Dérivés des Purines et Pyrimidines
Les purines possèdent une structure bicyclique, composée d’un cycle à six membres fusionné avec un cycle à cinq membres, tous deux contenant des atomes d’azote à des positions clés. Les dérivés des purines, tels que l’adénine et la guanine, sont essentiels à la formation de l’ADN et de l’ARN. Ces composés ont des applications thérapeutiques dans le traitement du cancer et des maladies virales en inhibant la réplication cellulaire. Les pyrimidines, quant à elles, possèdent une structure monocyclique à six membres avec deux atomes d’azote. Leurs dérivés, tels que la cytosine, la thymine et l’uracile, sont également des composants essentiels de l’ADN et de l’ARN et sont utilisés en chimiothérapie et dans les traitements antiviraux.
Chez CymitQuimica, nous proposons des dérivés des purines et pyrimidines pour la recherche en biologie moléculaire, génomique et le développement de thérapies innovantes.
8896 produits trouvés pour "Dérivés des Purines et Pyrimidines"
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4-(3,4-dimethylphenyl)-6-(3-methylphenyl)pyrimidin-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :289.38198852539064-(4-Oxobutyl)benzoic Acid Methyl Ester
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications 4-(4-Oxobutyl)benzoic Acid Methyl Ester is used as a reagent in the preparation of Pemetrexed (P219500) and furoxanoxyalkyl esters of Pemetrexed as antifolates and nitric oxide donors for use as anticancer agents.<br>References Zhao, D., et al.: Zhongguo Yaowu Huaxue Zazhi, 18, 445 (2008); Yi, B., et al.: Zhongguo Yiyao Gongye Zazhi, 37, 798 (2006); Min, T., et al.: Med. Chem. Res., 18, 495 (2009)<br></p>Formule :C12H14O3Couleur et forme :NeatMasse moléculaire :206.241-(4-(3-Amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea
CAS :Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :375.4070129394531N4-Methylene Zolmitriptan
CAS :Produit contrôlé<p>Applications Zolmitriptan (Z639000) impurity.<br></p>Formule :C17H21N3O2Couleur et forme :NeatMasse moléculaire :299.37N-Nitroso Zolmitriptan (>80%)
Produit contrôléFormule :C16H20N4O3Degré de pureté :>80%Couleur et forme :NeatMasse moléculaire :316.355Ethyl Tosylate
CAS :<p>Applications Ethyl Tosylate (cas# 80-40-0) is a compound useful in organic synthesis.<br></p>Formule :C9H12O3SCouleur et forme :NeatMasse moléculaire :200.26(6-Benzhydryloxycarbonylamino-purin-9-yl)-acetic acid
CAS :Degré de pureté :97.0%Couleur et forme :SolidMasse moléculaire :403.398010253906251-tert-Butyl 3-ethyl 4-ureido-1H-pyrrole-1,3(2H,5H)-dicarboxylate
CAS :Degré de pureté :95.0%Masse moléculaire :299.32699584960944-(3,4-dimethylphenyl)-6-(3,4,5-trimethoxyphenyl)pyrimidin-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :365.43301391601564-(2H-1,3-benzodioxol-5-yl)-6-(thiophen-2-yl)pyrimidin-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :297.32998657226564,6-Diaminopyrimidin-2(1H)-one hydrochloride
CAS :Degré de pureté :97%Masse moléculaire :162.58000183105474-(6-Thiophen-2-yl-pyridin-3-yl)-pyrimidin-2-ylamine
Degré de pureté :95.0%Masse moléculaire :254.30999755859375ethyl 2-morpholin-4-yl-4-(trifluoromethyl)pyrimidine-5-carboxylate
Masse moléculaire :305.25698852539062-CHLORO-N-(4-CHLOROPHENYL)-9-METHYL-9H-PURIN-6-AMINE
CAS :Degré de pureté :95.0%Masse moléculaire :294.14001464843751-Phenyl-2-pyrimidin-4-yl ethanol
CAS :Formule :C12H12N2ODegré de pureté :95%Masse moléculaire :200.2414-(1H-Pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine
CAS :Degré de pureté :95%Masse moléculaire :211.227996826171884-(Benzylamino)-2-((3-chloro-4-hydroxyphenethyl)amino)pyrimidine-5-carboxamide
CAS :Degré de pureté :95.0%Masse moléculaire :397.8599853515625N-1-Adamantyl-N'-(2-hydroxy-1,1-dimethylethyl)urea
CAS :Degré de pureté :95.0%Masse moléculaire :266.3850097656256-Aminopyrimidin-4-ol
CAS :Formule :C4H5N3ODegré de pureté :97.0%Couleur et forme :SolidMasse moléculaire :111.104(S)-Methyl 2-benzamido-5-guanidinopentanoate hydrochloride
