Nucléosides
Les nucléosides sont des building blocks fondamentaux des acides nucléiques, composés d'une base azotée attachée à une molécule de sucre. Dans cette section, vous trouverez une large gamme de nucléosides essentiels pour la recherche en biologie moléculaire, biochimie et pharmacologie. Ces composés jouent des rôles cruciaux dans la synthèse de l'ADN et de l'ARN, et sont également vitaux dans divers processus métaboliques. Les nucléosides sont utilisés pour étudier le matériel génétique, développer des thérapies antivirales et anticancéreuses, et comprendre les mécanismes cellulaires. Chez CymitQuimica, nous proposons des nucléosides de haute qualité pour soutenir vos besoins en recherche et développement, garantissant pureté et fiabilité pour vos applications expérimentales.
3571 produits trouvés pour "Nucléosides"
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2'-Deoxy-5'-O-MMT-inosine 3'-CE phosphoramidite
2'-Deoxy-5'-O-MMT-inosine 3'-CE phosphoramidite is a modified nucleoside that is used in the synthesis of DNA. It has been shown to inhibit the replication of HIV, herpes simplex virus type 1 and type 2, influenza A virus and vesicular stomatitis virus. The antiviral activity has been attributed to its ability to inhibit viral DNA polymerase, which prevents viral replication. This compound also inhibits human cytomegalovirus (CMV) DNA polymerase in vitro.Formule :C39H45N6O6PDegré de pureté :Min. 95%Masse moléculaire :724.8 g/molO6-Methylguanosine
CAS :Intermediate in the synthesis of nelarabineFormule :C11H15N5O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :297.27 g/mol3'-Deoxy-3'-fluorothymidine
CAS :3'-Deoxy-3'-fluorothymidine is a nucleoside analog that is used to diagnose and treat cancer. It is a prodrug that is metabolized intracellularly by deoxycytidine kinase to the 3'-deoxy-3'-fluoro derivative of thymidine, which competes with natural thymidine for incorporation into DNA. Uptake of 18F-flouride (18F-FDG) in tumor cells has been shown to be proportional to the rate constant (k) of cellular uptake. This process can be quantified using positron emission tomography imaging. The cell cycle inhibitor activity of 3'-deoxy-3'-fluorothymidine has also been demonstrated in vitro and in vivo, inhibiting the proliferation of tumor cells and normal cells in culture, respectively.Formule :C10H13FN2O4Degré de pureté :Min. 97 Area-%Couleur et forme :White Off-White PowderMasse moléculaire :244.22 g/molN4-Benzoyl-5'-O-DMT-5-methylcytidine
CAS :N4-Benzoyl-5'-O-DMT-5-methylcytidine is a deoxyribonucleoside that has been modified to make it resistant to nucleases. N4-Benzoyl-5'-O-DMT-5-methylcytidine is an antiviral agent, which inhibits the synthesis of viral DNA by inhibiting the activity of viral DNA polymerase. It also acts as an activator for cellular DNA polymerases and phosphoramidites. The drug can be used in the treatment of HIV and other retroviruses, herpes viruses, and certain types of cancer.Formule :C38H37N3O8Degré de pureté :Min. 95%Couleur et forme :White SolidMasse moléculaire :663.73 g/molN4,N4-Dimethylcytidine
CAS :N4,N4-Dimethylcytidine is a nucleoside that is an analog of cytidine. It has antiviral potency against influenza virus and inhibits the RNA-dependent DNA polymerase. N4,N4-Dimethylcytidine can be used to treat influenza and other viruses that are resistant to other antiviral drugs. This drug can be used in cell culture to inhibit the production of mismatched DNA strands, which is important for the replication of RNA viruses such as influenza. N4,N4-Dimethylcytidine also has been shown to be an inhibitor of miRNA activity in mammalian cells.
