Nucléosides

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<p>Citicoline is a complex organic molecule, a form of B-vitamin choline that acts as an intermediate in many biosynthetic pathways, for example, in the biosynthesis of cell membrane phospholipids. As a dietary supplement, citicoline is a source of choline and cytidine, two components that are quickly absorbed in the intestine and across the blood-brain barrier. The neuroprotective properties of citicoline improves mental performance increasing the levels of other brain-related chemicals like dopamine and norepinephrine, helping with recovery in stroke patients, reducing memory loss due to aging and improving vision in patients with glaucoma.</p>

<p>N2-Benzoylguanosine is a nucleotide derivative that is formed by the acetylation of guanosine. It has been shown to act as a buffer in alkaline solutions and isomerizes to its n-oxide form when heated. N2-Benzoylguanosine reacts with peroxides such as hydrogen peroxide, glyoxal, and organic peroxides, forming hydroperoxide intermediates that can be converted into other products. The acidic hydrolysis of N2-benzoylguanosine yields the corresponding 6-benzoyladenosines. It has been shown to enhance the activity of uridine in inhibiting bacterial growth, while also acting as an inhibitor of viral RNA synthesis. This compound also reacts with nitrous acid to form an n6-benzoyladenosine derivative that inhibits the formation of RNA chains during transcription.</p>

<p>N4-Acetyl-2'-O-tert-butyldimethylsilylcytidine is a novel nucleoside that has been extensively studied for its anticancer and antiviral properties. It is a modified nucleoside that inhibits the production of DNA, RNA, and protein. This product is also used as an activator in the synthesis of oligonucleotides. N4-Acetyl-2'-O-tert-butyldimethylsilylcytidine can be used in vitro to study the effects of different cancer cells on DNA replication. It has been shown to inhibit the growth of human leukemia cells in culture.</p>

<p>Pyruvate kinase substrate</p>

<p>2'-Deoxy-3'-O-DMT-N2-isobutyrylguanosine 5'-CE phosphoramidite is a 5'-3’ “reverse” (or “inverse”) amidite.</p>

<p>Focuses is a chemical compound that does not have any known commercial or industrial uses.</p>

<p>Pyruvate kinase substrate</p>

<p>Kinetin riboside-5'-monophosphate sodium salt is a synthetic nucleotide that has been modified to include a phosphate group at the 5' position. Kinetin riboside-5'-monophosphate sodium salt is an activator of DNA synthesis and can be used for the treatment of viral infections. It also shows anticancer activity and is effective against cancer cells that are resistant to other cancer drugs.</p>

<p>DMT-2²O-TC-rC(ac) Phosphoramidite is a novel nucleoside that has been modified with a 2,2'-O, TC-rC(ac) group. This compound is an analogue of the natural nucleoside cytidine and can be used in both DNA and RNA synthesis. DMT-2²O-TC-rC(ac) Phosphoramidite is phosphorylated by ATP to form diphosphate, which is then incorporated into DNA or RNA. The CAS number for this compound is 1219089-87-8.</p>

<p>8-Iodoadenosine is a macrocyclic inhibitor that binds to the phosphate group on ATP. This binding prevents ATP from being hydrolyzed to ADP and inorganic phosphate, which inhibits the formation of ATP. 8-Iodoadenosine has been shown to inhibit the proliferation of some cancer cells by interfering with their ability to synthesize proteins. It has also been shown to be an effective treatment for parasitic infections caused by Entamoeba histolytica. 8-Iodoadenosine has also been shown to inhibit protein synthesis in bacteria, fungi, and parasites.</p>

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<p>Cytidine-5'-O-(1-thiotriphosphate) lithium salt is a monophosphate nucleotide analog. It is soluble in water, and is used in the synthesis of DNA and RNA. Cytidine-5'-O-(1-thiotriphosphate) lithium salt has antiviral, anticancer, and anti-inflammatory properties. This compound can be used as an activator for phosphoramidites in the synthesis of DNA or RNA. Cytidine-5'-O-(1-thiotriphosphate) lithium salt is a novel nucleoside that can be used in the synthesis of modified oligonucleotides.</p>