CAS :Formule :C14H21ClN4O3Degré de pureté :95.0%Masse moléculaire :328.86-Amino-1,3-dimethyluracil
CAS :Degré de pureté :97.0%Couleur et forme :SolidMasse moléculaire :155.156997680664064-(6-PHENYLPYRIDIN-3-YL)PYRIMIDIN-2-AMINE
CAS :Degré de pureté :97.0%Masse moléculaire :248.289001464843752,5-Ethyl Acetate Febuxostat
CAS :Produit contrôlé<p>Applications Febuxostat (F229000) is the parent compound for 2,5-Ethyl Acetate Febuxostat. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),<br></p>Formule :C20H25NO5SCouleur et forme :NeatMasse moléculaire :391.48N-Acetyl Memantine
CAS :Produit contrôlé<p>Applications N-Acetyl Memantine is an intermediate used for preparation of Memantine (M218000).<br>References Gerzon, K., et al.: J. Med. Chem., 6, 760 (1963), Reddy, J., et al.: Org. Process Res. Dev., 11, 268 (2007),<br></p>Formule :C14H23NOCouleur et forme :WhiteMasse moléculaire :221.34Hypoxanthine-13C2,15N (Mixture)
CAS :<p>Applications A metabolite of Purine in cocaine addiction.<br>References Jansen, R., et al.: Clin. Biochem., 38, 362 (2005), Vorst, O., et al.: Metabolomics, 1, 169 (2005), Want, E., et al.: ChemBioChem., 6, 1941 (2005), van der Werf, M., et al.: Anal. Biochem., 370, 17 (2007),<br></p>Formule :C3C2H4N3NOCouleur et forme :NeatMasse moléculaire :139.09Mono-POC Isopropyl Tenofovir(Mixture of Diastereomers)
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Tenofovir (T018500) impurity.<br></p>Formule :C17H28N5O7PCouleur et forme :White SolidMasse moléculaire :445.41Theophylline-7-acetic Acid
CAS :Produit contrôlé<p>Applications A xanthine derivative with bronchodilator activity. Typically combined as salt component with other medications such as Ambroxol to treat bronchial and pulmonary diseases.<br>References Kim, S., et al.: J. Med. Chem., 45, 2131 (2002), Bruno-Blanch, L., et al.: Bioorg. Med. Chem. Lett., 13, 2749 (2003), Foppoli, A., et al.: J. Pharm. Sci., 96, 1139(2007),<br></p>Formule :C9H10N4O4Couleur et forme :NeatMasse moléculaire :238.201-Methyl Xanthine
CAS :Produit contrôléFormule :C6H6N4O2Couleur et forme :WhiteMasse moléculaire :166.143,5-Dinitropyridine
CAS :Produit contrôlé<p>Applications 3,5-Dinitropyridine is used as an azabenzyne pyrolytic precursor. The anion radical of 3,5-dinitropyridine aundergoes reversible dimerization reactions.<br>References Winkler, M., et al.: J. Am. Chem. Soc., 126, 6135 (2004); Macias-Ruvalcaba, N., et al.: J. Electroanal. Chem., 600, 294 (2007)<br></p>Formule :C5H3N3O4Couleur et forme :NeatMasse moléculaire :169.10N-Methyl Pemetrexed
CAS :Produit contrôlé<p>Impurity Pemetrexed EP Impurity A<br>Applications N-Methyl Pemetrexed (Pemetrexed EP Impurity A) is an impurity of Pemetrexed (P219500), an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes.<br>References Kjell, D.P., et al.: Org. Proc. Res. Develop., 9, 738 (2005);<br></p>Formule :C21H23N5O6Couleur et forme :NeatMasse moléculaire :441.44Oxo-Pemetrexed acid
CAS :Produit contrôléFormule :C15H14N4O4Couleur et forme :NeatMasse moléculaire :314.34,6-Dihydroxypyrazolo[3,4-d]pyrimidine
CAS :Produit contrôlé<p>Stability Hygroscoipic<br>Applications 4,6-Dihydroxypyrazolo[3,4-d]pyrimidine is a major metabolite of Allopurinol (A547300). It is a xanthine oxidase inhibitor.<br>References Pacher, P., et al.: Pharmacol. Rev., 58, 87 (2006); Marro, P., et al.: Brain Res., 650, 9 (1994); Abramov, A., et al.: J. Neurosci., 27, 1129 (2007); Day, R., et al.: Clin. Pharmacokinet., 46, 623 (2007);<br></p>Formule :C5H4N4O2Couleur et forme :Off White SolidMasse moléculaire :152.11Nicotinic Acid-d3 (major)
