Nucléosides

<p>N2-DMF-5'-O-DMT-2'-O-methylguanosine is a novel nucleoside analog that has antiviral, anticancer and immunomodulating properties. It is synthesized from 2′,3′-dideoxyadenosine 5′-monophosphate by the condensation of 2,6-dimethylaniline with methylguanosine 5′-monophosphate and 5,6-dimethylaniline. The modification of the guanine base in N2-DMF-5'-O-DMT-2'-O-methylguanosine to an O6 -methyl group results in increased affinity for the ribonucleotide reductase enzyme (RNR) and inhibition of DNA synthesis.</p>

<p>5-(Aminomethyl)-2-thiouridine is a bifunctional molecule that can be used in chromatography and as a precursor for the epigenetic modifications of DNA. 5-(Aminomethyl)-2-thiouridine has been shown to have an effect on the methyltransferase pathway, which is involved in the epigenome. This molecule has also been shown to affect the growth rate of bacteria in vitro.</p>

<p>Polyinosinic acid is a single stranded RNA analog which is combined with polycytidylic acid (poly C) to form a stable duplex structure known as Polyinosinic acid-polycytidylic acid (Poly I:C). PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations.  Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes. We can supply PolyI:C to all stages of your project - from R&amp;D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.<br>For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'</p>

<p>3'-Azido-2',3'-dideoxyuridine is an analog of the nucleoside dideoxyuridine that inhibits HIV replication. It has a high inhibitory dose and low toxicity. 3'-Azido-2',3'-dideoxyuridine is converted to its active form, 3'-azido-2',3'-dideoxythymidine (AZT), by dephosphorylation in human serum. AZT inhibits HIV replication by competing with the natural substrate for viral DNA polymerase, thereby inhibiting synthesis of viral DNA. 3'-Azido-2',3'-dideoxyuridine has been shown to be effective against hepatitis B virus and hepatitis C virus in cell cultures.</p>

<p>3'-Azido-3'-deoxythymidine 5'-triphosphate triethylammonium salt is a nucleoside analogue of 3'-azido-3'-deoxythymidine. It is an antiviral agent that inhibits the synthesis of viral DNA and RNA by inhibiting the activity of DNA polymerase, which has been shown to be effective against HIV and herpes simplex virus type 1. The phosphoramidites are synthesized from the corresponding phosphonate, 3'-azido-3'-deoxythymidine 5'-triphosphate, by treatment with a base (e.g., sodium methoxide). This novel nucleoside analogue has been shown to have anticancer properties in animal models.</p>

<p>Please enquire for more information about Guanosine hydrate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>3'-Deoxy-3'-C-methylcytidine is a monophosphate nucleotide that is used as an activator for DNA synthesis. It is a novel, synthetic nucleoside with high purity and high quality. 3'-Deoxy-3'-C-methylcytidine has been shown to inhibit viral replication, including human immunodeficiency virus type 1 (HIV-1), herpes simplex virus type 1 (HSV-1) and Epstein Barr virus (EBV) in cell culture. It also inhibits the growth of cancer cells in vitro by inhibiting the synthesis of DNA, RNA, and protein.</p>

<p>Cytidine 5'-monophosphate sodium salt is a nucleotide that is found in RNA and DNA. Cytidine 5'-monophosphate sodium salt is an intermediate in the biosynthesis of uridine, choline, and saccharose. It also plays an important role in the immune system as it can be a precursor for immunoglobulins. The reaction rate of cytidine 5'-monophosphate sodium salt with lipase has been shown to be constant at pH 7.5-8.0 and 37°C. This product has been shown to have emulsifying properties by forming micelles with water-immiscible solvents such as hexane or heptane, which may be due to its ability to form hydrogen bonds with other molecules such as saccharose or guanosine. Cytidine 5'-monophosphate sodium salt can also be used as a chromatographic material for separating saccharose from other sugars</p>

<p>LDA is a technique for extracting spectral features from a set of spectra. It uses the probabilistic model of discriminant analysis to discriminate between groups of spectra. LDA has been shown to outperform other techniques, such as PCA and MDA, in analyzing datasets with a small number of variables. The algorithm is incrementally updated with new data points and parameters, which makes it an attractive choice for real-time applications.</p>