Nucléosides

<p>5-Carbamoylmethyluridine is a nucleoside that is structurally related to uridine. It is synthesized from uridine by methyl esterification with carbamic acid and methoxycarbonyl chloride. 5-Carbamoylmethyluridine interacts with actin filaments and has been shown to alter the expression of messenger RNA in eukaryotes. 5-Carbamoylmethyluridine also acts as a competitive inhibitor of the formation of a ternary complex, which includes ATP, GTP, and UTP, at the level of ribonucleotide reductase. This inhibition leads to decreased synthesis of messenger RNA in cells.</p>

<p>N2-Acetyl-6-[2-(4-nitrophenyl)ethoxy]-2'-O-trifluoromethanesulfonyl-3',5'-di-O-tritylguanosine is a novel nucleotide that is activated by the addition of 2'-deoxyribonucleosides and has antiviral activity. It was synthesized from 2'-deoxynucleoside 5'-triphosphates and 4,4'-dimethoxytrityl chloride in high yield. The compound is also shown to have anticancer activity against human leukemia cells and breast cancer cells.</p>

<p>N6-Benzoyl-2'-O-(2-methoxyethyl)adenosine is a novel nucleoside that can be used as an antiviral agent. It is an activator of viral polymerase and inhibits the proliferation of cells infected with HIV. This compound has been synthesized from 2'-deoxyadenosine monophosphate, which is a precursor to RNA and DNA synthesis. N6-Benzoyl-2'-O-(2-methoxyethyl)adenosine has also been shown to inhibit the growth of experimental tumors in mice. The synthesis of this compound is reliable and reproducible, making it a high quality product.</p>

<p>2'-Deoxy-L-adenosine is an adenosine analogue that has been shown to inhibit the growth of tumor cells in mice. The mechanism of this inhibition is not well understood, but it is thought that 2'-deoxy-L-adenosine inhibits the adenosine A3 receptor and blocks the activation of toll-like receptors. This drug also has been shown to have anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis. It has been used as a model system for studying cellular responses to DNA damage caused by ultraviolet radiation. 2'-Deoxy-L-adenosine also has been shown to have a cytotoxic effect on human HL60 cells, which is mediated by nuclear DNA fragmentation.</p>

<p>3'-O-Acetyl-5'-O-DMT-5-iodo-2'-O-methyuridine is a novel nucleoside analog with antiviral and anticancer activities. It is an activator that binds to the ribonucleotide reductase enzyme, which is essential for the production of RNA and DNA. This compound has been shown to inhibit the growth of several cancer cells in vitro.</p>

<p>Anti-viral; anti-neoplastic</p>

<p>3'-O-Methyl-5-methylcytidine is a nucleoside with antiviral and anticancer properties. It has been shown to be an activator of RNA polymerase, the enzyme that catalyzes the transcription of DNA into RNA. 3'-O-Methyl-5-methylcytidine binds to the active site of RNA polymerase and is able to stimulate transcription in vitro. This drug has also been shown to have high purity and high quality.</p>

<p>N4-Acetyl-5'-O-DMT-2'-O-methylcytidine is a cytidine analogue that has been synthesized to be used as an enzyme-linked probe. It is labelled with biotin and can be detected by binding to an antibody which has been labelled with a fluorescent tag. Cytidine analogues are synthesized on a solid phase and then cleaved from the support material. The spacer arm is added to the 5' end of the nucleotide and the 3'-OH group is modified with 2'-O-methyl groups. N4-Acetyl-5'-O-DMT-2'-O-methylcytidine has been shown to be sensitive in techniques such as solid phase synthesis, nucleic acid research, and immunoassays.</p>

<p>2'-Deoxy-5'-O-pixyluridine (2DPU) is a novel, synthetic nucleoside that is an active ingredient in antiviral and anticancer drugs. 2DPU has been shown to inhibit the replication of human immunodeficiency virus type 1 (HIV-1) by inhibiting the viral enzyme HIV reverse transcriptase. The phosphoramidite form of 2DPU is used as a building block for DNA synthesis and for the synthesis of other nucleosides. The monophosphate form of 2DPU is used in the synthesis of antiviral drugs, including acyclovir, zidovudine, and ribavirin.</p>

<p>Clofarabine is FDA-approved for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children after at least two other types of treatment have failed</p>

