Dérivés du Benzimidazole et de l’Imidazole
Le benzimidazole est un composé constitué d’un noyau benzénique fusionné à un noyau imidazole, une structure à cinq membres contenant deux atomes d’azote. Les dérivés du benzimidazole, comme l’albendazole, sont connus pour leur activité antiparasitaire et antifongique, utilisés dans le traitement des infections parasitaires et de certaines maladies parasitaires chez les animaux et les humains. L’imidazole, quant à lui, est une structure à cinq membres avec deux atomes d’azote, présente dans divers composés biologiquement actifs. Les dérivés de l’imidazole, comme le métronidazole, possèdent des propriétés antimicrobiennes et antiparasitaires. Ces composés sont également utilisés dans l’industrie pharmaceutique pour le traitement des infections bactériennes, des maladies parasitaires et de certaines infections fongiques, ainsi qu’en chimie organique comme catalyseurs.
Chez CymitQuimica, nous proposons des benzimidazoles et des imidazoles de haute pureté pour la recherche en chimie médicinale, pharmacologie et biotechnologie.
10354 produits trouvés pour "Dérivés du Benzimidazole et de l’Imidazole"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
3-Methoxy-temazepam
CAS :Produit contrôléFormule :C17H15ClN2O2Couleur et forme :Off-White To Light YellowMasse moléculaire :314.771-Tritylimidazole-4-carboxaldehyde
CAS :Degré de pureté :95.0%Couleur et forme :Solid, White to reddish yellow powderMasse moléculaire :338.4100036621094(1-Phenyl-1H -tetrazol-5-ylsulfanyl)-acetic acid
CAS :Formule :C9H8N4O2SDegré de pureté :95+%Couleur et forme :SolidMasse moléculaire :236.254-(5-Methyl-1 H -benzoimidazol-2-yl)-phenylamine
CAS :Degré de pureté :95.0%Couleur et forme :Solid, No data available.Masse moléculaire :223.27900695800781-(Cyclopropylmethyl)-1H-indazol-3-amine
CAS :Degré de pureté :95.0%Masse moléculaire :187.246002197265626-fluoro-2-(pyridin-2-yl)-1H-1,3-benzodiazole
CAS :Degré de pureté :97%Masse moléculaire :213.214996337890622-(3-Chloro-thiophen-2-yl)-1H-benzoimidazole-5-carboxylic acid
CAS :Couleur et forme :SolidMasse moléculaire :278.7099914550781Triazolam
CAS :Produit contrôlé<p>Applications Sedative, hypnotic.Controlled substance (depressant).<br>References Lomen, P., et al.: J. Int. Med. Res., 4, 55 (1976), Allens, G.S., et al.: J. Int. Med. Res., 6, 343 (1978), Pakes, G.E., et al.: Drugs, 22, 81 (1981)<br></p>Formule :C17H12Cl2N4Couleur et forme :WhiteMasse moléculaire :343.215-Amino-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
CAS :Formule :C14H19N3O2Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :261.325Triclabendazole Sulfoxide-D3
CAS :Produit contrôlé<p>Applications Triclabendazole Sulfoxide-D3 is a stable isotopically labelled metabolite of Triclabendazole (T774175), an anthelmintic.<br>References Wolff, K., et al.: Vet. Parasitol., 13, 145 (1983)<br></p>Formule :C14H6D3Cl3N2O2SCouleur et forme :NeatMasse moléculaire :378.682-Phenylmethanesulfonyl-1h-1,3-benzodiazole
CAS :Degré de pureté :95%Masse moléculaire :272.320007324218751,3-Di(1H-imidazol-1-yl)benzene
CAS :Degré de pureté :97%Couleur et forme :SolidMasse moléculaire :210.240005493164062-(1H-INDAZOL-1-YL)THIAZOLE-4-CARBOXYLIC ACID
CAS :Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :245.259994506835941,2,4-Triazole
CAS :<p>Applications 1,2,4-Triazole is present in a large variety of fungicides as C14-demethylase-inhibitors. In addition they are used in synthetic chemical reactions such as the design and preparation of ghrelin receptor ligand antagonists, like JMV 2959.<br>References Moulin, A. et al.: Amino Acids., 44, 301 (2013); Worthington, P. et al.: Bioact. Hetero. Comp. Class., 129, 2012<br></p>Formule :C2H3N3Couleur et forme :WhiteMasse moléculaire :69.07(S)-a,a-Diphenyl-3-pyrrolidineacetamide L-Tartrate
CAS :Produit contrôléFormule :C18H20N2O·C4H6O6Couleur et forme :NeatMasse moléculaire :430.45(R)-5-Hydroxymethyl Tolterodine
CAS :Produit contrôlé<p>Applications A metabolite of Tolterodine (T535800), a muscarinic receptor antagonist used in the treatment of urinary incontinence.<br>References Palmer, L., et al.: J. Pharm. Biomed. Anal., 16, 155 (1997), Hills, C., et al.: Drugs, 55, 813 (1998), Wefer, J., et al.: World J. Urol., 19, 312 (2001),<br></p>Formule :C22H31NO2Couleur et forme :NeatMasse moléculaire :341.493-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinemethanol
CAS :Produit contrôléFormule :C9H10F3NO2Couleur et forme :Light Beige To Light BrownMasse moléculaire :221.072-Chloro-5-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol
CAS :Degré de pureté :95.0%Masse moléculaire :347.79998779296875(1-allyl-1H-benzimidazol-2-yl)methanol
CAS :Degré de pureté :95.0%Masse moléculaire :188.229995727539062-(phenoxymethyl)-1H-benzimidazole
CAS :Degré de pureté :95.0%Couleur et forme :Solid, Light brown powderMasse moléculaire :224.263000488281254-(2-Keto-1-benzimidazolinyl)piperidine
CAS :Formule :C12H15N3ODegré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :217.2722-(1,2,3,4-Tetrahydronaphthalen-1-yl)-1H-imidazole
CAS :Produit contrôlé<p>Applications 2-(1,2,3,4-Tetrahydronaphthalen-1-yl)-1H-imidazole is a novel 2-imidazole derivative with potent and selective α1A adrenoceptor partial agonists.<br>References Whitlock, G.A., et al.: Bioorg. Med. Chem. Lett., 18, 2930 (2008);<br></p>Formule :C13H14N2Couleur et forme :White To Light BeigeMasse moléculaire :198.26(R)-Omeprazole Sodium Salt
CAS :<p>Applications R-Form of Omeprazole. Gastric proton-pump inhibitor.<br>References Stenhoff, H., et al.: J. Chromatogr., 734, 191 (1999), Johnson, D.A., et al.: Expert Opin. Pharmacother., 4, 253 (2003),<br></p>Formule :C17H18N3O3S·NaCouleur et forme :NeatMasse moléculaire :367.40Lamotrigine-13C3
CAS :Formule :C3C6H7Cl2N5Couleur et forme :White To Light BeigeMasse moléculaire :259.071-(4-Chloro-2-(2-fluorobenzoyl)phenyl)-2-methyl-1H-imidazole-5-carboxylic Acid
CAS :Produit contrôlé<p>Applications 1-(4-Chloro-2-(2-fluorobenzoyl)phenyl)-2-methyl-1H-imidazole-5-carboxylic Acid is a metalobilite of Midazolam(M343000) which is a anesthetic; anticonvulsant; sedative; hypnotic. Positive allosteric modulator of the GABAA receptor. Neuroprotective & Neuroresearch products.<br>References Dundee, J. W., et al.: Drugs, 28, 519 (1984), Lahat, E., et al.: Br. Med. J., 321, 83 (2000),<br></p>Formule :C18H12ClFN2O3Couleur et forme :NeatMasse moléculaire :358.75Di-2-thienylmethanone
CAS :<p>Di-2-thienylmethanone is a pyrazole with an activation energy of about 10.5 kcal/mol. It has been found to be toxic and can cause cell lysis. This molecule has been used in the synthesis of a number of drugs, including thiopental, a barbiturate that is used as an anaesthetic. Di-2-thienylmethanone is also the precursor for the synthesis of fluoroquinolones, which are potent antibacterial agents. The Friedel-Crafts reaction is one way this molecule is synthesized, and it involves the addition of an alkyl halide to an unsaturated double bond. This reaction is named after Charles Friedel and James Crafts who first discovered it in 1877.</p>Formule :C9H6OS2Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :194.28 g/mol1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylidene)methylpiperidine
CAS :<p>1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylidene)methylpiperidine is an analytical standard and a drug product. It is a synthetic compound that has been shown to have pharmacological effects similar to those of the analgesic or opioid drugs. 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylidene)methylpiperidine can be used as an impurity standard for HPLC analyses as well as metabolic studies. This compound is also known to have potential interactions with other drugs.</p>Formule :C24H27NO3Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :377.48 g/mol2,3-Dichlorobenzoic acid
CAS :<p>2,3-Dichlorobenzoic acid is an organic compound that belongs to the class of carboxylates. It is used as a drug substance in the treatment of mycobacterial infections. 2,3-Dichlorobenzoic acid has been shown to have antimicrobial activity against Mycobacterium tuberculosis and other mycobacteria. The sensitivity index for this compound was determined using a chromatographic method with human erythrocytes as the test organism. 2,3-Dichlorobenzoic acid displays its antibacterial activity by inhibiting protein synthesis and cell division. This drug also forms crystalline solids that are soluble in organic solvents such as chloroform or benzene.</p>Formule :C7H4Cl2O2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :191.01 g/molMethyl 2,2-dithienylglycolate
CAS :<p>Intermediate for tiotropium bromide synthesis</p>Formule :C11H10O3S2Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :254.33 g/mol(R)-5-Hydroxymethyl tolterodine