<p>Morpholino A is a modified nucleoside amidite used to prepare morpholino oligomers</p>

<p>N6-Benzyladenosine 5'-triphosphate sodium salt - 10 mM aqueous solution is an analog of adenosine triphosphate (ATP). It is used in the study of protein kinase C. ATP and its analogs are able to phosphorylate proteins and regulate their activity. This study has shown that N6-benzyladenosine 5'-triphosphate sodium salt - 10 mM aqueous solution is an atp analog that activates protein kinase C, leading to the phosphorylation of proteins. This analog also inhibits tyrosine kinases, which may be due to its ability to inhibit the reuptake of serotonin and other transmitters.</p>

<p>Ribavirin triphosphate is the biologically active metabolite of antiviral nucleoside analog ribavirin. In cells, the prodrug ribavirin gets triphosphorylated and in it inhibits viral RNA polymerases, interfering with the synthesis of newly formed RNA.</p>

<p>Emtricitabine is a nucleoside reverse transcriptase inhibitor with activity against human immunodeficiency virus and hepatitis B virus</p>

<p>Uridine diphosphate choline (UDPC) sodium is a nucleotide that is used as a phosphoramidite for DNA synthesis. The chemical formula for UDPC is C8H14N4O8P. The activation of the molecule occurs in acidic conditions, which may be due to the formation of an amide bond between the terminal phosphate and the amino group on the phosphorylcholine. This same reaction can also occur in alkaline conditions. UDPC has been shown to inhibit viral replication, including HIV-1, by blocking reverse transcription of viral RNA into DNA. It also has anticancer effects, as it inhibits cell proliferation and induces apoptosis in cancer cells. UDPC does not have any known side effects or toxicity.</p>

<p>2',3',5'-Tri-O-acetyl-8-bromoguanosine is a synthetic nucleoside analog that inhibits the growth of tumor cells. It has been shown to inhibit the progression of prostate cancer and cervical cancer by binding to guanosine, preventing its conversion into ATP. This compound also prevents proliferation in hek293 and glioblastoma cells. The mechanism of action may be due to oxidative phosphite formation, which causes DNA damage and subsequent apoptosis.</p>

<p>Nucleoside phosphoramidites are used in the chemical synthesis of oligonucleotides containing 2’-O-(2-methoxyethyl) adenosine nucleoside units. Using a chemical approach rather than an enzymatic one allows custom-made oligonucleotides of a desired sequence to be obtained. 3’-Cyanoethyl phosphoramidites are typically modified by reaction with an appropriate alcohol in the presence of an azole catalyst such as imidazole or 1H-tetrazole. N6-Benzoyl-5'-O-DMT-2'-O-MOE-adenosine 3'-CE phosphoramidite has been used in the synthesis of 2’-modified oligonucleotides as protein binding modulators.</p>

<p>2-Fluoroadenosine is a nucleoside that has shown high resistance to the enzyme cyclase. This property may be due to its structural and conformational properties, which are different from those of adenosine. 2-Fluoroadenosine has been shown to inhibit the synthesis of ATP in ventricular myocardium and fat cells, as well as increase levels of adenylate kinase in blood. It has also been shown to have potential as a drug target for autoimmune diseases, such as multiple sclerosis. 2-Fluoroadenosine can be used for biochemical and pharmacokinetic studies because it is rapidly metabolized by the liver and excreted in urine.<br>2-Fluoroadenosine can also be used to measure changes in the ratio of adenylate kinase:adenylate kinase reductase (AKAR) in blood plasma.</p>

