Dérivés des Purines et Pyrimidines
Les purines possèdent une structure bicyclique, composée d’un cycle à six membres fusionné avec un cycle à cinq membres, tous deux contenant des atomes d’azote à des positions clés. Les dérivés des purines, tels que l’adénine et la guanine, sont essentiels à la formation de l’ADN et de l’ARN. Ces composés ont des applications thérapeutiques dans le traitement du cancer et des maladies virales en inhibant la réplication cellulaire. Les pyrimidines, quant à elles, possèdent une structure monocyclique à six membres avec deux atomes d’azote. Leurs dérivés, tels que la cytosine, la thymine et l’uracile, sont également des composants essentiels de l’ADN et de l’ARN et sont utilisés en chimiothérapie et dans les traitements antiviraux.
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LY-338979
CAS :<p>Applications LY 338979 is a metabolite of the antifolate Pemetrexed (P219500).<br>References Woodland, J.M. et al.: Drug Metab. Dispos., 25, 693 (1997);<br></p>Formule :C20H21N5O7Couleur et forme :NeatMasse moléculaire :443.41Methopterine (>90%)
CAS :Produit contrôlé<p>Impurity Methotrexate EP Impurity C; Methotrexate USP Related Compound C<br>Applications Methopterine (Methotrexate EP Impurity C) is a Folic acid (F680300) analogue. Methopterine is effective in the treatment of ectopic pregnancy. Methotrexate USP Related Compound C<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McNamara, P., et al.: Drug Metab. Dispos., 20, 302 (1992), Soldin, O., et al.: Ther. Drug Monit., 24, 1 (2002), Nicoli, S., et al.: J. Pharm. Biomed. Anal., 41, 994 (2006),<br></p>Formule :C20H21N7O6Degré de pureté :>90%Couleur et forme :NeatMasse moléculaire :455.42(S)-Tenofovir
CAS :Produit contrôlé<p>Applications (S)-Tenofovir is an S-enatiomeric derivative of Tenofovir (T018500). (S)-Tenofovir displays virucidal activity against herpes, visna virus and retrovirus. The S enantiomer of Tenofovir (T018500) is less effective against HIV than their (R)-enantiomeric counterparts.<br>References Balzarini, J. et al: Biochem. Biophys. Res. Comm., 219, 337 (1996); Balzarini, J. et al.: Antimicrob. Agents. Ch., 37, 332 (1993); Thormar, H. et al.: Antimicorb. Agents. Ch., 37, 2540 (1993)<br></p>Formule :C9H14N5O4PCouleur et forme :NeatMasse moléculaire :287.21Febuxostat
CAS :<p>Applications Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),<br></p>Formule :C16H16N2O3SCouleur et forme :White To Off-WhiteMasse moléculaire :316.37Ondansetron
CAS :Produit contrôlé<p>Applications Ondansetron is a specific serotonin (5-HT3) receptor antagonist. Antiemetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kris, M.G., et al.: J. Clin. Oncol., 6, 659 (1988); Faris, P..L., et al.: Lances, 355, 792 (2000)<br></p>Formule :C18H19N3OCouleur et forme :White To Light BeigeMasse moléculaire :293.36Caffeine-13C3
CAS :<p>Applications Caffeine-13C3 is a labelled analogue of Caffeine (C080100), a bitter, white crystalline xanthine alkaloid that acts as a stimulant drug and a reversible acetylcholinesterase inhibitor. Caffeine is found in varying quantities in the seeds, leaves, and fruit of some plants, where it acts as a natural pesticide that paralyzes and kills certain insects feeding on the plants. In humans, caffeine acts as a central nervous system stimulant, temporarily warding off drowsiness and restoring alertness. Caffeine is a cardiac and respiratory stimulant; diuretic. Caffeine is toxic at sufficiently high doses.A study at Johns Hopkins University indicates that caffeine can improve pattern separation memory.<br>References Zubair, U.M., et al.: Anal. Profiles Drug Subs., 15, 71 (1986); Cherrah, Y., et al.: Biochem. Pharmacol., 37, 1311 (1988); Chem. and Eng. News p.34, Jan. 20, (2014)<br></p>Formule :C3C5H10N4O2Couleur et forme :White To Off-WhiteMasse moléculaire :197.17Telbivudine-d3