CAS :Produit contrôlé<p>Applications Labelled Nicotinic acid. It is a precursor of the coenzymes NAD and NADP. Widely distributed in nature; appreciable amounts are found in liver , fish, yeast and cereal grains. Dietary deficiency is associated with pellagra. The term “niacin” has also been applied to nicotinamide or to other derivatives exhibiting the biological activity of nicotinic acid. Vitamin (enzyme cofactor).A representative lot contains >20% d4.<br>References Darby, W.J., et al.: Nutr. Rev., 33, 289 (1975), Black, A., et al.: Eur. J. Clin. Nutr., 54, 395 (2000), Cole, T., et al.: Br. Med. J., 320, 1240 (2000), Forshee, R., et al.: J. Nutr., 134, 2733 (2004),<br></p>Formule :C6H2D3NO2Couleur et forme :NeatMasse moléculaire :126.13Theophylline-d6
CAS :Produit contrôlé<p>Applications Xanthine derivative with diuretic, cardiac stimulant and smooth muscle relaxant activities; isomeric with theobromine. Small amounts occur in tea. Bronchodilator.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cohen, J.L., et al.: Anal. Profiles Drug Subs., 4, 466 (1975), Svedmyr, K., et al.: Allergy, 37, 111 (1982),<br></p>Formule :C72H6H2N4O2Couleur et forme :White To Off-WhiteMasse moléculaire :186.20S(+)-N-(2-(2-Thienyl)ethyl)-2-chlorophenyl Glycine Methyl Ester Hydrochloride
CAS :Produit contrôlé<p>Applications S(+)-N-(2-(2-Thienyl)ethyl)-2-chlorophenyl Glycine Methyl Ester Hydrochloride is an impurity from Clopidogrel (C587250) which acts as an anti-platelet agent.<br>References Zhu, Y. et al.: ACS. Med. Chem. Lett., 4, 349 (2013); Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)<br></p>Formule :C15H16ClNO2S·ClHCouleur et forme :NeatMasse moléculaire :346.27N-Nitroso Desmethyl Rizatriptan
Produit contrôléFormule :C14H16N6OCouleur et forme :NeatMasse moléculaire :284.316(E/Z)-3-[(2-Cyano-3-ethoxy-3-oxo-1-propenyl)amino]-1H-Pyrazole-4-carboxylic Acid Ethyl Ester
CAS :<p>Applications Impurity of Allopurinol (A547300), an xanthine oxidase inhibitor used in treatment of hyperuricemia and chronic gout. Antiurolithic.<br>References Benezra, S.A., et al.: Anal. Profiles Drug Subs., 7, 1, (1978), Dalbeth, N., et al.: Rheumatology, 44, 1090 (2005), Dinarello, C., et al.: J. Exp. Med., 201, 1355 (2005),<br></p>Formule :C12H14N4O4Couleur et forme :NeatMasse moléculaire :278.27Orotic Acid-15N2 Monohydrate
CAS :<p>Applications Orotic Acid-15N2 Monohydrate is a labelled analogue of Orotic Acid Monohydrate (O691500(P)), which is used in the preparation of therapeutic agents for chronic obstructive pulmonary disease (COPD) treatment.<br>References Furukawa, S.: PCT Int. Appl. (2009), WO 2009069291 A1<br></p>Formule :C5H415N2O4·H2OCouleur et forme :NeatMasse moléculaire :177.09Methotrexate a-Methyl Ester (>90%)
CAS :Produit contrôlé<p>Impurity Methotrexate EP Impurity I<br>Applications Methotrexate α-methyl ester is an impurity of Methotrexate (M260675), a folic acid antagonist. Used as a antineoplastic and antirheumatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Formule :C21H24N8O5Degré de pureté :>90%Couleur et forme :NeatMasse moléculaire :468.47Methotrexate-d3
CAS :Produit contrôlé<p>Applications Labelled Methotrexate (M260675). A Folic acid antagonist. Used as a antineoplastic and antirheumatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Formule :C20H19D3N8O5Couleur et forme :NeatMasse moléculaire :457.461,7-Dimethyluric Acid
CAS :Produit contrôlé<p>Applications A metabolite of Caffeine.<br>References Kalow, W., et al.: Clin. Pharmacol. Ther., 53, 503 (1993), Sharma, S., et al.: Cancer Res., 54, 5848 (1994), Sugawara, M., et al.: J. Biol. Chem., 275, 16473 (2000), Takeda, M., et al.: J. Pharmacol. Exp. Ther., 302, 666 (2002),<br></p>Formule :C7H8N4O3Couleur et forme :NeatMasse moléculaire :196.162-Fluoroadenosine
CAS :Produit contrôlé<p>Applications 2-Fluoroadenosine is a fluorinated analog of Adenoside (A280400) nucleotide.<br>References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010);<br></p>Formule :C10H12FN5O4Couleur et forme :NeatMasse moléculaire :285.23Ethyl 3-Amino-4-pyrazolecarboxylate
CAS :Produit contrôléFormule :C6H9N3O2Couleur et forme :White To BeigeMasse moléculaire :155.153-Descyano Febuxostat