<p>2'-Deoxy-a-adenosine is a nucleoside that contains an adenine base. It has been studied for its biological properties, including its reaction with solution and its use as an antimicrobial agent. 2'-Deoxy-a-adenosine has been shown to inhibit the growth of bowel disease in mice by binding to the adenosine A3 receptor on the surface of cells. This nucleoside also binds to nuclear DNA and may be used as a pharmacological agent, but more research is needed to determine whether it would be effective against cancer cells. 2'-Deoxy-a-adenosine may also be useful as a potential drug target for the treatment of cancer due to its ability to bind with dna duplexes, which are found in all cancer cells.</p>

<p>Nucleotide analogue for use in oligonucleotide synthesis</p>

<p>5'-C-Methylcytidine is an analogue of cytidine</p>

<p>2-Amino-9-(2'-deoxy-b-D-ribofuranosyl)purine is a nucleoside analog that has been found to be effective in the treatment of leukemia.</p>

<p>Inhibitor of adenylyl and guanylyl cyclase</p>

<p>7-Deaza-2'-C-ethynyladenosine (7DAA) is a research inhibitor that is classified as a polymerase inhibitor. It binds to the active site of the viral NS5B polymerase and inhibits RNA synthesis, which leads to virus replication. 7DAA has shown activity against hepatitis B virus (HBV) and hepatitis C virus (HCV). It also shows multifunctional properties in its inhibition of HBV genotypes A1, A3, and D1. In addition, 7DAA interacts with the RNA binding site on HCV polymerase protein and prevents binding of the viral RNA genome to this site. 7DAA also inhibits HIV replication by preventing assembly of the reverse transcriptase enzyme complex at an early stage.</p>

<p>Functionalised adenosine riboside</p>

<p>2'-O-(2-Methoxyethyl)adenosine 5'-a-thiotriphosphate sodium salt is a synthetic nucleoside with antiviral and anticancer properties. It is an analog of adenosine 5'-triphosphate (ATP) in which the ribose sugar has been replaced by a 2'-O-(methoxyethyl) moiety. It has shown to be cytotoxic against cancer cells, and it is a potent activator of human telomerase, the enzyme that synthesizes telomeres at the end of chromosomes. This compound has been shown to have high purity and quality and does not have any CAS numbers assigned to it.</p>

<p>8-Aza-7-deaza-2'-deoxyguanosine is an alkynylated, cross-linked, single stranded nucleic acid. It has been shown to be effective at cross-linking and cross-linking nucleic acids. 8-Aza-7-deaza-2'-deoxyguanosine binds to the 7 deazapurine residues in DNA, forming a covalent bond between the two strands of the helix. This binding prevents the strand from unwinding and prevents the replication of DNA. The thermodynamic data for this compound shows that it is stable in both hot and cold water, which makes it a good candidate for use in research as well as in clinical settings.</p>

<p>A hetero-base functionalised ara-nucleoside</p>

<p>Uridine 5'-triphosphate tris salt is a pyrimidine nucleotide that is used in the synthesis of RNA. It has been shown to be an effective inhibitor of hamster ovary and human ovarian cells. Uridine 5'-triphosphate tris salt is water-soluble and does not interfere with cellular assays or microfluidic devices. Uridine 5'-triphosphate tris salt has also been shown to have potential as a model system for analytical chemistry and pharmacological research.</p>

<p>5'-O-Tosylthymidine is a bifunctional reagent that is used in the synthesis of DNA. It is a nucleophilic, inorganic compound that reacts with the electrophilic acrylonitrile group on 5'-hydroxythymidine to form a stable thiophosphate linkage. The reaction takes place stepwise and is catalyzed by an enzyme called DNA polymerase. This product has been used as an antimetabolite in medicine, mainly for treating leukemia.</p>

<p>5-Iodocytidine 5'-triphosphate sodium salt is a novel antiviral agent. It is the sodium salt of 5-iodocytidine 5'-triphosphate and is used to inhibit viral replication. It inhibits RNA synthesis by interfering with the incorporation of deoxyribonucleosides into the growing DNA chain, which blocks DNA synthesis. This inhibition prevents virus production and may be useful in treating cancer.</p>

