Anti-inflammatoires non stéroïdiens (AINS)

<p>Applications Droxicam is a non-steroidal anti-inflammatory drug.<br>References Lapeyre-Mestre, M., et. al.: Fundam. Clin. Pharm., 20, 391 (2006)<br></p>

<p>Applications 4-O-β-D-Glucosyl-5-O-methyllvisamminol is a novel epigenetic suppressor of histone H3 phosphorylation. Potent anti-inflammatory and anti-carcinogenic agent.<br>References Kang, J. et al.: Bioorg. Med. Chem. Lett., 24, 4763 (2014); Kong, X. et al.: J. Ethnopharm., 148, 842 (2013);<br></p>

<p>Applications 6-Hydroxy Etodolac is an Etodolac (E933100) metabolite.<br>References Humber, L., et al.: J. Med. Chem., 32, 2582 (1989), Koupai-Abyazani, M., et al.: J. Anal. Toxicol., 23, 200 (1999),<br></p>

<p>Applications An intermediate for the preparation of 3-Hydroxy Desloratadine.<br></p>

<p>Stability Hygroscopic<br>Applications Tenofovir Monohydrate is an HIV-1 RT inhibitor and antiretroviral drug.<br>References Zhao, Z., et al.: Method for preparing medical salts and/or derivatives of tenofovir disoproxil, and their application for preventing and/or treating HBV and HIV/AIDS infections, CN 101574356 (2009);<br></p>

<p>Stability Hygroscopic<br>Applications Troglitazone Sulfate is the major metabolite of Troglitazone (T892500), a hypoglycemic agent with cholestatic effect.<br>References Ciaraldi, T.P., et al.: Metabolism, 39, 1056 (1990); Kuzuya, T., et al.: Diabetes Res. Clin. Pract., 11, 147 (1991); Kellerer, M., et al.: Diabetes, 43, 447 (1994); Adachi, Y., et al.: Mol. Pharmacol., 67, 923 (2005);<br></p>

<p>Applications Diamino-5-phenylthiazole Hydrobromide is an phenylthiazole derivative used in the preparation of antiallergic and antiinflammatory agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ban, M. et al.: Bioorg. Med. Chem., 6, 1069 (1998);<br></p>

<p>Applications Bromfenac is a non-steroidal anti-inflammatory agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Obach, R., et al.: Drug Metab. Disposition, 36, 1385 (2008), MacDonald, J., et al.: Toxicol. Sci., 110, 40 (2009), Varma, M., et al.: J. Med. Chem., 52, 4844 (2009),<br></p>

<p>Impurity Clobetasol Propionate EP Impurity J<br>Applications 9α-Fluoro-11β-hydroxy-16-β-methyl-3-oxoandrosta-1,4-diene-17(R)-spiro-2’-[4’-chloro-5’-ethylfuran-3’(2’H)-one (Clobetasol Propionate EP Impurity J) is an impurity in the synthesis of Clobetasol 17-Propionate (C583500), a topical corticosteroid. Glucocorticoid; anti-inflammatory.<br>References Olsen, E.A., et al.: J. Am. Acad. Dermatol., 15, 246 (1986),<br></p>

<p>Applications A non-steroidal anti-inflammatory ophthalmic agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mathur, K., et al.: Bioorg. Med. Chem., 11, 1915 (2003), Zhao, M., et al.: Bioorg. Med. Chem., 15, 2815 (2007), Roy, K., et al.: Eur. J. Med. Chem., 44, 2913 (2009),<br></p>

<p>Applications A metabolite of Benzydamine (B209950).<br>References Kataoka, S., et al.: Chem. Pharma. Bull., 21, 358 (1973),<br></p>

<p>Applications Pranoprofen is an anti-inflammatory used in ophthalmology.<br>References Ayaki, M., et al.: Biocont. Sci., 15, 97 (2010); Lee, X., et al.: For. Toxicol., 28, 96 (2010);<br></p>

<p>Applications The main metabolite of Nimesulide (N477500).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Facino, R.M., et al.: Drugs, 46 (Suppl1),15 (1993), Westphal, J., et al.: J. Antimicrob. Chemother., 33, 387 (1994), Castell, J., et al.: Cell Biol. Toxicol., 13, 331 (1997), Georges, H., et al.: Life Sci., 65, 151 (1999), Singla, A.K., et al.: J. Pharm. Pharmacol., 52, 467 (2000),<br></p>

<p>Ketoprofen ethyl ester is a non-steroidal anti-inflammatory drug (NSAID) that is used to reduce inflammation and relieve pain. It is administered orally or by intravenous injection. Ketoprofen ethyl ester has been shown to inhibit the production of lipolytic enzymes in human liver cells, which may be due to its stereoselective inhibition of acyl chain hydrolases. Ketoprofen ethyl ester also inhibits the activity of type strain x-ray diffraction data, which indicates that it can be used as an inhibitor of hydrogen bond formation. The effective dose for ketoprofen ethyl ester is not yet known, but toxicity studies show that it does not cause any significant adverse effects on the central nervous system or other organs in rats at doses up to 2g/kg.</p>

<p>Apomorphine is a chemical compound that can be used as an analytical tool to study the effects of dopamine on physiological processes, and pharmacological agents on pharmacokinetics. It is also used in the treatment of Parkinson's disease. Apomorphine is a potent agonist at dopaminergic receptors in the central nervous system, and has been shown to increase locomotor activity and improve the rotarod test performance in rats. Apomorphine binds to dopamine receptors in the brain, replacing dopamine as it becomes depleted. The drug also blocks reuptake of dopamine by neurons and increases release of dopamine from nerve terminals. Apomorphine has a short half-life of about 2 hours, but may have potential for long-term treatment because its effects can last up to 24 hours.</p>

