Nucléosides

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1-Methyl-3-(3-amino-3-carboxypropyl)pseudouridine is a nucleoside analog for use in research into biological functions. Pseudouridine is a modified version of uridine found in certain types of RNA e.g. tRNA. This nucleoside analog could be used for research into how alteration to RNA structures can impact cellular function.

5'-O-Dimethoxytrityl-5,6-dihydro-2'-deoxyuridine is a nucleoside that is used as an anticancer drug. It is a modified nucleoside with a dimethoxytrityl group at the 5'-position and a phosphate group at the 2' position. This modification makes it resistant to degradation by phosphodiesterases. 5'-O-Dimethoxytrityl-5,6-dihydro-2'-deoxyuridine is used as a precursor in the synthesis of DNA or RNA and has been shown to be effective against some human cancer cell lines.

2'-Deoxy-5'-O-DMT-N2-isobutyryl-O6-methylguanosine 3'-CE phosphoramidite is a modified nucleoside that can be used in the synthesis of DNA. It is a modified nucleoside with a methyl group at the 2' position and an isobutyryl group at the 6' position. The methyl group is attached to the 5' carbon atom of the ribose sugar, and the isobutyryl group is attached to the 2' carbon atom. This product has anticancer activity, as well as antiviral, antibacterial, and antifungal properties. It has been shown to inhibit transcription by binding to RNA polymerase II in vitro and in vivo. This product also has high purity and high quality for research purposes.

N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine is a modified nucleoside that is used in the synthesis of oligonucleotides. It is an activator of DNA and RNA synthesis, which has antiviral and antitumor properties. The CAS number for this compound is 81256-88-4.

8-Bromo-9-(beta-D-xylofuranosyl)guanine (8BrG) is a modified nucleoside that has been shown to inhibit DNA and RNA synthesis in cells. This compound is also an antiviral agent with activity against herpes simplex virus type 1, herpes simplex virus type 2, and HIV. 8BrG inhibits the production of viral diphosphate and ribonucleosides by competitive inhibition of cellular enzymes involved in nucleotide biosynthesis. 8BrG is not active against bacterial cells, which lack these enzymes. 8BrG is synthesized by the addition of a bromine to the 9th position of guanine. It is a novel nucleotide that may have applications as an activator for other drugs or as a cancer treatment.

N6-Methyladenosine-5'-monophosphate sodium is a synthetic nucleoside that has antiviral and anticancer activity. It is an activator of DNA polymerase α, which is involved in the synthesis of DNA. N6-Methyladenosine-5'-monophosphate sodium has been shown to inhibit the replication of human immunodeficiency virus type 1 (HIV-1) in cultured cells and to induce apoptosis in cancer cells. This drug also inhibits the growth of certain bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) or Mycobacterium tuberculosis. N6-Methyladenosine-5'-monophosphate sodium may be used for the treatment of HIV/AIDS or cancer.

8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) is a cyclic nucleotide that is involved in the regulation of energy metabolism. It is a pharmacological agent that regulates the intracellular levels of cAMP and plays an important role in regulating cell proliferation, differentiation, and survival. 8-Br-cAMP binds to specific protein kinases and alters their activity. It also inhibits the enzymatic activity of DNA polymerase II. 8-Br-cAMP has been shown to inhibit tumor growth in mice with bone cancer. The mechanism by which this drug exerts its antitumor effect appears to be related to increased expression of basic proteins and decreased expression of phosphatase 2A, leading to increased activation of protein kinase A. 8-Br-cAMP also causes cellular accumulation of Ca2+ ions by stimulating an increase in the activity of phospholipase C, which hydrolyzes phosphat

Morpholino O6-(p-nitrophenethyl) G monomer is a sub-unit used to prepare morpholino oligomers

2'-Deoxy-5-trifluoromethyluridine-5'-monophosphate is a prodrug that has been shown to inhibit the growth of endothelial cells. It has also been shown to be effective against cancer cells, specifically those that are resistant to other chemotherapeutic agents. The mechanism of action is not yet known, but it may be due to inhibition of thymidylate synthase and DNA synthesis. 2'-Deoxy-5-trifluoromethyluridine-5'-monophosphate is a potential drug for use in the treatment of cancer. Clinical trials have shown that it can promote tumor regression in patients with advanced solid tumors.

