Modulateur d'interaction protéine-protéine
Les modulateurs d'interactions protéine-protéine sont des composés qui influencent l'interaction entre les protéines, soit en renforçant, soit en perturbant leur liaison. Ces modulateurs sont des outils précieux pour étudier les réseaux de protéines, comprendre les mécanismes des maladies et développer de nouvelles stratégies thérapeutiques. Les interactions protéine-protéine sont fondamentales pour de nombreux processus biologiques, notamment la transduction des signaux, la réponse immunitaire et la régulation cellulaire. Chez CymitQuimica, nous offrons une gamme diversifiée de modulateurs d'interactions protéine-protéine de haute qualité pour soutenir vos recherches en biochimie, biologie moléculaire et découverte de médicaments.
63 produits trouvés pour "Modulateur d'interaction protéine-protéine"
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17-Allylaminogeldanamycin
CAS :<p>17-AAG is the first clinically tested hsp90 inhibitor that exhibits antitumor activity. Its antitumor effects are documented in vivo for various animal models, including erbB2-dependent breast cancer, prostate cancer models, and melanoma.</p>Formule :C31H43N3O8Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :585.69 g/molEED 226 monohydrate
CAS :<p>Potent and selective inhibitor of polycomb repressive complex 2 (PRC2), by binding to the K27me3-pocket of the regulatory EED subunit. Inhibits H3K27 methylation in histone 3. Has anti-tumor activity in murine xenograft models. Synergistic with EZH2 inhibitor against cancer cell growth.</p>Formule :C17H15N5O3S·H2ODegré de pureté :Min. 95%Couleur et forme :White To Yellow SolidMasse moléculaire :387.41 g/molBardoxolone methyl
CAS :<p>Activater of the Nrf2 pathway and an inhibitor of the NF-κB pathway. Possible applications have extended to anti-viral treatment of COVID-19.</p>Formule :C32H43NO4Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :505.69 g/molCBR 470-1
CAS :<p>Activates NRF2 signalling</p>Formule :C14H20ClNO4S2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :365.9 g/molCCG 63808
CAS :<p>Reversible inhibitor of RGS proteins</p>Formule :C25H15FN4O2SDegré de pureté :Min. 95%Masse moléculaire :454.08998AMG 510
CAS :<p>KRAS G12C inhibitor</p>Formule :C30H30F2N6O3Degré de pureté :(%) Min. 98%Couleur et forme :PowderMasse moléculaire :560.59 g/molAPTO 253
CAS :<p>Induces Kruppel like factor 4 (KLF4) and reduces the expression of MYC. Anti-tumor activity of APTO 253 has been demonstrated in AML and haematological malignancies. Inducing KLP4 expression in ovarian cancer cells using APT0 253 sensitises cells to cisplatin and paclitaxel. BRCA1/2-deficient cancer cells are hypersensitive to APTO 253, which mediates its action by causing DNA damage.</p>Formule :C22H14FN5Degré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :367.38 g/molMCC 950 sodium
CAS :<p>Inhibitor of NLRP3 inflammasome and suppressor of the inflammatory cytokine IL-1β secretion. The compound was tested in diabetic mice and was shown to decrease the incidence of cardiac arrythmias, which are common secondary complications in diabetes mellitus. MCC 950 has potential to reverse diabetes-induced pathologies in cardiac electrophysiology.</p>Formule :C20H23N2O5S·NaDegré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :426.46 g/molVinorelbine
CAS :Produit contrôlé<p>Microtubule disrupter; anti-mitotic drug; anti-cancer alkaloid</p>Formule :C45H54N4O8Degré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :778.93 g/molPaquinimod
CAS :<p>A calcium-binding protein S100A9 inhibitor with immunomodulatory activity that reduces pathology in experimental collagenase-induced osteoarthritis.</p>Formule :C21H22N2O3Degré de pureté :Min. 98 Area-%Couleur et forme :White Off-White PowderMasse moléculaire :350.41 g/molObatoclax mesylate
CAS :<p>Obatoclax mesylate is a synthetic small molecule, which is derived from chemical synthesis with a primary mode of action as a pan-BCL-2 inhibitor. This compound antagonizes multiple anti-apoptotic proteins within the BCL-2 family, ultimately promoting apoptosis in malignant cells. Its ability to inhibit these proteins disrupts the survival mechanisms that cancer cells exploit, potentially restoring apoptotic pathways that are often dysregulated in cancerous tissues.</p>Formule :C20H19N3O·CH4O3SDegré de pureté :Min. 95%Couleur et forme :Black SolidMasse moléculaire :413.49 g/molWS 383 hydrochloride
CAS :<p>Potent inhibitor of the interaction between defective cullin neddylation protein DCN1 and NEDD8-conjugating enzyme UBC12 with IC50 of 11 nM. WS 383 blocks the DCN1-UBC12 interaction in a reversible manner, selectively inhibits Cul3/1 neddylation and induces accumulation of p21, p27, and NRF2 proteins.</p>Formule :C18H20ClN9S2·HClDegré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :498.46 g/molSR 18292
CAS :<p>Inhibitor of transcriptional coactivator PGC-1a; anti-diabetic agent</p>Formule :C23H30N2O2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :366.5 g/mol(2R-)Arimoclomol
CAS :<p>A co-inducer of HSP that acts through heat shock factor 1 (HSF1) in cells undergoing cellular stress. Has therapeutic potential in motor neuron degenerative diseases. Potential treatment for liposomal storage disorders, such as Niemann-Pick disease type C.</p>Formule :C14H20ClN3O3Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :313.78 g/molABT 737
CAS :<p>Inhibits anti-apoptotic proteins Bcl-2, Bcl-xl and Bcl-w. Synergistic with chemotherapy and radiotherapy in several tumour cell lines. Potent activity as a single agent in lymphoid cancer and small cell lung cancer (SCLC) cell lines. Causes tumour regression in SCLC xenograft tumour in vivo.</p>Formule :C42H45ClN6O5S2Degré de pureté :Min. 95%Couleur et forme :Yellow SolidMasse moléculaire :813.43 g/molRCM 1
CAS :<p>Inhibitor of the Forkhead box M1 (FOXM1), an oncogene and a transcription factor regulating cell cycle progression, DNA damage repair and cell renewal. RCM 1 weakens the FOXM1 activity by inhibiting its nuclear localisation and increasing its degradation in proteasomes. The compound showed potential for asthma treatment since it inhibited goblet cell metaplasia and IL-13 signalling in mice.</p>Formule :C20H12N2OS4Degré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :424.59 g/molRVX 208
CAS :<p>Inhibitor of BET bromodomain</p>Formule :C20H22N2O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :370.4 g/molSirt-IN-1
CAS :<p>Inhibitor of pan-sirtuins (IC50 = 15, 10, 33 µM for SIRT1, 2 and 3 respectively), by binding to the active catalytic site. Selectivity for sirtuins was demonstrated when tested for activity on a panel of kinases, nuclear receptors, ion channels, transporters and GPCRs.</p>Formule :C19H27N5O2SDegré de pureté :Min. 95%Masse moléculaire :389.52 g/molNutlin 3A
CAS :<p>Antagonist of proto-oncogene MDM2 and its interaction with p53</p>Formule :C30H30Cl2N4O4Degré de pureté :Min. 95%Masse moléculaire :581.49 g/molVinorelbine tartrate
CAS :Produit contrôlé<p>Microtubule disrupter; anti-mitotic drug; anti-cancer alkaloid</p>Formule :C53H66N4O20Degré de pureté :(Hplc) Min. 98.0%Couleur et forme :White PowderMasse moléculaire :1,079.11 g/mol