CAS :Produit contrôlé<p>Applications 3-Descyano Febuxostat is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Kadivar, M.H., et. al.: J. Pharmaceut. Biomed. Anal., 56, 749 (2011); Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)<br></p>Formule :C15H17NO3SCouleur et forme :NeatMasse moléculaire :291.37Methotrexate a-tert-Butyl Ester
CAS :Produit contrôlé<p>Applications Methotrexate α-tert-Butyl Ester is an intermediate to the synthesis of folic acid antagonist Methotrexate (M260675) used in the study of membrane-associated folate transporters from L1210 cells.<br>References Yoshii, T., et al.: J. Am. Chem. Soc., 136, 16635 (2014);<br></p>Formule :C24H30N8O5Couleur et forme :NeatMasse moléculaire :510.5462-Chloro Adenosine
CAS :<p>Applications A selective A1-adenosine receptor agonist. Induces apoptosis.<br>References Evans, et al.: Neurosci. Lett., 83, 287 (1987), Szondy, Z.: Biochem. J., 304, 877 (1994)<br></p>Formule :C10H12ClN5O4Couleur et forme :Off-WhiteMasse moléculaire :301.692,4-Pteridinediamine-6-methanol
CAS :Produit contrôléFormule :C7H8N6OCouleur et forme :NeatMasse moléculaire :192.18Acetal
CAS :<p>Stability Volatile<br>Applications Acetal is a flavouring component of Baiju and Rum. It is also a useful reactant in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Franitza, Laura, et al.: J. of Agric. and Food Chem., 64(47), 9041-9053 (2016);<br></p>Formule :C6H14O2Couleur et forme :ColourlessMasse moléculaire :118.17Sumatriptan
CAS :Produit contrôlé<p>Applications Sumatriptan is a serotonin 5HT1-receptor agonist.<br>References Humphrey, P.P.A., et al.: Brit. J. Pharmacol., 94, 1123 (1988); Doenicke, A., et al.: Lancet 1, 1309 (1988)<br></p>Formule :C14H21N3O2SCouleur et forme :White To Light YellowMasse moléculaire :295.40N-[[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]hydroxyphosphinyl]-D-alanine 1-Methylethyl Ester
CAS :Produit contrôlé<p>Applications N-[[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]hydroxyphosphinyl]-D-alanine 1-Methylethyl Ester prorug of PMPA, phenyl monophosphoramidate, and is a Tenofovir (T018500) derivative, an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007), Lee, W. et al.: Antimicrob. Agents Chemother., 49, 1898 (2005);<br></p>Formule :C15H25N6O5PDegré de pureté :>85%Couleur et forme :NeatMasse moléculaire :400.37N-{4-[(4,6-Dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-3-methylbenzamide
CAS :Masse moléculaire :396.4700012207031MTIC-d3
CAS :Produit contrôlé<p>Applications A labelled metabolite of Temozolomide, an antineoplastic.<br></p>Formule :C5H5D3N6OCouleur et forme :Off White SolidMasse moléculaire :171.182-Methylimidazole
CAS :<p>Applications 2-Methylimidazole is a monomethylated imidazole that can be used as a building block in the preparation of a wide range of biologically active compounds. 2-Methylimidazole as well as other imidazoles can be use as catalyst for refolding of enhanced coloured fluorescent protein. 2-Methylimidazole has been identified as a byproduct of fermentation and is detected in foods and mainstream and side-stream tobacco smoke.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shi, R. et al.: Arch. Biochem. Biophys., 459, 122 (2007); Chan, P.C. et al.: Arch. Toxicol., 82, 399 (2008); Nishie, K. et al.: Toxicol. Appl. Pharmacol., 14, 301 (1969);<br></p>Formule :C4H6N2Couleur et forme :NeatMasse moléculaire :82.10Methotrexate Triglutamate Trifluoroacetate
CAS :Produit contrôlé<p>Applications Methotrexate Triglutamate is a metabolite of Methotrexate (M260675); a folic acid antagonist, antineoplastic, and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)<br></p>Formule :C30H36N10O11xC2HF3O2Couleur et forme :NeatMasse moléculaire :712.67Ioxitalamic Acid-d4
CAS :Produit contrôlé<p>Applications A substituted 2,4,6-triiodobenzoic acid, an excellent contrast media for ventriculography, radiculography, lumbar myelography and x-rays of the cardiovascular system.<br>References Frocrain, L., et al.: Radiology, 170, 531 (1989), van Waes, P.F., et al.: Eur. J. Radiology, 9,179 (1989)<br></p>Formule :C12H7D4I3N2O5Couleur et forme :White To Light BrownMasse moléculaire :647.96Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