CAS :Produit contrôlé<p>Applications Labelled nucleoside analog; specific inhibitor of hepatitis B virus (HBV) replication. Antiviral.<br>References Standring, D.N., et al.: Antiviral. Chem. Chemother., 12, 119 (2001), Hernandez-Santiago, B., et al.: Antimicrob. Agents Chemother., 46, 1728 (2002), Lai, C.-L., et al.: Hepatology, 40, 719 (2004), Han, S.-H.B., et al.: Expert Opin. Invest. Drugs, 14, 511 (2005),<br></p>Formule :C10H11D3N2O5Couleur et forme :NeatMasse moléculaire :245.251-Bromo-3-methyladamantane
CAS :Produit contrôléFormule :C11H17BrCouleur et forme :NeatMasse moléculaire :229.162-pyrimidineacetic acid ethyl ester
CAS :Formule :C8H10N2O2Degré de pureté :97%Couleur et forme :LiquidMasse moléculaire :166.185-[(1S)-1-(2-Chlorophenyl)-2-methoxy-2-oxoethyl]-6,7-dihydro-Thieno[3,2-c]pyridinium Bromide
CAS :Produit contrôléFormule :C16H15BrClNO2SCouleur et forme :NeatMasse moléculaire :400.72Methotrexate Diglutamate Trifluoroacetate
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Methotrexate Diglutamate is a metabolite of Methotrexate (M260675); a folic acid antagonist, antineoplastic, and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)<br></p>Formule :C25H29N9O8xC2HF3O2Couleur et forme :NeatMasse moléculaire :583.55Methotrexate Dimethyl Ester
CAS :Produit contrôléFormule :C22H26N8O5Couleur et forme :Light YellowMasse moléculaire :482.494-(4-Methoxyphenyl)-2-(methylthio)pyrimidine
CAS :Degré de pureté :95.0%Masse moléculaire :232.3000030517578MTIC
CAS :<p>Applications A metabolite of Temozolomide, an antineoplastic.<br></p>Formule :C5H8N6OCouleur et forme :Off-WhiteMasse moléculaire :168.16Isonicotinic Acid
CAS :<p>Applications Used in the biological study of differentiation induced by nicotinic acid, nicotinamide and isonicotinic acid in human leukemia cell lines.<br>References Zeilinger, S., et al.: J. Biol. Chem., 271, 25624 (1996), Panagiotou, G., et al.: J. Biotechnol., 118, 304 (2005),<br></p>Formule :C6H5NO2Couleur et forme :Light BrownMasse moléculaire :123.114-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide
CAS :Degré de pureté :99.0%Couleur et forme :SolidMasse moléculaire :482.82000732421875Ref: 10-F361865
1gÀ demander5gÀ demander10gÀ demander25gÀ demander10mgÀ demander50mgÀ demander100mgÀ demander250mgÀ demander500mgÀ demander5-{[(4,6-dimethylpyrimidin-2-yl)thio]methyl}-4-(4-fluorophenyl)-4H-1,2,4-triazole-3-thiol
CAS :Degré de pureté :95.0%Masse moléculaire :347.067465668Allopurinol-13C,15N2
CAS :Produit contrôlé<p>Applications Allopurinol-13C,15N2, is the labeled analogue of Allopurinol (A547300), acting as an Xanthine oxidase inhibitor, and used in treatment of hyperuricemia and chronic gout.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Benezra, S.A., et al.: Anal. Profiles Drug Subs., 7, 1, (1978), Dalbeth, N., et al.: Rheumatology, 44, 1090 (2005), Dinarello, C., et al.: J. Exp. Med., 201, 1355 (2005),<br></p>Formule :C413CH4N215N2OCouleur et forme :NeatMasse moléculaire :139.09Methotrexate Dimethylamide (>90%)
CAS :Produit contrôlé<p>Applications Methotrexate Dimethylamide is an impurity of Methotrexate (M260675) which is a folic acid antagonist. Used as a antineoplastic and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Formule :C22H27N9O4Degré de pureté :>90%Couleur et forme :NeatMasse moléculaire :481.508Febuxostat-d7