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<p>2',3'-Dideoxy-2',3'-didehydro-2'-fluorocytidine (ddC) is a nucleoside with antiviral activity. The mechanism of action is not well understood, but ddC has been shown to inhibit the proliferation of human immunodeficiency virus (HIV). It is also active against isolates of herpes simplex virus and vesicular stomatitis virus. The elimination half-life of ddC in humans is about 8 hours. In humans, this drug is eliminated by methylation and glucuronidation reactions. The pharmacokinetics of ddC have been studied in animals, including rats and rabbits, with preliminary indications that the elimination half-life may be longer than in humans.</p>

<p>2'-Deoxy-N2-methylguanosine is a nucleoside with anticancer properties. It is a phosphoramidite, which is an analog of the natural nucleotide guanosine, where the 2'-hydroxyl group has been replaced by a methylene group. This compound is used in DNA synthesis and RNA synthesis. It can be used as a monophosphate or diphosphate. It also has antiviral and anti-inflammatory activities, as well as N2-methylamino moiety that can be used for the treatment of cancer and inflammatory diseases such as arthritis.</p>

<p>2'-Deoxyadenosine is a nucleoside that is found in DNA. It has been shown to have potent anticancer activity against carcinoma cell lines and to bind to the adenosine receptor A3. 2'-Deoxyadenosine has also been shown to inhibit the production of inflammatory cytokines, such as tumor necrosis factor-α and interleukin-6, from nuclear extracts of mouse tumor cells. This nucleoside may be a potential drug target for the treatment of cancer and inflammation.</p>

<p>3'-Deoxy-5-methyluridine (3'-DMAU) is a synthetic nucleoside that is used in the treatment of viral infections. 3'-DMAU has antiviral and anticancer activity, and it has been used to synthesize DNA for genetic engineering. It has shown promising results in the treatment of HIV as well as in the prevention of cancer metastasis. 3'-DMAU inhibits DNA synthesis by binding to the enzyme RNA polymerase, which blocks its interaction with ribonucleosides, thus inhibiting RNA synthesis. In addition, 3'-DMAU causes cell death by inhibiting protein synthesis. The drug is activated by phosphorylation to form 5'-triphosphate and 5'-diphosphate derivatives, which inhibit DNA and RNA synthesis at multiple sites within the cell.</p>

<p>Oleoyl coenzyme A lithium salt is a fatty acid that belongs to the class of organic compounds known as aliphatic acyl-coenzyme A. It is synthesized by the enzyme synthetase and can be used to diagnose cascading, linear response, and aldehyde synthesis in carbon nanotubes. Oleoyl coenzyme A lithium salt has been shown to bind to sephadex G-100 and immobilize it on a surface. This immobilization process aids in the diagnosis of various diseases such as diabetes mellitus, cancer, and cardiovascular problems. The chloride anion present in oleoyl coenzyme A lithium salt buffers and stabilizes the pH levels during this process. Oleoyl coenzyme A lithium salt also binds to multi-walled carbon nanotubes (MWNTs) due to its hydrophobic nature, which aids in the detection of markers such as lipids or proteins using immunological techniques.</p>

<p>5′-O-DMT-LNA N-Bz adenosine is a novel nucleoside that has been modified with an aminooxy group. The compound is synthesized by the phosphoramidite method and it is designed for use in antiviral and anticancer research. 5′-O-DMT-LNA N-Bz adenosine can be used as a substrate for DNA polymerases and other enzymes to produce nucleic acid strands. This product is CAS No. 206055-74-5, monophosphate, Phosphoramidites, Synthetic, Deoxyribonucleosides, Anticancer, Ribonuclesides, High purity.</p>

<p>Propionyl coenzyme A lithium salt is a phosphoramidite that can be used in the synthesis of DNA and RNA. It is a novel chemical compound that has been modified to include ribonucleosides in addition to deoxyribonucleosides. This product is of high purity and quality, with a CAS number of 108321-21-7.</p>

