Système complémentaire
Le système du complément est une partie cruciale de la réponse immunitaire, composée d'une série de petites protéines qui améliorent la capacité des anticorps et des cellules phagocytaires à éliminer les agents pathogènes d'un organisme. Ces protéines travaillent ensemble pour opsoniser les agents pathogènes, induire des réponses inflammatoires et lyser directement les membranes des pathogènes, jouant un rôle vital dans l'immunité innée et la fonction immunitaire globale. Chez CymitQuimica, nous proposons des protéines du système du complément de haute qualité pour soutenir vos études immunologiques et recherches cliniques.
156 produits trouvés pour "Système complémentaire"
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Complement factor D-IN-2
CAS :<p>Complement factor D-IN-2 is an inhibitor of Complement factor D and reduces the excessive activation of complement factor D.</p>Formule :C27H24BrN7O3Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :574.43Complement C5a Protein, Human, Recombinant
<p>Complement C5 Protein, Human, Recombinant (Complement C5a) is expressed in E.</p>Degré de pureté :SDS-PAGE: 94.9%; SEC-HPLC: 93.5%Couleur et forme :Lyophilized PowderMasse moléculaire :8.3 kDa (predicted); 8.3 kDa (reducing conditions)AMY-101 acetate
<p>AMY-101 acetate (Cp40 acetate) is a peptide, an inhibitor of C3 Complement in gingivitis and periodontitis, reduces inflammation and lowers MMP-8 and MMP-9.</p>Formule :C85H121N23O20S2Degré de pureté :98.80% - 99.98%Couleur et forme :SolidMasse moléculaire :1849.14Complement factor I Protein, Rat, Recombinant (His & Myc)
<p>Complement factor I Protein, Rat, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :69.2 kDa (predicted)Complement C5 Protein, Rat, Recombinant (His & Myc)
<p>Complement C5 Protein, Rat, Recombinant (His & Myc) is expressed in E.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :14.0 kDa (predicted)C1QA Protein, Mouse, Recombinant (E. coli, His)
<p>C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system.</p>Degré de pureté :98%Couleur et forme :Lyophilized PowderMasse moléculaire :29.1 kDa (predicted)Complement factor B Protein, Mouse, Recombinant (His)
<p>Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :87.0 kDa (predicted)Complement C8a Protein, Human, Recombinant (His)
<p>Complement C8a Protein, Human, Recombinant (His) is expressed in E. coli.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :65.8 kDa (predicted)Complement C5a Protein, Pig, Recombinant (His)
<p>Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :10.6 kDa (predicted)Complement C8b Protein, Human, Recombinant (His)
<p>Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of</p>Couleur et forme :Lyophilized PowderMasse moléculaire :67.0 kDa (predicted)Properdin Protein, Mouse, Recombinant (His & Myc)
<p>A positive regulator of the alternate pathway of complement.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :53 kDa (predicted)C1QL3 Protein, Mouse, Recombinant (His & Myc)
<p>May regulate the number of excitatory synapses that are formed on hippocampus neurons.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :28.6 kDa (predicted)Complement C4-B Protein, Human, Recombinant (His & SUMO)
<p>Complement C4-B Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :49.1 kDa (predicted)C1QL1 Protein, Mouse, Recombinant (His)
<p>May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :26.9 kDa (predicted)C5AR1 Protein, Mouse, Recombinant (His & KSI)
<p>Expression system: E. coli<br>Length: 306-351, Partial<br>Activity: Not Tested</p>Couleur et forme :Lyophilized PowderMasse moléculaire :20.4 kDa (Predicted)Complement factor D Protein, Rat, Recombinant (His & Myc)
<p>Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate</p>Couleur et forme :Lyophilized PowderMasse moléculaire :29.8 kDa (predicted)C5AR1 Protein, Human, Recombinant (Cell-Free, His)
<p>Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a.</p>Degré de pureté :90%Couleur et forme :Lyophilized PowderMasse moléculaire :40.7 kDa (predicted)Complement C4-B Protein, Mouse, Recombinant (His)
