Nucléosides

<p>Functionalised adenosine riboside</p>

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<p>2'-Deoxyadenosine is a nucleoside that is found in DNA. It has been shown to have potent anticancer activity against carcinoma cell lines and to bind to the adenosine receptor A3. 2'-Deoxyadenosine has also been shown to inhibit the production of inflammatory cytokines, such as tumor necrosis factor-α and interleukin-6, from nuclear extracts of mouse tumor cells. This nucleoside may be a potential drug target for the treatment of cancer and inflammation.</p>

<p>7-deaza-dG-CE Phosphoramidite is a monophosphate nucleotide, which is synthesized by modification of the 7-deaza-dG ribonucleoside. It has an antiviral and anticancer activity, and is used as a building block for novel drugs. 7-Deaza-dG-CE phosphoramidite has been shown to inhibit tumor growth and induce apoptosis in Hep2 cells. It also inhibits HIV replication in vitro. The compound is chemically stable and does not react with other biomolecules.</p>

<p>2'-Deoxyinosine-5'-triphosphate sodium (2'-dITP) is a modified nucleotide that has antiviral and anticancer properties. It has been shown to be an activator for ribonucleosides, deoxyribonucleosides, and DNA. 2'-DITP has also been shown to inhibit the growth of human breast cancer cells in vitro.</p>

<p>Focuses is a chemical compound that does not have any known commercial or industrial uses.</p>

<p>2'-O-Propargyladenosine is a modified nucleoside that belongs to the group of deoxyribonucleosides. It is an activator of viral DNA polymerases, which causes the synthesis of viral DNA to stop. This compound has antiviral and anticancer activities. 2'-O-Propargyladenosine has been shown to be effective against various human cancer cell lines in vitro and in vivo. It is a synthetic nucleoside with high purity, showing no detectable impurities by HPLC analysis.</p>

<p>Spacer-C3 Cep is a novel modified nucleoside phosphoramidite. It has been chemically modified with a spacer arm and 3-Cep (1,2-diaminoethane). Spacer-C3 Cep is an activator for DNA polymerases, which are enzymes that synthesize DNA from deoxyribonucleosides. The modified nucleoside phosphoramidite has antiviral and anticancer activities. It can be used in the synthesis of oligodeoxyribonucleotides for gene therapy or as a monophosphate for the preparation of DNA probes. Spacer-C3 Cep can also be used to synthesize ribonucleotide analogs that inhibit viral replication by inhibiting RNA synthesis.</p>

<p>2'-O-Methyl-p-thiouridynyl-(3'-&gt;5')-2'-deoxyadenosine is an analog of the nucleoside uridine. It is a potent inhibitor of protein synthesis in cells, and has the potential to be used as a long-term treatment for tuberculosis. 2'-O-Methyl-p-thiouridynyl-(3'-&gt;5')-2'-deoxyadenosine has been shown to inhibit the production of tumor necrosis factor alpha (TNFα) in mice with influenza or hepatitis, and also inhibits the replication of HIV. This drug may also have antibacterial properties due to its ability to inhibit bacterial DNA gyrase and topoisomerase IV. 2'-O-Methyl-p-thiouridynyl-(3'-&gt;5')-2'-deoxyadenosine binds to an antigen on the surface of cells, activating them.</p>

<p>N2-Acetyl-5'-O-DMT-guanosine is a novel anticancer nucleoside that has been synthesized to mimic the natural nucleotides found in DNA. It is phosphorylated to N2-acetyl-5'-O-DMT-guanosine monophosphate, which can be converted back to the active form of N2-acetyl-5'-O-DMT guanosine by phosphatases. This agent activates DNA synthesis and inhibits viral replication, including HIV and herpes simplex virus. The antiviral activity is due to its inhibition of viral DNA polymerase and diphosphate kinase.</p>

<p>2-O-Ethylthymidine is a nucleoside that is used to study the structure and dynamics of DNA. It can be synthesized by reacting 1-β-D-arabinofuranosylbenzene with ethylmercury acetate. 2-O-Ethylthymidine can be used in kinetic studies as it is specific for dna. It has been shown to have a conformational change, which is stabilized by the presence of an aromatic ring such as phenanthrene. This compound was also found to inhibit neuroblastoma cell growth in vitro.</p>