CAS :<p>Applications Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate is an impurity of Febuxostat (F229000), which is a xanthine oxidase/xanthine dehydrogenase inhibitor, used for treatment of hyperuricemia and chronic gout.<br>References Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005);<br></p>Formule :C18H21NO4SCouleur et forme :NeatMasse moléculaire :347.43Nicotinamide-d4 N-Oxide (d4 Major)
CAS :Produit contrôlé<p>Applications A labelled metabolite of Nicotinamide.<br>References Musfeld, C., et al.: J. Pharm. Biomed. Anal., 24, 391 (2001), Sakakibara, Y., et al.: Brain Res., 931, 68 (2002), Zielonka, J., et al.: Chem. Res. Toxicol., 19, 668 (2006), Wieczorkowska, M., et al.: Pharmacol. Rep., 59, 216 (2007),<br></p>Formule :C6H2D4N2O2Couleur et forme :NeatMasse moléculaire :142.15Memantine Lactose Adduct
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications A lactose adduct of Memantine (M218000). Intermediate in the synthesis of reducing carbohydrate Adamantane amines for use in treating Gram positive or Gram negative bacteria infections.<br>References Kustimur, et al.: Chinese Med. J., 116, 633 (2003),<br></p>Formule :C24H41NO10Couleur et forme :NeatMasse moléculaire :503.582-Amino-6-mercaptopurine-9-D-riboside Hydrate
CAS :<p>Stability Hygroscopic<br>Applications 2-Amino-6-mercaptopurine-9-D-riboside Hydrate (cas# 345909-25-3) is a compound useful in organic synthesis.<br></p>Formule :C10H13N5O4S·x(H2O)Couleur et forme :Light Yellow PowderMasse moléculaire :299.31N-Desacetyl 5-Azido Oseltamivir
CAS :Produit contrôlé<p>Applications Intermediate in the production of Oseltamivir. It is a COVID19-related research product.<br>References Williams, M., et al.: Bioorg. Med. Chem. Lett., 7, 1837 (1997),<br></p>Formule :C14H24N4O3Couleur et forme :NeatMasse moléculaire :296.37N-Desmethyl Zolmitriptan
CAS :<p>Impurity Zolmitriptan USP Related Compound A<br>Stability Hygroscopic<br>Applications A metabolite of Zolmitriptan (Z639000). Zolmitriptan USP Related Compound A.<br>References Chen, J., et al.: J. Pharm. Biomed. Anal., 35, 639 (2004), Srinivasu, M., et al.: J. Pharm. Biomed. Anal., 37, 453 (2005),<br></p>Formule :C15H19N3O2Couleur et forme :NeatMasse moléculaire :273.335-Nitro Nicotinic Acid
CAS :Produit contrôlé<p>Applications An intermediate in the synthesis of nicotinamide with potential anticoccidial activity.<br>References Morisawa, Y. et al.: J. Med. Chem., 20, 129 (1977);<br></p>Formule :C6H4N2O4Couleur et forme :NeatMasse moléculaire :168.11Memantine Hydrochloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Used as an antiparkinsonian and antispasmodic.<br>References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)<br></p>Formule :C12H21N·ClHCouleur et forme :White To Off-WhiteMasse moléculaire :215.764-[6-(4-Methoxy-phenyl)-pyridin-3-yl]-pyrimidin-2-ylamine
Degré de pureté :95.0%Masse moléculaire :278.31500244140625Methotrexate-Cadaverine-Biotin Conjugate
Produit contrôlé<p>Applications Methotrexate-Cadaverine-Biotin Conjugate is biotin labelled Methotrexate. Methotrexate (M260675) is a folic acid antagonist and it is used as a antineoplastic and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Formule :C35H48N12O6SDegré de pureté :>85%Couleur et forme :NeatMasse moléculaire :764.9(S)-Tenofovir Disoproxil Fumarate
CAS :Produit contrôlé<p>Impurity Tenofovir Disoproxil USP Related Compound A<br>Applications The S-enantiomeric impurity of the antiviral Tenofovir Disoproxil Fumarate (T018505(P)), which is an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor and used as an anti-HIV agent.Tenofovir Disoproxil USP Related Compound A.<br>References Shaw, J. P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)<br></p>Formule :C19H30N5O10P·C4H4O4Couleur et forme :White SolidMasse moléculaire :635.524-Chloro Kynurenine-13C2,15N
