Modulateur d'interaction protéine-protéine
Les modulateurs d'interactions protéine-protéine sont des composés qui influencent l'interaction entre les protéines, soit en renforçant, soit en perturbant leur liaison. Ces modulateurs sont des outils précieux pour étudier les réseaux de protéines, comprendre les mécanismes des maladies et développer de nouvelles stratégies thérapeutiques. Les interactions protéine-protéine sont fondamentales pour de nombreux processus biologiques, notamment la transduction des signaux, la réponse immunitaire et la régulation cellulaire. Chez CymitQuimica, nous offrons une gamme diversifiée de modulateurs d'interactions protéine-protéine de haute qualité pour soutenir vos recherches en biochimie, biologie moléculaire et découverte de médicaments.
63 produits trouvés pour "Modulateur d'interaction protéine-protéine"
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AMG 510
CAS :<p>KRAS G12C inhibitor</p>Formule :C30H30F2N6O3Degré de pureté :(%) Min. 98%Couleur et forme :PowderMasse moléculaire :560.59 g/molCBR 470-1
CAS :<p>Activates NRF2 signalling</p>Formule :C14H20ClNO4S2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :365.9 g/molBT 18
CAS :<p>Activator of RET signalling cascade and a derivative of a GFL mimetic compound BT 13. Molecular docking calculations and molecular dynamics simulations were performed in GDNF−GFRα1−RetA complex and showed that BT 18 binds to the allosteric site in GFRα1 as well as RetA surface interfacing GFRα1.</p>Formule :C30H31F4N3O6SDegré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :637.64 g/molCCG 63808
CAS :<p>Reversible inhibitor of RGS proteins</p>Formule :C25H15FN4O2SDegré de pureté :Min. 95%Masse moléculaire :454.08998(2R)-Arimoclomol maleate
CAS :<p>(2R)-Arimoclomol maleate is an investigational pharmaceutical compound, which is an orally bioavailable small molecule with pharmacological activity primarily targeting cellular protein homeostasis mechanisms. This therapeutic agent is derived from molecular chaperones and operates by selectively enhancing the expression of heat shock proteins (HSPs). The mechanism of action involves the modulation of the heat shock response, wherein (2R)-Arimoclomol maleate amplifies the natural cellular defense pathways against protein misfolding and aggregation.</p>Formule :C18H24ClN3O7Degré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :429.85 g/molBardoxolone methyl
CAS :<p>Activater of the Nrf2 pathway and an inhibitor of the NF-κB pathway. Possible applications have extended to anti-viral treatment of COVID-19.</p>Formule :C32H43NO4Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :505.69 g/molH 151
CAS :<p>A potent inhibitor of STING protein (stimulator of interferon genes), a protein that partakes in intracellular DNA sensing pathway. H 151 blocks palmitoylation of STING, which is required for the formation of multimeric complexes for recruiting downstream signalling molecules. Inhibition of STING by H 151 reduces pro-inflammatory cytokine synthesis.</p>Formule :C17H17N3ODegré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :279.34 g/molCytochalasin D
CAS :<p>Inhibits actin polymerization</p>Formule :C30H37NO6Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :507.62 g/molAMG 510 racemate
CAS :<p>Racemic mixture of AMG 510</p>Formule :C30H30F2N6O3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :560.59 g/molNL 1
CAS :<p>Inhibits the mitochondrial outer mebrane protein mitoNEET, anti-leukaemic</p>Formule :C18H25NO3SDegré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :335.46 g/molLF3
CAS :<p>A potent inhibitor of Wnt/β-catenin signalling pathway that interferes with β-catenin/TFC4 interaction. Reduces growth and motility of colon cancer cells. Inhibits self-renewal, whilst inducing differentiation in cancer stem cells.</p>Formule :C20H24N4O2S2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :416.56 g/molDocetaxel - Bio-X ™
CAS :<p>Docetaxel is an antineoplastic agent that is used to treat various cancers such as breast and prostate cancer. This drug interferes with the normal function of microtubule growth. It is an anti-mitotic drug used in chemotherapy. Research has shown that this drug also induces programmed cell death in cancer cells.</p>Formule :C43H53NO14Degré de pureté :Min. 90 Area-%Couleur et forme :White/Off-White SolidMasse moléculaire :807.88 g/molNAcM-OPT
CAS :<p>Inhibits N-Acetyl-mediated interaction between BE2M (E2 conjugating enzyme) and DCN1 (a component of E3 ligase complex). Also has inhibitory action on DCN2 and NEDD8 ubiquitin-like protein. Reduces anchorage-independent growth in DCN1-amplified cell line.</p>Formule :C23H29Cl2N3ODegré de pureté :Min. 95%Couleur et forme :solid.Masse moléculaire :434.4 g/molAutogramin 2
<p>Autophagy inhibitor that selectively targets the StART domain of GRAMD1A</p>Formule :C21H27N3O4SDegré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :417.52 g/molABBV 075
CAS :<p>Inhibitor of BET bromodomain; antineoplastic</p>Formule :C22H19F2N3O4SDegré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :459.47 g/molGNE 371
CAS :<p>A chemical probe for the dual bromodomains of human transcription-initiation-factor TFIID subunit 1 (TAF1). GNE 371 binds TAF1 with an IC50 of 10 nM and is selective over other bromodomain family members. Exerts anti-proliferative effects in synergy with BET inhibitor JQ1.</p>Formule :C24H25N5O3Degré de pureté :(Hplc-Ms) Min. 98 Area-%Masse moléculaire :431.49 g/molES9-17
CAS :<p>Inhibitor of clathrin-mediated endocytosis (CME) and ligand to the clathrin heavy chain (CHC). ES9-17 is an inhibitor of the CHC function with EC50 of 13 μM in plant model Arabidopsis thaliana. ES9-17 is a non-protonophoric CME inhibitor and it does not alter the cytoplasmic pH levels substantially. In a mammalian cell line HeLa, ES9-17 reduced the uptake of transferrin, which is a CME-driven process.</p>Formule :C10H8BrNO2S2Degré de pureté :Min. 95%Couleur et forme :Off-White PowderMasse moléculaire :318.21 g/mol17-Allylaminogeldanamycin
CAS :<p>17-AAG is the first clinically tested hsp90 inhibitor that exhibits antitumor activity. Its antitumor effects are documented in vivo for various animal models, including erbB2-dependent breast cancer, prostate cancer models, and melanoma.</p>Formule :C31H43N3O8Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :585.69 g/molEED 226 monohydrate
CAS :<p>Potent and selective inhibitor of polycomb repressive complex 2 (PRC2), by binding to the K27me3-pocket of the regulatory EED subunit. Inhibits H3K27 methylation in histone 3. Has anti-tumor activity in murine xenograft models. Synergistic with EZH2 inhibitor against cancer cell growth.</p>Formule :C17H15N5O3S·H2ODegré de pureté :Min. 95%Couleur et forme :White To Yellow SolidMasse moléculaire :387.41 g/molAPTO 253
CAS :<p>Induces Kruppel like factor 4 (KLF4) and reduces the expression of MYC. Anti-tumor activity of APTO 253 has been demonstrated in AML and haematological malignancies. Inducing KLP4 expression in ovarian cancer cells using APT0 253 sensitises cells to cisplatin and paclitaxel. BRCA1/2-deficient cancer cells are hypersensitive to APTO 253, which mediates its action by causing DNA damage.</p>Formule :C22H14FN5Degré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :367.38 g/mol
