Bêta-bloquants

Applications A metabolite of the antihypertensive agent, Labetalol (L096500).
References Gal, J., et al.: Res. Comm. Chem. Pathol. Pharmacol., 62, 3 (1988),

Applications Bivalirudin 1-11 Fragment is an impurity of Bivalirudin, a direct thrombin inhibitor acting as an anticoagulant through inhibition of the enzyme thrombin.
References Bertrand, O. et al.: Am. J. Cardio., 110, 599 (2012); Patti, G. et al.: Am. J. Cardio., 110, 478 (2012)

Applications 1-Chloro-3-(1H-indol-4-yloxy)-2-propanol, is an impurity of Pindolol (P468000), a mixed β-adrenergic blocker and serotonin 5HT1A-receptor antagonist. Antihypertensive; antianginal; antiarrhythmic; antiglaucoma.
References Dreshfield, L.J., et al.: Neurochem. Res., 21, 557 (1996), Perez, V., et al.: Lancet, 349, 1594 (1997),

Applications Antihypertensive; antiarrhythmic (class II); antianginal; antiglaucoma agent.
References Wasson, et al.: J. Med. Chem., 15, 651 (1972), Franciosa, et al.: Clin. Pharmacol. Ther., 13, 138 (1972), Heel, R.C., et al.: Drugs, 17, 38 (1979), Rofman, B.A., et al.: Hypertension, 2, 643 (1980), Mazzo, D.J., et al.: Anal. Profiles Drug Subs., 16, 641 (1987),

Applications Labelled Penbutolol (P220500). A β-adrenoceptor antagonist. Antihypertensive.
References Armstrong, D., et al.: Anal. Chem., 66, 1473 (1994), Kato, M., et al.: J. Pharm. Biomed. Anal., 30, 1845 (2003),

Applications An impurity in Simvastatin (S485000).
References Sankar, D. et al.: Asian J. Chem., 21, 4294 (2009); Vuletic, M. et al.: J. Pharmac. Biomed. Anal., 37, 715 (2005);

Applications CMPD101 is a potent and selective GRK2/3 inhibitor.
References Lowe, J.D., et al.: Mol. Pharmacol., 88, 347 (2015); Ikeda, S., et al.: PCT Int. Appl. WO 2007034846 A1 20070329. Mar 29, 2007

Applications 4-Methyl-1-hydrazinophthalazine is used in the synthesis of novel phthalazine derivatives as antihypertensive agents.

Applications A metabolite of Eplerenone. Used in combination therapy for treatment of cardiovascular disorders.
References Staessen, J., et al.: J. Endocrinol., 91, 457 (1981), de Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987), MacFadyen, R., et al.: Cardiovasc. Res., 35, 30 (1997),

Impurity Atorvastatin 2-Hydroxy Lactone
Stability Hygroscopic
Applications A metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.

Applications Rescinnamine is an angiotensin-converting enzyme inhibitor used as an antihypertensive drug.
References Fife, R., et al.: Brit. Med. J., 2, 1848 (1960); Balsevich, J., et al.: Planta Med., 44, 91 (1982)

Applications Lodoxamide-15N2,d2 is the labelled form of Lodoxamide which is an antiallergic drug that acts as a mast cell stabilizer. It is effective in the treatment of allergic conjunctivitis and in decreasing vascular permeability.
References Ciprandi, G., et al.: Allergy, 51(12), 946-951 (1996); Bayer, Atilla., et al.: Ophthalmologica, 217(2), 119-123 (2003)

Applications Pindolol (P468000) impurity.

Applications Hexobendine is used as vasodilator (coronary).
References Rdudolph, et al.: Arzneim.-Forsch., 20, 637 (1970), Kolassa, P., et al.: Biochem. Pharmacol., 20, 490 (1971), Zommer-Urbanska, S., et al.: Pharmazie, 40, 419 (1985),

Stability Hygroscopic
Applications Atorvastatin impurity in bulk drug and tablets.
References Posvar, E., et al.: J. Clin. Pharmacol., 36, 728 (1996), Lea, A., et al.: Drugs, 53, 828 (1997), Miao, X., et al.: J. Chromatogr., 998, 133 (2003),

Applications A metabolite of Carvedilol (C184625). It is used in the treatment of hypertension.
References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., ET AL.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 10, 958 (1998),

Applications (±)-Betaxolol-d7 HCl (iso-propyl-d7) (CAS# 1219802-92-2) is a useful isotopically labeled research compound.

Applications Pindolol (P468000) impurity.
References Ohia, S., et al.: Pharmacol. Exp. Ther., 255, 11 (1990), Juteau, H., et al.: Bioorg. Med. Chem., 9, 1977 (2001),

Applications A Labelled metabolite of Carvedilol which is a multiple-action, neurohormonal antagonist that is used in the treatment of hypertension.
References Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 958 (1998).