CAS :<p>(R)-5-Hydroxymethyl tolterodine is a prodrug that is metabolized by cytochrome P450 3A4 (CYP3A4) in the liver to its active form, tolterodine. This drug can be used as an alternative for gabapentin in the treatment of detrusor muscle overactivity associated with neurogenic bladder dysfunction. The pharmacokinetic properties of (R)-5-hydroxymethyl tolterodine are similar to those of gabapentin, including the elimination half-life and volume of distribution. However, unlike gabapentin, which has been shown to increase the glomerular filtration rate (GFR) and renal blood flow, there is no evidence that this drug has any effect on GFR or renal blood flow. There is also no evidence that (R)-5-hydroxymethyl tolterodine causes any symptoms that may be attributed to</p>Formule :C22H31NO2Degré de pureté :Min. 98 Area-%Couleur et forme :Off-White PowderMasse moléculaire :341.49 g/mol6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione
CAS :<p>6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione is a chlorinating agent that converts alcohols to alkyl chlorides. It is used for the conversion of diazotizable aromatic compounds to diazo compounds. This compound has been shown to be neuroprotective in animal models and provides protection against glutamate excitotoxicity. 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione also reacts with nitrite ions to form the corresponding nitroso derivatives. These derivatives can cause DNA damage and are mutagenic. 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione has been shown to react with aminoguanidine to produce a chromat</p>Formule :C9H5Cl2N3O2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :258.06 g/molAlbendazole sulfoxide
CAS :<p>Albendazole sulfoxide is a sulfoxide of albendazole. The molecular docking analysis of the two molecules showed that the sulfoxide group is located in the same position as the hydroxyl group on albendazole. It has been shown that this replacement of hydroxyl with a sulfoxide group increases the solubility and stability of albendazole, which may be due to hydrogen bonding interactions between these groups. Albendazole sulfoxide has been shown to be an effective treatment for infections caused by parasites such as helminths. However, it should not be used in combination with drugs that are metabolized by cytochrome P450 enzymes because it can inhibit their activity.</p>Formule :C12H15N3O3SDegré de pureté :Min. 97 Area-%Couleur et forme :White PowderMasse moléculaire :281.33 g/mol2-[[[(4-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfonyl]-1H-benzimidazole
CAS :<p>2-[[[(4-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfonyl]-1H-benzimidazole is a protonated sulfonamide that is used as an analytical method to detect the presence of other drugs in human liver tissue. It has been shown to inhibit the activity of cytochrome P450 3A4 (CYP3A4), one of the enzymes responsible for metabolizing many drugs. Bromoenol lactone and powder diffraction spectrum are two additional analytical methods that can be used to detect 2-[([(4-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfonyl]-1H-benzimidazole.</p>Formule :C18H21N3O4SDegré de pureté :Min. 95%Couleur et forme :White/Off-White SolidMasse moléculaire :375.44 g/mol4-Desmethoxy omeprazole sulfide
CAS :<p>4-Desmethoxy omeprazole sulfide is a metabolite of omeprazole, a drug that is used to treat ulcers and gastroesophageal reflux disease. 4-Desmethoxy omeprazole sulfide is not an impurity in the production of omeprazole, but is present as a natural component of omeprazole. This compound has been shown to be an impurity standard for HPLC analysis. The pharmacopoeia defines 4-desmethoxy omeprazole sulfide as an API impurity in drug products. It is also being studied for its potential use in drug development and research and development.</p>Formule :C16H17N3OSDegré de pureté :Min. 95%Couleur et forme :White to off-white solid.Masse moléculaire :299.39 g/mol5-Methoxy-2-[[(3,5-dimethyl-2-pyridinyl)methyl]sulphinyl]-1H-benzimidazole
CAS :<p>5-Methoxy-2-[[(3,5-dimethyl-2-pyridinyl)methyl]sulphinyl]-1H-benzimidazole is a natural product. It is an impurity in the drug development process and may be present as an analytical marker for impurities. 5-Methoxy-2-[(3,5-dimethylpyridinium)methyl]sulfinyl]-1Hbenzimidazole is used as a pharmacopoeia standard and can be synthesized on request.</p>Formule :C16H17N3O2SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :315.39 g/mol2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-dimethoxybenzoic acid sodium salt