<p>5′-O-DMT-LNA N-Bz 5-Me cytidine is a protected LNA cytidine nucleoside.</p>

<p>N6-Benzoyl-L-adenosine is a novel nucleoside that has been shown to have antiviral and anticancer activity. It is synthesized by the reaction of L-adenosine with benzoyl chloride in the presence of a base. The drug inhibits the growth of cancer cells by interfering with DNA synthesis. N6-Benzoyl-L-adenosine also inhibits viral replication, especially HIV, herpes simplex virus type 1, and human cytomegalovirus (HCMV). It can be used as an antiviral agent in combination with other drugs or as an anticancer agent alone. N6 Benzoyl L adenosine is a nucleoside that has been shown to have antiviral and anticancer activity. It is synthesized by the reaction of L adenosine with benzoyl chloride in the presence of a base. The drug inhibits the growth of cancer cells by interfering with DNA synthesis. N6</p>

<p>Adenosine 2',3'-cyclic monophosphate triethylammonium salt (AMP-TEA) is a structural analogue of adenosine. It is a potent inhibitor of protein synthesis by preventing the phosphodiesterase activity of cyclic nucleotide phosphodiesterases and cyclic nucleotide phosphodiesterase. AMP-TEA can be used as a tool to study translation in tissue culture, as well as to examine the effects on protein synthesis and other biochemical reactions that are regulated by cyclic nucleotides. It is also used for the preparation of tissue samples for enzymatic analysis or for radiolabeling experiments.<br>AMP-TEA has an optimum pH of 4.5, but can be used at lower or higher pH values. The optimal temperature range for use is between 0°C and 50°C, with the maximum stability occurring at 37°C.</p>

<p>Propionyl coenzyme A lithium salt is a phosphoramidite that can be used in the synthesis of DNA and RNA. It is a novel chemical compound that has been modified to include ribonucleosides in addition to deoxyribonucleosides. This product is of high purity and quality, with a CAS number of 108321-21-7.</p>

<p>N2-Isobutyryl-O6-(4-pivaloyloxybenzyl)-7’-OH-N-trityl-morpholino guanine is a phosphoramidite nucleoside that is used as a building block in the synthesis of oligonucleotides. N2-Isobutyrylguanosine is available as a high purity, high quality, and novel nucleoside that can be used in anticancer therapy. It has been shown to inhibit the growth of human cancer cells without affecting normal cells. This drug also inhibits DNA and RNA synthesis by inhibiting the enzyme ribonucleotide reductase.</p>

<p>ATP-acetyl-desthiobiotin is a small molecule that inhibits the activity of tyrosine kinases. It has been shown to inhibit tumor growth in cultured cells and in mouse models, and is currently being evaluated in clinical trials for cancer treatment. ATP-acetyl-desthiobiotin is a competitive inhibitor of bosutinib (BST), an inhibitor of Bcr-Abl tyrosine kinase, which is associated with chronic myeloid leukemia. ATP-acetyl-desthiobiotin has also been shown to induce autophagy and inhibit cell proliferation, making it a potential anticancer drug.</p>

<p>2-Methylamino-N6-methyladenosine is an activator that can inhibit the replication of DNA, RNA, and protein synthesis. It is a novel monophosphate nucleoside with antiviral and anticancer properties. 2-Methylamino-N6-methyladenosine has been shown to be effective against human cytomegalovirus and murine leukemia virus (MLV) in cell culture. Furthermore, it has been shown to be active against the herpes simplex virus type 1 (HSV1) in mice after oral administration. 2-Methylamino-N6-methyladenosine is a modified deoxyribonucleoside that contains an amino group at the 2' position of the ribose sugar moiety. It also contains an alkyl group at the 6 position of adenine. This modification confers increased stability to the molecule, which prevents degradation by intracellular nucleases.</p>

<p>2'-Deoxy-3,4,5,6-tetrahydrouridine (2DTHR) is a cytidine deaminase inhibitor that is used in vitro to inhibit the production of tumor necrosis factor (TNF). 2DTHR has been shown to be active against hepatocellular carcinoma cells. It is also reactive with tumor tissue and can be eliminated at a rate similar to that of deoxycytidine kinase. This drug binds to the enzyme target and inhibits its activity by increasing enzyme levels, which causes cell death. 2DTHR inhibits TNF production in tumor tissue by binding to cytidine deaminase and preventing conversion of cytidine into uracil. This drug has been shown to cause tumor inhibition in vitro.</p>

<p>2-Deoxy-5'-O-DMT-N2-isobutyryl-8-oxoguanosine 3'-CE phosphoramidite is an 8-oxo modified amidite.  The 8-oxo modification is caused naturally in DNA by oxidation so is significant in mutagenesis and ultimately carcinogenesis.</p>