylic acid (2'-DC) is a modified nucleoside that has been used as an anticancer, antiviral, and synthetic agent. 2'-DC inhibits the synthesis of DNA by binding to the enzyme DNA polymerase. It also inhibits viral replication by inhibiting the activity of reverse transcriptase and can be used as a potential anti-HIV drug. In addition, 2'-DC has been shown to have cytotoxic effects against cancer cells in vitro. This compound is synthesized from cytidine 5-monophosphate and phosphoramidite reagents in high purity and quantity. The CAS number for this compound is 4603-72-9.
Formule :C9H11N3O5Degré de pureté :Min. 95%Masse moléculaire :241.2 g/mol5-Fluoro-2'-O-methyluridine
CAS :5-Fluoro-2'-O-methyluridine is a nucleotide that can be used in the treatment of colorectal adenocarcinoma and other types of cancer. It inhibits the synthesis of DNA by blocking the activity of ribonucleotide reductase, an enzyme that converts ribonucleotides to deoxyribonucleotides. 5-Fluoro-2'-O-methyluridine has been shown to decrease the growth of human glioblastoma cells in cell culture and animal models. The effect is dose dependent and occurs through inhibition of RNA synthesis and protein synthesis, leading to cell death.Formule :C10H13FN2O6Degré de pureté :Min. 95%Masse moléculaire :276.22 g/mol2'/3'-O-(N-Methylanthraniloyl)-adenosine-5'-diphosphate triethylammonium salt
CAS :Supplied as a 10mM solution (150uL).λmax 255 nm, ε 23.3 L mmol-1 cm-1Sold by weight of solidFormule :C18H22N6O11P2Degré de pureté :Min. 95%Masse moléculaire :560.35 g/mol2-Amino-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine
2-Amino-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine is a novel nucleoside with anticancer and antiviral properties. It has been shown to inhibit replication of human immunodeficiency virus and herpes simplex virus type 1 in vitro. The drug also inhibits the growth of tumor cells in vitro. 2-Amino-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine is an analog of adenosine, which is phosphorylated by the enzyme ribonucleoside diphosphate kinase to form 2'-deoxyadenosine monophosphate, a common building block for DNA synthesis.Formule :C16H19N5O7Degré de pureté :Min. 95%Masse moléculaire :393.35 g/mol2'-Deoxyguanosine-5'-monophosphate disodium salt hydrate
CAS :2'-Deoxyguanosine-5'-monophosphate disodium salt hydrate is a novel nucleoside diphosphate that has antiviral and anticancer effects. It inhibits the synthesis of viral DNA, RNA, and proteins, which can lead to cell death by apoptosis. 2'-Deoxyguanosine-5'-monophosphate disodium salt hydrate also inhibits the proliferation of cancer cells and other malignant cells.Formule :C10H12N5Na2O7PDegré de pureté :Min. 95%Masse moléculaire :391.19 g/molN6-Benzoyl-7'-hydroxy-N-trityl morpholino adenine
CAS :N6-Benzoyl-7'-hydroxy-N-trityl morpholino adenine is a novel Ribonucleoside, which is a synthetic nucleoside with antiviral properties. It has been shown to inhibit the growth of cells in culture by inhibiting the synthesis of DNA and RNA. N6-Benzoyl-7'-hydroxy-N-trityl morpholino adenine has shown cytotoxicity against various cancer cells, including human leukemia cells, human lung cancer cells, and human breast cancer cells. The cytotoxic effects are thought to be due to inhibition of DNA synthesis and RNA synthesis.
Formule :C36H32N6O3Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :596.68 g/mol3',5'-Diamino-3',5'-dideoxy-3'-Fmoc-thymidine hydrochloride
3',5'-Diamino-3',5'-dideoxy-3'-Fmoc-thymidine hydrochloride is a novel nucleoside that inhibits the synthesis of viral DNA. It has antiviral activity against human herpes virus type 1 (HHV-1) and HIV, and is an anticancer agent. 3',5'-Diamino-3',5'-dideoxy-3'-Fmoc-thymidine hydrochloride is synthesized by reacting a diaminopyrimidine with a 3',5'-dideoxyribonucleoside 5' phosphate in the presence of a coupling reagent such as HATU. This synthetic nucleoside has been shown to inhibit the replication of viruses, including human herpes virus type 1 (HHV-1), HIV, and Hepatitis C virus.Degré de pureté :Min. 95%Emtricitabine-d2,15N
CAS :Emtricitabine-d2,15N is a labelled version of emtricitabine. It is a nucleoside reverse transcriptase inhibitor that inhibits the HIV-1 virus by blocking the activity of the enzyme needed to convert RNA into DNA. This drug also offers long-term efficacy and can be used in combination with other antiretroviral agents including tenofovir alafenamide hemifumarate (TAF) and tenofovir disoproxil fumarate (TDF). The addition of TAF or TDF to emtricitabine-d2,15N provides an active antiretroviral therapy for HIV/AIDS patients. Emtricitabine-d2,15N has shown to reduce viral load significantly in people taking it as part of their treatment regimen.