<p>2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-dimethoxybenzoic acid sodium salt is a white to off-white crystalline powder. It is soluble in water and sparingly soluble in alcohol. This product is used as an analytical standard and has been found to be a metabolite of the drug clozapine. 2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-dimethoxybenzoic acid sodium salt has also been found to be an impurity in the drug product lamotrigine.</p>Formule :C24H29NO5•NaDegré de pureté :Min. 95%Masse moléculaire :434.49 g/mol2-Hydroxy-2,2-bis(2-thienyl) acetic acid
CAS :<p>2-Hydroxy-2,2-bis(2-thienyl) acetic acid is a long-acting bronchodilator that can be administered by inhalation. It has been used in the clinical development of medicines for the treatment of asthma and chronic obstructive pulmonary disease. 2-Hydroxy-2,2-bis(2-thienyl) acetic acid is chemically related to pyridinium compounds. It is a potent inhibitor of muscarinic receptors and has an anticholinergic profile similar to atropine. The safety profile of this drug seems to be favourable in humans with no major side effects reported so far.</p>Formule :C10H8O3S2Degré de pureté :Min. 95%Couleur et forme :Yellow PowderMasse moléculaire :240.3 g/mol5,6-Dimethoxy-2-(4-piperidinyl)methyleneindan-1-one (donepezil impurity)
CAS :<p>5,6-Dimethoxy-2-(4-piperidinyl)methyleneindan-1-one (donepezil impurity) is an analytical standard used as a reference in HPLC assays for donepezil. It is also a metabolite of donepezil and has been found to have pharmacological activity similar to that of the parent compound. This impurity is present in donepezil drug products at levels up to 0.5%.</p>Formule :C17H21NO3Degré de pureté :Min. 95%Masse moléculaire :287.35 g/mol2-Hydroxybenzimidazole
CAS :<p>2-Hydroxybenzimidazole is a benzimidazole compound that is used in the treatment of nervous system diseases. It has been shown to have anti-inflammatory properties and can be used in the treatment of syncytial virus infection. 2-Hydroxybenzimidazole inhibits the production of reactive oxygen species and nitric oxide, which are involved in neurodegenerative disorders. The mechanism of action for 2-Hydroxybenzimidazole involves the formation of hydrogen bonds with hydroxyl groups on proteins. It also has been shown to reduce locomotor activity and increase sleep time in mice, which may be due to inhibition of acetylcholine release from cholinergic neurons.</p>Formule :C7H6N2ODegré de pureté :Min. 97.5 Area-%Couleur et forme :Off-White PowderMasse moléculaire :134.14 g/mol(1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
CAS :<p>(1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is a drug used to treat depression. It is an antidepressant drug that inhibits the reuptake of serotonin and norepinephrine in the brain by blocking their transport into the nerve cells. The drug acts as a weak inhibitor of monoamine oxidase (MAO). It also has an effect on bladder function. This compound is synthesized from 1-phenyl-2,5-dihydrothiazole by way of a sequence of reactions that includes the formation of an amine salt via reaction with phosphorus pentoxide and chloroacetic acid followed by conversion to the chloride with thionyl chloride.</p>Formule :C15H15NDegré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :209.29 g/molN-(2-Phenethyl)benzamide
CAS :<p>N-(2-Phenethyl)benzamide (NPEB) is a molecule that belongs to the group of reactive molecules. It has been shown to be toxic to gram-positive bacteria, such as Staphylococcus aureus and Bacillus subtilis, but not gram-negative bacteria such as Escherichia coli. NPEB also has been shown to have locomotor activity in animals, which may be due to its ability to inhibit the mitochondrial electron transport chain and inhibit ATP production. NPEB's biological properties are well characterized. FTIR spectroscopy showed that this molecule has an amide functional group and is a small molecule with a molecular weight of 176.4 g/mol. This molecule was also found to be able to bind to mitochondria in animals.</p>Formule :C15H15NODegré de pureté :Min. 97 Area-%Couleur et forme :PowderMasse moléculaire :225.29 g/molOmeprazole impurity F and G