Formule :C11H17N3O5Degré de pureté :(%) Min. 95%Couleur et forme :White PowderMasse moléculaire :271.27 g/mol3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine
CAS :Used as a protected guanosine nucleoside in RNA synthesis. The 1,1,3,3-tetraisopropyl-1,3-disiloxanediyl (TIPDS or TBDPSi2) group acts as a bulky and selectively acid-labile protecting group for the 3' and 5' hydroxyl groups of the guanosine ribonucleoside during RNA oligonucleotide synthesis.Formule :C22H39N5O6Si2Degré de pureté :Min. 97 Area-%Couleur et forme :PowderMasse moléculaire :525.76 g/mol1-Methyl-2'-O-methylinosine
CAS :1-Methyl-2'-O-methylinosine is a nucleoside that is naturally found in RNA. It is the methylated form of inosine, which is a nonessential amino acid and purine nucleotide. 1-Methyl-2'-O-methylinosine's chemical name is β--D--ribofuranosyl-(1'→2')--N--(6-fluoro-3-indoxyl)glycinamide monohydrochloride. This nucleoside has been researched for its potential use as an indexing tool for phylogenetic research of DNA and RNA. 1-Methyl-2'-O-methylinosine has also been shown to be structurally similar to other nucleic acids and has been classified as a nucleoside.Formule :C12H16N4O5Degré de pureté :Min. 95%Masse moléculaire :296.28 g/molCytidine 3'-monophosphate lithium salt
CAS :Cytidine 3'-monophosphate lithium salt is a synthetic nucleoside that is used to inhibit the synthesis of DNA in cells. It is an analog of cytidine, with a phosphate group at the 3' position and a lithium cation at the 5' position. Cytidine 3'-monophosphate lithium salt has been shown to be effective in treating cancer and viral infections, although it does not have antiviral activity against influenza A virus.Formule :C9H14N3O8P·xLiDegré de pureté :Min. 95%Masse moléculaire :323.2 g/molAdenosine 5′-phosphosulfate triethylammonium salt
Adenosine 5′-phosphosulfate triethylammonium salt serves as a donor of sulfate groups in biochemical processes, such as in the synthesis of sulfate esters. The triethylammonium salt form improves the solubility and stability of the compound, making it useful in laboratory applications involving enzymatic assays and the synthesis of sulfated biomolecules.
Formule :C10H14N5O10PS·xC6H15NDegré de pureté :Min. 98.0 Area-%Couleur et forme :PowderMasse moléculaire :427.29 g/mol3'-Deoxy-5'-O-DMT-3'-C-methyluridine
3'-Deoxy-5'-O-DMT-3'-C-methyluridine is an activator of DNA synthesis, which can be used to synthesize deoxyribonucleosides and ribonucleosides. 3'-Deoxy-5'-O-DMT-3'-C-methyluridine has been shown to have anticancer activity in vitro and in vivo. It is a novel synthetic monophosphate nucleoside that can be modified for use as a phosphoramidite or a ribonucleoside. 3'-Deoxy-5'-O-DMT-3'-C-methyluridine has also been shown to have antiviral activity against HIV in vitro.Degré de pureté :Min. 95%2-Amino-2'-deoxy-2'-fluoroadenosine
CAS :2-Amino-2'-deoxy-2'-fluoroadenosine is a modified nucleoside. Fluorination modifications can make molecules have increased resistance to enzymatic degradation, which has useful applications in drug development. The extra amino group could also enhance binding properties or alter biological activity.Formule :C10H13FN6O3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :284.25 g/mol8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic monophosphate sodium salt
CAS :8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic monophosphate sodium salt (8-CPT-cAMP) is a cyclic nucleotide that activates adenyl cyclase, which increases intracellular levels of the second messenger cAMP. It also inhibits P2Y receptors and other ion channels. 8-CPT-cAMP has been shown to be effective in activating cells expressing the enzyme camp levels, such as those found in heart muscle cells. This drug is used clinically to lower blood pressure, as it has been shown to activate amp-activated protein kinase and calcium chelator. 8-CPT-cAMP may have clinical applications for the treatment of cancer due to its ability to induce cell cycle arrest and apoptosis.Formule :C17H16ClN5O6PS·NaDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :507.82 g/mol5'-Azido-5'-deoxythymidine
CAS :5'-Azido-5'-deoxythymidine is a synthetic analogue of thymidine. The compound has been synthesised and fluorescently labelled with ferrocene. 5'-Azido-5'-deoxythymidine is not cytotoxic to cancer cells, but it is shown to be an effective inhibitor of DNA synthesis by binding to the enzyme DNA polymerase. This causes a decrease in the rate of DNA synthesis and thus inhibits cancer cell growth.Formule :C10H13N5O4Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :267.24 g/mol8-Azaadenosine
