Dérivés des Purines et Pyrimidines
Les purines possèdent une structure bicyclique, composée d’un cycle à six membres fusionné avec un cycle à cinq membres, tous deux contenant des atomes d’azote à des positions clés. Les dérivés des purines, tels que l’adénine et la guanine, sont essentiels à la formation de l’ADN et de l’ARN. Ces composés ont des applications thérapeutiques dans le traitement du cancer et des maladies virales en inhibant la réplication cellulaire. Les pyrimidines, quant à elles, possèdent une structure monocyclique à six membres avec deux atomes d’azote. Leurs dérivés, tels que la cytosine, la thymine et l’uracile, sont également des composants essentiels de l’ADN et de l’ARN et sont utilisés en chimiothérapie et dans les traitements antiviraux.
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8901 produits trouvés pour "Dérivés des Purines et Pyrimidines"
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(1R,5S,6S)-rel-5-(1-Ethylpropoxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic Acid Methyl Ester
CAS :Produit contrôlé<p>Applications This compound is used in the preparation of azidoalkanes. As well it is an intermediate in the synthesis of neuraminidase inhibitors.<br>References Braese, S. et al.: Sci. Synth. 41, 543 (2010); Jarinrat K. et al.: Bioorg. Med. Chem. Lett., 20, 2152 (2012);<br></p>Formule :C13H20O4Couleur et forme :NeatMasse moléculaire :240.30N-(2-Chloro-5-methoxypyrimidin-4-yl)-1H-indazol-6-amine
CAS :Degré de pureté :98%Masse moléculaire :275.70001220703125Methyl 4-((6-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-yl)oxy)benzoate
CAS :Degré de pureté :97.0%Masse moléculaire :324.33999633789061-tert-Butyl 3-ethyl 4-ureido-1H-pyrrole-1,3(2H,5H)-dicarboxylate
CAS :Degré de pureté :95.0%Masse moléculaire :299.32699584960944,6-Diaminopyrimidin-2(1H)-one hydrochloride
CAS :Degré de pureté :97%Masse moléculaire :162.5800018310547N-Benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyladenosine
CAS :Degré de pureté :95%Masse moléculaire :687.7536-Amino-1,3-dimethyluracil
CAS :Degré de pureté :97.0%Couleur et forme :SolidMasse moléculaire :155.15699768066406Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate
CAS :<p>Applications Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate is used in the synthesis of the major metabolites of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Li, X., et. al.: Lett. Org. Chem., 12, 217 (2015); Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)<br></p>Formule :C13H13NO3SCouleur et forme :NeatMasse moléculaire :263.311,2,3,9-Tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one
CAS :Produit contrôlé<p>Impurity Ondansetron EP Impurity D; Ondansetron USP Related Compound D<br>Applications 1,2,3,9-Tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one (Ondansetron EP Impurity D; Ondansetron USP Related Compound D) is an impurity of Ondansetron (O655000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Feng, R. et al.: Zhong. Yaox. Zaz., 46, 1436 (2011); Zizkovsky, V. et al.: J. Pharm. Biomed. Anal., 44, 1048 (2007)<br></p>Formule :C14H13NOCouleur et forme :WhiteMasse moléculaire :211.26(R)-9-[2-(Hydroxypropyl] Adenine(Desphosphoryl Tenofovir)
CAS :Produit contrôlé<p>Applications (R)-9-[2-(Hydroxypropyl] Adenine (Desphosphoryl Tenofovir) (cas# 14047-28-0) is a useful reagent for preparing the antiviral drug tenofovir.<br>References Dietz, J.-P., et al.: ChemRxiv, 1 (2020)<br></p>Formule :C8H11N5OCouleur et forme :NeatMasse moléculaire :193.21N-Methyl Pemetrexed