<p>6mer oligonucleotide</p>

<p>3’-Deoxy-5-fluoro-3’-methyluridine is a nucleoside that has antiviral and anticancer properties. It is synthesized from 5-fluorouracil, which is a prodrug that is activated by 3’-deoxy-5-fluoro-3’-methyl uridine to produce 5′,6′ difluorodeoxyadenosine. This compound can be used in the treatment of hepatitis B virus and hepatitis C virus infections. 3’-Deoxy-5-fluoro-3’ methyluridine has also been shown to inhibit the growth of cancer cells in vitro.</p>

<p>1-(2'-O-4-C-Methylene-b-D-ribofuranosyl)adenine is an important compound in the field of nucleoside chemistry and has potential applications in research</p>

<p>2'-Deoxy-5-formylcytidine is a nucleoside analog that is used as a chemotherapeutic agent. It is cytotoxic to cells by binding to DNA and preventing the synthesis of DNA, RNA, and protein. The drug has been shown to induce cellular senescence in human fibroblasts, which can be reversed by the addition of deuterium. 2'-Deoxy-5-formylcytidine also inhibits the production of reactive oxygen species (ROS) by inducing the expression of antioxidant enzymes such as superoxide dismutase 2 and glutathione peroxidase 1. The oxidation products are misincorporated into DNA strands, leading to intramolecular hydrogen bonds with cytosine bases. These modifications lead to denaturation of DNA and inhibition of transcription and replication.<br>2'-Deoxy-5-formylcytidine also interacts with oligodeoxynucleotides, which leads to misinc</p>

<p>2-Chloro-N6-cyclopentyladenosine hemihydrate is a synthetic adenosine analog with potential research applications</p>

<p>OBEA-Fluorescein-2'-deoxy-5'-O-DMT-cytidine 3'CE-amidite is an anticancer drug that belongs to the class of deoxyribonucleosides. It is a novel nucleoside analogue that has been modified with fluorescein and a cytidine derivative. The synthesis of this compound is carried out by coupling a cytidine derivative with fluorescein and the phosphoramidite of the corresponding ribonucleotide. OBEA-Fluorescein-2'-deoxy-5'-O-DMT-cytidine 3'CE amidite has antiviral activity against DNA viruses, such as hepatitis B virus and human immunodeficiency virus, as well as RNA viruses, such as influenza A virus. This compound also has antiinflammatory activities.</p>

<p>2-Methylthioadenosine is a purine nucleoside which induces necrotic cell death. It is the first of its kind to be shown to have activity against squamous carcinoma cells, and is activated by nucleoside phosphorylase in order to produce its cytotoxic form. 2-Methylthioadenosine also inhibits the transcription-polymerase chain reaction and increases oxidative injury. This drug has been shown to have receptor activity in brain cells, as well as chemotactic activity for gland cells. 2-Methylthioadenosine has been used as a model organism for polymerase chain reactions, and has been shown to inhibit p2y receptors in the human colon cancer cell line HT29.</p>

<p>N4-Acetyl-2'-deoxy-5'-O-DMT-5-methylcytidine 3'-CE phosphoramidite is a novel nucleoside and deoxyribonucleoside that has been synthesized by the chemical modification of cytidine. It is an anticancer drug and antiviral agent, which has been shown to activate DNA polymerase, inhibit RNA synthesis and have antiviral activities against HIV, HSV, CMV, and VZV. N4-Acetyl-2'-deoxy-5'-O-DMT-5-methylcytidine 3'-CE phosphoramidite has high purity with low impurities (0.1% DMSO), making it a valuable nucleoside for use in synthesis of ribonucleotide analogues.</p>

<p>1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)-5-ethyluracil is a nucleoside analog with modifications to alter its biological activity. It contains a β-D-arabinofuranose sugar instead of the standard β-D-deoxyribose in natural nucleosides and<br>the fluorine (F) at the 2'-position increases resistance to enzymatic degradation and alters its biological activity. The 5-ethyl modification on the uracil ring enhances its interaction with viral polymerases.</p>

<p>N4-Benzoyl-5'-O-benzoyl-2'-O-tert-butyldimethylsilylcytidine 3'-CE phosphoramidite is a novel nucleoside that has been modified by the addition of a benzoyl group to the 5' position of the ribonucleotide moiety. N4-Benzoyl-5'-O-benzoyl-2'-O-tert-butyldimethylsilylcytidine 3'-CE phosphoramidite is an anticancer and antiviral agent that inhibits viral replication by competitive inhibition of DNA polymerase. N4-Benzoyl-5'-O-benzoyl -2'-O -tert -butyldimethylsilylcytidine 3'-CE phosphoramidite is active against HIV, herpes virus, and cytomegalovirus. This compound also inhibits the synthesis</p>