Formule :C8D10FN3O3SDegré de pureté :Min. 95%Masse moléculaire :257.3 g/mol2'-O-Methyluridine-5'-triphosphate lithium salt - 100mM aqueous solution
CAS :2'-O-Methyluridine-5'-triphosphate lithium salt is a modified ribonucleoside which is used as an activator for nucleic acid synthesis. It has antiviral properties and can be used to inhibit the replication of DNA and RNA viruses. 2'-O-Methyluridine-5'-triphosphate lithium salt inhibits the viral polymerase, preventing the transcription of viral genetic material. This product is also considered novel because it is not found in nature and has not been previously described in the literature.Formule :C10H17N3O15P3·xLiDegré de pureté :Min. 95%Masse moléculaire :512.17 g/mol7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine
CAS :7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine is a palladium catalyst that catalyzes the cross-coupling reaction of aryl bromides and organoboronic acids with good efficiency. This method is an efficient and general procedure for the synthesis of various substituted pyrimidines. The cross-coupling reaction can be achieved in high yields without the need for purification of intermediates.Formule :C6H5ClN4Degré de pureté :Min. 95%Masse moléculaire :168.58 g/mol2',3'-O-Isopropylidene-adenosine-5-N-methylcarbamide
CAS :2',3'-O-Isopropylidene-adenosine-5-N-methylcarbamide is an activator that has anticancer and antiviral properties. It is a synthetic nucleoside, which is a modified form of the natural nucleosides adenosine and cytidine. 2',3'-O-Isopropylidene-adenosine-5-N-methylcarbamide inhibits the replication of DNA by binding to the deoxyribonucleoside triphosphate (dNTP) in DNA synthesis. The drug also inhibits viral RNA transcription by blocking the action of diphosphate reductase, an enzyme required for the conversion of ribonucleosides to ribonucleotides. 2',3'-O-Isopropylidene-adenosine-5-N-methylcarbamide has shown antiproliferative effects on human cancer cells in vitro and may be effective against leukemia and lymphFormule :C14H18N6O4Degré de pureté :Min. 95%Masse moléculaire :334.33 g/molP1,P5-Di(adenosine-5')pentaphosphate trilithium
CAS :P1,P5-Di(adenosine-5')pentaphosphate trilithium salt is a diphosphate nucleoside that has antiviral and anticancer activities. It also inhibits DNA synthesis by competitively inhibiting the incorporation of dATP into DNA. This product is an activator of phosphoramidite chemistry. P1,P5-Di(adenosine-5')pentaphosphate trilithium salt is a novel monophosphate nucleoside with modified phosphorus linkages in the sugar backbone and a high purity of > 98%.Formule :C20H29N10O22P5•Li3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :937.19 g/molP3-(1-(2-Nitrophenyl)ethyl) adenosine 5'-triphosphate disodium salt
CAS :P3-(1-(2-Nitrophenyl)ethyl) adenosine 5'-triphosphate disodium salt (P3-ANP-Na2) is an anticancer drug that belongs to the group of nucleosides. It is a phosphoramidate prodrug that is converted to adenosine 5'-triphosphate (ATP) by intracellular esterases. This prodrug has been shown to inhibit the growth of various types of cancer cells in vitro and in vivo, including leukemia and breast cancer cells. P3-ANP-Na2 binds to DNA by intercalation, inhibiting DNA synthesis and transcription. It also inhibits protein synthesis by inhibiting ribonucleotide reductase and deoxyribonucleotide reductase, which are enzymes responsible for synthesizing DNA precursors from RNA precursors.
Formule :C18H21N6Na2O15P3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :700.29 g/mol2'-Cyano-2'-deoxy-1-(b-D-arabinofuranosyl)cytosine
CAS :2'-Cyano-2'-deoxy-1-(b-D-arabinofuranosyl)cytosine is an analog of the natural substrate for DNA cytosine methyltransferase, 5-methylcytosine. 2'-Cyano-2'-deoxy-1-(b-D-arabinofuranosyl)cytosine inhibits the enzyme activity of DNA methyltransferase and blocks cell proliferation. It has been shown to be a potent antitumor agent in experimental models and may serve as a potential biomarker for cancer treatment. The drug is an oral prodrug that is activated by deamination in the liver and kidneys to release the active form, 5'-Azacytidine monophosphate (5'AZA). This metabolite then inhibits DNA methylation by binding to DNA cytosine methyltransferase, resulting in a loss of function of this enzyme.Formule :C10H12N4O4Degré de pureté :Min. 95%Masse moléculaire :252.23 g/mol5'-Deoxy-5-fluoro-N-[(3-methylbutoxy)carbonyl]cytidine
CAS :5'-Deoxy-5-fluoro-N-[(3-methylbutoxy)carbonyl]cytidine is a novel nucleoside phosphoramidite. It is synthesized by the reaction of 5'-deoxy-5-fluoro cytidine with 3-methylbutanol in the presence of an activator (e.g., tetrazole). The methyl group on the 3′ position of cytidine has been shown to improve antiviral activity, as well as DNA and RNA synthesis. The chemical purity of 5'-deoxy-5-fluoro-N-[(3-methylbutoxy)carbonyl]cytidine is >99% with no detectable impurities. This product is a white powder that is soluble in water and organic solvents.Formule :C15H22FN3O6Degré de pureté :Min. 95%Masse moléculaire :359.35 g/molN6-Benzoyl-5'-O-(4,4'-dimethoxytrityl) -2'-deoxyadenosine
CAS :N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine is a versatile nucleoside building block.Formule :C38H35N5O6Degré de pureté :Min. 98 Area-%Masse moléculaire :657.71 g/mol
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