CAS :8-Azaadenosine is a purine nucleoside that is used as a template for DNA replication. The zwitterionic form of 8-Azaadenosine is found in plants and is converted to the charged form by enzymatic reactions. 8-Azaadenosine binds to the dna template strand and acts as a hydrogen bond donor, which stabilizes the transition state of the reaction and inhibits enzyme activity. This drug has been shown to affect polymerase chain reaction (PCR) by inhibiting DNA synthesis and it has been used in cancer cell lines with resistant mutants, such as Herpes simplex virus type 1 (HSV1).Formule :C9H12N6O4Degré de pureté :Min. 97 Area-%Couleur et forme :Off-White PowderMasse moléculaire :268.23 g/mol4’-C-Methyl-N6-methyladenosine
CAS :4’-C-Methyl-N6-methyladenosine (4’-MeA) is a novel, synthetic nucleoside that has antiviral activity. It is a phosphoramidite nucleoside that is modified by the methylation of the adenosine moiety to give it antiviral activity. 4’-MeA can be used as an activator for oligonucleotide synthesis and as a potential anticancer drug.Degré de pureté :Min. 95%5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite
CAS :5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite is a modified, phosphoramidite nucleoside. It is used in the synthesis of DNA and RNA. 5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite is an antiviral agent that inhibits viral replication by inhibiting viral protein synthesis. It has been shown to be active against HIV, Hepatitis B virus, and Hepatitis C virus. The compound also has anticancer properties and has been shown to inhibit tumor growth in animal models. 5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite is a novel synthetic nucleoside that can be used as an alternative to deoxyribonucleosides in the synthesis of DNA and RNA.Formule :C40H49N4O9PDegré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :760.83 g/mol2'-Amino-2'-deoxyguanosine
CAS :2'-Amino-2'-deoxyguanosine is a modified nucleoside, based on guanosine. The 2'-hydroxyl has been replaced by an amino group, which can form different hydrogen bonds compared to a hydroxyl or just a hydrogen, altering the way the sugar interacts in a DNA or RNA strand.Formule :C10H14N6O4Degré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :282.26 g/molN3-Methyl-2’-O-(2-methoxyethyl)uridine
CAS :N3-Methyl-2’-O-(2-methoxyethyl)uridine is a modified nucleoside that is synthesized from deoxyribonucleosides and ribonucleosides. It has antiviral, anticancer, and antifungal properties. N3-Methyl-2’-O-(2-methoxyethyl)uridine has been shown to be an effective inhibitor of HIV replication in vitro and in vivo. This drug also inhibits the growth of human cancer cells in vitro and has been shown to be active against breast cancer cells. N3-Methyl-2’-O-(2-methoxyethyl)uridine is phosphorylated by cellular enzymes to form its active form, which binds to the viral reverse transcriptase enzyme and prevents DNA synthesis.Formule :C13H20N2O7Degré de pureté :Min. 95%Masse moléculaire :316.31 g/mol2'-Deoxy-5'-O-MMT-uridine
CAS :2'-Deoxy-5'-O-MMT-uridine is a monophosphate nucleoside that is an antiviral and anticancer drug. It is synthesized from the pentaphosphate derivative of cytosine and uracil, and inhibits RNA synthesis by forming a covalent bond with the enzyme ribonucleotide reductase. This product can be used as a starting material for the synthesis of other nucleosides, such as 2'-deoxy-5'-O-methylcytidine. 2'-Deoxy-5'-O-MMT-uridine can also be used to modify DNA by replacing uracil residues in DNA with their corresponding 2'-deoxy counterparts.Formule :C29H28N2O6Degré de pureté :Min. 95%Masse moléculaire :500.56 g/mol2'-Deoxy-2'-fluoro-L-uridine
CAS :2'-Deoxy-2'-fluoro-L-uridine is a synthetic nucleoside analog of uridine where the sugar is both fluorinated at the 2' position and in the L-configuration, which is the mirror image of naturally occurring D-nucleosides. This modification makes it structurally distinct and biologically significant for certain applications in drug development and biochemical research.
Formule :C9H11FN2O5Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :246.2 g/mol
