Hormones dans les Protéines Recombinantes

Erythropoietin is a hormone that stimulates the production of red blood cells, and is used for patients with anemia. It is a recombinant human erythropoietin (rhEPO) that has been produced by genetic engineering. Erythropoietin binds to receptors on the surface of many types of cells, including those in the bone marrow. This binding stimulates the production of red blood cells from precursor cells in the bone marrow, and increases oxygen-carrying capacity in blood. The half-life of erythropoietin is approximately 36 hours. This drug also can be used to reduce high blood pressure and improve responsiveness to other drugs that are given intravenously. Erythropoietin can cause an increase in asialoglycoprotein levels in serum, which may be due to its effects on hepatocytes or erythrocytes.