CAS :Produit contrôlé<p>Applications Febuxostat-d7, is the labeled analogue of Febuxostat-d7 (F229000), a Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),<br></p>Formule :C16H9D7N2O3SCouleur et forme :NeatMasse moléculaire :323.427-Methyl Xanthine
CAS :Produit contrôlé<p>Applications Metabolite of Theophylline and Caffeine.<br>References Yu, Ch. et al.: J. Bacteriol. 191, 4624 (2009); Geraets, L. et al.: Biochem. Pharmacol. 72, 902 (2006).<br></p>Formule :C6H6N4O2Couleur et forme :NeatMasse moléculaire :166.14Tryptamine
CAS :<p>Applications Tryptamine is a monoamine alkaloid found in plants. Tryptamine is commonly used in the preparation of biologically active compounds such as neurotransmitters and psychedelics.<br>References Nichols, D. E., et al.: Curr. Top. Behav. Neurosci., 36, 1(2018); Espinoza, S., et al.: Top. Med. Chem., 23, 175 (2017)<br></p>Formule :C10H12N2Couleur et forme :YellowMasse moléculaire :160.22Urea-13C
CAS :<p>Applications Labelled Urea. Physiological regulator of nitrogen excretion in mammals; synthesized in the liver as an end-product of protein catabolism and excreted in urine. Also occurs normally in skin. Emollient; diuretic.<br>References Demetriou, A., et al.: Science, 233, 1190 (1986); Aebischer, P., et al.: Nat. Med., 2, 696(1996); Prakash, S., et al.: Biotechnol. Bioeng., 46, 621(1995);<br></p>Formule :CH4N2OCouleur et forme :NeatMasse moléculaire :61.051-Methyluric Acid-d3
CAS :Produit contrôlé<p>Applications A labelled metabolite of Theophylline.<br>References Chen, Y., et al.: Clin. Exper. Pharmacol. Physiol., 36, 828 (2009), Yu, C., et al.: J. Bacteriol., 191, 4624 (2009), Jetter, A., et al.: Eur. J. Clin. Pharmacol., 65, 411 (2009),<br></p>Formule :C62H3H3N4O3Couleur et forme :NeatMasse moléculaire :185.163-Descyano-3-formyl Febuxostat
CAS :Formule :C16H17NO4SCouleur et forme :NeatMasse moléculaire :319.384-(3-Bromo-4-oxobutyl)benzoic Acid Methyl Ester
CAS :Produit contrôlé<p>Applications 4-(3-Bromo-4-oxobutyl)benzoic Acid Methyl Ester is used as a reagent in the synthesis of furoxanoxyalkyl esters of pemetrexed as antifolates and nitric oxide donors for use as anticancer agents and their activities against four human cancer cell lines.<br>References Min, T., et al.: Med. Chem. Res., 18, 495 (2009); Barnett, C.J., et al.: Org. Process Res. Dev., 3, 184 (1999)<br></p>Formule :C12H13BrO3Couleur et forme :NeatMasse moléculaire :285.13Aminopterin
CAS :<p>Impurity Methotrexate EP Impurity B<br>Applications Aminopterin (Methotrexate EP Impurity B) is a folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Matherly, L.H., et al.: Cancer Res., 45, 1073 (1985), Rumberger, B.G., et al.: Cancer Res., 50, 4639 (1990), Roy, K., et al.: J. Biol. Chem., 273, 2526 (1998),<br></p>Formule :C19H20N8O5Couleur et forme :YellowMasse moléculaire :440.41Thyroxine-13C6 4'-O-β-D-Glucuronide Disodium Salt
CAS :Produit contrôléFormule :C1513C6H17I4NNa2O10Couleur et forme :NeatMasse moléculaire :1002.91Succinimide
CAS :<p>Applications Succinimide is a reagent that is used in the synthesis of Lumiflavin (L473900), which is a toxic photolysis product of vitamin B2 (R415000).<br>References Zhao, X. et al.: Chemosphere, 63, 1116 (2006); Litke, S.V. et al.: Khim. Fiz., 10, 48 (1991); Ye, W. et al.: Guang. Yaox. Xueb., 12, 175 (1996);<br></p>Formule :C4H5NO2Couleur et forme :White To Off-WhiteMasse moléculaire :99.09Urea-13C,15N2