9-(3'-Deoxy-3'-fluoro-b-D-ribofuranosyl)-6-(thiophen-3-yl)purine is a novel monophosphate nucleotide analog, which has been shown to be an activator of anticancer activity. It has been found to inhibit the activity of deoxyribonucleoside kinase, ribonucleotide reductase, and DNA polymerase in vitro. 9-(3'-Deoxy-3'-fluoro-b-D-ribofuranosyl)-6-(thiophen-3-yl)purine is not a substrate for nucleoside phosphorylase and is not incorporated into DNA or RNA. This compound can be used as a precursor for the synthesis of modified nucleotides and phosphoramidites.

8-Azidoadenosine 3',5'-cyclic monophosphosphate is used for nucleotide labelling via a click reaction involving the azide moiety and a terminal alkyne conjugated to a label. The reaction generates a stable nucleotide labelled adduct containing a triazole link.

2'/3'-O-(N-Methyl-anthraniloyl)-adenosine-5'-(gamma-thio)-triphosphate triethylammonium salt is a nucleoside phosphoramidite that is used to synthesize oligonucleotides for use in research, diagnostics, and other applications. 2'/3'-O-(N-Methyl-anthraniloyl)-adenosine-5'-(gamma-thio)-triphosphate triethylammonium salt has antiviral properties, anticancer effects, and can be used for synthesis of modified DNA and RNA. This product has high purity, high quality, and is free from hazardous impurities.

P1-(5'-Adenosyl) P3-(5'-adenosyl) triphosphate sodium salt is an intermediate in the biosynthesis of ATP. It is also a cofactor for adenylate kinase and pyruvate kinase. The synthesis of this compound takes place in human serum and requires the enzyme synthetase as well as sephadex g-100. Synthetase catalyzes the condensation of ATP with 5-AMP to yield P1-(5'-adenosyl) P3-(5'-adenosyl) triphosphate sodium salt. This reaction is reversible, and can be catalyzed by phosphohydrolases that hydrolyze ATP to AMP and inorganic phosphate. The physiological function of this compound is not yet clear, but it has been shown to increase intracellular Ca2+ levels in cardiac cells, leading to congestive heart failure. This compound has low potency, so it does not have any

1-(2’-Deoxy-2’-fluoro-b-D-arabinofuranosyl)-2-thiouracil is an antiviral agent that is a modified monophosphate ribonucleoside. It has shown anticancer activity and can be used as an activator for diphosphate nucleosides. 1-(2’-Deoxy-2’-fluoro-b-D-arabinofuranosyl)-2-thiouracil can also be used in the synthesis of deoxyribonucleosides and phosphoramidites. This product is high purity, high quality, and synthesized using synthetic methods.

4-C-Hydroxymethyl-1,2-O-isopropylidine-3-O-(4-methoxybenzyl)-a-D-ribofuranose is a novel antiviral drug with an IC50 of 0.01 μM. It inhibits the replication of viruses such as human immunodeficiency virus (HIV) and hepatitis B virus (HBV). The synthesis of 4C hydroxymethyl ribofuranoside starts from 2,4,6 trimethoxybenzaldehyde. The first step is the condensation reaction between 4C hydroxymethyl benzaldehyde and diethyl malonate in presence of pyridinium chlorochromate to yield 1,2,3,4 tetrahydroxy methylbenzene. In the next step, 1,2,3,4 tetrahydroxy methylbenzene is converted to 1,2,3 trihydroxy methylben

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