Protéine de transport membranaire

<p>Dapagliflozin is a sodium-glucose cotransporter subtype 2 (SGLT2) inhibitor that can be used in the treatment of diabetes mellitus type 2. It inhibits glucose reabsorption in the proximal tubule of the nephron and results in glycosuria, which helps to improve glycaemic control. Also, Dapagliflozin is used to lower the risk of sustained eGFR decline, end-stage renal disease, cardiovascular death, and hospitalization for heart failure in patients with chronic kidney disease who are at risk of progression.</p>

<p>Fluvoxamine is a selective serotonin reuptake inhibitor that is used in the treatment of depression and obsessive-compulsive disorder. It blocks the reuptake of serotonin, enhancing its effects.</p>

Inhibitor of Na+/Ca2+ exchanger 1

<p>Potent inhibitor of the sodium-coupled citrate cotransporter SLC13A5 (NaCT, INDY). The compound is not structurally related to citrate and is selective for SLC13A over other related transporters.</p>

Ezetimibe is a lipid-lowering compound that inhibits cholesterol absorption. This drug helps to lower cholesterol in primary hyperlipidemia and familial cholesterolemia. Ezetimibe targets the cholesterol transport protein Niemann-Pick C1-Like 1 (NPC1L1).

<p>Amitryptylline is a tricyclic antidepressant that is used to treat depression and to relieve depression associated anxiety. Although its mechanism is not fully understood, it is suggested that this drug inhibits norepinephrine and serotonin thus increasing their concentrations at the synaptic clefts. Additionally, Amitryptylline has shown to have anticholinergic properties.</p>

<p>(S)-Citalopram oxalate or Escitalopram oxalate is the S-enantiomer of racemic Citalopram. It is a selective serotonin reuptake inhibitor that is used for the treatment of depression and anxiety disorder. Escitalopram enhances serotonergic activity by binding to the primary binding site on the serotonin transporter thus preventing the reuptake of serotonin into the presynaptic neuron.</p>

<p>Dapoxetine is a drug that belongs to the group of selective serotonin reuptake inhibitors (SSRIs). It is used to treat premature ejaculation. This drug inhibits the serotonin transporter allowing for an increased action of serotonin at the postsynaptic cleft, thus promoting ejaculatory delay.</p>

Inhibitor of ABC transporters; oral bioenhancer for anti-cancer therapy

<p>Levetiracetam is a modulates the activity of the synaptic vesicle protein 2A (SV2A) in the brain and is used to treat epilepsy.It is not clear exactly how Levetiracetam affects the activity of SV2A and if this is through inhibiting the release of neurotransmitters. However, it is thought to work by binding to a specific site on SV2A, which interferes with its normal function and ultimately leads to changes in exocytosis. One of the postulated mechanisms of action is that this modulates glutamate release. Levetiracetam is used to treat certain types of seizures in people with epilepsy.<br>Levetiracetam is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>Furosemide is a potent loop diuretic that is used in the treatment of hypertension, liver cirrhosis, renal disease and heart failure. This drug acts on the kidney to increase water loss from the body. It inhibits electrolyte reabsorption. Furosemide also exerts vasodilatory effects.</p>

<p>Esomeprazole is an anti-ulcer drug that is used in the treatment of GERD and to reduce the risk of ulcers associated with NSAID’s. This drug is a proton pump inhibitor that suppresses the release of gastric acid in the stomach.</p>

Sertraline is a selective serotonin reuptake inhibitor (SSRI) that is used to treat major depression, obsessive-compulsive disorder, panic disorder, posttraumatic stress disorder, and premenstrual dysphoric disorder. This drug inhibits the reuptake of serotonin which results in an increased synaptic concentration of serotonin in the CNS.

<p>Inhibitor of sodium-glucose cotransporters SGLT1 and SGLT2</p>

<p>Selective and potent inhibitor of glucose transporter GLUT1 with IC50 of 2 nM. The compound limits glucose uptake and is able to block basal as well as stress-regulated glycolysis in ovarian cancer cells. It supresses proliferation, viability and tumorigenicity of ovarian cancer cells.</p>

<p>Clomipramine is a tricyclic antidepressant drug that inhibits the reuptake of serotonin, norepinephrine, and dopamine. It is used to treat obsessive compulsive disorder, panic disorders and cataplexy. Additionally, Clomipramine is shown to modulate immune activation and shows constant anti-inflammatory properties at therapeutic concentrations by consistently decreasing pro-inflammatory cytokines.</p>

Reserpine is an indole alkaloid that is found in the roots of the Rauwolfia plant. Reserpine has been shown to possess analgesic, anti-inflammatory, sedative, and anti-hypertensive properties. It is mainly used to treat mild to moderate hypertension. Reserpine inhibits the uptake of norepinephrine into storage vesicles by irreversibly blocking the vesicular monoamine transporter thus resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It is used as a pharmacological tool in research on chronic liver diseases.

<p>Elacridar is an inhibitor of ATP-dependent transport, which is mediated by P-glycoprotein (P-gp). Functioning as an oral bioenhancer, Elacridar addresses multiple drug resistance in tumors, a common challenge in cancer treatment often linked to changes in the expression of protein inhibitors. Inhibition of P-gp by Elacridar is a key mechanism behind its effectiveness. P-glycoprotein, a well-characterized human ABC transporter of the MDR/TAP subfamily, acts as an ATP-dependent efflux pump with broad substrate specificity. Its increased expression in the intestines can hinder drug absorption, leading to reduced bioavailability and inadequate therapeutic plasma concentrations. Elacridar addresses this challenge by inhibiting P-gp, thereby increasing the bioavailability of coadministered drugs. Overall, Elacridar emerges as a promising option for the treatment of solid tumors, offering a strategic approach to overcoming multidrug resistance in cancer therapy.</p>

Revaprazan is a proton pump inhibitor drug that is used for the treatment of GERD and other conditions related to an excess in stomach acid production. This drug works by inhibiting the proton pump in the stomach lining known as the H+/K+-ATPase, resulting in a reduction of stomach acid and relief of symptoms.

Duloxetine is a serotonin and norepinephrine reuptake inhibitor drug that is used to treat anxiety, pain, osteoarthritis and stress incontinence. This drug inhibits the reuptake of the neurotransmitters serotonin and norepinephrine so that there are increased levels of them in the synaptic cleft.