CAS :<p>Omeprazole is a proton pump inhibitor that inhibits the H+/K+-ATPase enzyme in gastric parietal cells. Omeprazole impurity F and G are metabolites of omeprazole. Omeprazole impurity F is a metabolite of omeprazole that forms by oxidation of the methylthio group in omeprazole to form a sulfoxide. Omeprazole impurity G is formed by hydrolysis of the methylthio group in omeprazole to form an alcohol. The purity of this product is high and can be custom synthesized based on customer's needs. It is also available as an HPLC standard or as an API impurity for use in metabolism studies.</p>Formule :C16H13N3O2SDegré de pureté :Min. 95%Couleur et forme :Red PowderMasse moléculaire :311.36 g/molCarbendazim
CAS :<p>Carbendazim is a fungicide that inhibits the growth of fungi and bacteria. It has been shown to be potent inducers of polymerase chain reaction (PCR) amplification, with a rate constant of 0.0103 per minute. Carbendazim also has a significant effect on electrochemical impedance spectroscopy (EIS). The EIS analysis was used to compare carbendazim-treated cells with untreated cells, which showed that carbendazim causes an increase in the resistance across the cell membrane. This research suggests that carbendazim may be genotoxic, as it increased the amount of DNA damage observed in wild-type strains and altered the optical properties of DNA. Carbendazim is also an effective inhibitor of nitrite ion oxidation and colloidal gold deposition, which has led to its use as a water vapor control agent for plants.</p>Formule :C9H9N3O2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :191.19 g/molN-Desmethyl galanthamine
CAS :Produit contrôlé<p>N-Desmethyl galanthamine is a plant alkaloid that is found in the Huperzia serrata plant. It has been shown to have cholinergic activity and calcium binding properties. N-Desmethyl galanthamine inhibits acetylcholinesterase, an enzyme responsible for the breakdown of acetylcholine, which is a neurotransmitter. This inhibition leads to increased levels of acetylcholine, which results in increased neuron stimulation and improved memory function. N-Desmethyl galanthamine also binds to β2 nicotinic receptor sites and blocks the binding of nicotine, leading to decreased nicotine dependence.</p>Formule :C16H19NO3Degré de pureté :Min. 95%Masse moléculaire :273.33 g/mol5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]thio]-1H-benzimidazole
CAS :<p>Omeprazole is a drug that belongs to the class of benzimidazole compounds. It is an inhibitor of gastric acid secretion in the stomach, reducing the production of hydrochloric acid and pepsin. Omeprazole has been shown to have greater chemical stability than other proton pump inhibitors (PPIs), with a higher solubility in water and a longer shelf life. Omeprazole also has anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis. Omeprazole also exhibits pharmacokinetic properties that are different from other PPIs. Omeprazole is rapidly absorbed following oral administration and has a high bioavailability, which can be attributed to its hydroxyl group. This hydroxyl group allows for esomeprazole (a prodrug) to be formed by hydrolysis in the gut or liver, increasing omeprazole's absorption and bioavailability.</p>Formule :C17H19N3O2SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :329.42 g/mol3-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-5(4H)-one
CAS :<p>3-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-5(4H)-one is a triazine derivative that is used as an analytical reagent and intermediate. It has been used as a wastewater analysis method to measure the concentration of carbamazepine. 3-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-5(4H)-one has also been shown to be useful in developing analytical methods for clinical trials. 3DCTKP has also been used to test the matrix effect of carbamazepine by analyzing it in different matrices such as water and human plasma.</p>Formule :C9H6Cl2N4ODegré de pureté :Min. 95 Area-%Couleur et forme :PowderMasse moléculaire :257.08 g/mol
![2-[[[(4-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfonyl]-1H-benzimidazole](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FIM57866.webp&w=3840&q=75)
![5-Methoxy-2-[[(3,5-dimethyl-2-pyridinyl)methyl]sulphinyl]-1H-benzimidazole](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FIM57917.webp&w=3840&q=75)
![5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]thio]-1H-benzimidazole](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FIM57923.webp&w=3840&q=75)