<p>Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat pain and inflammation. It belongs to the group of fatty acid derivatives, which are drugs that block the production of prostaglandins. Ibuprofen has been shown to have contraceptive effects in humans and experimental models, as well as an effect on human serum lipoproteins. Ibuprofen has also been shown to inhibit the synthesis of prostaglandins in rat liver microsomes and asymmetric synthesis in wastewater treatment. Its pharmacokinetic properties are determined by its absorption rate, distribution volume, and metabolism rate. The kinetic behavior of ibuprofen is affected by matrix effect and the kinetic behavior of ibuprofen is also affected by its pharmacokinetic properties such as isooctane, carcinoma cell lines, etc.</p>

<p>Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used for the treatment of pain, fever and inflammation. Ibuprofen is an inhibitor of cyclooxygenase 1 (COX-1), which blocks the production of prostaglandins that cause pain and inflammation. Ibuprofen has been shown to inhibit the growth of bacteria in cell culture by inhibiting protein synthesis. This drug also has a toxic effect on respiratory system cells, which may be due to its ability to induce apoptosis. Ibuprofen has been shown to inhibit the production of tumour necrosis factor-α (TNF-α) and serum enzymes, such as dismutase activity, in mice with lung cancer.</p>

<p>Naloxone hydrochloride is a competitive antagonist at mu-, delta- and kappa-opioid receptors. Naloxone binding to receptors blocks the effects of opioids such as morphine, heroin, or oxycodone. Naloxone has been shown to be effective in treating acute overdoses of these drugs and reversing the depression of respiratory function that accompanies opioid overdose. It is also used to alleviate withdrawal symptoms and in the treatment of neonatal abstinence syndrome (NAS). NAS is a condition that occurs when infants are exposed to addictive levels of opioids in utero and go through withdrawal after birth.</p>

<p>Acrivastine is a drug that belongs to the group of combination therapy. It is used in the treatment of autoimmune diseases, such as choroidal neovascularization. Acrivastine inhibits the production of prostaglandin E2 (PGE2) and inhibits the release of histamine from mast cells. Acrivastine also has immunosuppressive effects. It binds to H1 receptors and blocks their activation by histamine, which may be responsible for its therapeutic effect on eye disorders and infectious diseases. Acrivastine is chemically stable in acidic or alkaline conditions, but does not dissolve in organic solvents.</p>

<p>Apomorphine hydrochloride is the salt form of apomorphine, a morphine derivative D2 dopamine agonist. The high selectivity for D2, D3, D4 and D5 receptors makes apomorphine hydrochloride a possible drug candidate and it is in clinical trials for diagnosis and treatment of Parkinsons disease. Moreover, apomorphine and apomorphine hydrochloride have been investigated in diverse studies for treating movement disorders.</p>

<p>9-alpha,-14-alpha-3-Methoxy-17-methylmorphinan (914) is a drug that is used in the treatment of bowel disease. It has been shown to inhibit the activity of enzymes such as polymerase chain, which is responsible for DNA replication and repair. 914 also inhibits dextromethorphan, an opioid that is used in cough suppressant medications. The effects of 914 on dextromethorphan are seen in human subjects who have been given the drug intravenously or orally. 914 binds to receptors that are found on cells in the brain and spinal cord, which explains its analgesic properties. This drug can be dangerous when taken with nonsteroidal anti-inflammatory drugs because it can cause kidney damage or failure.</p>

<p>Lopinavir M-1 is a metabolite of lopinavir, which is an HIV protease inhibitor. Lopinavir M-1 has been shown to have antiviral activity against HIV-1 and other retroviruses. It is a versatile building block that can be used as a reagent or a complex compound in the synthesis of other compounds. Lopinavir M-1 also has antiviral activity against HIV-2 and SIV, but not against the influenza virus.</p>

<p>Inhibits cyclooxygenase-1 and -2; non-steroidal anti-inflammatory drug</p>

<p>Darunavir is a HIV-1 protease inhibitor used orally in the treatment of patients with multi-drug resistant HIV-1 infection (Ghosh, 2007). It has also been shown to be effective against other infectious diseases such as hepatitis C virus and SARS coronavirus. Metabolized by cytochrome P450 3A (CYP3A) isoenzymes, darunavir is often administered together with ritonavir that prolongs its bioavaiability, giving a terminal elimination half-life (t1/2) of 15 hours (Back, 2008). The effect of darunavir on natural compounds such as matrix proteins and toll-like receptor activity has also been studied via high performance liquid chromatography (HPLC) experiments.</p>

<p>Inhibitor of prostaglandin production; non-steroidal COX inhibitor</p>

<p>Rivaroxaban is a natural drug that is a direct factor Xa inhibitor. It has been shown to be an effective therapy for the treatment of atrial fibrillation, deep vein thrombosis (DVT) and pulmonary embolism (PE). It works by inhibiting the enzyme, thrombin, which is responsible for the formation of blood clots. Rivaroxaban also has an effect on the coagulation system by decreasing the levels of fibrinogen and increases in antithrombin III. This drug does not have any specific antidote, but it can be reversed with heparin. Pharmacodynamics and drug interactions have been studied extensively in preclinical models, demonstrated by the concentration–time curves.</p>

<p>Anti-viral; HIV protease inhibitor</p>

<p>Please enquire for more information about Rivastigmine N-Oxide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Acetylcholinesterase and butyrylcholinesterase inhibitor</p>