CAS :Produit contrôlé<p>Applications 7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application.<br>References Leeson, P., et al.: J. Med. Chem., 37, 4053 (1994), Hilmas, C., et al.: J. Neurosci., 2001, 21, 7463 (2001), Palmer, G., et al.: Curr. Drug Targets, 2, 241 (2001), Wu, H., et al.: Exp. Neurol., 177, 222 (2002),<br></p>Formule :C813C2H11ClN15NO3Couleur et forme :NeatMasse moléculaire :245.64N-Hydroxymethyl Sumatriptan
CAS :Produit contrôlé<p>Applications Hydroxymethyl Sumatriptan is an analog of Sumatriptan (S810000), a serotonin 5HT1-receptor agonist.<br>References Humphrey, P.P.A., et al.: Brit. J. Pharmacol., 94, 1123 (1988), Doenicke, A., et al.: Lancet 1, 1309 (1988),<br></p>Formule :C15H23N3O3SCouleur et forme :NeatMasse moléculaire :325.43Nitroso-Caffeidine
CAS :Produit contrôléFormule :C7H11N5O2Couleur et forme :NeatMasse moléculaire :197.2Ethyl-S-(+)-Clopidogrel Sulfate
CAS :Produit contrôlé<p>Stability Very Hygroscopic<br>Applications Ethyl-(S)-(+)-Clopidogrel Sulfate is an analogue of S-(+)-Clopidogrel Hydrogen Sulfate (C587250) which is used as an antithrombotic.<br>References Mills, D.C.B., et al.: Arterioscler. Thromb., 12, 430 (1992), Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)<br></p>Formule :C17H20ClNO6S2Couleur et forme :White To Off-WhiteMasse moléculaire :433.93Pemetrexed Sodium Methyl Ester
Produit contrôlé<p>Applications Pemetrexed Sodium Methyl Ester is an impurity of Pemetrexed(P219550). Pemetrexed Disodium Heptahydrate is an chemotherapy drug for the treatment of pleural mesothelioma and non-small cell lung cancer. Pemetrexed Disodium Heptahydrate exhibit inhibitory activities towards thymidylate synthase as well as other folate dependent enzymes.<br>References Vogelzang, N.J., et al.: J. Clin. Oncol., 21,2636 (2003); Paz-Ares, L., et al.: Lancet. Oncol., 13, 247 (2012);<br></p>Formule :C21H22N5NaO6Couleur et forme :NeatMasse moléculaire :463.419(S)-4-(4-Aminobenzyl)-2-(1H)-oxazolidinone
CAS :Produit contrôlé<p>Impurity Zolmitriptan USP Related Compound G<br>Applications An intermediate of Zolmitriptan, as a novel inhibitor of the cytochrome P-450 enzyme aromatase. Zolmitriptan USP Related Compound G.<br>References Ahmed, S., et al.: Bioorg. Med. Chem. Lett., 5, 2789(1995), Ahmed, S., et al.: Drug. Des. Discov., 15, 239 (1998), Brodie, A., et al.: Steroids, 65, 171 (2000),<br></p>Formule :C10H12N2O2Couleur et forme :NeatMasse moléculaire :192.21Tenofovir Alafenamide-d5 (Diastereomers)
CAS :Produit contrôléFormule :C212H5H24N6O5PCouleur et forme :NeatMasse moléculaire :481.501,3,7-Trimethyluric Acid-d3
CAS :Produit contrôlé<p>Stability Store in freezer<br>Applications A caffeine metabolite.<br>References Regal, K.A., et al.: J. of Chromatography B, 708, 75 (1998)<br></p>Formule :C82H3H7N4O3Couleur et forme :NeatMasse moléculaire :213.21(R)-9-[2-(Diethylphosphonomethoxy)propyl] Adenine
CAS :Produit contrôlé<p>Applications A acyclic phosphonate nucleotide.<br></p>Formule :C13H22N5O4PCouleur et forme :White SolidMasse moléculaire :343.32Urea-urethane Compound (~85%)
CAS :Produit contrôlé<p>Applications Urea-urethane Compound is a reaction product of 4,4'-sulfonylbis[benzenamine] and 2,4-TDI.<br></p>Formule :C42H36N6O8SDegré de pureté :~80%Couleur et forme :NeatMasse moléculaire :784.84N-(6-Amino-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetamide
CAS :<p>Applications N-(6-Amino-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetamide is an intermediate in synthesizing 5-Acetylamino-6-formylamino-3-methyluracil (A168210), which is a metabolite of Caffeine (C080100).<br>References Grant, D.M., et al.: Clin. Pharm. and Ther., 33, 591 (1983),<br></p>Formule :C7H10N4O3Couleur et forme :Off White SolidMasse moléculaire :198.18D-Neopterin
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Precursor in the biosynthesis of Biopterin. First isolated from the pupae of bees.<br>References Kobashi, I., et al.: Agric. Biol. Chem., 35, 47 (1971), Fukushima, S., et al.: J. Biol. Chem., 247, 4549 (1972),<br></p>Formule :C9H11N5O4Couleur et forme :NeatMasse moléculaire :253.21LY 368962
