Protéine de transport membranaire

Inhibits protein translocation from ER to Golgi; fungal metabolite

Inhibitor of sodium-glucose cotransporter SGLT2

Potent inhibitor of the sodium-coupled citrate cotransporter SLC13A5 (NaCT, INDY). The compound is not structurally related to citrate and is selective for SLC13A over other related transporters.

A potent inhibitor of CETP that inhibits transfer of cholesteryl esters and triglycerides. Raises HDL cholesterol levels whilst lowering LDL cholesterol. Reduces cardiovascular events in patients with atherosclerotic vascular disease that receive statin treatment.

AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with binding affinity of 1.6 nM, 6-fold selective for MTC1 over MCT2.

Clomipramine is a tricyclic antidepressant drug that inhibits the reuptake of serotonin, norepinephrine, and dopamine. It is used to treat obsessive compulsive disorder, panic disorders and cataplexy. Additionally, Clomipramine is shown to modulate immune activation and shows constant anti-inflammatory properties at therapeutic concentrations by consistently decreasing pro-inflammatory cytokines.

Inhibits P-gp transporters ; modulates P-gp-mediated multidrug resistance

Inhibitor of CETP exchange protein

Serotonin uptake inhibitor; anti-depressant

Inhibitor of sulphonylurea receptor SUR1; hypoglycemic agent

Fluvoxamine is a selective serotonin reuptake inhibitor that is used in the treatment of depression and obsessive-compulsive disorder. It blocks the reuptake of serotonin, enhancing its effects.

GABA reuptake inhibitor

Potent P-glycoprotein (P-gp) inhibitor

Methyl-d3-magnesium iodide solution, 1.0 M in diethyl ether, is a specialized organometallic reagent used extensively in synthetic chemistry. This compound is a labeled Grignard reagent, where the methyl group is fully deuterated. It is sourced through the synthesis involving the reaction of deuterated methyl iodide with magnesium in an anhydrous diethyl ether solvent.