Nucléosides

<p>5'-O-p-Anisoylthymidine is a novel activator and ribonucleoside that has been synthesized by modifying the structure of thymidine. This compound is active against cancer and antiviral, such as herpes simplex virus type 1, herpes simplex virus type 2, varicella zoster virus, influenza A/PR/8/34 (H1N1), and influenza B/Yamagata/16/88. 5'-O-p-Anisoylthymidine activates viral transcription in cells infected with these viruses by inhibiting the synthesis of deoxyribonucleosides. It also inhibits DNA synthesis by inhibiting the incorporation of deoxyribonucleotides into DNA during replication. This product is CAS No. 138581-03-2 and comes in high purity and high quality.</p>

<p>2'-Deoxy-5-methyl-isocytidine triphosphate (2'-DMI-dTP) is a novel nucleoside that is synthesized by phosphoramidite chemistry. 2'-DMI-dTP has antiviral and anticancer activities, and can be used for the treatment of hepatitis B virus (HBV) and human papillomavirus (HPV). It has shown protective effects in animal models of HBV infection. 2'-DMI-dTP inhibits HBV replication by inhibiting DNA synthesis. In addition, it decreases levels of reactive oxygen species in cells treated with HBV. 2'-DMI-dTP also inhibits HPV replication through inhibition of DNA synthesis, which may lead to cancer prevention or treatment.<br>2'-DMI-dTP may be a useful drug candidate for the treatment of other viral infections such as influenza A virus and HIV type 1.</p>

<p>5'-(R)-C-Methyl-2-thiouridine is an antiviral agent that inhibits the synthesis of viral RNA by acting as a substrate for thymidine kinase, which converts it to 5'-(R)-C-methyluracil. This drug also has anticancer properties and may be useful in the treatment of leukemia.</p>

<p>Anti-viral; reverse transcriptase inhibitor</p>

<p>Queuine is a modified nucleoside found in tRNA. It is synthesized from guanosine by the enzyme queuine tRNA-ribosyltransferase, which converts guanosine to queuosine. Queuine hydrochloride is a synthetic form of queuine that can be used for research purposes to examine the anticodon loop and other structural features of the molecule. The prokaryotic and eukaryotic organisms studied showed different levels of synthesis of queuine, with bacteria synthesizing more than mammals. Bacteria were found to have a greater affinity for queuine than eukaryotes, which may be due to modification of the trna anticodon loop or to differences in ribosomal proteins.</p>

<p>3'-b-Azido-2',3'-dideoxy-5'-O-DMT-uridine is a modified nucleoside that is synthesized by the phosphoramidite method. It is a novel antiviral drug with anticancer properties. This active compound has been shown to be an activator of ribonucleotide reductases, which are enzymes that catalyze the conversion of ribonucleotides to deoxyribonucleotides. 3'-b-Azido-2',3'-dideoxy-5'-O-DMT-uridine is not cytotoxic at concentrations up to 40 mM, and it has been shown to inhibit replication of human immunodeficiency virus type 1 (HIV) in tissue culture.</p>

<p>7-Deaza-2'-deoxyguanosine is an analog of guanosine that has been shown to inhibit the activity of telomerase. This enzyme synthesizes a sequence of DNA called a telomere, which protects the ends of chromosomes from deterioration and prevents chromosomal end-to-end fusion. 7-Deaza-2'-deoxyguanosine has an inhibitory effect on the polymerase chain reaction (PCR) in mammalian cells and inhibits the transcription-polymerase chain reaction (PCR) in vitro. It has also been shown to be potent against cancer cells. 7-Deaza-2'-deoxyguanosine is synthesized by solid phase synthesis, which is a chemical process that involves attaching one molecule to another molecule with similar structure, using organic solvents as intermediates.</p>

<p>5’(R)-C-Methyladenosine is a nucleoside that is used as an antiviral and anticancer agent. It has been shown to inhibit the replication of the human immunodeficiency virus type 1 (HIV-1) in a dose-dependent manner, with an IC50 value of about 0.4 μM for HIV-1 reverse transcriptase activity. In addition, 5’(R)-C-Methyladenosine has been shown to inhibit DNA synthesis and promote apoptosis in cancer cells by inhibiting transcription and translation. The compound also inhibits the growth of tumor cells in mice without affecting normal tissue growth.</p>

<p>1,5-Anhydro-2,3-dideoxy-2-(N6-benzoyladenin-1-yl)-D-glucitol is a novel modified nucleoside that is used as an activator in the synthesis of oligodeoxynucleotides and ribonucleosides. It is also used for the synthesis of phosphoramidites for DNA and RNA molecules. This product is available in high purity and quality.</p>