CAS :Produit contrôlé<p>Applications LY 368962 is a metabolite of the antifolate Pemetrexed (P219500).<br>References Woodland, J.M. et al.: Drug Metab. Dispos., 25, 693 (1997);<br></p>Formule :C19H21N5O7Couleur et forme :NeatMasse moléculaire :431.40DAMPA-d3
CAS :Produit contrôlé<p>Applications Labelled Methotrexate (M260675) analog. DAMPA is an antitumor agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Martinelli, J.E., et al.: J. Med. Chem., 22, 869 (1979);<br></p>Formule :C152H3H12N7O2Couleur et forme :Dark OrangeMasse moléculaire :328.341-Methyl Xanthine-d3
CAS :Produit contrôlé<p>Applications A labelled metabolite of Theophylline.<br>References ottrup, A., et al.: Pharmacol. Toxicol., 67, 340 (1990), El-Kadi, A., et al.: Drug Metab. Dispos., 28, 1112 (2000), Kim, S., et al.: J. Med. Chem., 45, 2131 ( 2002), Hansel, T., et al.: Drugs Today, 40, 55 (2004),<br></p>Formule :C62H3H3N4O2Couleur et forme :NeatMasse moléculaire :169.16O-Desisobutyl-O-n-propyl Febuxostat
CAS :Formule :C15H14N2O3SCouleur et forme :NeatMasse moléculaire :302.35Tetrabenazine-d6
CAS :Produit contrôlé<p>Applications Labelled Tetrabenazine. Dopamine depleting agent. An antidyskinetic; antipsychotic.<br>References Schwartz, et al.: Biochem. Pharmacol., 15, 645 (1966), Janovic, J., et al.: Ann. Neurol., 11, 41 (1982), Janovic, J., et al.: Neurology, 38, 391 (1988),<br></p>Formule :C19H21D6NO3Couleur et forme :NeatMasse moléculaire :323.464-(5-methylfuran-2-yl)-6-(3,4,5-trimethoxyphenyl)pyrimidin-2-amine
CAS :Degré de pureté :95.0%Masse moléculaire :341.367004394531252-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl] Sumatriptan (>90%)
CAS :Produit contrôlé<p>Impurity Sumatriptan EP Impurity A<br>Stability Light Sensitive<br>Applications 2-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl] Sumatriptan Succinate (Sumatriptan EP Impurity A) is an impurity of Sumatriptan (S810000), a serotonin 5HT-1-receptor agonist.<br>References Skwierawska, A.. et al.: Poish. J. Chem., 77, 329 (2003);<br></p>Formule :C27H37N5O2SCouleur et forme :Off White SolidMasse moléculaire :495.68Methotrexate-d3 Diglutamate Trifluoroacetate
CAS :Produit contrôlé<p>Applications Methotrexate-d3 Diglutamate is the isotope labelled analog of Methotrexate Diglutamate (M260720); a metabolite of Methotrexate (M260675) which is a folic acid antagonist, antineoplastic, and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)<br></p>Formule :C25H26D3N9O8•x(C2HF3O2)•xH2SO4Couleur et forme :NeatMasse moléculaire :586.58114029813,4-Dihydro Naratriptan Oxalate
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications 3,4-Dihydro Naratriptan Oxalate is the basic form of 3,4-Dihydro Naratriptan(D449205); it is an impurity of Naratriptan (N378730), It is a triptan drug and is used for the treatment of migraine headaches.<br>References Dulery, B.D., et al.: J. Pharm. Biomed. Anal., 15, 1009 (1997), Havanka, H., et al.: Clin. Ther., 22, 970 (2000),<br></p>Formule :C17H23N3O2S·C2H2O4Couleur et forme :White To Light YellowMasse moléculaire :333.45 + 90.036,6'-Binicotinic Acid
CAS :Produit contrôlé<p>Applications A Nicotinic acid (N429250) derivative for treatment of hypercholesterolemia and hyperlipidemia and cardiovascular disease.<br>References Hales, N.J., et al.: J. Med. Chem., 36, 3853 (1993),<br></p>Formule :C12H8N2O4Couleur et forme :NeatMasse moléculaire :244.204-Hydroxyphenylpyruvic Acid
CAS :Formule :C9H8O4Couleur et forme :Light Yellow To OrangeMasse moléculaire :180.16Chloromethyl Isopropyl Carbonate
CAS :Produit contrôlé<p>Stability Moisture sensitive<br>Applications Chloromethyl Isopropyl Carbonate is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mackman, R., et al.: Bioorg. Med. Chem., 15, 5519 (2007), Baudy, R., et al.: J. Med. Chem., 52, 771 (2009),<br></p>Formule :C5H9ClO3Couleur et forme :NeatMasse moléculaire :152.582-[3-(Aminocarbonyl)-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid
