Dérivés des Purines et Pyrimidines
Les purines possèdent une structure bicyclique, composée d’un cycle à six membres fusionné avec un cycle à cinq membres, tous deux contenant des atomes d’azote à des positions clés. Les dérivés des purines, tels que l’adénine et la guanine, sont essentiels à la formation de l’ADN et de l’ARN. Ces composés ont des applications thérapeutiques dans le traitement du cancer et des maladies virales en inhibant la réplication cellulaire. Les pyrimidines, quant à elles, possèdent une structure monocyclique à six membres avec deux atomes d’azote. Leurs dérivés, tels que la cytosine, la thymine et l’uracile, sont également des composants essentiels de l’ADN et de l’ARN et sont utilisés en chimiothérapie et dans les traitements antiviraux.
Chez CymitQuimica, nous proposons des dérivés des purines et pyrimidines pour la recherche en biologie moléculaire, génomique et le développement de thérapies innovantes.
8895 produits trouvés pour "Dérivés des Purines et Pyrimidines"
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nPOC-POC Tenofovir Fumarate(Mixture of Diastereomers)
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Tenofovir (T018500) impurity.<br></p>Formule :C19H30N5O10P·C4H4O4Couleur et forme :White To Off-WhiteMasse moléculaire :635.51Descarboxyl Febuxostat
CAS :Produit contrôléFormule :C15H16N2OSCouleur et forme :NeatMasse moléculaire :272.374-Hydroxy-1,3-benzenedicarbonitrile
CAS :Produit contrôlé<p>Applications 4-Hydroxy-1,3-benzenedicarbonitrile is used in the preparation of febuxostat (F229000), a non-purine xanthine oxidase inhibitor used as a treatment for hyperuricaemia and chronic gout.<br>References Smith, C.J., et al.: Bioorg. Med. Chem. Lett., 20, 346 (2010); Cramp. S., et al.: BIoorg. Med. Chem. Lett., 20, 2516 (2010); Sato, T., et al.: Bioorg. Med. Chem. Lett., 19, 184 (2009);<br></p>Formule :C8H4N2OCouleur et forme :NeatMasse moléculaire :144.13Hydroxy Urea-15N
CAS :Produit contrôlé<p>Applications Labelled Hydroxyurea. An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide.<br>References Ratcliffe, W., et al.: Lancet, 339, 164 (1992), Roodman, G., et al.: Cancer, 80, 1557 (1997), Horwitz, M., et al.: J. Clin. Endocrinol. Metab., 2003, 88, 1603 (2003),<br></p>Formule :CH415NNO2Couleur et forme :NeatMasse moléculaire :77.055-Aminoimidazole-4-carboxamide-15N2 Hydrochloride (>90%)
CAS :Produit contrôléFormule :C4H7ClN215N2ODegré de pureté :>90%Couleur et forme :NeatMasse moléculaire :164.56N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid
CAS :Produit contrôlé<p>Applications N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid, referred to as Pemetrexed, is used in the treatment of malignant pleural mesothelioma (MPM).<br>References Pasello, G. et al.: Anticanc. Res., 32, 5393 (2012);<br></p>Formule :C20H21N5O6Couleur et forme :NeatMasse moléculaire :427.411-(3-(2-(Dimethylamino)ethyl)-1-((5-((N-methylsulfamoyl)methyl)-1H-indol-3-yl)methyl)-1H-indol-5-yl)-N-methylmethanesulfonamide Formate Salt
CAS :Produit contrôléFormule :C25H33N5O4S2·CH2O2Couleur et forme :NeatMasse moléculaire :531.694603(1R,5R,6R)-5-(1-Ethylpropoxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic Acid Ethyl Ester
CAS :Produit contrôlé<p>Applications This compound is an isomer of compound (E925685) used in the synthesis of neuraminidase inhibitors.<br>References Jarinrat K. et al.: Bioorg. Med. Chem. Lett., 20, 2152 (2012);<br></p>Formule :C14H22O4Couleur et forme :NeatMasse moléculaire :254.32Ethyl 2-(4-Butoxy-3-cyanophenyl)-4-methylthiazole-5-carboxylate
Produit contrôlé<p>Applications Ethyl 2-(4-Butoxy-3-cyanophenyl)-4-methylthiazole-5-carboxylate, is an impurity in the synthesis of Febuxostat n-Butyl Isomer (F229035).<br></p>Formule :C18H20N2O3SCouleur et forme :NeatMasse moléculaire :344.43Febuxostat 67M-2
CAS :Produit contrôlé<p>Applications Febuxostat 67M-2 is a derivative compound of Febuxostat 67M-1 (F229005) which is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and also used to reduce the risk of gout or kidney stone formation.<br>References Du, J., et al.: Handbook of Metabolic Pathways of Xenobiotics, 4, 1395 (2014)<br></p>Formule :C16H16N2O4SCouleur et forme :NeatMasse moléculaire :332.372-Pyrimidinemethanamine