CAS :Produit contrôlé<p>Applications Labelled Urea. Physiological regulator of nitrogen excretion in mammals; synthesized in the liver as an end-product of protein catabolism and excreted in urine. Also occurs normally in skin. Emollient; diuretic.<br>References Demetriou, A., et al.: Science, 233, 1190 (1986), Aebischer, P., et al.: Nat. Med., 2, 696 (1996), Prakash, S., et al.: Biotechnol. Bioeng., 46, 621 (1995),<br></p>Formule :CH415N2OCouleur et forme :NeatMasse moléculaire :63.031,3-Diallylurea
CAS :Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :140.186004638671884-Chloro-2,6-diphenylpyrimidine
CAS :Degré de pureté :95.0%Couleur et forme :SolidMasse moléculaire :266.73001098632816-Methyl-5-((3-(2-(methylthio)pyrimidin-4-yl)pyridin-2-yl)oxy)naphthalen-1-amine
CAS :Degré de pureté :98%Masse moléculaire :374.4599914550781[1-(2-Chloro-pyrimidin-4-yl)-piperidin-3-yl]-methyl-amine hydrochloride
CAS :Degré de pureté :95.0%Masse moléculaire :263.17001342773441-(4-((3'-Chloro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea
CAS :Degré de pureté :95.0%Masse moléculaire :366.85000610351562-[5-amino-3-(2-thienyl)-1H-pyrazol-1-yl]-6-methylpyrimidin-4(3H)-one
CAS :Degré de pureté :95.0%Masse moléculaire :273.309997558593752-chloro-6-methyl-3,4-dihydropyrimidin-4-one
CAS :Degré de pureté :98%Masse moléculaire :144.559997558593753-(2-CHLOROPYRIMIDIN-4-YL)-7-METHYL-1H-INDOLE
Degré de pureté :90.0%Masse moléculaire :243.690002441406255-cyclopropyl-N-(diaminomethylidene)-1-(quinolin-5-yl)-1H-pyrazole-4-carboxamide
CAS :Degré de pureté :98%Masse moléculaire :320.35598754882815-((tert-Butoxycarbonyl)amino)pyrimidine-2-carboxylic acid
CAS :Degré de pureté :95%Masse moléculaire :239.2310028076172Uridine-3'-monophosphate disodium salt
CAS :Degré de pureté :99.0%Couleur et forme :SolidMasse moléculaire :368.14498901367194-(Tert-butyl)-N-(4-(N-(2,6-dimethylpyrimidin-4-yl)sulfamoyl)phenyl)benzamide
CAS :Degré de pureté :98%Masse moléculaire :438.549987792968755,6-dimethyl-2-(pyridin-2-yl)-1,4-dihydropyrimidin-4-one
CAS :Degré de pureté :95%Masse moléculaire :201.22900399-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-3H-purin-6-one
CAS :Degré de pureté :97%Masse moléculaire :270.22000122070311-Methyl Xanthine-d3
CAS :Produit contrôlé<p>Applications A labelled metabolite of Theophylline.<br>References ottrup, A., et al.: Pharmacol. Toxicol., 67, 340 (1990), El-Kadi, A., et al.: Drug Metab. Dispos., 28, 1112 (2000), Kim, S., et al.: J. Med. Chem., 45, 2131 ( 2002), Hansel, T., et al.: Drugs Today, 40, 55 (2004),<br></p>Formule :C62H3H3N4O2Couleur et forme :NeatMasse moléculaire :169.163-Nitropyridine
CAS :Produit contrôlé<p>Applications Used in the novel synthesis of biologically active nitro heterocyclic compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pawar, N., et al.: Eur. J. Pharm. Sci., 21, 115 (2004), Badgujar, D., et al.: J. Sci. Ind. Res., 66, 250 (2007),<br></p>Formule :C5H4N2O2Couleur et forme :NeatMasse moléculaire :124.10(5-Methylpyrimidin-2-yl)methanamine hydrochloride
CAS :Degré de pureté :95.0%Masse moléculaire :159.6199951171875Phenylhydrazine
CAS :Produit contrôlé<p>Applications An aryl hydrazine used in the preparation of various dyes and pharmaceutical compounds. It is used in the investigation of oligosaccharides as well as the structure of photosystem II.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lattova, E. et al.: Meth. Mol. Biol., 534, 65 (2009); Anderson, L.B. et al.: J. Biol. Chem., 275, 4920 (2000);<br></p>Formule :C6H8N2Couleur et forme :Yellowish LiquidMasse moléculaire :108.14
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