<p>Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :39.0 kDa (predicted)C1RA Protein, Mouse, Recombinant (His & Myc)
<p>C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :85.7 kDa (predicted)Complement C3 Protein, Mouse, Recombinant (His & SUMO)
<p>Complement C3 Protein, Mouse, Recombinant (His & SUMO) is expressed in E.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :55.3 kDa (predicted)C1QA Protein, Human, Recombinant (His & Myc)
<p>C1QA Protein, Human, Recombinant (His & Myc) is expressed in E. coli.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :30.7 kDa (predicted)C5AR1 Protein-VLP, Human, Recombinant (His)
<p>Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :41.1 kDa (predicted)Properdin Protein, Mouse, Recombinant (His)
<p>A positive regulator of the alternate pathway of complement.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :51.9 kDa (predicted)C5AR1 Protein, Mouse, Recombinant (MBP & His-Avi), Biotinylated
<p>Expression system: E. coli<br>Length: 306-351, Partial<br>Activity: Not Tested</p>Couleur et forme :Lyophilized PowderMasse moléculaire :52.8 kDa (Predicted)Complement C8g Protein, Human, Recombinant (His)
<p>C8 is a constituent of the membrane attack complex.</p>Degré de pureté :95%Couleur et forme :Lyophilized PowderMasse moléculaire :26.4 kDa (predicted)CR1 Protein, Human, Recombinant
<p>Expression system: E. coli<br>Length: 41-234, Partial<br>Activity: Not Tested</p>Couleur et forme :Lyophilized PowderMasse moléculaire :21.6 kDa (Predicted)C1SB Protein, Mouse, Recombinant (His & Myc)
<p>C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :82.4 kDa (predicted)C1QA Protein, Mouse, Recombinant (His)
<p>C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system.</p>Degré de pureté :90% - 92%Couleur et forme :Lyophilized PowderMasse moléculaire :25.6 kDa (predicted)Complement C3 Protein, Bovine, Recombinant (His & SUMO)
<p>Complement C3 Protein, Bovine, Recombinant (His & SUMO) is expressed in E.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :39.5 kDa (predicted)Complement factor D Protein, Rat, Recombinant (His)
<p>Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate</p>Couleur et forme :Lyophilized PowderMasse moléculaire :27.8 kDa (predicted)Empasiprubart
CAS :<p>Empasiprubart (anti-C2 mAb) inhibits classical & lectin complement pathways upstream of C3, showing efficacy in autoimmune models.</p>Degré de pureté :95%Couleur et forme :LiquidCrovalimab
CAS :<p>Crovalimab (SKY59; RO7112689) is an humanised monoclonal antibody that binds to complement C5 , paroxysmal nocturnal haemoglobinuria (PNH).</p>Degré de pureté :95%Couleur et forme :LiquidGefurulimab
CAS :<p>Gefurulimab (ALXN-1720) is a bispecific antibody derived from humans, targeting complement C5 and albumin.</p>Couleur et forme :LiquidRiliprubart
CAS :<p>Riliprubart (SAR445088) is a humanized monoclonal antibody that acts as an anti-C1s inhibitor in the proximal part of the classical complement system. It selectively targets activated C1s, inhibiting its enzymatic activity on substrates C4 and C2, thereby preventing the formation of the classical pathway C3 convertase, C4b2a [1].</p>Degré de pureté :95% - 95%Couleur et forme :LiquidIsocyclosporin A
CAS :<p>Isocyclosporin A is a rearranged degradation product. It is formed by acid treatment of cyclosporin A under aqueous and non-aqueous conditions.</p>Formule :C62H111N11O12Couleur et forme :SolidMasse moléculaire :1202.61C5aR-IN-2
CAS :<p>C5aR-IN-2, a potent C5aR inhibitor, shows promise for researching inflammatory diseases.</p>Formule :C36H40FN5O2Couleur et forme :SolidMasse moléculaire :593.73BCX 1470
CAS :<p>BCX 1470 inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively.</p>Formule :C14H10N2O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :302.37NRP1 antagonist 2
CAS :<p>NRP1 antagonist 2 (Compound 1) is an NRP1 antagonist.</p>Formule :C20H17ClN6OS2Couleur et forme :SolidMasse moléculaire :456.97FD-IN-1