CAS :Produit contrôlé<p>Applications 2-Pyrimidinemethanamine (cas# 75985-45-4) is a useful research chemical.<br></p>Formule :C5H7N3Couleur et forme :NeatMasse moléculaire :109.13nPOC-POC Tenofovir(Mixture of Diastereomers)
CAS :Produit contrôlé<p>Applications An impurity of Tenofovir (T018500(P)). Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>Formule :C19H30N5O10PCouleur et forme :NeatMasse moléculaire :519.44D-Alanine Isopropyl Ester Hydrochloride
CAS :Produit contrôlé<p>Applications D-Alanine Isopropyl Ester Hydrochloride is a chiral reagent used in the synthesis of nucleotide prodrugs such as (PSI-7977) for the treatment of hepatitis C. Also used in the preparation of synthetic sweeteners.<br>References Sofia, M. et al.: J. Med. Chem., 53, 7202 (2010); Mazur, R. et al.: J. Med. Chem., 16, 1284 (1973);<br></p>Formule :C6H14ClNO2Degré de pureté :~90%Couleur et forme :NeatMasse moléculaire :167.63Oseltamivir Acid Methyl Ester Phosphate Salt
CAS :<p>Applications An impurity of the antiviral drug Oseltamivir (O700100). It is a COVID19-related research product.<br></p>Formule :C15H29N2O8PCouleur et forme :NeatMasse moléculaire :396.375-Hydroxymethyl-N,N-dimethyltryptamine
CAS :Produit contrôlé<p>Applications Degradation product of Sumatriptan Succinate (S810000).<br>References Xu, X. et al.: J. Pharmaceut. Biomed. 367, 26 (2001)<br></p>Formule :C13H18N2OCouleur et forme :WhiteMasse moléculaire :218.29Picolinamide
CAS :Produit contrôlé<p>Applications A nicotinic acid derivative for prevention and treatment of cancer by activating RUNX3 gene.<br>References Ludwig, et al.: Cancer Res., 50, 2470 (1990), Gupta., et al.: Biomed. Environ. Sci., 13,122 (2000), Cai., et al.: J. Med. Chem., 46, 2474 (2003),<br></p>Formule :C6H6N2OCouleur et forme :NeatMasse moléculaire :122.121,3-Dihydro-6-methylfuro[3,4-c]pyridin-7-ol
CAS :<p>1,3-Dihydro-6-methylfuro[3,4-c]pyridin-7-ol is a compound that contains impurities such as fatty acids and uridine. It has been found to be an inhibitor of α-mangostin adduct formation with fatty acids. Additionally, it has been shown to inhibit the activity of GSK-3β, an enzyme involved in various cellular processes. This compound also exhibits inhibitory effects on monascus and safranal, two enzymes involved in the production of certain compounds. Furthermore, it has been found to inhibit calpain, an enzyme responsible for protein degradation. The compound can be used in various research applications involving electrode modification and polylysine immobilization. It may also have potential interactions with other drugs such as cefdinir.</p>Formule :C8H9NO2Degré de pureté :Min. 95%Masse moléculaire :151.16 g/molPemetrexed impurity C
CAS :<p>Pemetrexed is a drug product that belongs to the group of drugs called antifolate agents. It is used in the treatment of cancer and is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. The impurity C is a natural metabolite that can be found in urine as well as in plasma. This impurity has not been identified as a major metabolite of pemetrexed.</p>Formule :C40H40N10O13Degré de pureté :Min. 95%Masse moléculaire :868.81 g/molAllopurinol impurity A
CAS :<p>Allopurinol is an anticancer drug that is used to treat leukemia and other cancers. Allopurinol impurity A is a byproduct of the production of allopurinol, which has been shown to have anticancer properties. It has been shown to suppress the expression of suppressor genes and up-regulated genes in pancreatic cancer cells. This compound also induces apoptosis in orthotopic liver cells in a process involving activation of caspase 3 and suppression of Akt signaling.</p>Degré de pureté :Min. 95%(S)-Tenofovir
CAS :<p>(S)-Tenofovir ((S)-PMPA) is the less active S-enantiomer of Tenofovir which is a nucleotide reverse transcriptase inhibitor.</p>Formule :C9H14N5O4PDegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :287.21
![N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FA604980.webp&w=3840&q=75)
![(1R,5R,6R)-5-(1-Ethylpropoxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic Acid Ethyl Ester](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FE925690.webp&w=3840&q=75)
![1,3-Dihydro-6-methylfuro[3,4-c]pyridin-7-ol](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FID27319.webp&w=3840&q=75)