CAS :Produit contrôlé<p>Impurity Pemetrexed EP Impurity A<br>Applications N-Methyl Pemetrexed (Pemetrexed EP Impurity A) is an impurity of Pemetrexed (P219500), an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes.<br>References Kjell, D.P., et al.: Org. Proc. Res. Develop., 9, 738 (2005);<br></p>Formule :C21H23N5O6Couleur et forme :NeatMasse moléculaire :441.44Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
CAS :<p>Applications Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)<br></p>Formule :C18H20N2O3SCouleur et forme :NeatMasse moléculaire :344.431-Bromo-3,5-dimethyladamantane
CAS :Produit contrôlé<p>Applications 1-Bromo-3,5-dimethyladamantane (cas# 941-37-7) is a compound useful in organic synthesis.<br></p>Formule :C12H19BrCouleur et forme :ColourlessMasse moléculaire :243.18Febuxostat-d9
CAS :Produit contrôlé<p>Applications Labelled Febuxostat (F229000). Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),<br></p>Formule :C16D9H7N2O3SCouleur et forme :NeatMasse moléculaire :325.43N-Demethyl Ondansetron
CAS :<p>Applications A metabolite of Ondansetron (O655000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bayliss, M., et al: Xenobiotica, 24, 231 (1994), Atkins, W., et al.: J. Biol. Chem., 277, 33258 (2002), De Graaf, I., et al.: Drug Metab. Dispos., 30, 1129 (2002),<br></p>Formule :C17H17N3OCouleur et forme :White To BrownMasse moléculaire :279.34Tenofovir Diphosphate Triethylamine Salt (Mixture of Diastereomers)
CAS :<p>Stability Very Hygroscopic<br>Applications A metabolite of Tenofovir (T018500).<br>References Hazra, R., et al.: Antimicrob. Agents Chemother., 48, 124 (2004), Piketty, C., et al.: Antivir. Ther., 11, 213 (2006), Molto, J., et al.: Ther. Drug Monit., 29, 648 (2007),<br></p>Formule :C9H16N5O10P3·C6H15NCouleur et forme :Off-White To Light YellowMasse moléculaire :447.17Isoguanosine Hydrate
CAS :Produit contrôlé<p>Applications A useful synthetic intermedate. A naturally occuring, biologically active isomer of guanosine. Reported to stimulate the accumulation of cyclic-AMP in the brain. It is an inhibitor of IMP pyrophosphorylase, and its 5’-di and -tri-phosphates inhibit glutamic acid dehydrogenase. May contain approximately 0.6 moles of water.<br>References Divakar, K.J., et al.: J. Chem. Soc. Perkin Trans., 1, 771 (1991), Montsch, H.H., et al: Biochemistry, 14, 5593 (1975), Hagen, C.: Biochim. Biophys. Acta., 293, 105 (1973), Huang, M., et al.: J. Med. Chem., 15, 462 (1972)<br></p>Formule :C10H13N5O5·H2OCouleur et forme :NeatMasse moléculaire :301.26Chloromethyl Ethyl Carbonate
CAS :Produit contrôlé<p>Applications A reagent used in the preparation of hepatitis C virus NS3 protease inhibitors and PMPA prodrugs with antiretroviral activity.<br>References Sheng, X. et al.: Bioorg, Med. Chem. Lett., 169, 3453 (2009); Arimilli, M.N. et al.: Antiviral Chem. Chemother., 8, 557 (1997);<br></p>Formule :C4H7ClO3Couleur et forme :Colourless OilyMasse moléculaire :138.556-Mercaptopurine-13C2,15N (major)
CAS :Produit contrôlé<p>Applications An immunosuppressive drug used to treat leukemia. It is also used for pediatric non-Hodgkin’s lymphoma, polycythemia vera, and psoriatic arthritis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Naguib, F., et al.: Biochem. Pharmacol., 50, 1685 (1995), Zeng, H., et al.: Biochem. Pharmacol., 68, 911 (2004).<br></p>Formule :C313C2H4N315NSCouleur et forme :NeatMasse moléculaire :155.16
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