CAS :<p>FD-IN-1: Factor D inhibitor, IC50=12 nM; blocks FXIa, Tryptase β2 (IC50s: 7.7 μM, 6.5 μM); key in innate immunity.</p>Formule :C23H23NO4Couleur et forme :SolidMasse moléculaire :377.43EG00229
CAS :<p>EG00229 blocks VEGF-A/NRP1 binding, IC50 of 3 μM; doesn't affect VEGFR-1/2. It's an NRP1 antagonist.</p>Formule :C19H20F3N7O7S3Degré de pureté :98.23%Couleur et forme :SolidMasse moléculaire :611.6C3a Receptor Agonist
CAS :<p>C3a Receptor Agonist activates C3aRs, inhibits neutrophil mobilization in ischemia, and promotes neural progenitor differentiation.</p>Formule :C27H35N3O2Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :433.59NDT 9513727
CAS :<p>NDT 9513727 is a potent, selective and competitive C5aR1 inverse agonist for the study of inflammatory and immune disorders.</p>Formule :C36H35N3O4Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :573.68Complement C5-IN-1
CAS :<p>Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5).</p>Formule :C24H32N2O6Degré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :444.52Factor D inhibitor 6
CAS :<p>Factor D inhibitor 6 is a potent, highly selective, and orally active compound that specifically inhibits the activity of factor D (FD) with an IC50 of 30 nM and a Kd of 6 nM. It does not exhibit inhibitory effects against factor B, classical and lectin complement-pathway activation, or a broad array of receptors, ion channels, kinases, and proteases.</p>Formule :C23H22ClFN6O3Couleur et forme :SolidMasse moléculaire :484.92W-54011
CAS :<p>W-54011: potent non-peptide C5a receptor blocker; binds 125I-C5a (Ki=2.2nM); stops Ca2+ movement, chemotaxis, ROS in neutrophils (IC50=1.6-3.1nM).</p>Formule :C30H37ClN2O2Degré de pureté :96.8%Couleur et forme :SolidMasse moléculaire :493.08Factor B-IN-2
CAS :<p>Factor B-IN-2 is a potent inhibitor (IC50: 1.5 μM) of complement factor B. Factor B-IN-2 can be used to study inflammatory and immune-related diseases.</p>Formule :C25H32N2O4Couleur et forme :SolidMasse moléculaire :424.53EG01377
CAS :<p>EG01377 is a NRP1 antagonist with antiangiogenic, antimigratory, and antitumor activity, Kd 1.32 μM, IC50s 609 nM for NRP1-a1/b1, inactive on NRP2.</p>Formule :C26H30N6O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.68C5aR-IN-1
CAS :<p>C5aR-IN-1, a potent C5aR inhibitor, may aid in researching autoimmune and inflammatory diseases.</p>Formule :C36H39F4N3O2Couleur et forme :SolidMasse moléculaire :621.71Iptacopan
CAS :<p>Iptacopan (LNP023) is an inhibitor with high affinity to factor B, with a KD value of 7.9 nM and an IC50 value of 10 nM. Cost-effective and quality-assured.</p>Formule :C25H30N2O4Degré de pureté :99.07% - >99.99%Couleur et forme :SolidMasse moléculaire :422.52C5aR-IN-3
CAS :<p>C5aR-IN-3, a potent C5aR inhibitor, may treat autoimmune and inflammatory diseases.</p>Formule :C36H40FN5O3Couleur et forme :SolidMasse moléculaire :609.73(Rel)-Factor B-IN-5
CAS :<p>(Rel)-Factor B-IN-5 is a complement factor B inhibitor that can be used to study diseases associated with activation of the alternative complement pathway.</p>Formule :C27H32N2O4Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :448.55Factor B-IN-3
CAS :<p>Factor B-IN-3 is a potent inhibitor of complement factor B. Factor B-IN-3 can be used to study inflammatory and immune-related diseases.</p>Formule :C24H29N3O4Couleur et forme :SolidMasse moléculaire :423.5Pelecopan
CAS :<p>Pelecopan (BCX9930), an oral complement factor D inhibitor, prevents hemolysis in PNH (IC50=14.3 nM).</p>Formule :C23H19FN2O4Couleur et forme :SolidMasse moléculaire :406.41Factor B-IN-4
CAS :<p>Factor B-IN-4 is a potent inhibitor (IC50: 1 μM) of complement factor B. Factor B-IN-4 can be used to study inflammatory and immune-related diseases.</p>Formule :C27H32N2O4Couleur et forme :SolidMasse moléculaire :448.55TLQP-21 TFA
<p>TLQP-21 TFA is a VGF-derived peptide, C3aR1 agonist (mouse EC50: 10.3μM; human EC50: 68.8μM), that raises intracellular Ca2+ for nociception research.</p>Degré de pureté :98%Couleur et forme :LiquidTLQP-21 TFA
<p>TLQP-21 TFA （TLQP-21 Trifluoroacetate） 是一种 VGF 衍生肽，可通过结合后折叠机制激活C3aR1 受体。</p>Degré de pureté :98%