CAS :Produit contrôlé<p>Applications 2-[3-(Aminocarbonyl)-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid is an impurity of Febuxostat (F229000), an xanthine oxidase/xanthine dehydrogenase inhibitor used for the treatment of hyperuricemia and chronic gout.<br>References Kadivar, M.H., et al.: J. Pharma. Biomed. Anal., 56, 749 (2011);<br></p>Formule :C16H18N2O4SCouleur et forme :White To Off-WhiteMasse moléculaire :334.394-Hydroxythiobenzamide
CAS :<p>Applications 4-Hydroxythiobenzamide is used in the synthesis of PPARα agonists used in increasing HDLc levels. Also used in the synthesis of potent CDK5 inhibitors in the treatment of Alzheimer’s disease.<br>References Sierra, M. et al.: J. Med. Chem., 50, 685 (2007); Zhong, W. et al.: Bioorg. Med. Chem. Lett., 17, 5384 (2007);<br></p>Formule :C7H7NOSCouleur et forme :NeatMasse moléculaire :153.2Iso Rizatriptan
CAS :Produit contrôlé<p>Impurity Rizatriptan EP Impurity C<br>Applications Iso Rizatriptan (Rizatriptan EP Impurity C) is a potential impurity of Rizatriptan. A regioisomer of Rizatriptan.<br>References Dill, K., et al.: J. Phys. Chem., 91, 1980 (1987), Cole, L., et al.: Anal. Chem., 64, 1317 (1992), Street, L., et al.: J. Med. Chem., 1995, 38, 1799<br></p>Formule :C15H19N5Couleur et forme :NeatMasse moléculaire :269.34Chloromethyl Methyl Carbonate
CAS :Produit contrôlé<p>Applications A reagent used in the preparation of prodrugs of diacidic nonpeptide angiotensin II antagonist as well as pyrrolothiazole platelet activating factor antagonist.<br>References Aungst, B.J. et al.: Pharmac. Res., 12, 763 (1996); Davidsen, S.K. et al.: J. Med. Chem., 37, 4423 (1994);<br></p>Formule :C3H5ClO3Couleur et forme :NeatMasse moléculaire :124.52Caffeine-d3 (7-methyl-d3)
CAS :Produit contrôlé<p>Applications Caffeine-d3 (7-methyl-d3) (CAS# 26351-04-2) is a useful isotopically labeled research compound.<br></p>Formule :C8D3H7N4O2Couleur et forme :White To Off-WhiteMasse moléculaire :197.209N-Butyldeoxynojirimycin Hydrochloride-d9
CAS :Produit contrôlé<p>Applications N-Butyldeoxynojirimycin Hydrochloride-d9 is labelled N-Butyldeoxynojirimycin Hydrochloride (B691000) which is an inhibitor of a-glucosidase 1 as well as being an inhibitor of HIV cytopathicity.<br>References Hettkamp, H., et al.: Eur. J. Biochem., 142, 85 (1984), Szumilo, T., et al.: Arch. Biochem. Biophys., 247, 261 (1986), Fleet, G.W.J., et al.: FEBS Letters, 237, Number 1,2, 128 (1988), Kolter, T., et al.: Angew. Chem. Int. Ed. Engl., 36, 1955 (1997),<br></p>Formule :C10H13D9ClNO4Couleur et forme :NeatMasse moléculaire :264.79Paraquat-d8 Dichloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Labelled Paraquat Dichloride, a commonly used heribicide. Paraquat Dichloride is a fast-acting and non-selective viologen derivative that kills green plant tissue on contact. Studies suggest that there might be a possible link between Paraquat Dichloride and the development of Parkinson’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Heylings, J.R. et al.: Toxicology, 241, 1 (2007); Wibawa, W. et al.: Int. J. Agric. Biol., 11, 145 (2009); Franco, R. et al.: Chem.-Biol. Inter., 188, 289 (2010);<br></p>Formule :C122H8H6N2·2ClCouleur et forme :ColourlessMasse moléculaire :265.21(6R)-5,6,7,8-Tetrahydrobiopterin Dihydrochloride
CAS :<p>Stability Hygroscopic<br>Applications Tetrahydrobiopterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin, melatonin, dopamine, norepinephrine , epinephrine, and is a cofactor for the production of nitric oxide by the nitric oxide synthases. Chemically, its structure is that of a reduced pteridine derivative.<br>References Levy, Harvey L., et al.: Lancet, 370, 504 (2007); Isojima, Yasushi., et al.: Proc Natl Acad Sci USA .,106, 15744 (2009); Burton, B. K., et al.: J. Inherit. Metab. Dis., 30, 700 (2007)<br></p>Formule :C9H15N5O3·2(HCl)Couleur et forme :White To Off-WhiteMasse moléculaire :241.25 + 2(36.46)
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