<p>Spacer-C3 Cep is a novel modified nucleoside phosphoramidite. It has been chemically modified with a spacer arm and 3-Cep (1,2-diaminoethane). Spacer-C3 Cep is an activator for DNA polymerases, which are enzymes that synthesize DNA from deoxyribonucleosides. The modified nucleoside phosphoramidite has antiviral and anticancer activities. It can be used in the synthesis of oligodeoxyribonucleotides for gene therapy or as a monophosphate for the preparation of DNA probes. Spacer-C3 Cep can also be used to synthesize ribonucleotide analogs that inhibit viral replication by inhibiting RNA synthesis.</p>

<p>2'-Deoxyuridine-5'-monophosphate disodium salt (2DUMP) is a nucleoside analog that inhibits the synthesis of DNA and RNA by inhibiting the enzyme thymidylate synthase. 2DUMP is a covalent inhibitor of thymidylate synthase, which prevents the formation of dTMP from deoxyuridine 5'-triphosphate. This compound has been shown to be effective in treating squamous cell cancer and hyperproliferative diseases such as chronic myelogenous leukemia. 2DUMP is also used as an antiviral agent against HIV, herpes simplex virus, and varicella zoster virus. It has been shown to bind to benzalkonium chloride (BAK) in biological samples such as serum or plasma.<br>2DUMP binds to BAK through a covalent linkage between the 3' hydroxyl group on BAK and the phosphate group on 2DUMP</p>

<p>5′-O-DMT-LNA N-Bz 5-Me cytidine is a protected LNA cytidine nucleoside.</p>

<p>8-Nitroguanosine is a nucleotide analogue that inhibits the activity of cyclic GMP in cells. It has been found to inhibit the growth of bacteria and cancer cells, as well as to stimulate the production of reactive oxygen species in brain cells. 8-Nitroguanosine has also been shown to inhibit the activity of cyclase enzymes in liver cells, which may be useful for treating liver disease. 8-Nitroguanosine is used as a chemical base for monoclonal antibodies that are used to study brain functions and pathogenic mechanisms.</p>

<p>N2-Acetyl-5'-O-DMT-guanosine is a novel anticancer nucleoside that has been synthesized to mimic the natural nucleotides found in DNA. It is phosphorylated to N2-acetyl-5'-O-DMT-guanosine monophosphate, which can be converted back to the active form of N2-acetyl-5'-O-DMT guanosine by phosphatases. This agent activates DNA synthesis and inhibits viral replication, including HIV and herpes simplex virus. The antiviral activity is due to its inhibition of viral DNA polymerase and diphosphate kinase.</p>

<p>3'-Adenylyl-5'-guanosine ammonium salt is a dinucleoside that competes with guanosine for binding to the enzyme adenylate cyclase. This reaction leads to increased levels of cyclic AMP, which causes an increase in the rate of viral replication. 3'-Adenylyl-5'-guanosine ammonium salt has been shown to inhibit the growth of pyogenic bacteria such as Streptococcus pyogenes and has also been used to treat influenza infections. 3'-Adenylyl-5'-guanosine ammonium salt is an inorganic compound that is found in tobacco. It can be synthesized from uridine and p-nitrophenyl phosphate by the reaction: 3'--O--(CH2)4--COOH + H2N--PO4--&gt; 3'--O--(CH2)4--CONH2 + H3PO4</p>

<p>5-Methoxyuridine-5'-triphosphate is a monophosphate nucleoside that serves as a precursor for the synthesis of 5-methoxyuridine (5MU) and other nucleosides. It has antiviral effects, and is used in the treatment of herpes zoster infection. 5-Methoxyuridine-5'-triphosphate is an analog of uridine and deoxyribonucleosides with antiviral activity, which can be used to treat herpes zoster infection. This drug also has anticancer properties, which may be due to its ability to inhibit DNA synthesis by inhibiting ribonucleotide reductase and DNA polymerase, leading to cell death.</p>