<p>N6-Carbamoylthreonyladenosine sodium salt is a fatty acid that is found in the bacterial cell wall. It has been shown to be an essential component of the cell wall for Gram-positive and Gram-negative bacteria. N6-Carbamoylthreonyladenosine sodium salt has been used to study the mechanism of protein synthesis in bacteria, especially how enzymes are involved in this process. Chemical biology studies have shown that this molecule can bind to DNA and inhibit bacterial growth. The crystal structure of N6-Carbamoylthreonyladenosine sodium salt has also been determined using x-ray diffraction data. This molecule inhibits the binding of proteins to DNA, which prevents transcription and replication. The reaction mechanism involves hydrogen bonding between the oxygen atoms on N6-Carbamoylthreonyladenosine sodium salt and divalent metal ions such as magnesium or zinc, which are required for protein synthesis.</p>

<p>1-(2R,3R,4R,5R)-3-Hydroxy-5-(hydroxymethyl)-4-methoxytetra hydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione is a nucleoside that is a novel anticancer drug. It has been shown to have potent antineoplastic activity in vitro and in vivo. This compound is an activator of the p53 tumor suppressor gene and may also act as a transcriptional inhibitor of NF-κB.</p>

<p>3-Deaza-2'-O-methyluridine is a nucleoside that is used as an antiviral agent and in the treatment of leukemia. It has been shown to inhibit the growth of L1210 cells in a dose-dependent manner. 3-Deaza-2'-O-methyluridine also inhibits the synthesis of DNA, RNA, and proteins. The compound is eliminated by renal excretion with a plasma elimination half life of 9 hours. This drug can be administered intramuscularly or intravenously at a dosage of 10 mg/kg every 8 hours, but should not be given more than 5 days without interruption due to accumulation in tissues.</p>

<p>Adenosine 3',5'-bisphosphate triethylammonium salt is a metabolite of adenosine and an ester of triethylamine. The conjugate acid has been isolated from mouse urine. It is a metabolite of adenosine in the liver and is hydrolyzed to adenosine monophosphate and bisphosphate. Adenosine 3',5'-bisphosphate triethylammonium salt is used to study the metabolism of adenosine in mice. It has also been shown that this metabolite can inhibit the growth of E. coli (a bacterium) and mouse erythrocyte mitochondria by blocking ATP synthesis at the level of substrate-level phosphorylation.</p>

<p>N4-Acetyl-3'-deoxy-3'-C-methylcytidine is a novel antiviral drug that is modified from cytidine. It is an activator of the monophosphate pathway of DNA synthesis, which causes the incorporation of N4-acetyl-3'-deoxy-3'-C-methylcytidine into ribonucleosides and deoxyribonucleosides. This compound has been shown to be active against a variety of cancers, including leukemia, colon cancer, breast cancer, and prostate cancer.</p>

<p>A non-physiological analog of nicotinamide adenine dinucleotide (NAD+) in biochemical research, particularly as a tool to study the mechanisms of NAD+-dependent enzymes.</p>

<p>5'-Azido-5'-deoxyguanosine is an analog of guanosine that can be synthesized in a solid-phase reaction. It can also be enzymatically generated from 5'-azido-5'-deoxyadenosine. This molecule is reactive and has been shown to be an effective inhibitor of DNA synthesis in vivo assays. The use of 5'-azido-5'-deoxyguanosine has been explored as a potential treatment for leishmaniasis, a disease caused by the protozoan parasite Leishmania donovani.</p>

<p>Fluorescein-5(6)-carboxamidocaproyl-[5(3-aminoallyl)2-deoxyuridine-5-triphosphate] is a modified nucleoside analog that is used as an antiviral agent against herpesviruses. This compound is phosphorylated by the virus encoded thymidine kinase, which converts it to the monophosphate form. Fluorescein-5(6)-carboxamidocaproyl-[5(3-aminoallyl)2-deoxyuridine-5-triphosphate] inhibits DNA synthesis by inhibiting viral DNA polymerase and has been shown to be active against human papillomavirus type 16 (HPV16) in vitro. It has also been shown to inhibit tumor cell proliferation and induce apoptosis in some types of cancer cells.</p>

<p>3'-O-Propargylcytidine is a monophosphate nucleoside that belongs to the group of synthetic, novel nucleosides and deoxyribonucleosides. It is a modified form of cytidine with an extra methyl group attached to the 3' position of the ribose sugar. 3'-O-Propargylcytidine has been shown to inhibit cancer cells by binding to DNA and preventing transcription and replication. This compound also inhibits virus replication and has antiviral properties. 3'-O-Propargylcytidine is highly pure and high quality, which makes it a good candidate for use in pharmaceuticals or other applications requiring high purity.</p>

<p>11mer_5'P oligonucleotide</p>

<p>O2-3'-anhydro-beta-D-fructofuranosyluracil is a novel nucleoside analogue that has antiviral and anticancer properties. It is synthesized by the reaction of beta-D-fructofuranosyluracil with phosphoramidites. The product is purified by HPLC and characterized by IR spectroscopy, UV spectroscopy, and mass spectrometry.</p>